Abstract: The present invention relates to regulatory nucleic acid sequences, in particular NS-specific promoters, cell specific promoters, multi-cell specific promoters, and elements thereof. The invention also relates to expression constructs, vectors, virions, pharmaceutical compositions and cells comprising such promoters and to methods of their use. The regulatory nucleic acid sequences are of particular utility for gene therapy applications.

Abstract: A fitting for connecting a branch conduit to a liner installed in a main pipe is configured to mechanically connect to the branch conduit as it is inserted into the branch conduit from inside the main pipe. The mechanical connection is established without rotating the fitting. The fitting can include a body having an outer shaft section for being received in the branch conduit and an inner flange section for opposing the liner within the main pipe. The fastener include one or more teeth that extend radially from the exterior of the shaft section. The teeth can be secured to the shaft section by deforming portions of the fitting body against the teeth. The flange section supports a gasket for sealing against the liner when the fitting is installed. The flange section can include a rim that maintains the gasket in the proper position.

Abstract: The present application relates to formulations comprising a combination of an NAD+ agonist and a flavonoid polyphenol. Also provided herein are methods of administering a combination of an NAD+ agonist and a flavonoid for use in methods for treating, ameliorating, or preventing at least one symptom or indication an age-related disease or disorder in a subject.

Abstract: The invention provides methods of modulating and regulating NHD protein-protein interactions through nicotinamide mononucleotide, analogs and derivatives thereof, such as NAD+. Such modulation may be useful in methods of treating and preventing cancer, aging, cell death, radiation damage, radiation exposure, among others, may improve DNA repair, cell proliferation, cell survival, among others, and may increase the life span of a cell or protect it against certain stresses, among others.

Abstract: A robotic system includes a movable platform disposed at a bottom of a work volume, the movable platform being configured to transit outside the work volume, at least three lifters disposed about a perimeter of the work volume, two or more sensors disposed at fixed locations about the work volume, and a memory including a neural network. A controller is in operative communication with the memory, the two or more sensors, and the lifters. The controller is configured to receive output signals from the two or more sensors, determine, based processing on the received signals with the neural network, whether the deformable laundry article suspended by two lifters is repositioned, and instruct, based on a determination of the deformable laundry article being repositioned, the lifters to lower the repositioned deformable laundry article onto the movable platform.

Abstract: A post-deposition treatment universally applicable to a wide range of perovskite solar cell configurations and architectures. The methodology yields significant improvements in device efficiency and lifetime coupled with a reduction in inherent batch-to-batch variability in all performance metrics. Such improvements are achieved following an aerosol-induced recrystallisation of solution-deposited MAPbI3 thin films that result in a significant enlargement and improved homogeneity of grain size. The aerosol treatment is demonstrated as being suitable for a range of active layer thicknesses, interlayer choices, architectures and device active areas.

Abstract: A device for autonomously folding a deformable article includes a rotatable platform configured to receive the deformable article and at least one movable elongation in operable communication with at least one elongation drive. The at least one movable elongation is configured to raise and lower from the surface of the rotatable platform, move parallel to the surface, and manipulate the deformable article to thereby fold the deformable article at one of the one or more fold lines. The device includes a table drive configured to rotate the rotatable platform about a central axis such that the at least one elongation aligns with one of the one or more fold lines, and at least one sensor configured to detect the deformable article position and orientation on the rotatable platform. A controller is in operable communication with the at least one elongation drive, the table drive, and the at least one sensor.

Abstract: Dual roll sheet product dispensers of a compact design are provided herein. A sheet product dispenser comprises a first roll holder for a first product roll and a second roll holder for a second product roll. A housing includes a base portion and a cover that is movable relative to the base portion to define an open position and a closed position. A chassis is mounted between the first roll holder and the second roll holder and movable between a retracted position and an extended position. The chassis is movable to the extended position when the cover is in the open position. The chassis includes a first dispensing mechanism and a second dispensing mechanism.

Abstract: Device for measuring at least one first force (19) generated within a brake system (20) of a vehicle (9). The brake system (20) comprises at least caliper (16) and at least one brake disc (4). The at least two load pins (12, 13), connecting the caliper (16) and the vehicle (9) are arranged to measure the first force (19). A converting means (21) is arranged to convert a basic force (22) into the first force (19) to be measured.

Abstract: A system comprising a spinning disk is disclosed. The system comprises a semiconductor processing system, such as a high energy implantation system. The semiconductor processing system produces a spot ion beam, which is directed to a plurality of workpieces, which are disposed on the spinning disk. The spinning disk comprises a rotating central hub with a plurality of platens. The spinning disk rotates about a central axis. The spinning disk is also translated linearly in a directional perpendicular to the central axis. The spot ion beam strikes the spinning disk at a distance from the central axis, referred to as the radius of impact. The rotation rate and the scan velocity may both vary inversely with the radius of impact.

Abstract: Systems for providing on-demand cup printing and dispensing for food service are provided herein. A cup dispenser includes a cup source configured to hold a stack of cups and one or more cup-moving elements configured to cause a cup from the stack of cups to move through the cup dispenser. The cup dispenser includes a motor configured to operate the one or more cup-moving elements to cause the cup to move through the cup dispenser along a path. The cup dispenser also includes a printer configured to print at least one of order information or personalization information on the cup that is based on the food service order associated with the cup. The cup dispenser further includes a dispensing section that provides the cup, which includes the at least one of order information or personalization information printed thereon.

Abstract: Surgical robotic systems and navigation systems employ a robotic arm including a plurality of links. A link tracker assembly is located on the surface of one or more of the links to enable the link to be tracked by a localizer. The link tracker assemblies can utilize a plurality of tracker elements that can be removably coupled to the link. A photosensor assembly is located on the surface of one or more of the links to receive signals from the localizer for controlling the link tracker assembly. The robotic arm can be coupled to a base and the systems can be used in collaboration with a base tracker that is coupled to the base. The robotic arm can also include a mounting interface for receiving an end effector and the systems can be used in collaboration with an end effector tracker that is coupled to the end effector.

Abstract: The present disclosure provides an OCT imaging system to reduce or eliminate frequency-domain aliasing artifacts. The frequency is shifted using a carrier frequency to define a sampling range substantially centered on the carrier frequency. An image of the sample is generated from a displayed imaging range that consists of a subset of the frequencies within the sampling range. Furthermore, the system may be configured to determine the carrier frequency such that a Nyquist frequency corresponding to the shifted frequency is extended beyond either an upper or a lower bound of an OCT quality envelope corresponding to the first portion of light. Additionally, the carrier frequency may be determined such that a lower bound of the OCT quality envelope is greater or less than a zero-frequency DC limit.

Abstract: Provided is an incretin, or analogue thereof, an incretin receptor agonist, an incretin enhancer, or any combination thereof, for use in a method of reducing elevated intracranial pressure (ICP) in a subject. Methods of reducing elevated ICP in a subject may comprise administering an incretin, or analogue thereof, an incretin receptor agonist, an incretin enhancer, or any combination thereof to the subject. The elevated ICP may be associated with idiopathic intracranial hypertension (IIH), secondary pseudotumour cerebri, hydrocephalus, normal pressure hydrocephalus, raised intracranial pressure secondary to a brain tumour, meningitis, brain trauma, brain injury, and venous sinus thrombosis.

Abstract: Devices, systems, and methods for repositioning a deformable laundry article are described. For example, a robotic device includes a conveyor configured to transfer the deformable laundry article outside of a work volume, two or more lifters including grippers individually anchored about the perimeter of the work volume, two or more sensors disposed at fixed locations about the work volume, and a memory storing data indicative of repositioned deformable laundry articles. A controller is in operative communication with the memory, the two or more sensors, and the two or more lifters. The controller is configured to receive a signal from the sensors, identify grip points on the deformable laundry article suspended above the conveyor, instruct a lifter to grip and lift an identified grip point to the suspension height, determine whether the deformable laundry article is repositioned, and instruct the lifters to lower the repositioned deformable laundry article onto the conveyor.

Abstract: A sensor device is described herein. The sensor device includes a multi-dimensional optical sensor and processing circuitry, wherein the multi-dimensional optical sensor generates images and the processing circuitry is configured to output data that is indicative of hemodynamics of a user based upon the images. The sensor device is non-invasive, and is able to be incorporated into wearable devices, thereby allowing for continuous output of the data that is indicative of the hemodynamics of the user.

Abstract: There is provided a computer-implemented method of communication between a plurality of processes, each process being responsible for a region of a space, and each process maintaining a routing tree, each node of the routing tree representing a respective one of the plurality of processes and containing an indication of the represented process and an indication of an associated region for which the represented process is responsible. The method comprises: receiving, by a first process, a message addressed to a target region of the space; determining, by the first process and using the routing tree of the first process, a set of subregions of the target region and associated processes; and for each of the determined subregions in the set, sending the message from the first process to the process associated with the determined subregion in the set.

Abstract: Reel devices, systems, and related methods are disclosed. The reel devices are modular and include an automatic shift assembly that shifts to provide a mechanical advantage when used to tighten a cord. For instance, the reel devices are configured to provide a first drive ratio and automatically transition to a second drive ratio in response to a torque force. The reel devices include a drive assembly and a shift assembly. The drive assembly includes a cycloidal gear.

Abstract: Method of processing a polycrystalline diamond element may include laser ablating at least a portion of a polycrystalline diamond element to form a laser-shaped surface and exposing at least a portion of the laser-shaped surface to a leaching solution to define a leached polycrystalline diamond volume and an unleached polycrystalline diamond volume.

Abstract: An adhesive application apparatus is provided. The apparatus uses a rolled on adhesive applied to a substrate. After roll application, an adhesive activator is sprayed onto the substrate. By spraying an activator onto the substrate after the adhesive is applied, the adhesive may be made tacky for adhesion, but the adhesive used for rolling may be highly stable and slow to dry/cure without said activator, which enhances rolled application effectiveness.