Abstract: Embodiments of the present invention address deficiencies of the art in respect to user interface interaction automation and provide a method, system and computer program product for user interface interaction sequence detection and recording for user interface interaction automation. In an embodiment of the invention, a method for user interface interaction sequence detection and recording for user interface interaction automation can be provided. The method can include comparing a contemporary sequence of user interface actions in a user interface to a pre-stored sequence, and prompting for an expected user interface action if the contemporary sequence matches the pre-stored sequence. The method also can include prompting to store the contemporary sequence as a pre-stored sequence, and storing the contemporary sequence as a pre-stored sequence if directed in response to the prompting.

Abstract: This disclosure provides methods and pharmaceutical compositions for reducing or eliminating cardiotoxicity, particularly cardiotoxicity induced by a cancer treatment or other therapy. In some cases, the methods and compositions prevent or reduce cardiotoxicity caused by anthracycline treatment. The methods provided herein often comprise administering a protective agent such as myricetin, tricetin, robinetin, ficetin, vitexin, quercetin, dihydrorobinetin, kaempferol, 7,3?,4?,5?-tetrahydroxyflavone, and myricitrin in conjunction with the administration of a cancer drug or other treatment. They may comprise administering a protective agent in combination with dexrazoxane. The compositions provided herein include co-formulations of a protective agent with a different protective agent or with a cancer treatment (e.g., anthracycline drug).

Abstract: Embodiments presented herein provide systems and methods for unifying data that is stored in disparate namespaces. A system described herein receives an electronic request for data associated with an entity. The electronic request includes a first identifier of the entity in a first namespace. The system includes a digital relation that maps the first identifier to a primary identifier. The system determines additional identifiers that map to the primary identifier in the relation. The additional identifiers are associated with the entity in respective additional namespaces. The system retrieves a consolidated set of profile data associated with the primary identifier, including attributes of the entity within the first namespace and attributes of the entity within the additional namespaces. The system generates an electronic response to the electronic request based on the consolidated set of profile data and sends the response to an application that submitted the electronic request.

Abstract: This disclosure provides methods and pharmaceutical compositions for reducing or eliminating cardiotoxicity, particularly cardiotoxicity induced by a cancer treatment or other therapy. In some cases, the methods and compositions prevent or reduce cardiotoxicity caused by anthracycline treatment. The methods provided herein often comprise administering a protective agent such as myricetin, tricetin, robinetin, ficetin, vitexin, quercetin, dihydrorobinetin, kaempferol, 7,3?,4?,5?-tetrahydroxyflavone, and myricitrin in conjunction with the administration of a cancer drug or other treatment. They may comprise administering a protective agent in combination with dexrazoxane. The compositions provided herein include co-formulations of a protective agent with a different protective agent or with a cancer treatment (e.g., anthracycline drug).

Abstract: Individual biological micro-objects can be deterministically selected and moved into holding pens in a micro-fluidic device. A flow of a first liquid medium can be provided to the pens. Physical pens can be structured to impede a direct flow of the first medium into a second medium in the pens while allowing diffusive mixing of the first medium and the second medium. Virtual pens can allow a common flow of medium to multiple ones of the pens.

Abstract: A biosensor for detecting bacteria may use bacteriophages in a sandwich-assay system. The biosensor may include a capture element and a detection element. The capture element may include a substrate and a bacteriophage. The detection element may include a bacteriophage and a signal amplification element. The biosensor may be utilized such that the target bacterium is sandwiched between the capture element and the detection element, and a quantifiable signal may be generated to measure the amount of bacteria in a sample. The biosensor of the present invention utilizes direct sensing to detect the bacteria in the sample as opposed to indirect sensing methods.

Abstract: This disclosure provides methods and pharmaceutical compositions for reducing or eliminating cardiotoxicity, particularly cardiotoxicity induced by a cancer treatment or other therapy. In some cases, the methods and compositions prevent or reduce cardiotoxicity caused by anthracycline treatment. The methods provided herein often comprise administering a protective agent such as myricetin, tricetin, robinetin, ficetin, vitexin, quercetin, dihydrorobinetin, kaempferol, 7,3?,4?,5?-tetrahydroxyflavone, and myricitrin in conjunction with the administration of a cancer drug or other treatment. They may comprise administering a protective agent in combination with dexrazoxane. The compositions provided herein include co-formulations of a protective agent with a different protective agent or with a cancer treatment (e.g., anthracycline drug).

Abstract: A vane comprises an airfoil extending from a radially outer platform to a radially inner platform. A pair of legs extend radially inwardly from the radially inner platform, and an air flow passage extends through the radially outer platform, through the airfoil, and into a chamber defined between the pair of legs. One of the pair of legs includes a plurality of injector holes, configured to allow air from the radially outer platform to pass outwardly of the holes. A gas turbine engine is also disclosed.

Abstract: Individual biological micro-objects can be deterministically selected and moved into holding pens in a micro-fluidic device. A flow of a first liquid medium can be provided to the pens. Physical pens can be structured to impede a direct flow of the first medium into a second medium in the pens while allowing diffusive mixing of the first medium and the second medium. Virtual pens can allow a common flow of medium to multiple ones of the pens.

Abstract: A digital signal processor (DSP) slice is disclosed. The DSP slice includes an input stage to receive a plurality of input signals, a pre-adder coupled to the input stage and configured to perform one or more operations on one or more of the plurality of input signals, and a multiplier coupled to the input stage and the pre-adder and configured to perform one or more multiplication operations on one or more of the plurality of input signals or the output of the pre-adder. The DSP slice further includes an arithmetic logic unit (ALU) coupled to the input stage, the pre-adder, and the multiplier. The ALU is configured to perform one or more mathematical or logical operations on one or more of the plurality of input signals, the output of the pre-adder, or the output of the multiplier.

Abstract: A material blend for deposition of an abrasion-resistant overlay onto a metal substrate comprising a first metal particle component, a second metal particle component, and a carbide particle component and a method for the application thereof, wherein the overlay process conditions and the homogeneity of tungsten carbide distribution in the overlay are improved.

Abstract: A vane comprises an airfoil extending from a radially outer platform to a radially inner platform. A pair of legs extend radially inwardly from the radially inner platform, and an air flow passage extends through the radially outer platform, through the airfoil, and into a chamber defined between the pair of legs. One of the pair of legs includes a plurality of injector holes, configured to allow air from the radially outer platform to pass outwardly of the holes. A gas turbine engine is also disclosed.

Abstract: A protocol has been developed for genetically engineering an attenuated pathogen such as the influenza virus that can grow in cells without interferons but has suppressed growth in cells with the interferons. The protocol comprises systematically identifying immune evasion functions on the pathogen's genome, then eliminating the immune evasion functions while maintaining a certain replication fitness of the pathogen. The resulting attenuated pathogen causes a strong immunologic response and can be used in a live attenuated vaccine.

Abstract: In the context of a stem cell-based therapy in which differentiated cells are derived from pluripotent stem cells, this application discloses approaches for eliminating residual pluripotent stem cells that may remain in a batch of differentiated progeny cells. This advantageously prevents the formation of teratoma tumors when the differentiated cells are eventually used for the therapy. This can be accomplished by exposing the batch of differentiated progeny cells and the residual pluripotent stem cells to an alternating electric field for a period of time. The frequency and field strength of the alternating electric field are such that the pluripotent stem cells die off as a result of exposure to the alternating electric fields, while the differentiated cells remain substantially unharmed. This results in a purified batch of differentiated progeny cells that is rendered safe for use in the stem cell-based therapy.

Abstract: A peelable polyimide composite film includes a first polyimide film having a first surface and a second surface opposite to each other; and a second polyimide film attached to the first surface of the first polyimide film A difference in coefficient of thermal expansion between the first polyimide film and the second polyimide film is greater than or equal to 9 um/m° C., so that the first polyimide film and the second polyimide film can be peeled off from each other.

Abstract: Phase correction systems and methods capable of operating in a deployed antenna system are provided. The phase correction system includes a signal generator and a signal coupler. The signal coupler injects a signal at an end of a signal line adjacent an antenna element. Changes in an effective length of the signal line can be detected at a controller that monitors characteristics of the injected signal after it has passed through the signal line. The system can adapt to detected changes in the electrical length by controlling an adjustable phase shifter provided in line with the signal line or by applying suitable post-processing.

Abstract: A biosensor for detecting bacteria may use bacteriophages in a sandwich-assay system. The biosensor may include a capture element and a detection element. The capture element may include a substrate and a bacteriophage. The detection element may include a bacteriophage and a signal amplification element. The biosensor may be utilized such that the target bacterium is sandwiched between the capture element and the detection element, and a quantifiable signal may be generated to measure the amount of bacteria in a sample. The biosensor of the present invention utilizes direct sensing to detect the bacteria in the sample as opposed to indirect sensing methods.

Abstract: A circuit arrangement includes an array of MAC circuits, wherein each MAC circuit includes a cache configured for storage of a plurality of kernels. The MAC circuits are configured to receive a first set of data elements of an IFM at a first rate. The MAC circuits are configured to perform first MAC operations on the first set of the data elements and a first one of the kernels associated with a first OFM depth index during a first MAC cycle, wherein a rate of MAC cycles is faster than the first rate. The MAC circuits are configured to perform second MAC operations on the first set of the data elements and a second one of the kernels associated with a second OFM depth index during a second MAC cycle that consecutively follows the first MAC cycle.