Patents by Inventor Andreas Keller

Andreas Keller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9056812
    Abstract: A process for preparing 4-cyclohexyl-2-methyl-2-butanol, comprising: a) reaction of styrene with isopropanol at elevated temperature to obtain 2-methyl-4-phenyl-2-butanol, and b) heterogeneously catalyzed hydrogenation of 2-methyl-4-phenyl-2-butanol over a catalyst suitable for ring hydrogenation of aromatics, where the molar ratio of the styrene used in step a) to the isopropanol used in step a) is in the range from 1:below 5 to 1:0.5.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: June 16, 2015
    Assignee: BASF SE
    Inventors: Rudolf Schuch, Stefan Rüdenauer, Klaus Ebel, Ralf Pelzer, Andreas Keller
  • Publication number: 20150111772
    Abstract: The invention relates to methods for diagnosing multiple sclerosis with miRNA markers. Diagnosis of multiple sclerosis (MS) can be challenging in patients with atypical presentations and during a first neurological deficit possibly related to inflammatory demyelination. Towards the identification of biomarkers for diagnosis of MS, a comprehensive analysis of miRNA expression patterns was obtained. Significantly deregulated miRNAs were identified, which have previously not been related to MS according to the microRNA disease database. These miRNAs could potentially serve as future diagnostic biomarkers for MS and help in diagnosis, monitoring disease activity, and evaluation of treatment responses in patients with MS.
    Type: Application
    Filed: April 18, 2013
    Publication date: April 23, 2015
    Applicant: Siemens Healthcare Diagnostics Holding GmbH
    Inventors: Andreas Keller, Eckart Meese, Cord Friedrich Stähler, Andreas Kappel, Petra Leidinger, Christina Backes
  • Publication number: 20150064704
    Abstract: The present invention relates to non-invasive methods for early diagnosis and/or differential diagnosis of acute myocardial infarction in a blood sample of a subject. Further, the present invention relates to polynucleotides or sets of polynucleotides for detecting miRNAs or sets of miRNAs for early diagnosis and/or differential diagnosis of acute myocardial infarction in a blood sample of a subject.
    Type: Application
    Filed: April 4, 2013
    Publication date: March 5, 2015
    Inventors: Andreas Keller, Benjamin Meder, Hugo Katus, Britta Vogel, Markus Beier
  • Publication number: 20150045243
    Abstract: The present invention relates to non-invasive methods, kits and means for diagnosing and/or prognosing of a disease in a body fluid sample from a subject. Further, the present invention relates to set of polynucleotides or sets of primer pairs for detecting sets of miRNAs for diagnosing and/or prognosing of a disease in a body fluid sample from a subject.
    Type: Application
    Filed: October 5, 2012
    Publication date: February 12, 2015
    Inventors: Andreas Keller, Christina Backes, Markus Beier
  • Publication number: 20150037797
    Abstract: The invention relates to a method of detecting nucleic acid molecules by immunoassay detection. Detection of a specific nucleic acid molecule of interest is achieved by using a nucleic acid probe in solution which hybridizes in solution to the nucleic acid molecule of interest. Immunoassay detection is achieved by using an antibody specific for the hybrid formed by hybridization of the nucleic acid probe to the nucleic acid molecule of interest.
    Type: Application
    Filed: March 8, 2013
    Publication date: February 5, 2015
    Applicants: SIEMENS HEALTHCARE DIAGNOSTICS INC, SIEMENS HEALTHCARE DIAGNOSTICS PRODUCTS GMBH
    Inventors: Andreas Kappel, Andreas Keller, Cord Friedrich Stahler, Ian Wright, Linda Marie Anderson-Mauser, William Bedzyk, Herbert Schwarz, Michaela Wicke
  • Publication number: 20150037327
    Abstract: The present invention relates to methods of determining whether a patient responds to a therapeutic treatment of multiple sclerosis (MS), of monitoring the course of multiple sclerosis (MS) in a patient, of determining the risk for a relapse of multiple sclerosis (MS) in a patient, and of adjusting the dose of a therapeutic drug applied for therapeutic treatment of multiple sclerosis in a patient. Said methods are based on the determination of the level of at least one miRNA in a test sample isolated from the patient. The present invention also relates to a method of identifying a compound suitable for the treatment of multiple sclerosis in a patient.
    Type: Application
    Filed: March 7, 2013
    Publication date: February 5, 2015
    Inventors: Andreas Keller, Markus Beier, Matthias Scheffler, Anke Wendschlag, Orhan Aktas, Jens Ingwersen, Hans-Peter Hartung, Patrick Küry, Timour Prozorovski
  • Publication number: 20150031777
    Abstract: MicroRNAs (miRNA) are a recently discovered class of small non-coding RNAs (17-14 nucleotides). Due to their function as regulators of gene expression they play a critical role both in physiological and in pathological processes, such as cancer. The present invention provides novel methods for diagnosing a state of health based on the determination of specific miRNAs that have altered expression levels in different conditions, e.g. disease states compared to healthy controls.
    Type: Application
    Filed: June 23, 2014
    Publication date: January 29, 2015
    Applicant: Comprehensive Biomarker Center GmbH
    Inventors: Andreas KELLER, Eckart MEESE, Anne BORRIES, Markus BEIER
  • Publication number: 20150004201
    Abstract: The present invention relates to improved powderous formulations of organic acids or esters having an aromatic ring system, as well as to the production of such formulations.
    Type: Application
    Filed: February 6, 2013
    Publication date: January 1, 2015
    Inventors: Martin Gadient, Thomas Lindemann, Karl Manfred Voelker, Kai Urban, Stefanie Kirchen, Andreas Keller
  • Patent number: 8881659
    Abstract: A folding table for attachment to the rear side of a vehicle seat part has a fastening device (2a, 2c) for fastening the folding table to the vehicle seat (1a, 1b, 1c), a carrier element (4) which is connected to the fastening device (2a, 2c) and extends downward from the fastening device (2a, 2c) and a tabletop (6) rotatably connected to the carrier element (4). Supporting elements (7e) are arranged on the tabletop (6) which, when the tabletop (6) is in the working position, can be moved in the direction toward the vehicle seat part (1a, 1b, 1c) by a common actuating member (7a, 7d, 7b?, 7b?) and can be fixed in different positions by a manually releasable latching device (6h, 7b, 7c), so that the tabletop (6) can be aligned in a horizontal position.
    Type: Grant
    Filed: December 6, 2010
    Date of Patent: November 11, 2014
    Assignee: Kinetix AG
    Inventors: Peter Ackeret, Michael Andreas Keller
  • Patent number: 8850715
    Abstract: What is described is a process and an installation for drying articles, in particular painted vehicle bodies, in which the articles are moved through a drying zone in which they are hardened in an inert-gas atmosphere. Inert gas is taken from the drying zone constantly or intermittently and is first of all conducted along a first face which is at a first temperature at which higher-boiling contaminants condense out. The condensate that forms in the process is discharged. After that, the inert gas which has been pre-cleaned in this way is conducted along at least one second face which is at a lower temperature than the first face. Lower-boiling contaminants are precipitated at this point. These condensates, too, are then discharged. This process and installation work more favorably, energy-wise, and with higher cleaning efficiency than known processes and installations of a similar type.
    Type: Grant
    Filed: September 4, 2007
    Date of Patent: October 7, 2014
    Assignee: Eisenmann AG
    Inventors: Werner Swoboda, Andreas Keller
  • Publication number: 20140274789
    Abstract: The present invention relates to non-invasive methods, kits and means for diagnosing and/or prognosing of psoriasis in a body fluid sample from a subject. Further, the present invention relates to set of polynucleotides or sets of primer pairs for detecting sets of miRNAs for diagnosing and/or prognosing of psoriasis in a body fluid sample from a subject. In addition, the present invention relates to sets of miRNAs for diagnosing and/or prognosing of psoriasis in a body fluid sample from a subject.
    Type: Application
    Filed: August 3, 2012
    Publication date: September 18, 2014
    Inventors: Andreas Keller, Markus Beier, Eckart Meese, Petra Leidinger, Valesca Boisguerin
  • Publication number: 20140213476
    Abstract: The present invention relates to non-invasive methods, kits and means for diagnosing and/or prognosing of colon cancer in a body fluid sample from a subject. Further, the present invention relates to set of polynucleotides or sets of primer pairs for detecting sets of miRNAs for diagnosing and/or prognosing of colon cancer in a body fluid sample from a subject. In addition, the present invention relates to sets of miRNAs for diagnosing and/or prognosing of colon cancer in a body fluid sample from a subject.
    Type: Application
    Filed: August 3, 2012
    Publication date: July 31, 2014
    Inventors: Andreas Keller, Markus Beier, Eckart Meese, Petra Leidinger, Anke Wendschlag
  • Publication number: 20140193822
    Abstract: The present invention relates to non-invasive methods, kits and means for diagnosing and/or prognosing of kidney cancer in a body fluid sample from a subject. Further, the present invention relates to set of polynucleotides or sets of primer pairs for detecting sets of miRNAs for diagnosing and/or prognosing of kidney cancer in a body fluid sample from a subject. In addition, the present invention relates to sets of miRNAs for diagnosing and/or prognosing of kidney cancer in a body fluid sample from a subject.
    Type: Application
    Filed: August 3, 2012
    Publication date: July 10, 2014
    Applicant: Comprehensive Biomarker Center GmbH
    Inventors: Andreas Keller, Markus Beier, Eckart Meese, Petra Leidinger, Anke Wendschlag
  • Publication number: 20140194312
    Abstract: The present invention relates to non-invasive methods, kits and means for diagnosing and/or prognosing of dilated cardiomyopathy in a body fluid sample from a subject. Further, the present invention relates to set of polynucleotides or sets of primer pairs for detecting sets of miRNAs for diagnosing and/or prognosing of dilated cardiomyopathy in a body fluid sample from a subject. In addition, the present invention relates to sets of miRNAs for diagnosing and/or prognosing of dilated cardiomyopathy in a body fluid sample from a subject.
    Type: Application
    Filed: June 8, 2012
    Publication date: July 10, 2014
    Applicant: Comprehensive Biomarker Center GmbH
    Inventors: Andreas Keller, Benjamin Meder, Hugo Katus, Britta Vogel, Markus Beier
  • Publication number: 20140058752
    Abstract: A computer network system and a method for quality testing input clinical trial data are disclosed. The trial data is recorded by way of a form provided on a patient device or a physician device and is passed on in an encrypted, anonymized form to a central server. A quality testing device is installed on the server in order to test the recorded medical data sets with regard to the quality thereof. The scope of the quality test is configurable. In the event of successful testing, an incentive attribute is read out from a database in order to generate an incentive signal and to transmit the signal to the respective terminal device.
    Type: Application
    Filed: August 20, 2013
    Publication date: February 27, 2014
    Applicant: SIEMENS AKTIENGESELLSCHAFT
    Inventors: Mario BECHTOLD, Andreas KELLER, Rainer KUTH, Gerd SCHMIDT, Cord Friedrich Stähler
  • Publication number: 20140024554
    Abstract: The present invention relates to non-invasive methods, kits and means for diagnosing and/or prognosing of glioblastoma in a body fluid sample from a subject. Further, the present invention relates to set of polynucleotides or sets of primer pairs for detecting sets of miRNAs for diagnosing and/or prognosing of glioblastoma in a body fluid sample from a subject. In addition, the present invention relates to sets of miRNAs for diagnosing and/or prognosing of glioblastoma in a body fluid sample from a subject.
    Type: Application
    Filed: December 28, 2011
    Publication date: January 23, 2014
    Applicant: febit Holding GmbH
    Inventors: Andreas Keller, Markus Beier
  • Publication number: 20140012558
    Abstract: A system operating in a plurality of modes to provide an integrated analysis of molecular data, imaging data, and clinical data associated with a patient includes a multi-scale model, a molecular model, and a linking component. The multi-scale model is configured to generate one or more estimated multi-scale parameters based on the clinical data and the imaging data when the system operates in a first mode, and generate a model of organ functionality based on one or more inferred multi-scale parameters when the system operates in a second mode. The molecular model is configured to generate one or more first molecular findings based on a molecular network analysis of the molecular data, wherein the molecular model is constrained by the estimated parameters when the system operates in the first mode.
    Type: Application
    Filed: June 27, 2013
    Publication date: January 9, 2014
    Applicants: SIEMENS CORPORATION, SIEMENS AG OSTERREICH, SIEMENS AKTIENGESELLSCHAFT
    Inventors: Tommaso Mansi, Wei Keat Lim, Vanessa King, Andreas Kremer, Bogdan Georgescu, Xudong Zheng, Ali Kamen, Andreas Keller, Cord Friedrich Staehler, Emil Wirsz, Dorin Comaniciu
  • Patent number: 8608824
    Abstract: Integrated process, in which pure carbonyl iron powder (CIP) is prepared by decomposition of pure iron pentacarbonyl (IPC) in a plant A, carbon monoxide (CO) liberated in the decomposition of the IPC is used in plant A for the preparation of further CIP from iron or is fed to an associated plant B for the preparation of synthesis gas or is fed to an associated plant C for the preparation of hydrocarbons from synthesis gas, and the CIP prepared in plant A is used as catalyst or catalyst component in an associated plant C for the preparation of hydrocarbons from synthesis gas from plant B.
    Type: Grant
    Filed: September 2, 2009
    Date of Patent: December 17, 2013
    Assignee: BASF SE
    Inventors: Jochen Steiner, Ekkehard Schwab, Andreas Keller, Otto Watzenberger, Ulrich Gräβle, Manfred Julius
  • Publication number: 20130331290
    Abstract: The present invention relates to single polynucleotides or sets of polynucleotides for detecting single miRNAs or sets of miRNAs for diagnosing and/or prognosing of a lung disease in a biological sample from a patient. Further, the present invention relates to means for diagnosing and/or prognosing of a lung disease comprising said polynucleotides or sets of polynucleotides. Furthermore, the present invention relates to a method for diagnosing and/or prognosing of a lung disease based on the determination of expression profiles of single miRNAs or sets of miRNAs representative for a lung disease. In addition, the present invention relates to a kit for diagnosing and/or prognosing of a lung disease comprising means for determining expression profiles of single miRNAs or sets of miRNAs representative for a lung disease and optionally at least one reference and/or algorithm or mathematical function comprised on at least one data carrier.
    Type: Application
    Filed: January 26, 2012
    Publication date: December 12, 2013
    Applicant: febit Holding GmbH
    Inventors: Andreas Keller, Markus Beier
  • Publication number: 20130331278
    Abstract: The present invention relates to non-invasive methods, kits and means for diagnosing and/or prognosing of prostate diseases in a body fluid sample from a subject. Further, the present invention relates to set of polynucleotides or sets of primer pairs for detecting sets of miRNAs for diagnosing and/or prognosing of prostate diseases in a body fluid sample from a subject. In addition, the present invention relates to sets of miRNAs for diagnosing and/or prognosing of prostate diseases in a body fluid sample from a subject.
    Type: Application
    Filed: December 28, 2011
    Publication date: December 12, 2013
    Applicant: febit Holding GmbH
    Inventors: Andreas Keller, Markus Beier, Valesca Boisguerin, Eckart Meese, Petra Leidinger