Abstract: The invention relates to a thermal process for the production of directly tablettable granules and pharmaceutical preparations produced therefrom.
Type:
Grant
Filed:
May 23, 1995
Date of Patent:
September 16, 1997
Assignee:
Bayer Aktiengesellschaft
Inventors:
Ingrid Hurner, Peter Danz, Reinhard Walter, Joachim Maasz, Georg Frank
Abstract: Antacids comprise a pharmaceutically acceptable gum coated with simethicone and a pharmaceutically acceptable antacid to provide prolonged antacid treatment to the stomach while preventing acid rebound. Compatible active ingredients can be included in the antacids, including analgesics, antibiotics, gold salts, and fluorine compounds.
Abstract: In accordance with the present invention, there are provided compositions useful for the in vivo delivery of a biologic, wherein the biologic is associated with a polymeric shell formulated from a biocompatible material. The biologic can be associated with the polymeric shell itself, and/or the biologic, optionally suspended/dispersed in a biocompatible dispersing agent, can be encased by the polymeric shell. In another aspect, the biologic associated with polymeric shell is administered to a subject, optionally dispersed in a suitable biocompatible liquid.
Type:
Grant
Filed:
June 7, 1995
Date of Patent:
September 9, 1997
Assignee:
Vivorx Pharmaceuticals, Inc.
Inventors:
Mark W. Grinstaff, Patrick Soon-Shiong, Michael Wong, Paul A. Sandford, Kenneth S. Suslick, Neil P. Desai
Abstract: In accordance with the present invention, there are provided compositions useful for the in vivo delivery of a biologic, wherein the biologic is associated with a polymeric shell formulated from a biocompatible material. The biologic can be associated with the polymeric shell itself, and/or the biologic, optionally suspended/dispersed in a biocompatible dispersing agent, can be encased by the polymeric shell. In another aspect, the biologic associated with polymeric shell is administered to a subject, optionally dispersed in a suitable biocompatible liquid.
Type:
Grant
Filed:
June 7, 1995
Date of Patent:
September 9, 1997
Assignee:
Vivorx Pharmaceuticals, Inc.
Inventors:
Mark W. Grinstaff, Patrick Soon-Shiong, Michael Wong, Paul A. Sandford, Kenneth S. Suslick, Neil P. Desai
Abstract: Stable, pharmaceutical ketoprofen salts for oral administration are provided in oily solutions to avoid direct contact of acid forms of ketoprofen with the gastric or duodenal mucus membranes. Sodium, arginine, lysine and/or N-methylglucamine salts of ketoprofen are disclosed in solutions of polyoxyethyenatide vegetable oil, castor oil, esters of fatty acids and/or polyols. These oily solutions of ketoprofen may be administered orally in capsule form.
Abstract: A composition comprising material from the following herbs: Panax pseudo-ginseng Wall, Isatis Indigotica Fort, Ganoderma lucidum Karst, Dendranthema morifolium Tzvel, Glycyrrhiza glabra L., Scutellaria baicalensis Georgi, Rabdosia rubescens, Serenoa repens. Preferably, the material from each of such herbs is an alcohol extract of dried, cut plants and of the Panax the pseudo-ginseng Wall and each of the other materials are present in a dried, weight-to-weight range of about 1:1-6. The composition is administered orally or by suppository.
Abstract: A method of manufacturing a stabilized, essentially sodium free, granular aspirin compound mixed with a granular potassium bicarbonate compound comprising the steps of determining a desirable dose size of such aspirin compound which is to be packaged. Weighing out an amount of granular aspirin based on the dose size determined. Placing an amount of such granular potassium bicarbonate compound into a container which is uniformly distributed over a bottom surface of such container to a predetermined depth. Placing such container into a heat treating apparatus. Heat treating the granular potassium bicarbonate compound at a temperature which is at least sufficient to convert an outer surface layer of such granular potassium bicarbonate compound to potassium carbonate and for a time which is at least sufficient to ensure that essentially all of such outer surface layer of the granular potassium bicarbonate compound is converted to such potassium carbonate.
Abstract: A method for modulating the immune system by administering one or more vitamin D (analogues) to a subject in need of immune therapy, which method may (but need not) include simultaneous treatment with a second immune system modulating active agent. Preferably, the treatment method is used to induce primary or secondary prevention of type I diabetes in a subject susceptible to type I diabetes. Administration of the vitamin D (analogues) is enteral or parenteral.
Type:
Grant
Filed:
September 1, 1994
Date of Patent:
September 9, 1997
Assignee:
K.U. Leuven Research & Development
Inventors:
Chantal Mathieu, Mark Waer, Roger Bouillon
Abstract: A product for killing subsurface and surface soil pathogens including nematodes, wire worms, cut worms, worms, insects, fungi and plant and soil surface pests comprises an extract derived from the plant Tagetes minuta. The extract may be obtained by subjecting whole or parts of the plant Tagetes minuta to steam distillation or the plant or plant parts may be steeped in water for a predetermined period of time to produce a liquid brew. The liquid brew may be solubilized with cellulolytic enzymes or cellulytic organisms. Solvents may also be used to solubilize the extracted brew. The extract may desicated to form a powder and the powder may be compressed to form pellets.
Type:
Grant
Filed:
February 1, 1995
Date of Patent:
September 2, 1997
Inventors:
David Mocheo Okioga, Ambrose Harry Rajamannan
Abstract: The present invention relates to a pharmaceutical composition in a unit dosage form for peroral administration in a human or lower animal, having a gastrointestinal tract comprising a small intestine and a colon with a lumen therethrough having an inlet to the colon from the small intestine, comprising:a. a safe and effective amount of rapidly dissolving bisacodyl incorporated into or coated on the surface of a dosage form selected from the group consisting of a spherical substrate, an elliptical substrate, a hard capsule, or a compressed tablet, with a maximum diameter of about 3 mm to about 10 mm; andb. an enteric polymer coating material comprising at least one inner coating layer and one outer coating layer;wherein the dosage form has a smooth surface free from edges or sharp curves; the elliptical substrate and the hard capsule have a ratio of the long to short diameters of no greater than about 1.
Type:
Grant
Filed:
May 17, 1995
Date of Patent:
August 12, 1997
Assignee:
The Procter & Gamble Company
Inventors:
Gary Robert Kelm, Gary Lee Manring, Paula Denise Davis, Douglas Joseph Dobrozsi, Kenneth Gary Mandel
Abstract: The invention discloses a swallow tablet which is capable of disintegrating within less than about fifteen minutes and providing fast delivery of therapeutic drugs. The delivery system is composed of between 0.250 and 1.0 Gm of an alkali metal or alkaline-earth metal salt of an edible organic acid. A preferred delivery system is trisodium citrate.
Abstract: Disclosed herein are dietary lipid digestion-absorption inhibitory agents and ingesta, comprising as an active ingredient a mixture of chitosan and ascorbic acid or a salt thereof. Also disclosed is a therapeutic method for obesity, which comprises administering an effective amount of a mixture of chitosan and ascorbic acid or salt thereof to a person who requires treatment for obesity.
Abstract: The invention provides an agglomerate composition composed of units of aggregated fine particles and methods for its manufacture and use. The agglomerate composition units are composed of fine particles having a mean particle size in the range of 1 .mu.m to 5 .mu.m, and usually includes a medicament powder. The agglomerate units have a mean size in the range from 200 .mu.m to 500 .mu.m and have a friability index in the range from about 10 to 60.
Type:
Grant
Filed:
June 7, 1995
Date of Patent:
August 5, 1997
Assignee:
Inhale Therapeutic Systems
Inventors:
Keith A. Johnson, Marc S. Gordon, Shirley W. Lyons
Abstract: A magnetically controllable, or guided, carrier composition and methods of use and production are disclosed, the composition for carrying biologically active substances to a treatment zone in a body under control of a magnetic field. The composition comprises composite, volume-compounded ferrocarbon particles of 0.2 to 5.0 .mu.m in size, and preferably between 1.0 and 4.0 .mu.m, containing 1.0 to 95.0% by volume of carbon, and preferably between about 20 and 50%. The particles are produced by a joint deformation of a mechanical mixture of iron and carbon powders. The obtained particles are placed in a solution of a biologically active substance to absorb the substance onto the particles. The combination is administered in suspension.
Type:
Grant
Filed:
June 7, 1995
Date of Patent:
July 29, 1997
Assignee:
Magnetic Delivered Therapeutics, Inc.
Inventors:
Viktor A. Volkonsky, Sergei D. Dvukhsherstnov, Sergei V. Chernyakov
Abstract: A pharmaceutical dosage form is prepared from a multiplicity of coated potassium chloride crystals coated with two distinct layers, the first of ethylcellulose and the second of a hydrophilic coating polymer, preferably hydroxypropylcellulose, resulting in microcapsules. These microcapsules are capable of being compressed into tablets of suitable hardness and friability with minimum quantities of excipients. The resultant controlled release tablets are useful for treatment of potassium deficiencies in humans.
Abstract: In accordance with the present invention, there are provided compositions useful for the in vivo delivery of a biologic, wherein the biologic is associated with a polymeric shell formulated from a biocompatible material. The biologic can be associated with the polymeric shell itself, and/or the biologic, optionally suspended/dispersed in a biocompatible dispersing agent, can be encased by the polymeric shell. In another aspect, the biologic associated with polymeric shell is administered to a subject, optionally dispersed in a suitable biocompatible liquid.
Type:
Grant
Filed:
June 7, 1995
Date of Patent:
July 22, 1997
Assignee:
Vivorx Pharmaceuticals, Inc.
Inventors:
Mark W. Grinstaff, Patrick Soon-Shiong, Michael Wong, Paul A. Sandford, Kenneth S. Suslick, Neil P. Desai
Abstract: A fast dissolving, solid dosage form defined by a matrix containing gelatin, pectin and/or soy fiber protein and one or more amino acids having from about 2 to 12 carbon atoms is disclosed.
Type:
Grant
Filed:
May 22, 1995
Date of Patent:
July 15, 1997
Assignee:
Janssen Pharmaceutica Inc.
Inventors:
Dilip J. Gole, R. Saul Levinson, Paul K. Wilkinson, J. Desmond Davies
Abstract: The present invention reveals a multiple dosage medicine drop bottle or medicinal container having a germicide on at least the outside tip of the bottle or container. The present invention also reveals a method for reducing or eliminating the risk of contamination of the multiple dose medicine drop bottle or medicinal container and it contents. The bottle or container may also contain an aqueous solution of an anticlotting agent.
Abstract: A composition that describes a clear, colorless, odorless, aqueous solution that is safe and effective in restoring and maintaining normalcy of the keratinous tissues and the adjacent tissues of finger and toe nails and equine hooves. Cracking, splitting, peeling and breakage of nails and hooves caused by environmental factors that denature peptide bonds of keratin, interrupts water and lipid balance and further interrupts growth and normal metabolic processes, is stopped and compositional balance is re-established by application of the solution. The composition is effective for keratinous tissues that are either too dry or too wet. Application by dropper bottles or sprays is quick, easy and not messy. Beneficial effects are observed in 1-2 weeks and reinforcement treatments are required only once or twice per week, or as required to maintain normal status.
Abstract: Modified amino acid compounds useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
Type:
Grant
Filed:
October 25, 1994
Date of Patent:
July 1, 1997
Assignee:
Emisphere Technologies, Inc.
Inventors:
Andrea Leone-Bay, Duncan R. Paton, Koc-Kan Ho, Frenel DeMorin