Abstract: The invention relates to compositions of nicotinamide mononucleotide derivatives and their methods of use. The invention also relates to methods of preparing nicotinamide mononucleotide derivatives. The invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinamide mononucleotide derivative. The invention relates to methods of using nicotinamide mononucleotide derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for treating diseases and improving cell and tissue survival.

Abstract: The present invention provides a compound, or a pharmaceutically acceptable salt thereof, of formula (I): wherein R1, R2, R3, R4, R5, R26, R27, y, R, M, W, L, V, T, Y, J, K and A are as described herein, therapeutic uses of said compounds, uses of said compounds as research chemicals, a pharmaceutical composition and combinations comprising said compounds, and methods for manufacturing the compounds of the invention.

Abstract: Disclosed are methods of synthesis and/or purification of certain 3,7-diamino-phenothiazin-5-ium compounds (“diaminophenothiazinium compounds”) including Methylthioninium Chloride (MTC) (Methylene Blue), and the resulting high purity characterized by a purity greater than 98%, and very low levels of heavy metals and organic impurities Azure A, B, C and MVB. Also disclosed are methods of treatment of a tauopathy or methemoglobinemia in a patient in need thereof, comprising administering to the patient a therapeutically effective amount of the high-purity diaminophenothiazinium compound.

Abstract: Systems or methods of the present disclosure may provide a library including multiple macros that may be pre-compiled prior to implementation of the design. For example, a design may be mapped to one or more macros in the library, and the one or more macros may be placed into and routed between a portion of a region, one region, one or more regions of the integrated circuit device to implement the design. Since the macros may be pre-compiled, compilation time experienced by the designer may correspond to the placement and routing of the one or more macros, which may be less than compilation time for fine-grained operations. The pre-compiled logic within the macros may be set using a lookup table mask to set and/or adjust a functionality of the macro. Additionally or alternatively, the place and route operation may be performed at finer granularities to reduce bottle necks.

Abstract: The present disclosure relates to an air cleaning system comprising: a ducting section comprising an inlet and an outlet; at least one source of ultraviolet radiation arranged to emit ultraviolet radiation into an interior volume of the ducting section, the interior volume between the inlet and the outlet; and a reflective surface arranged to reflect ultraviolet radiation emitted by the source of ultraviolet radiation within the interior volume of the ducting section, wherein the reflective surface is capable of reflecting at least 60% of incident ultraviolet radiation.

Abstract: Devices, systems, and methods for autonomously separating and sorting a plurality of individual articles from a pile of laundry articles into two or more sorted loads for washing are described. For example, an autonomous sorting and separating system includes a stationary surface configured to receive thereon at a first location the pile of laundry articles. A plurality of actuatable grippers are disposed at spaced apart positions adjacent the stationary surface and comprise a first actuatable gripper configured to grasp, hoist, and deposit at a second location at least one of the plurality of individual articles within reach of a second actuatable gripper. A terminal gripper comprising at least one of the second actuatable gripper and another actuatable gripper is configured to release an individual article into one of the two or more sorted loads. At least one controller is in operable communication with the grippers.

Abstract: A method for slipforming a concrete trench drain channel using a slipform paving machine, said drain channel having frames defining an upper opening of said channel and adapted to receive a grate; and said frames therefor.

Abstract: Reel devices, systems, and related methods are disclosed. The reel devices are modular and include an automatic shift assembly that shifts to provide a mechanical advantage when used to tighten a cord. For instance, the reel devices are configured to provide a first drive ratio and automatically transition to a second drive ratio in response to a torque force. The reel devices include a drive assembly and a shift assembly. The drive assembly includes a cycloidal gear.

Abstract: Provided is an incretin, or analogue thereof, an incretin receptor agonist, an incretin enhancer, or any combination thereof, for use in a method of reducing elevated intracranial pressure (ICP) in a subject. Methods of reducing elevated ICP in a subject may comprise administering an incretin, or analogue thereof, an incretin receptor agonist, an incretin enhancer, or any combination thereof to the subject. The elevated ICP may be associated with idiopathic intracranial hypertension (IIH), secondary pseudotumour cerebri, hydrocephalus, normal pressure hydrocephalus, raised intracranial pressure secondary to a brain tumour, meningitis, brain trauma, brain injury, and venous sinus thrombosis.

Abstract: A mobile phone may include an enclosure including a front cover assembly defining a front exterior surface of the enclosure, a rear cover assembly defining a rear exterior surface of the enclosure, and a housing subassembly positioned between the front cover assembly and the rear cover assembly. The housing subassembly may include a first housing component defining a first side exterior surface of the enclosure, a second housing component defining a second side exterior surface of the enclosure opposite the first side exterior surface of the enclosure, and a lower chassis section extending between the first housing component and the second housing component. The mobile phone may further include a camera array coupled to the lower chassis section and positioned in an interior cavity defined between the lower chassis section and the front cover assembly.

Abstract: A coil inductor for use with a LINAC is disclosed. The coil inductor comprises one or more tubes, wherein each tube comprises an interior support structure to strengthen the tubes. By supporting the tube, the amount of vibration is reduced, allowing the coil to resonate at its natural frequency. In some embodiments, the interior structure comprises one or more interior walls. These interior walls may be used to create a plurality of fluid channels that allow the flow of coolant through the tubes. An end cap may be disposed on the second end of the tubes to allow fluid communication between the supply fluid channels and the return fluid channels. The first ends of the one or more tubes may be connected to a manifold that includes a supply port and a return port for the passage of coolant.

Abstract: A shoe may include various features to improve performance, increase manufacturing efficiency, and provide environmental benefits over traditional shoes. In some cases, a shoe includes an upper portion constructed from a continuous textile that includes multiple regions having different textile properties to improve the performance of the shoe, including durability and comfort. The upper portion may define a cuff region and a flex region adapted to expand to allow a wearer to put on the shoe and to contract to retain the shoe on the wearer's foot. The shoe may further include a heel retainer adapted to conform to a shape of the wearer's foot and retain the shoe on the wearer's foot. Eyelets of the shoe may be positioned along an external surface of the upper portion to improve comfort and simplify manufacturing.

Abstract: A coupling between lead and extension pile segments of a driven piling. The extension segment has a formed end, an opposite driven end and a body extending therebetween. The formed end has an inner diameter equal to an outer diameter of an exposed end of the lead segment and greater than an outer diameter of the extension segment's body. The formed end has an initial length prior to coupling the extension and lead segments; the formed end undergoes secondary end forming when a driving force is applied, such that the formed end has a final length exceeding the initial length after the extension and lead segments are coupled. In some embodiments, the extension segment has an external ring portion positioned upstream of the formed end, and the exposed end of the lead segment is cold extruded into and through the external ring portion of the extension segment.

Abstract: There is provided herein an examination table that is capable of being converted to render either an examination configuration or a seating configuration. The table includes a planar table member having a suitable surface for the examination of a subject and is adjustable between a horizontal orientation for medical evaluation of the subject and a vertical orientation when in the table member is not in use for exams.

Abstract: There is provided a computer-implemented method comprising, at an intermediary process acting as an intermediary between a publisher system and a plurality of subscriber processes, the intermediary process having a publisher data store storing one or more subscriptions for which the intermediary process is a publisher and a subscriber data store storing one or more subscriptions for which the intermediary process is a subscriber.

Abstract: Alignment features for an optical fibre assembly are formed directly into an ion trap chip to align an optical module with respect to the ion trap chip. This is achieved using microfabrication techniques to etch alignment elements into the surface of the ion trap chip, advantageously carried out with lithographic precision achieving the alignment accuracy required of the optical beam geometries for the application, with an alignment accuracy of a few micrometres. The alignment elements are advantageously etched along defined crystal planes of the silicon substrate of the chip. An external microstructure can be micromachined with lithographic precision to contain locating features that will fit, or “plug”, into the recesses of the chip, for instance ion microtrap chip.

Abstract: An ion-trap chip carrier (10) comprises a generally planar carrier substrate, the substrate having a front surface, a rear surface, and a chip receptacle. A chip support (22) is disposed in the chip receptacle of the carrier substrate, the chip support including at least one generally planar flange (22) extending in or generally parallel to a plane of the carrier substrate, and at least one aperture therein. The chip support comprises a chip receiving zone. The at least one chip support includes at least one front facing electrical terminal (15, 17) in the chip receiving zone, for coupling to a rear facing terminal of an ion-trap chip (50). At least one front facing wire bonding terminal (80, 82) is electrically coupled to the at least one front facing electrical terminal (15, 17), the at least one front facing wire bonding terminal being disposed outside of the chip receiving zone.

Abstract: A hair accessory includes a hair fastener portion, an elongated portion and a bead retaining portion. The hair fastener portion fastens the hair accessory to a hair braid; the elongated portion is able to be braided into the hair braid; and the bead retaining portion holds beads in place in the hair braid. The hair accessory negates a need for rubber bands for holding the beads, is easily removable without causing hair damage/tangling, reusable and easy to use with any hair length and any standard bead size.

Abstract: A method of reducing gallium particle formation in an ion implanter. The method may include performing a gallium implant process in the ion implanter, the gallium implant process comprising implanting a first dose of gallium ions from a gallium ion beam into a first set of substrates, while the first set of substrates are disposed in a process chamber of the beamline ion implanter. As such, a metallic gallium material may be deposited on one or more surfaces within a downstream portion of the ion implanter. The method may include performing a reactive gas bleed operation into at least one location of the downstream portion of the ion implanter, the reactive bleed operation comprising providing a reactive gas through a gas injection assembly, wherein the metallic gallium material is altered by reaction with the reactive gas.