Abstract: Spindles and cover assemblies for dispensing sheet product for use with coreless sheet product rolls. The spindle may include a hollow cylindrical body, which may have an elongated channel in a sidewall; a rod which extends partially out of the body; and a spring disposed within the body in biasing contact with the rod. The rod may include a flexible tab matingly engaged within the channel, permitting the rod to translate within the hollow cylindrical body without falling out. The hollow cylindrical body may have an end with an opening bounded by an inward facing ledge, and the rod may include a radial ledge, such that the rod can translate within the body but cannot fall out due to interference between the inward facing ledge and the radial ledge. The spindle may include a friction hub disposed about and rotatable around the hollow cylindrical body between ends of the body.

Abstract: Disclosed herein is an integrated heater and measurement (IHM) device comprising heating-sensing element(s) and heating-sensing circuit(s). A heating-sensing element generates heat and determines the temperature of the IHM device. In some embodiments, the heating-sensing element may operate in a plurality of modes: heating mode, sensing mode, and/or off mode. A controller may dynamically adjust the properties of the operation mode and/or time periods based on the determined temperature. The adjusted properties may include the duration of the heating mode, the ON time for a heating-sensing element, etc. The controller may adjust the duration of heating mode based on the temperature difference between the determined temperature and a set point temperature, such as decreasing the duration of the heating mode when there is a low temperature difference, and increasing the duration of the heating mode when there is a high temperature difference.

Abstract: Disclosed herein are various optimized nucleic acids encoding the fukutin-related protein (FKRP). Recombinant vectors comprising the optimized nucleic acid (e.g. operatively linked to a muscle specific promoter), such as recombinant adeno-associated virus vectors, for expressing the protein (e.g. in skeletal and cardiac muscle), and therapeutic compositions contains the vectors are also disclosed. Therapeutic methods of administration of the vectors to a subject for the treatment of a subject with a dystroglycanopathy disorder (e.g., limb-girdle muscular dystrophy 2I) are also disclosed.

Abstract: A method of constructing a cigar includes the providing of a plurality of frusto-conically shaped tubes, each tube being of a smokable material such as a spirally wrapped layer of tobacco material. The tubes are nested, one tube inside the other tube. The nested tubes are then attached to a mouthpiece having a socket that is internally threaded. The nested tubes and mouthpiece are packaged either filled with tobacco filler material, partially filled, or unfilled in a container.

Abstract: A bicycle safety enhancement device includes an elongated member having a distal portion mountable to a bicycle handlebar. A proximity sensor is coupled to a proximal portion of the elongated member and is arranged so that when the elongated member is mounted to a handlebar of a bicycle being ridden by a cyclist, the ultrasonic sensor detects objects adjacent to and/or behind the bicycle and which come within a prescribed distance of the bicycle. An illumination source is coupled to the proximal portion of the elongated member. The illumination source provides a visible warning signal directed toward the detected object when the elongated member is mounted to the handlebar of the bicycle. A camera is coupled to the proximal portion of the elongated member and is arranged to capture images of the detected object as the detected object passes in front of the bicycle being ridden by the cyclist.

Abstract: The invention relates to drinks bottles, a method of manufacturing a drinks bottle, a method of mixing drinks using a drinks bottle, and to a mixing component such as a frame or a mixing element for a drinks bottle, and a kit for a drinks bottle. The invention relates to a drinks bottle (10) comprising: a main body (2) for containing liquid, the main body (2) having at least one side wall (4) terminating at a proximal end in an upper edge (16) defining an opening (8), an inner surface of the side wall comprising a first screw thread (5) extending along the side wall (4) away from the upper edge (6) towards a distal end of the main body (2); a removable lid (12) closing the opening (8), the removable lid (12) comprising: a base portion (14) removably located at the upper edge (16) of the main body (2); a handle portion (16) rotatable with respect to the base portion (14); at least one rod (18) mounted on the handle portion (16) axially moveable (e.g.

Abstract: The present concepts relate to devices that can employ graspable controllers that can be employed in various scenarios, such as virtual reality scenarios and augmented reality scenarios. One example device can include multiple expansion assemblies having independently adjustable girths. The multiple expansion assemblies can be stacked adjacent to one another along an axis. A controller can be configured to expand or contract the girths of the expansion assemblies to collectively approximate girths of an object.

Abstract: Methods, computer systems and computer programs for generating a virtual representation of an interior space such as a room are provided. Techniques for capturing and normalizing sets of points for polygon mesh generation that utilize augmented reality toolkits are also described.

Abstract: An apparatus may include a drift tube assembly, the drift tube assembly defining a triple gap configuration, and arranged to accelerate and transmit an ion beam along abeam path. The apparatus may include a resonator, to output an RF signal to the drift tube assembly, and an RF quadrupole triplet, connected to the drift tube assembly, and arranged circumferentially around the beam path.

Abstract: Techniques for executing workgroups are provided. The techniques include executing, for a first workgroup of a first kernel dispatch, a workgroup dependency instruction that includes an indication to prioritize execution of a second workgroup of a second kernel dispatch, and in response to the workgroup dependency instruction, dispatching the second workgroup of the second kernel dispatch prior to dispatching a third workgroup of the second kernel dispatch, wherein no workgroup dependency instruction including an indication to prioritize execution of the third workgroup has been executed.

Abstract: The present disclosure provides a method for treating clinical or pre-clinical skin damage in a skin field of a subject, wherein the skin field has been allocated a skin cancerization field index (SCFI) score of at least 1 as determined by a process comprising the steps of: (i) assessing the number of keratoses in the skin field; (ii) assessing the thickness of the thickest keratosis in the skin field; and (iii) assessing the proportion of the field affected by clinical or subclinical skin damage. Based on the assessments made in (i), (ii) and (iii) the subject is optionally treated by at least one of (a) freezing one or more lesions, (b) shaving, curetting or surgically removing one or more lesions, (c) applying a topical treatment for actinic keratosis, basal cell carcinoma or squamous cell carcinoma, and (d) radiation therapy.

Abstract: An exciter for a high frequency resonator. The exciter may include an exciter coil inner portion, extending along an exciter axis, an exciter coil loop, disposed at a distal end of the exciter coil inner portion. The exciter may also include a drive mechanism, including at least a rotation component to rotate the exciter coil loop around the exciter axis.

Abstract: Devices, systems, and methods for autonomously sorting dirty laundry articles into batched loads for washing are described. For example, an autonomous sorting system includes an enclosed channel including a stationary floor extending between an inlet end and an outlet end of the channel, a plurality of arms disposed in series along the enclosed channel for selectively grasping at least one of the plurality of deformable articles in sequence. The system includes an outlet orifice adjacent the outlet end through which each separated deformable article exits the enclosed channel upon release by the terminal gripper of the one of the plurality of arms, and one or more conveyors disposed adjacent the outlet end configured for receiving thereon a plurality of bins for collecting for washing together two or more articles of the plurality of deformable articles released through the outlet orifice having a common sensor-detected one or more characteristics.

Abstract: Methods and apparatus for performing profile-guided optimization of integrated circuit hardware are provided. Circuit design tools may receive a source code and compile the source code to generate a hardware description. The hardware description may include profiling blocks configured to measure useful information required for optimization. The hardware description may then be simulated to gather profiling data. The circuit design tools may then analyze the gathered profiling data to identify additional opportunities for hardware optimization. The source code may then be modified based on the analysis of the profiling data to produce a smaller and faster hardware that is better suited to the application.

Abstract: Provided herein are engineered nucleic acids (e.g., expression vectors, including viral vectors, such as lentiviral vectors, adenoviral vectors, AAV vectors, herpes viral vectors, and retroviral vectors) that encode OCT4; KLF4; SOX2; or any combination thereof that are useful, for example, in inducing cellular reprogramming, tissue repair, tissue regeneration, organ regeneration, reversing aging, or any combination thereof. Also provided herein are recombinant viruses (e.g., lentiviruses, alphaviruses, vaccinia viruses, adenoviruses, herpes viruses, retroviruses, or AAVs) comprising the engineered nucleic acids (e.g.

Abstract: The present invention relates to methods of administration of rAAV vectors in a single administration method comprising a series of sub-administrations of sub-doses of rAAV vectors. The present invention also relates to rAAV vectors comprising cardiac-specific promoters, cardiac-cell specific promoters, multi-cell cardiac specific promoters, and elements thereof. The invention also relates to rAAV vectors, pharmaceutical compositions and uses thereof in methods for treating cardiovascular disease, heart diseases and heart failure in subjects in need thereof.

Abstract: A store includes first and second racks of shelving that are respectively viewed by first and second cameras. A computer system, including one or more processors and memory, defines a first convolutional neural network (CNN) trained to recognize a first set of items stocked on the first rack of shelving, and a second CNN trained to recognize a second set of items stocked on the second rack of shelving. (The first camera provides imagery for recognition by the first CNN, and the second camera provides imagery for recognition by the second CNN.) In such arrangement, the second neural network is trained to recognize a particular item that the first neural network is not trained to recognize, and the first neural network is trained to recognize a certain item that the second neural network is not trained to recognize. Many other features and arrangements are also detailed.

Abstract: Systems or methods of the present disclosure may provide a library including multiple regional bits streams that may be pre-generated by a manufacturer and/or custom generated by a designer that may be used to implement a design onto an integrated circuit device. The design may be decomposed into one or more regional bitstreams and stitched to form a larger combined bitstream to be implemented as coarse-grained operations on the integrated circuit device, thereby decreasing compilation time experienced by the designer. The combined bitstreams may be loaded into all or a portion of the integrated circuit device to realize the design. Additionally or alternatively, the integrated circuit device may include a hardened networks-on-chip to improve data routing within the combined bitstream.

Abstract: Systems and methods are disclosed for communication classification and escalation using a machine learning model. Metadata for a communication is obtained along with features of the content in the communication. Using a machine learning model, a likelihood that the communication comprises suspicious content or a topic of interest is determined from the metadata and or a communication transcript. If the likelihood that the communication comprises suspicious content or a topic of interest is at or above a predetermined threshold, then the communication is marked for review by a human agent; otherwise, the communication is ignored. A communication may have suspicious content or a topic of interest based upon the presence of keywords in the communication transcript either alone or in combined with metadata or other features of the content in the communication. The one or more keywords may be associated with illegal or unauthorized items, activities, or behaviors.

Abstract: Method and systems for preparing and analyzing a DNA sample from a subject are provided herein. Also provided are methods and systems for obtaining, analyzing, and manipulating genomic and proteomic sequence data. In particular, methods and systems provided herein involve transformation of raw genetic or proteomic sequence into a compressed data set and transmission of the compressed data set using a fixed binary encoding scheme capable of compressing the data by up to 75%. An interface is in communication with the compression module and configured to display transmitted genomic and proteomic sequence data.