Patents by Inventor A. Sinclair

A. Sinclair has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • In Vivo Methods for Enhancing Bioenergetic Status in Female Germ Cells
    Publication number: 20190002919
    Abstract: In vivo methods using bioenergetic agents for restoring the quality of aged oocytes, enhancing oogonial stem cells or improving derivatives thereof (e.g., cytoplasm or isolated mitochondria) for use in fertility-enhancing procedures, are described.
    Type: Application
    Filed: July 13, 2018
    Publication date: January 3, 2019
    Inventors: Jonathan L. Tilly, David A. Sinclair
  • FREQUENCY-DOMAIN OPTICAL COHERENCE TOMOGRAPHY WITH EXTENDED FIELD-OF-VIEW AND REDUCTION OF ALIASING ARTIFACTS
    Publication number: 20180372479
    Abstract: The present disclosure provides an OCT imaging system to reduce or eliminate frequency-domain aliasing artifacts. The frequency is shifted using a carrier frequency to define a sampling range substantially centered on the carrier frequency. An image of the sample is generated from a displayed imaging range that consists of a subset of the frequencies within the sampling range. Furthermore, the system may be configured to determine the carrier frequency such that a Nyquist frequency corresponding to the shifted frequency is extended beyond either an upper or a lower bound of an OCT quality envelope corresponding to the first portion of light. Additionally, the carrier frequency may be determined such that a lower bound of the OCT quality envelope is greater or less than a zero-frequency DC limit.
    Type: Application
    Filed: August 31, 2018
    Publication date: December 27, 2018
    Inventors: Eman NAMATI, Muhammad AL-QAISI, Matthew A. SINCLAIR, Benedikt GRAF, David VADER
  • Cold atom interferometry
    Patent number: 10157692
    Abstract: Improvements to atom interferometers. An improved atom interferometer has a single polarization-preserving fiber, coupled for propagation of beams of two Raman frequencies, and a parallel displacement beamsplitter for separating the laser beams into respective free-space-propagating parallel beams traversing at least one ensemble of atoms. A reflector generates one or more beams counterpropagating through the ensemble of atoms. Other improvements include interposing a beam-splitting surface common to a plurality of parallel pairs of beams counterpropagating through the ensemble of atoms, generating interference fringes between reflections of the beams to generate a detector signal; and processing the detector signal to derive at least one of relative phase and relative alignment between respective pairs of the counterpropagating beams.
    Type: Grant
    Filed: August 24, 2017
    Date of Patent: December 18, 2018
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Alexander Gill, Steven J. Byrnes, Jennifer Choy, Christine Y. Wang, Matthew A. Sinclair, Adam Kelsey, David Johnson
  • NAD BIOSYNTHESIS AND PRECURSORS FOR THE TREATMENT AND PREVENTION OF CANCER AND PROLIFERATION
    Publication number: 20180338991
    Abstract: Disclosed herein are novel compositions and methods for the treatment of age-related diseases, mitochondrial diseases, the improvement of stress resistance, the improvement of resistance to hypoxia and the extension of life span. Also described herein are methods for the identification of agents useful in the foregoing methods. Methods and compositions are provided for the treatment of diseases or disorders associated with mitochondrial dysfunction. The invention relates to methods for treatment and prevention of cancer by administering agents that increase levels of NAD+, such as NAD+ precursors or agents involved in NAD+ biosynthesis.
    Type: Application
    Filed: December 7, 2017
    Publication date: November 29, 2018
    Applicants: President and Fellows of Harvard College, NewSouth Innovations Pty Limited
    Inventors: David A. Sinclair, Ana P. Gomes, Lindsay Wu
  • REAL-TIME RENDERING WITH COMPRESSED ANIMATED LIGHT FIELDS
    Publication number: 20180322691
    Abstract: Systems, methods, and articles of manufacture for real-time rendering using compressed animated light fields are disclosed. One embodiment provides a pipeline, from offline rendering of an animated scene from sparse optimized viewpoints to real-time rendering of the scene with freedom of movement, that includes three stages: offline preparation and rendering, stream compression, and real-time decompression and reconstruction. During offline rendering, optimal placements for cameras in the scene are determined, and color and depth images are rendered using such cameras. Color and depth data is then compressed using an integrated spatial and temporal scheme permitting high performance on graphics processing units for virtual reality applications.
    Type: Application
    Filed: May 4, 2018
    Publication date: November 8, 2018
    Inventors: Kenneth J. MITCHELL, Charalampos KONIARIS, Malgorzata E. KOSEK, David A. SINCLAIR
  • Configurable Sunshade for Use with Multiple-Field-of-View Camera System
    Publication number: 20180227500
    Abstract: A configurable sunshade for use with a multiple-camera system that has multiple camera sensors with associated fields of view. The sunshade has multiple portions that are independently rotatable with respect to a fixed platform such that in distinct orientations with respect to each other, specified cameras may be blocked from receiving light from a scene, in whole or in part. In other embodiments, individual apertures of a multi-sunshade housing may be separately activated.
    Type: Application
    Filed: February 5, 2018
    Publication date: August 9, 2018
    Inventors: Matthew T. Jamula, Matthew A. Sinclair, Benjamin F. Lane, Adam Parolin, Adam Kelsey
  • Integrated Wide Field of View Optical System for Image Based Navigation Applications in G-hardened Package
    Publication number: 20180224657
    Abstract: An optical device is described for a wide field of view optical system. A device housing has an optical opening into an enclosed interior volume. A multi-element lens is molded across the optical opening and defined by: a. a field of view representing a volume of space from which light is collected, b. a plurality of optical paths through the lens defining one or more focal planes within the interior volume, and c. a boresight axis perpendicular to each of the one or more focal planes. Optical sensors are arranged on the one or more focal planes and configured for sensing light collected through the lens from the field of view. The device forms a single environmentally hardened package configured to absorb impulse shocks without disturbing the boresight axis or the plurality of optical paths.
    Type: Application
    Filed: February 5, 2018
    Publication date: August 9, 2018
    Inventors: Matthew T. Jamula, Matthew A. Sinclair, Juha-Pekka J. Laine, Paul A. Bohn, Robin Dawson
  • Enzymatic Systems and Methods for Synthesizing Nicotinamide Mononucleotide and Nicotinic Acid Mononucleotide
    Publication number: 20180163243
    Abstract: Enzyme-based systems and methods for synthesizing the NAD precursors NMN and NaMN are disclosed. Such methods and systems utilize a mutated form of phosphoribosylpyrophosphate synthetase (PRS) that is superactive and/or other enzyme or enzyme combinations that are immobilized onto a solid surface. The methods and systems substantially increase the efficiency and yield of NAD precursor synthesis.
    Type: Application
    Filed: December 11, 2017
    Publication date: June 14, 2018
    Inventors: Lindsay Wu, David A. Sinclair, Kyle Meetze
  • NICOTINAMIDE MONONUCLEOTIDE DERIVATIVES AND THEIR USES
    Publication number: 20180147227
    Abstract: The invention relates to compositions of nicotinamide mononucleotide derivatives and their methods of use. The invention also relates to methods of preparing nicotinamide mononucleotide derivatives. The invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinamide mononucleotide derivative. The invention relates to methods of using nicotinamide mononucleotide derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for treating diseases and improving cell and tissue survival.
    Type: Application
    Filed: January 23, 2018
    Publication date: May 31, 2018
    Inventors: Karl D. Normington, David A. Sinclair, David J. Livingston, James M. Mckearin, Bruce Szczpankiewicz, Jonathan N. Kremsky
  • Targeting NAD+ to Treat Chemotherapy and Radiotherapy Induced Cognitive Impairment, Neuropathies and Inactivity
    Publication number: 20180125871
    Abstract: Methods and compositions for preventing or treating peripheral neuropathy, cognitive deficits, inactivity, depression, chemotherapy and/or radiotherapy induced peripheral neuropathy and cognitive deficits, and improving cognitive performance, in a subject in need thereof are disclosed. The disclosed methods include the step of administering to the subject an effective amount of an agent that increases the level of NAD+ in the subject.
    Type: Application
    Filed: April 28, 2016
    Publication date: May 10, 2018
    Inventors: Lindsay Wu, David A. Sinclair
  • TREATMENT OF AGE-RELATED AND MITOCHONDRIAL DISEASES BY INHIBITION OF HIF-1 ALPHA FUNCTION
    Publication number: 20180118819
    Abstract: Disclosed herein are novel compositions and methods for the treatment of age-related diseases, mitochondrial diseases, the improvement of stress resistance, the improvement of resistance to hypoxia and the extension of life span. Also described herein are methods for the identification of agents useful in the foregoing methods. Methods and compositions are provided for the treatment of diseases or disorders associated with mitochondrial dysfunction.
    Type: Application
    Filed: May 26, 2017
    Publication date: May 3, 2018
    Applicants: President and Fellows of Harvard College, Massachusetts Institute of Technology
    Inventors: David A. Sinclair, Ana P. Gomes, Eric Bell
  • Systems and methods for offshore electrical energy generation
    Patent number: 9951753
    Abstract: In various embodiments, an offshore electrical energy generator is disclosed. The generator includes a buoy configured to float on a body of water. A wind turbine is mounted to the buoy. An air storage tank is configured for submersion. An air compressor is stowed within the buoy and coupled to the wind turbine and configured to charge the air storage tank in response to receiving wind energy collected by the wind turbine. An expansion turbine is stowed within the buoy and is configured to receive compressed air stored within the air storage tank and to decompress the compressed air to generate electrical energy.
    Type: Grant
    Filed: May 19, 2016
    Date of Patent: April 24, 2018
    Assignee: The United States of America as Represented by the Secretary of the Navy
    Inventors: Nathan A. Sinclair, David P. Wilkinson, Jeffrey P. Kilpatrick
  • Separated parallel beam generation for atom interferometry
    Patent number: 9952154
    Abstract: An atomic interferometer and methods for measuring phase shifts in interference fringes using the same. The atomic interferometer has a laser beam traversing an ensemble of atoms along a first path and an optical components train with at least one alignment-insensitive beam routing element configured to reflect the laser beam along a second path that is anti-parallel with respect to the first laser beam path. Any excursion from parallelism of the second beam path with respect to the first is rigorously independent of variation of the first laser beam path in yaw parallel to an underlying plane.
    Type: Grant
    Filed: January 10, 2017
    Date of Patent: April 24, 2018
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Matthew A. Sinclair, Adam Kelsey, Richard E. Stoner
  • Compositions and Methods for Enhancing Bioenergetic Status in Female Germ Cells
    Publication number: 20180100166
    Abstract: Compositions and methods comprising bioenergetic agents for restoring the quality of aged oocytes, enhancing oogonial stem cells or improving derivatives thereof (e.g., cytoplasm or isolated mitochondria) for use in fertility-enhancing procedures, are described.
    Type: Application
    Filed: November 17, 2017
    Publication date: April 12, 2018
    Inventors: Jonathan Lee Tilly, David A. Sinclair
  • SMALL MOLECULE CD38 INHIBITORS AND METHODS OF USING SAME
    Publication number: 20180085383
    Abstract: The invention provides methods and compositions for inhibiting CD38 activity, and methods of treating or preventing various disorders associated with CD38 activity.
    Type: Application
    Filed: May 9, 2017
    Publication date: March 29, 2018
    Inventors: David A. Sinclair, Nathan L. Price, Eduardo N. Chini, Jon C. Clardy, Shugeng Cao
  • Nicotinamide mononucleotide derivatives and their uses
    Patent number: 9919003
    Abstract: The invention relates to compositions of nicotinamide mononucleotide derivatives and their methods of use. The invention also relates to methods of preparing nicotinamide mononucleotide derivatives. The invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinamide mononucleotide derivative. The invention relates to methods of using nicotinamide mononucleotide derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for treating diseases and improving cell and tissue survival.
    Type: Grant
    Filed: March 20, 2017
    Date of Patent: March 20, 2018
    Assignee: Metro International Biotech, LLC
    Inventors: Karl D. Normington, David A. Sinclair, David J. Livingston, James M. McKearin, Bruce Szczpankiewicz, Jonathan N. Kremsky
  • NAD biosynthesis and precursors for the treatment and prevention of cancer and proliferation
    Patent number: 9877981
    Abstract: Disclosed herein are novel compositions and methods for the treatment of age-related diseases, mitochondrial diseases, the improvement of stress resistance, the improvement of resistance to hypoxia and the extension of life span. Also described herein are methods for the identification of agents useful in the foregoing methods. Methods and compositions are provided for the treatment of diseases or disorders associated with mitochondrial dysfunction. The invention relates to methods for treatment and prevention of cancer by administering agents that increase levels of NAD+, such as NAD+ precursors or agents involved in NAD+ biosynthesis.
    Type: Grant
    Filed: October 9, 2013
    Date of Patent: January 30, 2018
    Assignees: President and Fellows of Harvard College, NewSouth Innovations Pty Limited
    Inventors: David A. Sinclair, Ana P. Gomes, Lindsay Wu
  • PURIFICATION OF GERM STEM CELLS BY TARGETING MRP9
    Publication number: 20180002662
    Abstract: Provided herein are methods and compositions for the purification and detection of germ stem cells (e.g., oogonial stem cells) based on expression of MRP9.
    Type: Application
    Filed: January 12, 2016
    Publication date: January 4, 2018
    Applicant: President and Fellows of Harvard College
    Inventors: Michael B. Schultz, Michael S. Bonkowski, David A. Sinclair
  • Nicotinamide mononucleotide derivatives and their uses
    Patent number: 9855289
    Abstract: The invention relates to compositions of nicotinamide mononucleotide derivatives and their methods of use. The invention also relates to methods of preparing nicotinamide mononucleotide derivatives. The invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinamide mononucleotide derivative. The invention relates to methods of using nicotinamide mononucleotide derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for treating diseases and improving cell and tissue survival.
    Type: Grant
    Filed: August 5, 2016
    Date of Patent: January 2, 2018
    Assignee: Metro International Biotech, LLC
    Inventors: Karl D. Normington, David A. Sinclair, David J. Livingston, James M. McKearin, Bruce Szczpankiewicz, Jonathan N. Kremsky
  • Cold Atom Interferometry
    Publication number: 20170372808
    Abstract: Improvements to atom interferometers. An improved atom interferometer has a single polarization-preserving fiber, coupled for propagation of beams of two Raman frequencies, and a parallel displacement beamsplitter for separating the laser beams into respective free-space-propagating parallel beams traversing at least one ensemble of atoms. A reflector generates one or more beams counterpropagating through the ensemble of atoms. Other improvements include interposing a beam-splitting surface common to a plurality of parallel pairs of beams counterpropagating through the ensemble of atoms, generating interference fringes between reflections of the beams to generate a detector signal; and processing the detector signal to derive at least one of relative phase and relative alignment between respective pairs of the counterpropagating beams.
    Type: Application
    Filed: August 24, 2017
    Publication date: December 28, 2017
    Inventors: Alexander Gill, Steven J. Byrnes, Jennifer Choy, Christine Y. Wang, Matthew A. Sinclair, Adam Kelsey, David Johnson