Abstract: An optical switching system comprising a switching cell having first and second fixed-position bus waveguides and a moveable shunt waveguide is disclosed. The first bus waveguide includes an input and a first output. The second bus waveguide includes a second output. When the switching cell is in its unswitched state, the shunt waveguide is not optically coupled with either bus waveguide and a light signal can pass from the input to the first output while remaining in the first bus waveguide. When the switching cell is in its switched state, the shunt waveguide is optically coupled with both bus waveguides such that the light signal is coupled out of the first bus waveguide and into the second bus waveguide via the shunt waveguide. As a result, the light signal can pass from the input to the second output while bypassing the first input.

Abstract: The present invention relates to new medical uses of morphinans such as nalmefene and naltrexone and their related derivatives, pharmaceutical formulations thereof, and use thereof for prevention and treatment of NASH, NAFLD, and/or ASH.

Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR120 G protein-coupled receptor modulators which may be used as medicaments.

Abstract: A telescopic suitcase handle is provided for including a telescopic handle housing disposed within a suitcase, a lower extendible handle section movably disposed within the telescopic handle housing, and an upper extendible handle section movably disposed within the lower section. A spring loaded bullet disposed within the upper section releasably engages with one of a plurality of openings along the length of the lower section for temporarily holding the upper extendible handle section in place. A spring-loaded protrusion releasably engages with the lower extendible handle section for temporarily holding the lower section in place.

Abstract: A structure for providing a boundary for a chamber in a microfluidic apparatus can comprise dielectrophoresis (DEP) configurations each having an outer surface and electrowetting (EW) configurations each having an electrowetting surface. The DEP configurations can facilitate generating net DEP forces with respect to the outer surfaces of the DEP configurations to move micro-objects on the outer surfaces, and the EW configurations can facilitate changing wetting properties of the electrowetting surfaces to move droplets of liquid medium on the electrowetting surfaces.

Abstract: A system and methods for third-party access to a network-based system for providing location-based upcoming event information are described. The location-based upcoming event information may be accessed from the network-based system by a server-side web application implemented by a third party. The server-side web application may be configured to communicate with the network-based system that provides online marketplace and ticket fulfillment services and to generate a query based upon the location of a user and other event criteria. The server-side web application may communicate the query to the network-based system and, in response, receive location-based upcoming event information which may be displayed to a user as a list and/or information on a map. The location-based upcoming event information may comprise an aggregate of ticket inventory available from multiple online marketplaces providing the user with multiple purchasing options.

Abstract: A power turbine section for a gas turbine engine includes a heat shield assembly mounted to a bearing support, the heat shield assembly forms an outer diameter directed toward an inner vane platform of the power turbine vane array.

Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR120 G protein-coupled receptor modulators which may be used as medicaments.

Abstract: An example semiconductor device includes a first integrated circuit (IC) die including a first column of cascade-coupled resource blocks; a second IC die including a second column of cascade-coupled resource blocks, where an active side of the second IC die is mounted to an active side of the first IC die; and a plurality of electrical connections between the active side of the first IC and the active side of the second IC, the plurality of electrical connections including at least one electrical connection between the first column of cascade-coupled resource blocks and the second column of cascade-coupled resource blocks.

Abstract: A telescopic suitcase handle is provided for including a telescopic handle housing disposed within a suitcase, a lower extendible handle section movably disposed within the telescopic handle housing, and an upper extendible handle section movably disposed within the lower section. A spring loaded bullet disposed within the upper section releasably engages with one of a plurality of openings along the length of the lower section for temporarily holding the upper extendible handle section in place. A spring-loaded protrusion releasably engages with the lower extendible handle section for temporarily holding the lower section in place.

Abstract: A microfluidic optoelectronic tweezers (OET) device can comprise dielectrophoresis (DEP) electrodes that can be activated and deactivated by controlling a beam of light directed onto photosensitive elements that are disposed in locations that are spaced apart from the DEP electrodes. The photosensitive elements can be photodiodes, which can switch the switch mechanisms that connect the DEP electrodes to a power electrode between an off state and an on state.

Abstract: Individual biological micro-objects can be deterministically selected and moved into holding pens in a micro-fluidic device. A flow of a first liquid medium can be provided to the pens. Physical pens can be structured to impede a direct flow of the first medium into a second medium in the pens while allowing diffusive mixing of the first medium and the second medium. Virtual pens can allow a common flow of medium to multiple ones of the pens.

Abstract: A memory device can be used with a shared routing resource that provides access to the memory device. The memory device can include a random access memory (RAM) circuit that includes a plurality of ports configured to provide access to the RAM circuit by the shared routing resource. A memory partition register circuit can be configured to store a plurality of addresses specifying respective context partitions within the RAM circuit. A plurality of pointer register circuits that can each be associated with a corresponding port of the plurality of ports and can be configured to store a respective set of pointers that specify a location in the RAM circuit relative to a respective context partition. Addressing logic that can be configured to provide access to the RAM circuit using the respective set of pointers for each port.

Abstract: The present invention provides methods of producing a product or product precursor of a biosynthetic pathway in a genetically modified host cell. The present invention also provides genetically modified host cells comprising nucleic acids encoding a scaffold polypeptide and nucleic acids comprising nucleotide sequences encoding two or more enzymes in a biosynthetic pathway. The present invention further provides nucleic acids comprising nucleotide sequences encoding scaffold polypeptides, for use in a subject method.

Abstract: The present disclosure relates, according to some embodiments, to the fabrication of a flexible circuit board, which includes forming a base layer comprising polyimide, forming a polyimide layer on the base layer, the polyimide layer having a first surface and a second surface opposite to each other, the first surface being peelably adhered in contact with the base layer, forming a metal layer on the second surface of the polyimide layer, and peeling the base layer from the polyimide layer with the metal layer remaining on the second surface of the polyimide layer.

Abstract: The present invention relates to opioid and opioid-like compounds, and pharmaceutical formulations thereof, and use thereof for prevention and treatment of disorders such as septic shock and organ damage.

Abstract: A system includes global memory circuitry configured to store input tensors and output tensors. Row data paths are each connected to an output port of the memory circuitry. Column data paths are connected to an input port of the memory circuitry. Processing elements are arranged in rows and columns along the row data paths and column data paths, respectively. The processing elements include local memory circuitry configured to store multiple masks and processing circuitry. The processing circuitry is configured to receive portions of the input tensors from one of the row data paths; receive masks from the local memory circuitry; perform multiple tensor operations on a same received portion of an input tensors by applying a different retrieved mask for each tensor operation; and generate, using results of the multiple tensor operations, an output for a corresponding column data path.

Abstract: The present invention relates to new medical uses of morphinans such as naltrexone, nalmefene and their related derivatives. The present invention relates to Toll-like receptor 4 (TLR4) antagonist compounds, and pharmaceutical formulations thereof, and use thereof for prevention and treatment of autoimmune liver diseases including but not limited to autoimmune hepatitis.

Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein.