Abstract: The invention describes an explicit solvent all-atom molecular dynamics methodology (SILCS: Site Identification by Ligand Competitive Saturation) that uses no small aliphatic and aromatic molecules plus water molecules to map the affinity pattern of a large molecule for hydrophobic groups, aromatic groups, hydrogen bond donors, and hydrogen bond acceptors. By simultaneously incorporating ligands representative of all these functionalities, the method is an in silico free energy-based competition assay that generates three-dimensional probability maps of fragment binding (FragMaps) indicating favorable fragment:large molecule interactions. The FragMaps may be used to qualitatively inform the design of small-molecule ligands or as scoring grids for high-throughput in silico docking that incorporates both an atomic-level description of solvation and the large molecule's flexibility.

Abstract: A gastrointestinal device for implanting within a pylorus, a duodenal bulb, and a duodenum of a patient's gastrointestinal tract includes an expandable structure including a proximal portion having a plurality of spring arms and a distal portion having a plurality of spring arms, the proximal and distal portions coupled by a rigid central cylinder having a diameter capable of fitting within the pylorus and having a length greater than a width of the pylorus. An intestinal bypass sleeve is coupled to at least one of the proximal and distal portions of the expandable structure and having a length sufficient to extend at least partially into the duodenum. In the expanded configuration, the proximal portion has a diameter larger than a maximum opening diameter of the pylorus and further wherein, in the expanded configuration, the distal portion has a diameter larger than a maximum opening diameter of the pylorus.

Abstract: Systems and methods for information retrieval are provided that permit users and/or processing entities to access and define synthetic data, synthetic objects, and/or synthetic groupings of data in one or more collections of information. In one embodiment, data access on an information retrieval system can occur through an interpretation layer which interprets any synthetic data against data physically stored in the collection. Synthetic data can define virtual data objects, virtual data elements, virtual data attributes, virtual data groupings, and/or data entities that can be interpreted against data that may be stored physically in the collection of information. The system and methods for information retrieval can return results from the one or more collections of information based not only on the data stored, but also on the virtual data generated from interpretation of the stored data.

Abstract: A method and apparatus are described for managing a mass registration scenario in a two-way radio system. A site controller in a trunked radio system detects a mass registration condition in which registration requests by subscriber units are likely to collide on an inbound control channel. During the mass registration condition, the site controller initiates a restriction period by instructing subscriber units that are members of particular talkgroups to temporarily cease registration requests. Those talkgroup members are permitted to resume their registration requests when a predetermined delay time has passed since the members were instructed to cease registration, or when a particular silence time has passed without registration activity over the control channel.

Abstract: A method of forming a heater assembly for use in semiconductor processing includes thermally securing a heater substrate to an application substrate; and applying a layered heater having at least one functional layer to the heater substrate after the heater substrate is secured to the application substrate. The heater substrate defines a material having a coefficient of thermal expansion that is matched to a coefficient of thermal expansion of the functional layer. The material of the functional layer is not capable of withstanding the elevated temperature of the thermal securing step.

Abstract: A video oculography based neuro-otologic testing and evaluation apparatus and associated method comprises the steps of: Obtaining images of the subject's eyes with a digital camera; Selectively displaying visual stimulus to the subject on a display; Generating each visual stimulus to be displayed from a controller; Receiving and storing data signals from each digital camera in the controller; Calculating eye related data from the digital camera images and visual stimulus; Displaying the eye related data to users; Generating a video synchronization signal by the controller associated with each visual stimulus which identifies when the display is displaying the associated visual stimulus; Receiving and coupling the video synchronization signal with at least the eye data from the digital camera; and Synchronizing calculations based upon the eye data and the visual stimulus by the controller.

Abstract: A dynamic support apparatus. The dynamic support apparatus includes a cushion, at least one actuator wherein the at least one actuator defines an interior volume and wherein the interior volume may be configured to be at least partially filled with a fluid, and a support disposed in the interior volume wherein the support configured to support an occupant when the interior volume is not filled with the fluid such that the support is sufficient to support the occupant.

Abstract: An electronic device may be provided with a display. Backlight structures may be used to provide backlight for the display. The backlight structures may include a light guide plate. A rectangular ring-shaped chassis may have a rectangular opening that receives the light guide plate. One or more edges of the chassis may be provided with an array of notches that receive light-emitting diodes or other light sources. The light sources may launch light into edge portions of the light guide plate. The chassis may include a first plastic structure such as a light reflecting structure formed from a material such as white plastic. The first plastic structure may surround two or more peripheral edges of the light guide plate. The chassis may also include a second plastic structure such as a light blocking structure formed from a material such as black plastic that helps prevent light leakage.

Abstract: An opioid narcotics used for the treatment of moderate-to-severe pain that primarily exert their analgesic effects through ? receptors. Although, traditional ? agonists can cause undesired side effects, including tolerance, addition of ? antagonists can attenuate said side effects. The present invention includes 4a,9-dihydroxy-7a-(hydroxymethyl)-3-methyl-2,3,4,4a,5,6-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7(7aH)-one (UMB 425) a 5,14-bridged morphinan-based orvinol precursor, along with analogs of morphine, dihydromorphine, hydromorphone, codeine, dihydrocodeine, hydrocodone and ethylmorphine. Although UMB 425 lacks ?-specific motifs, conformationally sampled pharmacophore models for ? and ? receptors predict it to have efficacy similar to morphine at ? receptors and similar to naltrexone at ? receptors, due to the compound sampling conformations in which the hydroxyl moiety interacts with the receptors similar to orvinols.

Abstract: A technique is directed to launching an unmanned aerial vehicle (UAV). The technique involves attaching a UAV launcher to a hand-held weapon, and installing a UAV onto the UAV launcher while the UAV launcher is attached to the hand-held weapon. The technique further involves activating the hand-held weapon to launch the UAV into flight from the UAV launcher. Since a user already may be carrying the hand-held weapon for firing ammunition, the user simply needs to further carry the UAV launcher and the UAV which, in some situations, can be packaged into an easy-to-carry container such as a backpack, a carrying case, and so on.

Abstract: A method of treating a subterranean formation penetrated by a wellbore by contacting an energized fluid with the subterranean formation; and reducing a partial pressure of the energized fluid by an amount sufficient to form polymeric foam structure within the subterranean formation

Abstract: An apparatus includes an instruction decoder, first and second source registers and a circuit coupled to the decoder to receive packed data from the source registers and to unpack the packed data responsive to an unpack instruction received by the decoder. A first packed data element and a third packed data element are received from the first source register. A second packed data element and a fourth packed data element are received from the second source register. The circuit copies the packed data elements into a destination register resulting with the second packed data element adjacent to the first packed data element, the third packed data element adjacent to the second packed data element, and the fourth packed data element adjacent to the third packed data element.

Abstract: A method of forming a heater assembly for use in semiconductor processing includes thermally securing a heater substrate to an application substrate; and applying a layered heater to the heater substrate after the heater substrate is secured to the application substrate. The application of the layered heater includes applying a first dielectric layer onto the heater substrate, applying a resistive heating layer onto the first dielectric layer, and applying a second dielectric layer onto the resistive heating layer. The heater substrate defines a material having a coefficient of thermal expansion that is matched to a coefficient of thermal expansion of at least one of the first dielectric layer and a coefficient of thermal expansion of the resistive heating layer.

Abstract: The invention provides a method for dispensing liquid, comprising the steps of: (a) positioning a droplet to be dispensed in a gap of an electrowetting device using an electrowetting array; and (b) dispensing the droplet through a hole in a housing or substrate of the electrowetting device. The invention further provides a method for withdrawing liquid comprising the steps of: (a) positioning a droplet to be withdrawn from a gap of an electrowetting device using an electrowetting array; and (b) withdrawing the droplet through a hole in a housing or substrate of the electrowetting device.

Abstract: Compounds, and methods of using the same, are provided as therapies for the treatment leucine-rich repeat kinase-2 (LRRK2)-related disorders including, but not limited to, neurodegenerative and neuroinflammatory disorders, such as Parkinson's Disease.

Abstract: A conveyor drive roller for moving a conveyor medium. The conveyor roller has a hollow drum which is rotatably connected to a first and a second stationary shaft. An internal gear assembly is disposed inside the hollow drum and couples a motor to the hollow drum such that operation of the motor causes rotation of the hollow drum about the first and second stationary shafts. The hollow drum is configured to hold a liquid lubricant in contact with the internal gear assembly. Liquid lubricant flow paths are provided to move the liquid lubricant from inside the hollow drum to outside the hollow drum via the first or second stationary shafts, and vice versa. The liquid lubricant flow paths are configured for connection to a means for cooling the liquid lubricant.

Abstract: A heater assembly for use in semiconductor processing that includes an application substrate; a heater substrate secured to the application substrate by a thermal bonding process; and a functional layer disposed onto the heater substrate by a layered process. In this heater assembly, the heater substrate defines a material having a coefficient of thermal expansion that is matched to a coefficient of thermal expansion of the functional layer.

Abstract: A method of measuring and analyzing an ocular response in a subject comprising the steps of: Providing a video oculography based system for the subject with the system configured to collect eye images in excess of 60 hz and configured to resolve eye movements smaller than at least 3 degrees of motion; Collecting eye data with the video oculography based system wherein at least one stimulus is presented to only one eye of the subject and configured to yield a pupil eye response from at least one eye of the subject; Calculating pupilometry measurements from the eye data, wherein the pupil measurements are calculated independently for the subject's left and right eyes for each stimulus presented to the subject, and wherein comparative left and right pupilometry measurements from the eye data are calculated; analyzing a subject's ocular response based upon at least one of the calculated pupilometry measurements.

Abstract: Integrated media planning and buying systems and methods are provided. Integrated media planning and buying systems and methods can include integrated media planning and buying. The integrated media planning and buying systems and methods can facilitate creation and management of an advertising campaign, including locating placements which match an advertising campaigns goals, facilitating the purchase of placements, and providing the media plan to an advertising server to serve advertisements associated with the advertising campaign.

Abstract: Oil residues are removed from contaminated solids, in particular from cuttings produced from drilling a borehole using an oil-based drilling fluid, by contacting the solids with a washing fluid which comprises carbon dioxide and cosolvent under conditions at which carbon dioxide is a supercritical fluid and the cosolvent is in solution in the supercritical carbon dioxide and then separating washed solids from the washing fluid; wherein the washing fluid comprises at least 5% by volume of cosolvent which is one or more organic compounds with a Hildebrand solubility parameter in a range from 16 to 21 MPa1/2. The washing process may be applied to drilling cuttings produced offshore.