Abstract: A method of monitoring neural activity responsive to a stimulus in a brain, the method comprising: applying the stimulus to one or more of at least one electrode implanted in a target neural structure of the brain; detecting a resonant response from the target neural structure evoked by the stimulus at one or more of the at least one electrode in or near the target neural structure of the brain; and determining one or more waveform characteristics of the detected resonant response.

Abstract: Provided herein are exemplary systems and methods for using artificial intelligence for vehicle performance and tracking. The system and method are comprised of a plurality of sensory input devices such as ultra-wideband (UWB) positioned throughout the course, the sensors detecting vehicle movement and relaying data regarding vehicle movement to an onboard user device. The onboard user device may push such data to a central processing hub, which may then push such data to a cloud storage network. Additional users may access the data by way of the central processing hub or cloud storage network. Further embodiments may include a vehicular electronic control unit relaying internal vehicle data to the system, and the use of large language models and/or neural networks.

Abstract: Provided herein are methods and compositions for the capture of nucleic acids, for example by using a nucleic acid-guided nuclease-based system.

Abstract: A filter arrangement for a vacuum cleaning appliance includes: a filter enclosure having an enclosure opening; a filter configured to be received through the enclosure opening into the filter enclosure in an insertion direction; and retention means operable between latched and unlatched states for releasably retaining the filter in the filter enclosure. The filter includes an actuation portion configured to operate the retention means, wherein the actuation portion is moveable between at least first and second positions and is biased towards the second position. When the filter is in the filter enclosure, movement of the actuation portion in the insertion direction from the first position to a depressed position transitions the retention means to the unlatched state, whereinafter the actuation portion is moved to the second position in which at least a part of the actuation portion is elevated above the enclosure opening.

Abstract: A method of synchronising audio content arranged to be played by a second device with video content played by a first device, wherein the second device includes a camera, comprises: capturing at least a portion of the video content with the camera; performing image recognition on the captured video content to identify a set time point in the audio content; and commencing playing the audio content from a selected time point in the audio content corresponding to the set time point, such that the audio content is synchronous with the video content. A method of pre-preparing video content for use in such a synchronisation method is also described.

Abstract: The present disclosure generally relates to managing user profiles. An example method includes, at a computer system in communication with a display generation component and an input device: receiving, via the input device, a user input including a request to access a first restricted media item; and in response to the user input: in accordance with a determination the user input is a voice input and the voice input corresponds to a user profile authorized to access the first restricted media item using voice inputs, initiating playback of the first restricted media item; and in accordance with a determination the user input is a voice input and the voice input does not correspond to a user profile authorized to access the first restricted media item using voice inputs: forgoing initiating playback of the first restricted media item; and causing display, at the display generation component, of a validation user interface.

Abstract: The invention provides methods of modulating and regulating NHD protein-protein interactions through nicotinamide mononucleotide, analogs and derivatives thereof, such as NAD+. Such modulation may be useful in methods of treating and preventing cancer, aging, cell death, radiation damage, radiation exposure, among others, may improve DNA repair, cell proliferation, cell survival, among others, and may increase the life span of a cell or protect it against certain stresses, among others.

Abstract: A device for cleansing and applying a composition to the hair, including a body structure having a first, dispensing opening and a second, vacuum opening, a nebulizer with an outlet connected to the first, dispensing opening, a vacuum system with an inlet connected to the second, vacuum opening, and a handle extending the body structure, the body structure having a support having a peripheral edge delimited by a perimeter line, and application elements extending from a longitudinal face of the support.

Abstract: Disclosed are methods of synthesis and/or purification of certain 3,7-diamino-phenothiazin-5-ium compounds (“diaminophenothiazinium compounds”) including Methylthioninium Chloride (MTC) (Methylene Blue), and the resulting high purity characterized by a purity greater than 98%, and very low levels of heavy metals and organic impurities Azure A, B, C and MVB. Also disclosed are methods of treatment of a tauopathy or methemoglobinemia in a patient in need thereof, comprising administering to the patient a therapeutically effective amount of the high-purity diaminophenothiazinium compound.

Abstract: Described are methods of preparing reduced 3,7-diamino-10H-phenothiazine (DAPTZ) compounds of formula: wherein: R1 and R9 are independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of R3NA and R3NB is independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of R7NA and R7NB is independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of HX1 and HX2 is independently a protic acid; and pharmaceutically acceptable salts, solvates, and hydrates thereof. These methods are particularly useful for producing stable reduced forms, and with high purity. The stability and purity are especially relevant for pharmaceutical compositions for the treatment of disease. The compounds are useful for treatment of e.g. tauopathies, such as Alzheimer's disease, and also as prodrugs for the corresponding oxidized thioninium drugs.

Abstract: The present invention relates to a method of treating or preventing DNA damage in a cell or cellular senescence of a cell or induction of the senescence associated secretory phenotype (SASP) in a cell, or for treating or preventing the effects of aging, or for preventing or treating cellular senescence and/or induction of SASP associated with high caloric intake or obesity, or for reducing the side effects of chemotherapy, radiotherapy, corticoid treatment, anti-retroviral treatment, or PPAR? agonist treatment comprising administering an effective amount of an NAD+ agonist.

Abstract: An apparatus may include a drift tube assembly, comprising a plurality of drift tubes to conduct an ion beam along a beam propagation direction. The plurality of drift tubes may define a multi-gap configuration corresponding to a plurality of acceleration gaps, wherein the plurality of drift tubes further define a plurality of RF quadrupoles, respectively. As such, the plurality of quadrupoles are arranged to defocus the ion beam along a first direction at the plurality of acceleration gaps, respectively, where the first direction extends perpendicularly to the beam propagation direction.

Abstract: A processing system may include a plasma chamber operable to generate a plasma, and an extraction assembly, arranged along a side of the plasma chamber. The extraction assembly may include an extraction plate including an extraction aperture, the extraction plate having a non-planar shape, and generating an extracted ion beam at a high angle of incidence with respect to a perpendicular to a plane of a substrate, when the plane of the substrate is arranged parallel to the side of the plasma chamber.

Abstract: New lettuce varieties designated ‘Paonia’ and ‘Newcastle’ are described. ‘Paonia’ and ‘Newcastle’ are lettuce varieties exhibiting stability and uniformity.

Abstract: An apparatus may include a drift tube assembly having a plurality of drift tubes to conduct an ion beam along a beam propagation direction. The plurality of drift tubes may define a multi-gap configuration corresponding to a plurality of acceleration gaps, wherein at least one powered drift tube of the drift tube assembly is coupled to receive an RF voltage signal. The apparatus may also include a DC electrode assembly that includes a conductor line, arranged within a resonator coil that is coupled to receive a DC voltage signal into the at least one powered drift tube. The DC electrode assembly may also include a DC electrode arrangement, connected to the conductor line and disposed within the at least one powered drift tube.

Abstract: A device for autonomously folding a deformable article includes a rotatable platform configured to receive the deformable article and at least one movable elongation in operable communication with at least one elongation drive. The at least one movable elongation is configured to raise and lower from the surface of the rotatable platform, move parallel to the surface, and manipulate the deformable article to thereby fold the deformable article at one of the one or more fold lines. The device includes a table drive configured to rotate the rotatable platform about a central axis such that the at least one elongation aligns with one of the one or more fold lines, and at least one sensor configured to detect the deformable article position and orientation on the rotatable platform. A controller is in operable communication with the at least one elongation drive, the table drive, and the at least one sensor.

Abstract: Three-dimensional (3D) visualization of multi-layer networks include receiving data associated with a network, wherein the network includes interconnected network elements that operate at a plurality of levels that include any of network layers and encapsulations; displaying a plurality of three-dimensional icons each represent one of a plurality of network elements of the interconnected network elements; and displaying links between the plurality of three-dimensional icons each link representing one of a network layer connection and an encapsulation connection.

Abstract: A drug injection device includes a last dose setting having a main drive pin, a drive wheel, a driven wheel, an abutment element fixedly coupled to, or integrally formed with, the driven wheel. The drive wheel has a rotation axis parallel to a longitudinal axis and is configured to be driven about the longitudinal axis by a knob and to be periodically driven in rotation about the rotation axis by the main drive pin, during a drug dose setting. The driven wheel has a second rotation axis parallel or coaxial to said longitudinal axis and is configured to be periodically driven about the longitudinal axis by the drive wheel. The abutment element is configured to prevent the rotation of the drive wheel about the longitudinal axis when the knob has made a predetermined number of full and/or partial rotations about the longitudinal axis correlated to the predetermined drug volume.

Abstract: Pump maintenance data associated with each of plural components of each of plural frac pumps of each of plural frac pump transports of a frac fleet is accessed. The pump maintenance data includes usage data of plural well completion operations performed by the frac fleet. The usage data indicates actual component life intervals of each of the plural components and corresponding operating conditions. The pump maintenance data is analyzed to generate a maintenance prediction model that is configured to output for each of the plural components, a predicted component life interval as a function of an operating condition. A current operating condition corresponding to a current well completion operation of the frac fleet is accessed. The maintenance prediction model is applied to generate the predicted component life intervals for each of the plurality of components of the frac fleet based on the current operating condition.

Abstract: Well completion design data for completing plural stages of a well completion operation is accessed. Predicted component life intervals for each of a plurality of components of a frac fleet are accessed. Remaining component life intervals for each of the plurality of components of the frac fleet are determined based on the predicted component life intervals. A continuous completion event for the well completion operation is set based on the remaining component life intervals for each of the plurality of components. The continuous completion event includes a continuous pumping block identifying one or more contiguous stages from among the plurality of stages during which the well completion operation is performed with the frac fleet, and a maintenance block identifying one or more of the plurality of frac pumps to be subject to predetermined maintenance operations upon completion of the one or more contiguous stages of the continuous pumping block.