Patents by Inventor An C. Wu

An C. Wu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CYCLOBUTANE CONTAINING CARBOXYLIC ACID GPR120 MODULATORS
    Publication number: 20170247311
    Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR120 G protein-coupled receptor modulators which may be used as medicaments.
    Type: Application
    Filed: September 8, 2015
    Publication date: August 31, 2017
    Inventors: Yan Shi, Ying Wang, Peter T.W. Cheng, Shung C. Wu
  • PHARMACEUTICAL COMPOSITIONS AND METHODS FOR COUNTERING CHEMOTHERAPY INDUCED CARDIOTOXICITY
    Publication number: 20170224654
    Abstract: This disclosure provides methods and pharmaceutical compositions for reducing or eliminating cardiotoxicity, particularly cardiotoxicity induced by a cancer treatment or other therapy. In some cases, the methods and compositions prevent or reduce cardiotoxicity caused by anthracycline treatment. The methods provided herein often comprise administering a protective agent such as myricetin, tricetin, robinetin, ficetin, vitexin, quercetin, dihydrorobinetin, kaempferol, 7,3?,4?,5?-tetrahydroxyflavone, and myricitrin in conjunction with the administration of a cancer drug or other treatment. They may comprise administering a protective agent in combination with dexrazoxane. The compositions provided herein include co-formulations of a protective agent with a different protective agent or with a cancer treatment (e.g., anthracycline drug).
    Type: Application
    Filed: February 3, 2017
    Publication date: August 10, 2017
    Applicants: Stem Cell Theranostics, Inc., Capella Biosciences, Inc.
    Inventors: Christopher G. Armstrong, Kevin J. Kim, Lisa Maria Lucia Pham, Eunhye Park, Zhong Zhong, Guanyi Huang, Joseph C. Wu, Sidney Paul Elmer, Viwat Visuthikraisee, Eithon Michael G Cadag, Thomas Bernard Freeman, Pek Yee Lum
  • Power control over memory cell arrays
    Patent number: 9666266
    Abstract: In disclosed circuit arrangements, memory cell arrays are addressed by a first portion of an input address, and memory cells within each memory cell array are addressed by a second portion of the input address. A first first-in-first-out (FIFO) buffer is coupled to the memory cell arrays and delays the second portion of each input address to the memory cell arrays for a sleep period. Control circuits respectively coupled to the memory cell arrays include second FIFO buffers and decode the first portion of each input address and generate corresponding states of enable signals. The control circuits store the corresponding states of the enable signals in the second FIFO buffers concurrently with input of the second portion of each input address to the first FIFO buffer. The second FIFO buffers delay output of the corresponding states of the enable signals to the memory cell arrays for the sleep period.
    Type: Grant
    Filed: May 9, 2016
    Date of Patent: May 30, 2017
    Assignee: XILINX, INC.
    Inventors: Hongbin Ji, Ephrem C. Wu, Thomas H. Strader
  • Strap connector and methods thereof
    Patent number: 9661911
    Abstract: A strap connector for connecting a strap to an article is provided that may comprise a t-bar for attaching the strap to the article, a housing for receiving the t-bar, the housing secured to the article, the housing comprising a floor, and a bumper plate for maintaining the t-bar in a position within the housing, the bumper plate comprising a bumper protruding above the surface of the floor of the housing.
    Type: Grant
    Filed: June 24, 2013
    Date of Patent: May 30, 2017
    Assignee: TUMI, INC.
    Inventors: Peter C. Wu, Paul V. Scicluna
  • Digital closed-loop control for DC/DC switch-mode power converters with multiple outputs
    Patent number: 9660538
    Abstract: Apparatus and method for providing closed loop feedback control for switch-mode DC/DC power converter with multiple outputs using digital filter feedback, in contrast to analog error feedback. In the apparatus and method, multiple outputs for a switch-mode DC/DC power converter are regulated by digital means, including the allocating or partitioning of digital control resources among each of the multiple outputs. The partitioning of control resources may be in response to operating conditions.
    Type: Grant
    Filed: May 6, 2015
    Date of Patent: May 23, 2017
    Assignee: SWITCHING POWER, INC.
    Inventor: Keng C. Wu
  • COMPOSITIONS AND METHODS FOR RENDERING TUMOR CELLS SUSCEPTIBLE TO CD8+ T CELL-MEDIATED KILLING
    Publication number: 20170137493
    Abstract: The present invention provides an immunoconjugate having the formula: T-c-En-c-Fcn or T-c-Fcn-c-En; wherein, T is a single chain variable portion fragment of a monoclonal antibody (scFv) directed to a target protein, polypeptide, or fragment thereof, which is highly expressed on cancer cells; E is two or more foreign immunogenic CD8+ T cell antigenic epitopes; c is a peptide or polypeptide fragment thereof, capable of being cleaved by a specific protease; and Fc is two or more Fc portions of an IgG antibody. Nucleic acid sequences encoding the same and vectors containing said nucleic acid sequences are also provided. Methods of making the immunoconjugate, along with methods of making target cells susceptible to CTL mediated cell killing, and methods for treatment of cancers are also provided.
    Type: Application
    Filed: January 11, 2017
    Publication date: May 18, 2017
    Inventors: Chien-Fu Hung, T.C. Wu
  • FABRICATION OF A FLEXIBLE CIRCUIT BOARD
    Publication number: 20170064838
    Abstract: The present disclosure relates, according to some embodiments, to the fabrication of a flexible circuit board, which includes forming a base layer comprising polyimide, forming a polyimide layer on the base layer, the polyimide layer having a first surface and a second surface opposite to each other, the first surface being peelably adhered in contact with the base layer, forming a metal layer on the second surface of the polyimide layer, and peeling the base layer from the polyimide layer with the metal layer remaining on the second surface of the polyimide layer.
    Type: Application
    Filed: August 29, 2016
    Publication date: March 2, 2017
    Inventors: Paul S.C. Wu, Chun-Ting Lai, Yen-Po Huang, Sheng-Yu Huang
  • DEP FORCE CONTROL AND ELECTROWETTING CONTROL IN DIFFERENT SECTIONS OF THE SAME MICROFLUIDIC APPARATUS
    Publication number: 20170043343
    Abstract: A microfluidic apparatus can comprise a dielectrophoresis (DEP) configured section for holding a first liquid medium and selectively inducing net DEP forces in the first liquid medium. The microfluidic apparatus can also comprise an electrowetting (EW) configured section for holding a second liquid medium on an electrowetting surface and selectively changing an effective wetting property of the electrowetting surface. The DEP configured section can be utilized to select and move a micro-object in the first liquid medium. The EW configured section can be utilized to pull a droplet of the first liquid medium into the second liquid medium.
    Type: Application
    Filed: April 25, 2015
    Publication date: February 16, 2017
    Inventors: Igor Y. KHANDROS, J. Tanner NEVILL, Steven W. SHORT, Ming C. WU
  • ROLLER ASSEMBLY OF AN UNDERCARRIAGE SYSTEM
    Publication number: 20170043819
    Abstract: The disclosure provides a roller assembly for an undercarriage system of a machine. The undercarriage system includes a frame, which has a first inner surface defining a first opening. The roller assembly includes a roller supported on a roller shaft, and a spacer assembly. The spacer assembly includes a boss and a pad. The boss includes a second inner surface defining a second opening. The boss is fixedly attached to the frame, such that the second opening axially aligns with the first opening of the frame. The pad includes a third inner surface defining a third opening. The pad has a relatively greater hardness than the boss. The pad is fixedly attached to the boss, such that the third opening axially aligns with the second opening. Further, the roller shaft extends through the first opening, the second opening, and the third opening, to support the roller on the frame.
    Type: Application
    Filed: October 25, 2016
    Publication date: February 16, 2017
    Applicant: Caterpillar Global Mining LLC
    Inventors: Cheng-Kong C. Wu, Gregory H. Dubay
  • Compositions and methods for rendering tumor cells susceptible to CD8+ T cell-mediated killing
    Patent number: 9561275
    Abstract: The present invention provides an immunoconjugate having the formula: T-c-En-c-Fcn or T-c-Fcn-c-En; wherein, T is a single chain variable portion fragment of a monoclonal antibody (scFv) directed to a target protein, polypeptide, or fragment thereof, which is highly expressed on cancer cells; E is two or more foreign immunogenic CD8+ T cell antigenic epitopes; c is a peptide or polypeptide fragment thereof, capable of being cleaved by a specific protease; and Fc is two or more Fc portions of an IgG antibody. Nucleic acid sequences encoding the same and vectors containing said nucleic acid sequences are also provided. Methods of making the immunoconjugate, along with methods of making target cells susceptible to CTL mediated cell killing, and methods for treatment of cancers are also provided.
    Type: Grant
    Filed: September 13, 2013
    Date of Patent: February 7, 2017
    Assignee: The Johns Hopkins University
    Inventors: Chien-Fu Hung, T. C. Wu
  • Spallation-resistant multilayer thermal spray metal coatings
    Patent number: 9556506
    Abstract: A multilayer, wear- and corrosion-resistant coating on a metal substrate comprising a first metal coating layer comprising a composite carbide material; a second metal coating layer over the first metal coating layer comprising at least about 50 wt % of a metal selected from the group consisting of Co, Ni, and Fe; and a surface metal coating layer comprising a cemented carbide material having a third-layer carbide material and a third-layer Co-based or Ni-based binder material.
    Type: Grant
    Filed: November 18, 2013
    Date of Patent: January 31, 2017
    Assignee: KENNAMETAL INC.
    Inventors: David A. Lee, Heidi Lynette de Villiers-Lovelock, Danie Jacobus Dewet, James B. C. Wu
  • TELESCOPIC SUITCASE HANDLE
    Publication number: 20170000233
    Abstract: A telescopic suitcase handle is provided for including a telescopic handle housing disposed within a suitcase, a lower extendible handle section movably disposed within the telescopic handle housing, and an upper extendible handle section movably disposed within the lower section. A spring loaded bullet disposed within the upper section releasably engages with one of a plurality of openings along the length of the lower section for temporarily holding the upper extendible handle section in place. A spring-loaded protrusion releasably engages with the lower extendible handle section for temporarily holding the lower section in place.
    Type: Application
    Filed: July 1, 2016
    Publication date: January 5, 2017
    Inventors: Paul V. Scicluna, Peter C. Wu, Victor G. Sanz
  • Bicyclo [2.2.1] acid GPR120 modulators
    Patent number: 9518000
    Abstract: The present invention provides compounds of Formula (I): (I) or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR120 G protein-coupled receptor modulators which may be used as medicaments.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: December 13, 2016
    Assignee: Bristol-Myers Squibb Company
    Inventors: Yan Shi, Peter T. W. Cheng, Ying Wang, Shung C. Wu, Hao Zhang
  • ABRASION-RESISTANT WELD OVERLAY
    Publication number: 20160355922
    Abstract: A material blend for deposition of an abrasion-resistant overlay onto a metal substrate comprising a first metal particle component, a second metal particle component, and a carbide particle component and a method for the application thereof, wherein the overlay process conditions and the homogeneity of tungsten carbide distribution in the overlay are improved.
    Type: Application
    Filed: August 22, 2016
    Publication date: December 8, 2016
    Inventors: Thomas SWINGLEY, Kevin LUER, Rodrick WEBBER, James B.C. WU
  • DIGITAL CLOSED-LOOP CONTROL FOR DC/DC SWITCH-MODE POWER CONVERTERS WITH MULTIPLE OUTPUTS
    Publication number: 20160329813
    Abstract: Apparatus and method for providing closed loop feedback control for switch-mode DC/DC power converter with multiple outputs using digital filter feedback, in contrast to analog error feedback. In the apparatus and method, multiple outputs for a switch-mode DC/DC power converter are regulated by digital means, including the allocating or partitioning of digital control resources among each of the multiple outputs. The partitioning of control resources may be in response to operating conditions.
    Type: Application
    Filed: May 6, 2015
    Publication date: November 10, 2016
    Inventor: Keng C. Wu
  • SILICON-PHOTONICS-BASED OPTICAL SWITCH
    Publication number: 20160327751
    Abstract: An optical switching system comprising a switching cell having first and second fixed-position bus waveguides and a moveable shunt waveguide is disclosed. The first bus waveguide includes an input and a first output. The second bus waveguide includes a second output. When the switching cell is in its unswitched state, the shunt waveguide is not optically coupled with either bus waveguide and a light signal can pass from the input to the first output while remaining in the first bus waveguide. When the switching cell is in its switched state, the shunt waveguide is optically coupled with both bus waveguides such that the light signal is coupled out of the first bus waveguide and into the second bus waveguide via the shunt waveguide. As a result, the light signal can pass from the input to the second output while bypassing the first input.
    Type: Application
    Filed: January 9, 2015
    Publication date: November 10, 2016
    Inventors: Ming C. WU, Sangyoon HAN, Tae Joon SEOK, Niels QUACK, Byung-Wook YOO
  • Briefcase
    Patent number: D771942
    Type: Grant
    Filed: May 13, 2015
    Date of Patent: November 22, 2016
    Assignee: TUMI, INC
    Inventor: Peter C. Wu
  • Suitcase handle
    Patent number: D771946
    Type: Grant
    Filed: May 29, 2015
    Date of Patent: November 22, 2016
    Assignee: TUMI, INC
    Inventors: Peter C. Wu, Victor Sanz, Paul V. Scicluna
  • Zipper housing
    Patent number: D772576
    Type: Grant
    Filed: May 14, 2015
    Date of Patent: November 29, 2016
    Assignee: TUMI, INC
    Inventor: Peter C. Wu
  • Suitcase
    Patent number: D780451
    Type: Grant
    Filed: May 13, 2015
    Date of Patent: March 7, 2017
    Assignee: TUMI, INC.
    Inventor: Peter C. Wu