Patents by Inventor A. Sinclair

A. Sinclair has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12274733
    Abstract: Provided herein are engineered nucleic acids (e.g., expression vectors, including viral vectors, such as lentiviral vectors, adenoviral vectors, AAV vectors, herpes viral vectors, and retroviral vectors) that encode OCT4; KLF4; SOX2; or any combination thereof that are useful, for example, in inducing cellular reprogramming, tissue repair, tissue regeneration, organ regeneration, reversing aging, or any combination thereof. Also provided herein are recombinant viruses (e.g., lentiviruses, alphaviruses, vaccinia viruses, adenoviruses, herpes viruses, retroviruses, or AAVs) comprising the engineered nucleic acids (e.g.
    Type: Grant
    Filed: September 27, 2019
    Date of Patent: April 15, 2025
    Assignee: President and Fellows of Harvard College
    Inventors: David A. Sinclair, Yuancheng Lu
  • Publication number: 20250116851
    Abstract: A reimaging lens assembly includes a pentaprismatic optic that includes two reflective surfaces and two refractive surfaces. The reflective surfaces are powered surfaces, and the reflective surfaces may be spherical, aspherical, and/or freeform reflective surfaces. The pentaprismatic optic may receive light from a wide field of view (WFOV), and may change the angle of the output light from that of the input light, for example by 90 degrees. The pentaprismatic optic may be coupled to an image receiver, such as a cooled or uncooled camera. The reimaging lens assembly may include further optical elements between the pentaprismatic optic and the image receiver, such as one or more lenses, filters, and/or cold stops. The lens assembly provides a compact system, with a small number of optical elements, and with desensitized output that reduces image jitter.
    Type: Application
    Filed: October 6, 2023
    Publication date: April 10, 2025
    Applicant: Raytheon Company
    Inventors: Matthew A. Sinclair, Robert B. Chipper
  • Publication number: 20250114380
    Abstract: The invention provides methods and compositions for inhibiting CD38 activity, and methods of treating or preventing various disorders associated with CD38 activity.
    Type: Application
    Filed: June 10, 2024
    Publication date: April 10, 2025
    Applicants: President and Fellows of Harvard College, Mayo Foundation for Medical Education and Research
    Inventors: David A. Sinclair, Nathan L. Price, Eduardo N. Chini, Jon C. Clardy, Shugeng Cao
  • Patent number: 12252505
    Abstract: Provided herein are methods and compositions for preventing or treating aging, or an aging-related disorder, a disorder associated with inflammation, or for modulating an immune response in a subject in need thereof. In some embodiments, the methods comprise administering to the subject an effective amount of a compound of Formulas I-XIII.
    Type: Grant
    Filed: October 16, 2019
    Date of Patent: March 18, 2025
    Assignee: President and Fellows of Harvard College
    Inventors: David A. Sinclair, Conrad Rinaldi
  • Publication number: 20250067553
    Abstract: The present disclosure provides an OCT imaging system to reduce or eliminate frequency-domain aliasing artifacts. The frequency is shifted using a carrier frequency to define a sampling range substantially centered on the carrier frequency. An image of the sample is generated from a displayed imaging range that consists of a subset of the frequencies within the sampling range. Furthermore, the system may be configured to determine the carrier frequency such that a Nyquist frequency corresponding to the shifted frequency is extended beyond either an upper or a lower bound of an OCT quality envelope corresponding to the first portion of light. Additionally, the carrier frequency may be determined such that a lower bound of the OCT quality envelope is greater or less than a zero-frequency DC limit.
    Type: Application
    Filed: November 12, 2024
    Publication date: February 27, 2025
    Applicant: NINEPOINT MEDICAL, INC.
    Inventors: Eman Namati, Muhammad Al-Qaisi, Matthew A. Sinclair, Benedikt Graf, David Vader
  • Patent number: 12235362
    Abstract: A LiDAR system includes an array of optical emitters, an objective lens optically coupling each optical emitter to a respective unique portion of a field of view, an optical switching network coupled between a laser and the array of optical emitters and a controller coupled to the optical switching network and configured to cause the optical switching network to route light from the laser to a sequence of the optical emitters according to a dynamically varying temporal pattern and to vary the temporal pattern in a way that reduces risk of eye injury from the laser light.
    Type: Grant
    Filed: October 25, 2019
    Date of Patent: February 25, 2025
    Inventors: Michael G. Moebius, Steven J. Spector, Steven J. Byrnes, Christopher Bessette, Scott Evan Lennox, Matthew A. Sinclair, Francis J. Rogomentich
  • Publication number: 20250059054
    Abstract: The present disclosure relates to precipitated silicas characterized by a primary particle size mean of greater than 80 nm, a BET surface area of 10-40 m2/g, a total mercury intruded volume of 0.75-2.00 cc/g and an oil absorption of 60-120 cc/100 g. The inventive silica is produced by a process comprises (a) continuously feeding an acid and an alkali metal silicate or alkaline earth metal into a liquid medium at a silicate addition rate V1 and a temperature 70-96° C. with stirring to form the silica particles, (b) stopping the feed of alkali metal silicate or alkaline earth metal silicate and acid and then increasing the temperature to 90 to 100° C. with stirring, (c) adding an alkali metal silicate or alkaline earth metal silicate and an acid with stirring, wherein the silicate addition rate is 1 to 40% of the silicate addition rate V1 and the pH value of 9.0 to 10.
    Type: Application
    Filed: December 8, 2022
    Publication date: February 20, 2025
    Applicant: EVONIK OPERATIONS GMBH
    Inventors: Karl W. GALLIS, Fitzgerald A. SINCLAIR, Terry W. NASSIVERA, Michael S. DARSILLO, Eric G. LUNDQUIST
  • Patent number: 12169124
    Abstract: The present disclosure provides an OCT imaging system to reduce or eliminate frequency-domain aliasing artifacts. The frequency is shifted using a carrier frequency to define a sampling range substantially centered on the carrier frequency. An image of the sample is generated from a displayed imaging range that consists of a subset of the frequencies within the sampling range. Furthermore, the system may be configured to determine the carrier frequency such that a Nyquist frequency corresponding to the shifted frequency is extended beyond either an upper or a lower bound of an OCT quality envelope corresponding to the first portion of light. Additionally, the carrier frequency may be determined such that a lower bound of the OCT quality envelope is greater or less than a zero-frequency DC limit.
    Type: Grant
    Filed: May 15, 2023
    Date of Patent: December 17, 2024
    Assignee: NINEPOINT MEDICAL, INC.
    Inventors: Eman Namati, Muhammad Al-Qaisi, Matthew A. Sinclair, Benedikt Graf, David Vader
  • Publication number: 20240369814
    Abstract: A multi-band/multi-polarization reflective or catadioptric optical system yields differing effective focal lengths (EFLs) per band/polarization. This approach could be used to create an imaging system, for example. In such case, a sensor (imager, spectrometer, diode, etc.) is located at the one or more focal planes. On the other hand, it could also be used to create a projecting system or hybrid projecting and imaging system by locating an emitter such as an LED, laser, etc.) at the image or focal plane. The system employs polarizers and/or dichroic coatings nano patterns to create different focal lengths and/or fields of view using the same mirrors and/or lenses by, for example, including at least one dichroic coating optically in front of at least one additional mirror to separately reflect the different bands or polarizations.
    Type: Application
    Filed: July 15, 2024
    Publication date: November 7, 2024
    Inventors: Matthew A. Sinclair, Juha-Pekka Laine
  • Publication number: 20240350523
    Abstract: The invention relates to compositions of nicotinamide mononucleotide derivatives and their methods of use. The invention also relates to methods of preparing nicotinamide mononucleotide derivatives. The invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinamide mononucleotide derivative. The invention relates to methods of using nicotinamide mononucleotide derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for treating diseases and improving cell and tissue survival.
    Type: Application
    Filed: November 21, 2023
    Publication date: October 24, 2024
    Inventors: Karl D. Normington, David A. Sinclair, David J. Livingston, James M. McKearin, Bruce Szczepankiewicz, Jonathan N. Kremsky
  • Publication number: 20240316148
    Abstract: Provided herein are engineered nucleic acids (e.g., expression vectors, including viral vectors, such as lentiviral vectors, adenoviral vectors, AAV vectors, herpes viral vectors, and retroviral vectors) that encode OCT4; KLF4; SOX2; or any combination thereof that are useful, for example, in inducing cellular reprogramming, tissue repair, tissue regeneration, organ regeneration, reversing aging, or any combination thereof. Also provided herein are recombinant viruses (e.g., lentiviruses, alphaviruses, vaccinia viruses, adenoviruses, herpes viruses, retroviruses, or AAVs) comprising the engineered nucleic acids (e.g.
    Type: Application
    Filed: February 21, 2024
    Publication date: September 26, 2024
    Applicant: President and Fellows of Harvard College
    Inventors: David A. Sinclair, Yuancheng Lu
  • Patent number: 12066609
    Abstract: A multi-band/multi-polarization reflective or catadioptric optical system yields differing effective focal lengths (EFLs) per band/polarization. This approach could be used to create an imaging system, for example. In such case, a sensor (imager, spectrometer, diode, etc.) is located at the one or more focal planes. On the other hand, it could also be used to create a projecting system or hybrid projecting and imaging system by locating an emitter such as an LED, laser, etc.) at the image or focal plane. The system employs polarizers and/or dichroic coatings nano patterns to create different focal lengths and/or fields of view using the same mirrors and/or lenses by, for example, including at least one dichroic coating optically in front of at least one additional mirror to separately reflect the different bands or polarizations.
    Type: Grant
    Filed: June 27, 2019
    Date of Patent: August 20, 2024
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Matthew A. Sinclair, Juha-Pekka Laine
  • Publication number: 20240261370
    Abstract: Provided herein are engineered nucleic acids (e.g., expression vectors, including viral vectors, such as lentiviral vectors, adenoviral vectors, AAV vectors, herpes viral vectors, and retroviral vectors) that encode OCT4; KLF4; SOX2; or any combination thereof that are useful, for example, in inducing cellular reprogramming, tissue repair, tissue regeneration, organ regeneration, reversing aging, or any combination thereof. Also provided herein are recombinant viruses (e.g., lentiviruses, alphaviruses, vaccinia viruses, adenoviruses, herpes viruses, retroviruses, or AAVs) comprising the engineered nucleic acids (e.g.
    Type: Application
    Filed: February 21, 2024
    Publication date: August 8, 2024
    Applicant: President and Fellows of Harvard College
    Inventors: David A. Sinclair, Yuancheng Lu
  • Patent number: 11957703
    Abstract: The invention provides methods of modulating and regulating NHD protein-protein interactions through nicotinamide mononucleotide, analogs and derivatives thereof, such as NAD+. Such modulation may be useful in methods of treating and preventing cancer, aging, cell death, radiation damage, radiation exposure, among others, may improve DNA repair, cell proliferation, cell survival, among others, and may increase the life span of a cell or protect it against certain stresses, among others.
    Type: Grant
    Filed: May 5, 2022
    Date of Patent: April 16, 2024
    Assignees: President and Fellows of Harvard College, Metro International Biotech, LLC
    Inventors: David A. Sinclair, Jun Li, Karl D. Normington
  • Publication number: 20240051835
    Abstract: Spherical amorphous, non-porous silicas are useful for oral compositions. A method of making the spherical amorphous, non-porous silicas is also provided.
    Type: Application
    Filed: February 3, 2022
    Publication date: February 15, 2024
    Applicant: Evonik Operations GmbH
    Inventors: Nathan Motl, Terry W, NASSIVERA, Fitzgerald A. Sinclair, Scott Pentz, Michael S. Darsillo, Eric G. Lundquist
  • Patent number: 11878027
    Abstract: The invention relates to compositions of nicotinamide mononucleotide derivatives and their methods of use. The invention also relates to methods of preparing nicotinamide mononucleotide derivatives. The invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinamide mononucleotide derivative. The invention relates to methods of using nicotinamide mononucleotide derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for treating diseases and improving cell and tissue survival.
    Type: Grant
    Filed: July 26, 2022
    Date of Patent: January 23, 2024
    Assignee: Metro International Biotech, LLC
    Inventors: Karl D. Normington, David A. Sinclair, David J. Livingston, James M. McKearin, Bruce Szczepankiewicz, Jonathan N. Kremsky
  • Publication number: 20230338468
    Abstract: Provided herein are engineered nucleic acids (e.g., expression vectors, including viral vectors, such as lentiviral vectors, adenoviral vectors, AAV vectors, herpes viral vectors, and retroviral vectors) that encode OCT4; KLF4; SOX2; or any combination thereof that are useful, for example, in inducing cellular reprogramming, tissue repair, tissue regeneration, organ regeneration, reversing aging, or any combination thereof. Also provided herein are recombinant viruses (e.g., lentiviruses, alphaviruses, vaccinia viruses, adenoviruses, herpes viruses, retroviruses, or AAVs) comprising the engineered nucleic acids (e.g.
    Type: Application
    Filed: May 16, 2023
    Publication date: October 26, 2023
    Applicant: President and Fellows of Harvard College
    Inventors: David A. Sinclair, Yuancheng LU
  • Publication number: 20230293569
    Abstract: The invention provides methods of modulating and regulating NHD protein-protein interactions through nicotinamide mononucleotide, analogs and derivatives thereof, such as NAD+. Such modulation may be useful in methods of treating and preventing cancer, aging, cell death, radiation damage, radiation exposure, among others, may improve DNA repair, cell proliferation, cell survival, among others, and may increase the life span of a cell or protect it against certain stresses, among others.
    Type: Application
    Filed: May 5, 2022
    Publication date: September 21, 2023
    Inventors: David A. SINCLAIR, Jun Li, Karl D. Normington
  • Publication number: 20230277256
    Abstract: Surgical robotic systems and navigation systems employ a robotic arm including a plurality of links. A link tracker assembly is located on the surface of one or more of the links to enable the link to be tracked by a localizer. The link tracker assemblies can utilize a plurality of tracker elements that can be removably coupled to the link. A photosensor assembly is located on the surface of one or more of the links to receive signals from the localizer for controlling the link tracker assembly. The robotic arm can be coupled to a base and the systems can be used in collaboration with a base tracker that is coupled to the base. The robotic arm can also include a mounting interface for receiving an end effector and the systems can be used in collaboration with an end effector tracker that is coupled to the end effector.
    Type: Application
    Filed: March 1, 2023
    Publication date: September 7, 2023
    Applicant: MAKO Surgical Corp.
    Inventors: Victor Soto, Alan Ross, David Gene Bowling, Jochen Breisacher, Jonathan Mark Morgan, Dave A. Sinclair, David DiPietro, David Robert Whisler, Paul David Ekegren, Paul Shiels
  • Publication number: 20230280154
    Abstract: The present disclosure provides an OCT imaging system to reduce or eliminate frequency-domain aliasing artifacts. The frequency is shifted using a carrier frequency to define a sampling range substantially centered on the carrier frequency. An image of the sample is generated from a displayed imaging range that consists of a subset of the frequencies within the sampling range. Furthermore, the system may be configured to determine the carrier frequency such that a Nyquist frequency corresponding to the shifted frequency is extended beyond either an upper or a lower bound of an OCT quality envelope corresponding to the first portion of light. Additionally, the carrier frequency may be determined such that a lower bound of the OCT quality envelope is greater or less than a zero-frequency DC limit.
    Type: Application
    Filed: May 15, 2023
    Publication date: September 7, 2023
    Applicant: NINEPOINT MEDICAL, INC.
    Inventors: Eman Namati, Muhammad Al-Qaisi, Matthew A. Sinclair, Benedikt Graf, David Vader