Abstract: The present invention is concerned with the manufacture of solid dosage units (pharmaceutical and others). More specifically, the invention is related to powders of cross-linked amylose, having a specific cross-linking degree for use as tablet binders and disintegrants.

Abstract: A hard-candy based lozenge containing an antacid is produced in a manner compatible with a continuous process method of manufacture. Sucrose solution, corn syrup, and a carbonate antacid are mixed, the mixture is heated, the mixture is further heated and exposed to a vacuum. The mixture is then mixed with cold-flow enhancers, flavorings, and colorings, and finally tempered and formed into lozenges of exceptional efficacy and taste. The lozenges thus formed contain 600 mg of calcium carbonate or magnesium carbonate.

Abstract: Finely divided drug particles are coated with a lipid or bioadhesive polymer to form microspheres having a particle size of about 550 micrometers or less, and coated with two or more enteric coatings, at least one of which is water insoluble, to form microcapsules. The resultant microcapsules can be suspended in an aqueous solution to form stable oral doses of the drug.

Abstract: Disclosed are controlled rate-release devices for releasing a pharmaceutically active agent into the oral cavity by the dissolving action of the saliva, a process of preparing such devices and methods of preventing/treating conditions/diseases in a mammal by delivering a pharmaceutically active substance into the oral cavity.

Abstract: A pharmaceutical preparation for oral administration comprising(a) a core containing a medicinal active ingredient,(b) a press-coated layer comprising a pH-independently water-soluble polymer, said layer being provided around the core and(c) a film comprising an enteric polymer, said film being provided around the press-coated layer. In the pharmaceutical preparation of the present invention, the medicinal active ingredient is not released during residence in the stomach and, after forwarded from the stomach, until reaching a targeted site in the intestine, and thereafter is quickly released, so that the medicinal active ingredient is efficiently delivered to the targeted site in the intestinal tract.

Abstract: Novel coating materials for biomedical applications, particularly for use on biomedical implants, the coating material containing gel-derived titania where the material is capable of inducing calcium phosphate formation onto its surface under in vitro conditions, e.g. in a simulated body fluid and/or under in vivo conditions, processes for the preparation of the coating materials as well as their use in biomedical implant technology.

Abstract: The present invention relates to controlled release dosage forms composed of a naproxen layer which contains a delayed release granulate of naproxen compressed with an immediate release granulate of naproxen and an immediate release naproxen sodium layer compressed with the naproxen layer, designed to promptly exert a therapeutic effect while also maintaining the therapeutic blood concentration for a prolonged duration of 24 hours.

Abstract: The present invention is directed to methods of making a porous device utilizing at least one removable open-cell porous mold form comprising particles formed and shaped into a solidified mass of continuously interconnected particles defining continuously interconnected pores and connecting interstices. The primary mold form is made from a selected material comprising particles having predetermined sizes and shapes which is capable of forming a stable mold form under selected conditions and of being removed under selected conditions. The primary mold form can be used to mold a porous device directly or to mold a secondary mold form. Similarly, the secondary mold form can be used to mold a porous device directly or to mold a tertiary mold form. Depending on the number of mold forms used, the porous device contains pores and pore interconnections corresponding to either the continuously interconnected particles, or to the continuously interconnected pores.

Abstract: This invention is directed to a method of forming microencapsulated food or flavor capsules as well as the capsules produced by the method. The method includes providing food or flavor particles to be encapsulated, and forming a mixture of a warm water fish gelatin and the food or flavor particles in aqueous media. The method further includes microencapsulating the particles with the gelatin at elevated temperatures by complex coacervation to form the microencapsulated capsules. If desired, the method may further include the step of separating the capsules. In a preferred form, the method is conducted at a temperature of about 33.degree. C. to about 35.degree. C. Preferably, the warm water fish gelatin used in the encapsulation method has a bloom of from about 150 to about 300 bloom, more preferably from about 250 to about 300 bloom. Many different kinds of food or flavor particles may be used, such as for example, vegetable oil, lemon oil, garlic flavor, apple flavor or black pepper.

Abstract: The present invention relates to controlled-release microcapsules of acetylsalicylic acid which comprise particles of acetylsalicylic acid with a size of between 100 and 1000 .mu.m, coated with a coating material consisting of a mixture of a cellulosic film-forming polymeric derivative, an antiadherent, a plasticizer, a lubricant and a vinylic film-forming polymeric derivative. The invention further relates to a process for the preparation of said microcapsules.

Abstract: The present invention relates to compositions which provide both a skin cleansing and skin moisturizing benefit from the same product. These compositions provide improved lathering and cleansing characteristics, are extremely mild to the skin, and deliver a moisturizing agent to the skin. These compositions comprise at least one anionic surfactant, a dispersed, insoluble oil phase, at least one additional surfactant, an optional suspending agent, and water. This invention also relates to methods for providing combined cleansing and moisturization, and to methods for delivering these compositions as a foam.

Abstract: The present invention is related to a seamless capsule comprising a shell material encapsulating a center-filled core material, wherein the shell material is formed of a carbohydrate in glassy state, and a method and an apparatus for making the seamless capsule.

Abstract: Oral dosage forms are disclosed which are effective for treating of gastric disorders. The dosage forms contain, as active ingredients, famotidine and sucralfate. In the dosage form, the famotidine is provided with a barrier layer which prevents interaction between the famotidine and the sucralfate, which improves the stability of the dosage form.

Abstract: An improved wet powder, edible, film-forming composition for use in coating tablets and capsules consists essentially of powdered pigment particles, a film-forming, water soluble or water-dispersible, edible polymer and up to approximately 30% by weight of water. Such compositions are formed by blending the pigment particles and the polymer and applying the water onto the pigment-polymer blend in atomized form. Similar wet powder, edible, clear, film-forming compositions for use in coating tablets and capsules with a clear coating consist essentially of a film-forming, water soluble or water-dispersible, clear, edible polymer and up to approximately 30% by weight of water and are formed by applying the water onto the polymer in atomized form. The application of water in this manner preconditions the polymer and permits the preparation of smooth stable coating suspensions upon dilution with additional water and without the formation of fish eyes.

Abstract: A skin antiseptic and hand disinfectant composition is disclosed. The composition comprises a glycerol monoalkyl ether is a glycerol 1-C.sub.5 -C.sub.12 alkyl ether and an aliphatic C.sub.1 -C.sub.6 alkyl alcohol.

Abstract: A slow, release sodium valproate tablet with a coating layer, obtained by coating a core containing sodium valproate with a coating agent comprising ethyl cellulose having silicic acid anhydride dispersed therein. The slow-release tablets, while having a relatively small size, maintain a stable dissolution rate without being influenced by pH conditions to stably maintain the blood concentration of active agent over an extended period of time.

Abstract: The present invention is directed to methods of forming doubly porous devices having a first porous portion with continuously interconnected pores and a second porous portion with continuously interconnected pores utilizing at least one removable open-cell porous mold form. The mold form is made from a selected material comprising particles having predetermined sizes and shapes which is capable of forming a stable mold form under selected conditions and of being removed under selected conditions. At least one stable coating layer is molded from the mold form to define a membrane separating the first porous portion and the second porous portion of said device. Alternatively, two different materials can be molded with the mold form into a doubly porous device comprising interlocked materials.

Abstract: A biocidal protective coating for heat exchanger coils formed by applying a polymeric composition containing an organic water resistant polymer that has associated with it an effective amount of a biocidal compound to inhibit corrosion, fouling, and biocidal buildup on the coils.

Abstract: A microcrystalline cellulose-based excipient having improved compressibility, whether utilized in direct compression, dry granulation or wet granulation formulations, is disclosed. The excipient is an agglomerate of microcrystalline cellulose particles and from about 0.1% to about 20% silicon dioxide particles, by weight of the microcrystalline cellulose, wherein the microcrystalline cellulose and silicon dioxide are in intimate association with each other. The silicon dioxide utilized in the novel excipient has a particle size from about 1 nanometer to about 100 microns. Most preferably, the silicon dioxide is a grade of colloidal silicon dioxide.

Abstract: A process for quality control in tablet production by pressing by means of influencing the pressing force, the weight, the hardness, and the height of the tablets by means of a control mechanism. The task of the invention is to develop a process of the type according to this concept, according to which all necessary control mechanisms for maintaining a constant tablet weight, tablet height, and tablet hardness operate in such a way that a rapid control of deviations is assured, and according to which, the limiting values can be optimized automatically, is hereby resolved in that the control system is divided into several influential and essentially parallel running control circuits for the simultaneous control of the pressing force as well as the tablet parameters of weight, height, and hardness.