Abstract: Aspects of the disclosure include a first risk-transfer system, a second risk-transfer system, and an expert-system based circuit. The first risk-transfer system is configured to provide a first risk-transfer based on first risk-transfer parameters from a plurality of motor vehicles to the first risk-transfer system, and receive and store first payment parameters associated with risk exposures of the plurality of motor vehicles. The second risk-transfer system is configured to provide a second risk-transfer based on second risk-transfer parameters from the first risk-transfer system to the second risk-transfer system, and receive and store second payment parameters associated with risk exposures transferred to the first risk-transfer systems.

Abstract: The present invention provides novel methods for diagnosing a state of health based on the determination of specific miRNAs that have altered expression levels in different conditions, e.g. disease states compared to healthy controls.

Abstract: The present invention relates to non-invasive methods, kits and means for diagnosing and/or prognosing of kidney cancer in a body fluid sample from a subject. Further, the present invention relates to set of polynucleotides or sets of primer pairs for detecting sets of miRNAs for diagnosing and/or prognosing of kidney cancer in a body fluid sample from a subject. In addition, the present invention relates to sets of miRNAs for diagnosing and/or prognosing of kidney cancer in a body fluid sample from a subject.

Abstract: The invention relates to a method of determining an infection of a patient with Klebsiella species potentially resistant to antimicrobial drug treatment by detecting mutations in the genes, parC, KPN 01607, gyrA, KPN 02451, baeR, aceF, ybgH, ynjE, KPN 01951, KPN 01961, KPN 02114, mhpA, KPN 02128, KPN 02144, KPN 02149, ydiJ, btuE, oppC, pth, KPN 02298, KPN 02302, dadA, yoaA, ftn, cbl, hisB, yegQ, yehY, KPN 02580, yejH, KPN 02621, yfaW, KPN 02170, KPN 02025, livG, livM, livH, fliY, yedQ, abgB, treA, baeS, KPN 02399, ydcR, anmK, ccmF, KPN 02440, KPN 02540, KPN 01752, and KPN 04195, and/or KOX 26125, KOX 13365, KOX 16735, KOX 25695, KOX 12270, and KOX 15055; a method of selecting a treatment of a patient suffering from an antibiotic resistant Klebsiella infection; and a method of determining an antibiotic resistance profile for bacterial microorganisms of Klebsiella species, as well as computer program products used in these methods.

Abstract: The present invention provides novel methods for diagnosing diseases based on the determination of specific miRNAs that have altered expression levels in disease states compared to healthy controls.

Abstract: MicroRNAs (miRNA) are a recently discovered class of small non-coding RNAs (17-14 nucleotides). Due to their function as regulators of gene expression they play a critical role both in physiological and in pathological processes, such as cancer. The present invention provides novel methods for diagnosing prostate cancer based on the determination of specific miRNAs that have altered expression levels in different conditions, e.g. disease states compared to healthy controls.

Abstract: A holder is provided for releasably securing a flat device, such as a tablet computer or a smartphone, to a component, in particular a component of a motor vehicle. The holder comprises a mounting which can be secured to the component and a holder frame which can be releasably secured to the mounting for receiving the device. The mounting comprises a carrier having first connection elements, and the holder frame has second connection elements at two opposite edges. The first and second connection elements are designed in a complementary manner with respect to each other such that the first and second connection elements interlock for the purpose of mutual fixing when the holder frame is inserted into the mounting such that the holder frame cannot be moved out of the mounting in the holder frame plane and/or perpendicularly to the holder frame plane.

Abstract: The invention relates to a retaining device for a still or video camera in the interior of a motor vehicle with a fastening apparatus (5, 5a, 5b, 5c, 5d, 5e) for attaching the retaining device to a vehicle seat part, such as a backrest (2), headrest (3), or headrest holder (4, 4a, 4b) of a vehicle seat (1), and a carrier arm (6, 6?, 6?, 60, 60?, 60?, 62, 62?, 62?) which is oriented approximately horizontally and parallel with respect to the broad side of the backrest (2) and at one end of which a holder (7) is arranged for receiving a camera (8), wherein the carrier arm (6, 6?, 6?, 60, 60?, 60?, 62, 62?, 62?) protrudes beyond the vehicle seat part (2, 3, 4, 4a, 4b) to such an extent that the lens (8a) of the camera (8) has an uninterrupted view towards the front in the driving direction and/or towards the rear in the direction counter to the driving direction, and wherein the carrier arm (6, 6?, 6?, 60, 60?, 60?, 62, 62?, 62?) at its other end is connected via a first rotary joint (6a) with an approximately v

Abstract: The present invention provides novel methods for diagnosing a state of health based on the determination of specific miRNAs that have altered expression levels in different conditions, e.g. disease states compared to healthy controls.

Abstract: The invention relates to a method of diagnosis of neuromyelitis optica, in particular of differential diagnosis of neuromyelitis optica (NMO) vs. multiple sclerosis (MS) using miRNA biomarkers. These miRNAs could potentially serve as future diagnostic biomarkers for NMO and help in diagnosis, monitoring disease activity, and evaluation of treatment responses in patients with MS.

Abstract: Described herein are non-invasive methods, kits and means for diagnosing and/or prognosing of colon cancer a body fluid sample from a subject. Further described herein are sets of polynucleotides or sets of primer pairs for detecting sets of miRNAs for diagnosing and/or prognosing of colon cancer in a body fluid sample from a subject. In addition, described herein are sets of miRNAs for diagnosing and/or prognosing of colon cancer in a body fluid sample from a subject.

Abstract: The present invention relates to single polynucleotides or sets of polynucleotides for detecting single miRNAs or sets of miRNAs for diagnosing and/or prognosing of an acute coronary syndrome in a blood sample from a human. Further, the present invention relates to means for diagnosing and/or prognosing of an acute coronary syndrome comprising said polynucleotides or sets of polynucleotides. Furthermore, the present invention relates to a method for diagnosing and/or prognosing of an acute coronary syndrome based on the determination of expression profiles of single miRNAs or sets of miRNAs representative for an acute coronary syndrome compared to a reference. In addition, the present invention relates to a kit for diagnosing and/or prognosing of an acute coronary syndrome comprising means for determining expression profiles of single miRNAs or sets of miRNAs representative for an acute coronary syndrome and at least one reference.

Abstract: The present invention relates to a process for reacting isopulegol to menthone in the gas phase and to the use of the reaction products thus prepared as additives in foods, cosmetics, pharmaceutical products, tobacco formulations, household products, and laundry care products.

Abstract: The embodiments relate to a method of determining an antibiotic resistance profile for a bacterial microorganism and to a method of determining the resistance of a bacterial microorganism to an antibiotic drug, wherein the bacterial microorganism belongs to the species Escherichia coli (E. coli). The method includes determining a nucleic acid sequence information or determining the presence of a mutation of at least one gene.

Abstract: A securing device for removably attaching a device to two mutually spaced head support rods (1a, 1b) of a motor vehicle seat (1), having a receiving bushing (3e) for receiving a plug element (2a) which is arranged on the device (2) and having a first and a second securing element (3, 3?, 4, 4?) with which the receiving bushing (3e) can be secured on the head support rods (1a, 1b). The first and the second securing element (3, 3?, 4, 4?) are formed on opposing sides for arranging on the head support rods (1a, 1b), and connectors (5, 5a, 5b) are provided for reciprocally connecting the securing elements (3, 3?, 4, 4?), wherein sliding elements (6a, 6b) are arranged between the securing elements (3, 3?, 4, 4?) and the head support rods (1a, 1b).

Abstract: MicroRNAs (miRNA) are a recently discovered class of small non-coding RNAs (17-14 nucleotides). Due to their function as regulators of gene expression they play a critical role both in physiological and in pathological processes, such as cancer. The present invention provides novel methods for diagnosing a state of health based on the determination of specific miRNAs that have altered expression levels in different conditions, e.g. disease states compared to healthy controls.

Abstract: A process for preparing 4-cyclohexyl-2-methyl-2-butanol, comprising: a) reaction of styrene with isopropanol at elevated temperature to obtain 2-methyl-4-phenyl-2-butanol, and b) heterogeneously catalyzed hydrogenation of 2-methyl-4-phenyl-2-butanol over a catalyst suitable for ring hydrogenation of aromatics, where the molar ratio of the styrene used in step a) to the isopropanol used in step a) is in the range from 1:below 5 to 1:0.5.

Abstract: A wafer boat for receiving wafers, in particular semiconductor wafers, includes at least two elongated receiving elements made of quartz, each receiving element having a plurality of parallel receiving slots, which extend transverse to the longitudinal extension of the receiving elements, and two end plates, between which the receiving elements are arranged and attached such that the receiving slots of the receiving elements are aligned. For increasing the stability, the wafer boat includes a plurality of attachment pieces, via which the receiving elements are attached to the end plates, wherein each attachment piece has a circumference which is at least 1.5 times as large as the circumference of a receiving section of the receiving elements comprising the receiving slots, and wherein each attachment piece is welded or bonded to at least one of the following: an end plate and a receiving element.