Abstract: A delivery device for intravenous delivery of microparticles to a patient. The delivery device is fluidly connectable to (i) a first source of an injection medium and (ii) a second source of an injection medium. The delivery device includes: a first fluid inlet fluidly connectable to the first source of the injection medium, a fluid outlet, a fluid mixer fluidly connecting the first fluid inlet to the fluid outlet, a second fluid inlet fluidly connectable to the second source of the injection medium, and a source of microparticles fluidly connecting the second fluid inlet to the fluid mixer. When fluid flows from the second source of the injection medium into the delivery device: the second injection medium fluidly drives microparticles from the source of microparticles into the fluid mixer, and the fluid outlet dispenses to the patient an injection medium that includes the microparticles.

Abstract: A seamless interface with touchscreen functionality and the method of manufacture are disclosed. An apparatus utilizing the seamless interface with touchscreen functionality, and a method of manufacturing the apparatus are similarly disclosed. The seamless interface has a front member, adhesive means, and a support member with an opening. The apparatus includes a touchscreen device, a rear member, and the seamless interface. The rear member secures the touchscreen device in the opening of the support member, which thereby contacts the front member of the seamless interface. Partially laminating the front member with the support member having an opening utilizing an adhesive means creates the seamless interface. This design enables the touchscreen functionality of the touchscreen device placed behind the front member to transfer through the front member, thereby allowing a user to communicate with the touchscreen device through the seamless interface.

Abstract: A liquid-cooled power electronics unit includes a planar circuit board body having conductor tracks, a wet side with a wet space for carrying a dielectric cooling liquid, and a fluidically, separated dry side, wherein at least two high-voltage power semiconductors are arranged on the circuit board body on the wet side within the wet space, the high-voltage power semiconductors being cooled by the cooling liquid, and an electronic low-voltage circuit is arranged on the dry side of the circuit board body.

Abstract: Provided herein are systems, methods and computer readable media for programmatically generating and/or revising deal offers for a merchant based on one or more merchant self-service indicators. In providing such functionality, the system can be configured to, for example, facilitate registration and verification of merchant identities, monitor and analyze various deal offers for merchants with similar merchant self-service indicators, that enable the system to determine the relative successfulness of a deal offer for a merchant and/or category of merchant. In some embodiments, the system may be further configured to revise the deal offer programmatically and/or upon receiving the merchant's approval of the programmatically generated proposed edits to the deal offer.

Abstract: Method and apparatus for detecting and characterizing a pulse sequence using a finite impulse filter to determine a pulse width (PW) of pulses within the pulse sequence. The method and apparatus may also apply a histogram to the filtered pulses to determine the pulse rate interval (PRI) of pulses in the pulse sequence.

Abstract: Deep brain stimulation (DBS) can be used to treat many neurological conditions beyond traditional movement disorders. When patients do not suffer from traditional movement disorders, medical professionals cannot use traditional observation-based methods to configure the DBS system. A new method for selecting stimulation configurations can include recording internal data and external data as the patient performs (or attempts to perform) a motor task. The internal data is electrophysiology data recorded by a plurality of DBS electrodes, used to identify at least one of the plurality of electrodes closest to a neuronal population involved in control of the at least one motor task. The external data is electroencephalogram (EEG) data recorded by scalp electrodes, which is used to select at least one of the potential stimulation electrodes to deliver the DBS. When the electrode(s) delivering the DBS are selected, optimal parameters for the DBS are then chosen.

Abstract: The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and cardiac diseases, preferably heart failure with reduced and preserved ejection fraction (HFrEF, HFmrEF and HFpEF), hypertension (HTN), peripheral arterial diseases (PAD, PAOD), cardio-renal and kidney diseases, preferably chronic and diabetic kidney disease (CKD and DKD), cardiopulmonary and lung diseases, preferable pulmonary hypertension (PH), and other diseases, preferably neurodegenerative diseases and different forms of dementias, fibrotic diseases, systemic sclerosis (SSc), sickle cell disease (SCD), wound healing disorders such as diabetic foot ulcer (DFU).

Abstract: The invention provides methods for treating or preventing developmental disorders associated with mutations in the OCD1 gene.

Abstract: Methods and systems are provided for a multi-chambered container. In one example, a container comprising a first chamber is positioned between a liquid chamber and a second chamber, a first seal is positioned between the first chamber and the liquid chamber, and a second seal is positioned between the second chamber and the first chamber. By rotating a first external ring of the container that is positioned between the liquid chamber and the first chamber of the container a first liquid tight seal is opened to enable communication between the liquid chamber and the first chamber. The first external ring may be positioned at a first end of the liquid chamber that is opposite a second end of the liquid chamber that includes a drinking opening.

Abstract: The present invention concerns a hydraulic pressure amplifier device comprising a casing (10) having two chambers (12, 14) of different cross-sections which house a staged piston (20) comprising two piston sections (22, 24) with cross-sections respectively el matching the chambers (12, 14), and means (30) for controlling the movement of the piston (20), characterised by the fact that the control means (30) are formed of an electronic control driven by means for estimating the ends-of-stroke of the piston (20) without an end-of-stroke sensor or mechanical stop.

Abstract: A computer input system includes a mouse including a housing having an interior surface defining an internal volume and a sensor assembly disposed in the internal volume. A processor is electrically coupled to the sensor assembly and a memory component having electronic instructions stored thereon that, when executed by the processor, causes the processor to determine an orientation of the mouse relative to a hand based on a touch input from the hand detected by the sensor assembly. The mouse can also have a circular array of touch sensors or lights that detect hand position and provide orientation information to the user.

Abstract: Techniques for configuring device-specific skills as top-level skills are described. When a system receives a user input the system performs NLU processing to determine an intent of the user input. In some instances, the system may identify a device-specific skill associated with the device interacted with by the user. At least partially in parallel to performing NLU processing to determine the intent of the user input, the system may also perform NLU processing to determine a likelihood that the user input corresponds to an intent actionable by the device-specific skill. Once the system has finished NLU processing, the system may implement one or more prioritization rules to determine whether the user input should be sent to the device-specific skill or another skill of the system.

Abstract: There is disclosed a method of providing rider service for an autonomous vehicle (AV) system, including operating an AV to provide a trip to a passenger; associating the passenger with a unique passenger identifier (UPID); receiving passenger metadata for the passenger according to the UPID; and responding to a rider service instance, comprising customizing the response according to the UPID and the passenger metadata.

Abstract: The invention relates to methods of treating of subject that has breast cancer or is at risk of having said cancer, comprising administering to the subject in need thereof a combination of a therapeutically effective amount of an ErbB-2/ErbB-3 bispecific antibody and a therapeutically effective amount of an endocrine therapy drug, wherein the bispecific antibody has an antigen binding site that can bind an extra-cellular part of ErbB-2 and an antigen binding site that can bind an extra-cellular part of ErbB-3; and to means for said method.

Abstract: The invention concerns a method for determining a mechanical stress of a runner (40), of a hydraulic machine (10), wherein the runner is arranged to rotate around a rotation axis, wherein the hydraulic machine comprises a hydraulic channel delimited by hydraulic surfaces of the runner, the hydraulic surfaces being the surfaces against which a stream of water exerts the forces when the runner is driven in rotation by said stream of water, wherein the runner further comprises a sensor (G) on protected areas positioned away from the hydraulic channel, the method comprises the steps of: a) collecting a physical quantity measured by the sensor (G), b) determining a mechanical stress on a specific location of the hydraulic surface, via a transfer function that correlates the physical quantity measured in step a) and said mechanical stress on the specific location.

Abstract: Systems and methods are provided for semi-automated, portable, ultrasound guided cannulation. The systems and methods provide for image analysis to provide for segmentation of vessels of interest from image data. The image analysis provides for guidance for insertion of a cannulation system into a subject which may be accomplished by a non-expert based upon the guidance provided. The guidance may include an indicator or a mechanical guide to guide a user for inserting the vascular cannulation system into a subject to penetrate the vessel of interest.

Abstract: Devices, servers, systems and methods for content protection are provided. Disclosed embodiments improve temporal granularity of controlling access to the protected content and increase resilience against attacks attempting to prevent re-evaluation of conditions of access. Enforcement of re-evaluation may be based on the receipt and/or verification of tokens. In some embodiments, re-evaluation is enforced by periodically rendering content keys required for content decryption unuseable and/or clearing content keys already in use.

Abstract: A shingled magnetic recording (SMR) hard disk drive (HDD) receives a read command for data associated with a range of logical block addresses (LBAs). In situations where a first portion of valid data associated with the range of LBAs is stored in an SMR region of the HDD and a second portion of valid data associated with the range of LBAs is stored in a non-SMR region of the HDD, the first portion is read from the SMR region in a single disk access and copied to a first buffer of the HDD, and the second portion is read from the non-SMR region in one or more disk accesses and copied to a second buffer of the HDD. The valid data associated with the range of LBAs stored in the second buffer are copied to the first buffer to be combined with valid data associated with the range of LBAs stored in the first buffer, and the combined valid data is then transferred to the host to complete execution of the read command.