Abstract: A microfluidic optoelectronic tweezers (OET) device can comprise dielectrophoresis (DEP) electrodes that can be activated and deactivated by controlling a beam of light directed onto photosensitive elements that are disposed in locations that are spaced apart from the DEP electrodes. The photosensitive elements can be photodiodes, which can switch the switch mechanisms that connect the DEP electrodes to a power electrode between an off state and an on state.

Abstract: Disclosed herein are structure-based methods for ligand optimization. The methods involve the selection of a candidate ligand from a structural library based on the binding energy of the ligand with a cancer cell-surface protein. The binding energy is estimated from parameters including polar and mon-polar interactions between the ligand and the surface protein. In this way, candidate ligand(s) with desirable binding affinity to the cancer cell-surface protein can be selected.

Abstract: A vane comprises an airfoil extending from a radially outer platform to a radially inner platform. A pair of legs extend radially inwardly from the radially inner platform, and an air flow passage extends through the radially outer platform, through the airfoil, and into a chamber defined between the pair of legs. One of the pair of legs includes a plurality of injector holes, configured to allow air from the radially outer platform to pass outwardly of the holes. A gas turbine engine is also disclosed.

Abstract: Provided are methods for the preparation of certain substituted pyrrolidine compounds, forms of (2S,4R)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid hydrochloride, and methods for preparing and using these forms.

Abstract: An apparatus relates generally to time sharing of an arithmetic unit. In such an apparatus, a controller is coupled to provide read pointers and write pointers. A memory block is coupled to receive the read pointers and the write pointers. A selection network is coupled to the memory block and the arithmetic unit. The memory block includes a write-data network, a read-data network, and memory banks.

Abstract: A center pintle hub coupled to a base of a machine is disclosed. The center pintle hub is casted as a single piece. The center pintle hub includes a disc, a hole, a plurality of protrusions, a hollow cylindrical member, and a plurality of stiffening members. The disc couples to the base and includes a first surface and a second surface. The hole extends from the first surface to the second surface, along a central axis of the disc. The plurality of protrusions, disposed on the second surface, is arranged in an array of square configuration. The plurality of protrusions extends from the second surface and attach to a plurality of stiffeners of the base. The hollow cylindrical member is coupled to the first surface and arranged coaxially with the hole of the disc. The plurality of stiffening members is circumferentially disposed and equally spaced around the hollow cylindrical member.

Abstract: An outsole element for an article of footwear having a base and a lug that extends from the base. The outsole element includes a body and a cavity defined in the body. The cavity receives the lug to removably couple the body to the lug. Also, the cavity includes an internal undercut.

Abstract: A memory circuit includes an input stage having N input ports and N output ports, wherein N is an integer greater than one. The memory circuit further includes an N:1 port multiplexer coupled to the N output ports of the input stage and configured to time division multiplex the N output ports to one multiplexed port. The memory circuit also includes a random access memory matrix and a 1:N port multiplexer. The memory circuit is coupled to the multiplexed port. The 1:N port multiplexer is coupled to the random access memory matrix and is configured to de-multiplex signals received from the random access memory matrix into N output ports.

Abstract: A material blend for deposition of an abrasion-resistant overlay onto a metal substrate comprising a first metal particle component, a second metal particle component, and a carbide particle component and a method for the application thereof, wherein the overlay process conditions and the homogeneity of tungsten carbide distribution in the overlay are improved.

Abstract: A system and methods for third-party access to a network-based system for providing location-based upcoming event information are described. The location-based upcoming event information may be accessed from the network-based system by a server-side web application implemented by a third party. The server-side web application may be configured to communicate with the network-based system that provides online marketplace and ticket fulfillment services and to generate a query based upon the location of a user and other event criteria. The server-side web application may communicate the query to the network-based system and, in response, receive location-based upcoming event information which may be displayed to a user as a list and/or information on a map. The location-based upcoming event information may comprise an aggregate of ticket inventory available from multiple online marketplaces providing the user with multiple purchasing options.

Abstract: A microfluidic optoelectronic tweezers (OET) device can comprise dielectrophoresis (DEP) electrodes that can be activated and deactivated by controlling a beam of light directed onto photosensitive elements that are disposed in locations that are spaced apart from the DEP electrodes. The photosensitive elements can be photodiodes, which can switch the switch mechanisms that connect the DEP electrodes to a power electrode between an off state and an on state.

Abstract: The invention provides anti-IL-4 antibodies and bispecific antibodies and methods of using the same.

Abstract: An apparatus relating generally to encoding is disclosed. This apparatus includes a bus interface for communicating information from a first die including the bus interface to a second die. A first portion of a bus associated with the bus interface is associated with data bits. A second portion of the bus associated with the bus interface is associated with encoding bits. The bus interface is configured to encode a data word to provide an encoded word. The encoded word is associated with a combinatorial number system.

Abstract: Microfluidic devices in which electrokinetic mechanisms move droplets of a liquid or particles in a liquid are described. The devices include at least one electrode that is optically transparent and/or flexible.

Abstract: A system and methods for third-party access to a network-based system for providing location-based upcoming event information are described. The location-based upcoming event information may be accessed from the network-based system by a server-side web application implemented by a third party. The server-side web application may be configured to communicate with the network-based system that provides online marketplace and ticket fulfillment services and to generate a query based upon the location of a user and other event criteria. The server-side web application may communicate the query to the network-based system and, in response, receive location-based upcoming event information which may be displayed to a user as a list and/or information on a map. The location-based upcoming event information may comprise an aggregate of ticket inventory available from multiple online marketplaces providing the user with multiple purchasing options.

Abstract: The present disclosure provides methods for incorporating at least one non-natural amino acid into a polypeptide using a cell-free protein synthesis which includes a cell-free extract and is deficient in endogenous tRNA. The methods include providing the synthesis system with at least one non-natural amino acid, at least one orthogonal tRNA and one orthogonal aminoacyl-tRNA synthetase which aminoacylates the corresponding orthogonal tRNA with the non-natural amino acid. The methods may also include removing the endogenous tRNA in the cell-free protein synthesis system by treating the synthesis system with a ribonuclease to degrade the endogenous tRNA and providing the synthesis system with a minimal set of tRNAs for one or more natural amino acids and the corresponding amino-acyl tRNA synthetases, such that the lack of some tRNA will enable unique codons to encode for non-natural amino acid incorporation with no or a minimal amount of completion from the tRNA present.

Abstract: A power turbine section for a gas turbine engine includes a heat shield assembly mounted to a bearing support, the heat shield assembly forms an outer diameter directed toward an inner vane platform of the power turbine vane array.

Abstract: A power turbine section for a gas turbine engine includes an inlet duct upstream of a first power turbine vane array, the inlet duct including a lip.

Abstract: A method and system of transmitting data via a computer network to a plurality of end-users. Transmission of successive data units may be prompted by human-operated and/or automated central control. Successive arrays of data units may be transmitted over a plurality of channels, in parallel. Each end-user chooses which channel or channels to receive and may change channels at will. Transmission of successive arrays may coincide with successive occurrences during the course of a live event. Data units also may be transmitted over one or more channels asynchronously with transmissions over other channels. Controller-prompted transmissions, received passively by end-users, also may be integrated with a facility for end-users to browse data sources in a self-directed sequence and pace.