Abstract: The present invention relates to heterocyclic compounds, pharmaceutical compositions thereof, and methods which may be useful as inhibitors of IGF-1R for the treatment or prevention of thyroid eye disease (TED), also known as thyroid-associated ophthalmopathy (TAO), or Graves' ophthalmopathy or orbitopathy (GO).

Abstract: A chiplet-based architecture provides for a reduction in cache synchronization operations by tracking a relationship between chiplet execution kernels and array operands to elide synchronization when particular arrays are not in use in the caches of other chiplets or when the current target chiplet already has the array operand. Further efficiency is promoted in some embodiments by assigning chiplets for reuse based on previously received arrays.

Abstract: Well completion design data for completing plural stages of a well completion operation is accessed. Predicted component life intervals for each of a plurality of components of a frac fleet are accessed. Remaining component life intervals for each of the plurality of components of the frac fleet are determined based on the predicted component life intervals. A continuous completion event for the well completion operation is set based on the remaining component life intervals for each of the plurality of components. The continuous completion event includes a continuous pumping block identifying one or more contiguous stages from among the plurality of stages during which the well completion operation is performed with the frac fleet, and a maintenance block identifying one or more of the plurality of frac pumps to be subject to predetermined maintenance operations upon completion of the one or more contiguous stages of the continuous pumping block.

Abstract: The present invention relates to regulatory nucleic acid sequences, in particular muscle-specific promoters, elements thereof, and other such nucleic acid sequences, that are capable of enhancing muscle-specific expression of genes. The invention also relates to expression constructs, vectors and cells comprising such muscle-specific regulatory nucleic acid sequences, and to methods of their use. The regulatory nucleic acid sequences are of particular utility for gene therapy applications, but also find utility in other areas such as bioprocessing and biotechnology.

Abstract: A device comprises a treatment system to treat scalp or hair; one or more sensors configured to detect at least one spatial condition selected from device contact with scalp or hair, device distance to scalp or hair, and device location in relation to scalp or hair; a controller configured to send instructions to adjust the treatment system based on the detected spatial condition of the device.

Abstract: Provided are materials for making a hand rolled smoking article having a novel sheet. The sheet can include a rectangular portion and an irregular shaped portion. The sheet can be manufactured from tobacco leaf or foil, homogenized tobacco paper, or conventionally available rolling paper. The sheet can be filled with a filler material and rolled to form a cigar or cigarette.

Abstract: Embodiments described herein relate to a device for attenuating ultraviolet radiation in an air handling system, wherein the device is arranged for insertion in a ducting section of the air handling system, the device comprising: a plurality of elongate flow passages, wherein each of the plurality of elongate flow passages is configured to permit airflow through the elongate flow passage from an inlet of the device to an outlet of the device; wherein each of the elongate flow passages comprises one or more internal walls comprising a coating configured to absorb a proportion of incident ultraviolet radiation.

Abstract: An improved approach for the securement of digital objects is proposed, that, as described in various embodiments, can include increased levels of encryption, air-gap segregation, and redundancy for interaction with secure approved client withdrawal addresses. A combination of computational and physical securement approaches are described that provide a practical mechanism for improving security of transactions that are conducted using cryptographic systems that addresses security vulnerabilities related to uncontrolled transaction flow. Specifically, methods are proposed for implementation on computing devices which interact with a two-part air-gapped system that is adapted to control both a secure address approval process, and a withdrawal process to the approved address. These processes operate in combination.

Abstract: Embodiments herein are directed to a linear accelerator assembly for an ion implanter. In some embodiments, a LINAC may include a coil resonator and a plurality of drift tubes coupled to the coil resonator by a set of flexible leads.

Abstract: Provided herein are engineered nucleic acids (e.g., expression vectors, including viral vectors, such as lentiviral vectors, adenoviral vectors, AAV vectors, herpes viral vectors, and retroviral vectors) that encode OCT4; KLF4; SOX2; or any combination thereof that are useful, for example, in inducing cellular reprogramming, tissue repair, tissue regeneration, organ regeneration, reversing aging, or any combination thereof. Also provided herein are recombinant viruses (e.g., lentiviruses, alphaviruses, vaccinia viruses, adenoviruses, herpes viruses, retroviruses, or AAVs) comprising the engineered nucleic acids (e.g.

Abstract: A load lock in which the pumping speed is controlled so as to minimize the possibility of condensation is disclosed. The load lock is in communication with a vacuum pump and a valve. A controller is used to control the valve such that the supersaturation ratio within the load lock does not exceed a predetermined threshold, which is less than or equal to the critical value at which vapor condenses. In certain embodiments, a computer model is used to generate a profile, which may be a pumping speed profile or a pressure profile, and the valve is controlled according to the profile. In another embodiment, the load lock comprises a temperature sensor and a pressure sensor. The controller may calculate the supersaturation ratio based on these parameters and control the valve accordingly.

Abstract: The invention provides methods and compositions for inhibiting CD38 activity, and methods of treating or preventing various disorders associated with CD38 activity.

Abstract: A reimaging lens assembly includes a pentaprismatic optic that includes two reflective surfaces and two refractive surfaces. The reflective surfaces are powered surfaces, and the reflective surfaces may be spherical, aspherical, and/or freeform reflective surfaces. The pentaprismatic optic may receive light from a wide field of view (WFOV), and may change the angle of the output light from that of the input light, for example by 90 degrees. The pentaprismatic optic may be coupled to an image receiver, such as a cooled or uncooled camera. The reimaging lens assembly may include further optical elements between the pentaprismatic optic and the image receiver, such as one or more lenses, filters, and/or cold stops. The lens assembly provides a compact system, with a small number of optical elements, and with desensitized output that reduces image jitter.

Abstract: The disclosure relates to embodiments of optical measurement systems that are configured to perform spectroscopic measurements. The optical measurement systems are configured to provide compact arrangements for introducing light into a sample and collecting light returned from the sample. Reducing the size of the launch and/or collection architecture of an optical measurement system may make the overall optical measurement system smaller, thereby providing flexibility in integrating an optical measurement system into various form factors.

Abstract: Disclosed is a system and method for classifying a message comprising a text to determine whether to assign one or more classification categories to the message. The method comprises evaluating the received message using two or more general evaluators; analysing the received message to determine values of one or more properties of the received message; and determining a classification output on the basis of outputs of the general evaluators, dependent on the values of the one or more properties of the received message.

Abstract: The present disclosure generally relates to managing user profiles. An example method includes, at a computer system in communication with a display generation component and an input device: performing a configuration process for the computer system, wherein the configuration process includes in accordance with a determination that a set of personalized voice recognition criteria is not met for an active user profile of the computer system, causing display, via the display generation component, of a set of one or more user interfaces including an option that, when selected, initiates a process that enables voice recognition for the active user profile; and in accordance with a determination that the set of personalized voice recognition criteria is met for the active user profile, proceeding with the configuration process without providing the option to enable voice recognition for the active user profile during the configuration process.

Abstract: Some examples of the disclosure are directed to systems and methods for presenting extended reality environments and, more particularly, to displaying one or more images relating to exercises in a physical environment while presenting an extended reality environment. In some situations, the electronic device detects an initiation of an exercise activity of a user of the electronic device using at least an optical sensor. In some examples, the electronic device presents a user interface including a representation of the identified exercise activity in the extended reality environment. In some examples, in response to detecting progression of the identified exercise activity, the user interface is updated with the updated representation of the exercise activity. In some examples, the electronic device presents a rest user interface during rest periods and/or after detecting rest.

Abstract: A computer-implemented method for dynamic resource management can include evaluating, by at least one processor, whether a priority of one or more processes associated with a request for one or more shared resources meets a threshold condition. The method can additionally include determining, by the at least one processor and in response to an evaluation that the priority meets the threshold condition, whether the one or more shared resources is available to meet the request. The method can further include completing, by the at least one processor and in response to a determination that the one or more shared resources is available, execution of the one or more processes. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: The parameters of an optical code are optimized to achieve improved signal robustness, reliability, capacity and/or visual quality. An optimization program can determine spatial density, dot distance, dot size and signal component priority to optimize robustness. An optical code generator employs these parameters to produce an optical code at the desired spatial density and robustness. The optical code is merged into a host image, such as imagery, text and graphics of a package or label, or it may be printed by itself, e.g., on an otherwise blank label or carton. A great number of other features and arrangements are also detailed.