Abstract: The present invention provides methods, compositions and kits for assembling an enzyme-deoxyribonucleic acid (DNA) complex for use in preparing a double stranded DNA molecule comprising one or more loci of interest for determining the methylation status of the one or more loci of interest therein.

Abstract: A multi channel beamsplitter system operating over a wide spectral band has high optical performance despite the fact that the incoming and/or exiting light is not collimated and its material is dispersive. This is achieved using wavefront compensators that are matched to the curvature of the wavefronts of the incoming and/or exiting light.

Abstract: The present disclosure provides an OCT imaging system to reduce or eliminate frequency-domain aliasing artifacts. The frequency is shifted using a carrier frequency to define a sampling range substantially centered on the carrier frequency. An image of the sample is generated from a displayed imaging range that consists of a subset of the frequencies within the sampling range. Furthermore, the system may be configured to determine the carrier frequency such that a Nyquist frequency corresponding to the shifted frequency is extended beyond either an upper or a lower bound of an OCT quality envelope corresponding to the first portion of light. Additionally, the carrier frequency may be determined such that a lower bound of the OCT quality envelope is greater or less than a zero-frequency DC limit.

Abstract: The invention relates to compositions of nicotinamide mononucleotide derivatives and their methods of use. The invention also relates to methods of preparing nicotinamide mononucleotide derivatives. The invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinamide mononucleotide derivative. The invention relates to methods of using nicotinamide mononucleotide derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for treating diseases and improving cell and tissue survival.

Abstract: Techniques to facilitate compression of depth data and real-time reconstruction of high-quality light fields. A parameter space of values for a line, pairs of endpoints on different sides of the line, and a palette index for each pixel of a pixel tile of a depth image is sampled. Values for the line, the pairs of endpoints, and the palette index that minimize an error are determined and stored.

Abstract: Provided herein are engineered nucleic acids (e.g., expression vectors, including viral vectors, such as lentiviral vectors, adenoviral vectors, AAV vectors, herpes viral vectors, and retroviral vectors) that encode OCT4; KLF4; SOX2; or any combination thereof that are useful, for example, in inducing cellular reprogramming, tissue repair, tissue regeneration, organ regeneration, reversing aging, or any combination thereof. Also provided herein are recombinant viruses (e.g., lentiviruses, alphaviruses, vaccinia viruses, adenoviruses, herpes viruses, retroviruses, or AAVs) comprising the engineered nucleic acids (e.g.

Abstract: A radiofrequency (RF) localization system can include an RF sensing component, a signal-processing module and a visualization element. A plurality of antennas mounted on a belt, or on a helmet, or at least one extendable antenna attached within a backpack could be used for the RF sensing component. The signal-processing module can receive an RF Signal-of-Interest (SOI), and can further compute localization information for the RF SOI such as line of bearing, signal-to-noise ratio (SNR), and SSID information. The visualization element can be an augmented reality (AR) visor mounted on the helmet, or AR glasses. The signal-processing module can be mounted to the helmet, visor, or glasses, as applicable. The RF sensing component, signal module and said visualization element can be worn by the user, and can cooperate to provide hands free RF localization information in an AR format to an end user.

Abstract: The invention relates to compositions of nicotinamide mononucleotide derivatives and their methods of use. The invention also relates to methods of preparing nicotinamide mononucleotide derivatives. The invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinamide mononucleotide derivative. The invention relates to methods of using nicotinamide mononucleotide derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for treating diseases and improving cell and tissue survival.

Abstract: A device for compressing subject data. the device comprises a communication link, the communication link capable of receiving a set of subject data; a compression module, the compression module configured to apply a compression algorithm to the set of subject data, the compression algorithm compressing the set of subject data using a reference string of subject data; and a transmission module, the transmission module configured to transmit the compressed subject data. The device further comprising an encryption module for encrypting the subject data.

Abstract: Methods and compositions for preventing or treating peripheral neuropathy, cognitive deficits, inactivity, depression, chemotherapy and/or radiotherapy induced peripheral neuropathy and cognitive deficits, and improving cognitive performance, in a subject in need thereof are disclosed. The disclosed methods include the step of administering to the subject an effective amount of an agent that increases the level of NAD+ in the subject.

Abstract: A potentially small, gimballed, multi-sensor system employs a shared aperture for at least some of the image sensors. Applications include intelligence, surveillance, target acquisition and reconnaissance (ISTAR), and guiding autonomous vehicles. The system can actively blend images from multiple spectral bands for clarity and interpretability, provide remote identification of objects and material, provide anomaly detection, control lasers and opto-mechanics for image quality, and use shared aperture using folded optics.

Abstract: An optical system such as an imaging system, projecting system or combined imaging and projecting system, has complex dielectric coatings and/or reflecting polarizers to separate multiple spectral bands and/or polarizations on one or more of the system's curved mirrors.

Abstract: The disclosure provides methods, compositions, and kits for enhanced detection of microbes in samples and monitoring of antimicrobial activity in a subject.

Abstract: The present disclosure provides an OCT imaging system to reduce or eliminate frequency-domain aliasing artifacts. The frequency is shifted using a carrier frequency to define a sampling range substantially centered on the carrier frequency. An image of the sample is generated from a displayed imaging range that consists of a subset of the frequencies within the sampling range. Furthermore, the system may be configured to determine the carrier frequency such that a Nyquist frequency corresponding to the shifted frequency is extended beyond either an upper or a lower bound of an OCT quality envelope corresponding to the first portion of light. Additionally, the carrier frequency may be determined such that a lower bound of the OCT quality envelope is greater or less than a zero-frequency DC limit.

Abstract: Techniques to facilitate compression of depth data and real-time reconstruction of high-quality light fields. A parameter space of values for a line, pairs of endpoints on different sides of the line, and a palette index for each pixel of a pixel tile of a depth image is sampled. Values for the line, the pairs of endpoints, and the palette index that minimize an error are determined and stored.

Abstract: Provided herein are mutant reverse tetracycline transactivator (rtTA) proteins and engineered nucleic acids (e.g., viral vectors, including lentiviral vectors, adenoviral vectors, AAV vectors, herpes viral vectors, and retroviral vectors, and non-viral vectors, including RNA and plasmid DNA) that encode a mutant rtTA that are useful, for example, in regulating gene expression, inducing cellular reprogramming, tissue repair, tissue regeneration, organ regeneration, reversing aging, treating a disease (e.g., acute injuries, neurodegenerative disease, chronic diseases, proliferative diseases, cardiovascular diseases, genetic diseases, inflammatory diseases, autoimmune diseases, neurological diseases, hematological diseases, painful conditions, psychiatric disorders, metabolic disorders, cancers, aging, age-related diseases, and diseases affecting any tissue in a subject), or any combination thereof. Also provided herein are recombinant viruses (e.g.

Abstract: The disclosure provides methods, compositions, and kits for enhanced detection of microbes in samples and monitoring of antimicrobial activity in a subject.

Abstract: Provided herein are methods and compositions for preventing or treating aging, or an aging-related disorder, a disorder associated with inflammation, or for modulating an immune response in a subject in need thereof. In some embodiments, the methods comprise administering to the subject an effective amount of a compound of Formulas I-XIII.

Abstract: The present invention comprises a rigid device capable of separating whey from yogurt when inserted into yogurt. The bottom of the device and a portion of the lower sides are walled to a height great enough to create a whey collecting reservoir. An accompanying ladle which fits within the device and is at a sufficient height to allow the collection of liquid into the ladle when inserted in the device may be included as part of a sales package.

Abstract: The present disclosure provides an OCT imaging system to reduce or eliminate frequency-domain aliasing artifacts. The frequency is shifted using a carrier frequency to define a sampling range substantially centered on the carrier frequency. An image of the sample is generated from a displayed imaging range that consists of a subset of the frequencies within the sampling range. Furthermore, the system may be configured to determine the carrier frequency such that a Nyquist frequency corresponding to the shifted frequency is extended beyond either an upper or a lower bound of an OCT quality envelope corresponding to the first portion of light. Additionally, the carrier frequency may be determined such that a lower bound of the OCT quality envelope is greater or less than a zero-frequency DC limit.