Patents by Inventor Arthur James

Arthur James has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peptidase substrates
    Patent number: 8535902
    Abstract: The present invention relates to the use of a compound of the following formula (I) for detecting a peptidase activity and/or a variation in pH: according to which: Y1 is a peptide, H or an alkyl; W1, W2, W3 and W4 are independently H, Br, Cl, F, I, alkyl, alkoxy, thiomethyl, perfluoroalkyl, nitro, cyano, carboxyl (including the esters or amides thereof) or any combination thereof; n=0, 1 or 2; X is NR, CZ5Z6, S or O, R being H, alkyl, aralkyl, aryl, alkanoyl or alkylsulfonyl, Z5 and Z6 being an alkyl; Y is N or N+R, R being alkyl, aralkyl, aryl, alkanoyl or alkylsulfonyl; Z1, Z2, Z3 and Z4 being independently H, Br, Cl, F, I, alkyl, aryl, alkoxy, perfluoroalkyl, nitro, cyano, carboxyl, sulfonyl, including the carboxyl or sulfonyl esters or amides, and salts thereof.
    Type: Grant
    Filed: July 27, 2010
    Date of Patent: September 17, 2013
    Assignee: bioMërieux, S.A.
    Inventors: Olivier Fabrega, Arthur James, Sylvain Orenga, John Perry, Vindhya Salwatura, Stephen Stanforth
  • Peptidase substrates
    Patent number: 8535901
    Abstract: The present invention relates to the use of a compound of the following formula (I) for detecting a peptidase activity and/or a variation in pH: according to which: Y1 is a peptide, H or an alkyl; W1, W2, W3 and W4 are independently H, Br, Cl, F, I, alkyl, alkoxy, thiomethyl, perfluoroalkyl, nitro, cyano, carboxyl (including the esters or amides thereof) or any combination thereof; n=0, 1 or 2; U and V are N, N+R or CZ4, R being H, alkyl, aralkyl, aryl, alkanoyl or alkylsulfonyl; Z1, Z2, Z3 and Z4 being independently H, Br, Cl, F, I, alkyl, aryl, alkoxy, perfluoroalkyl, nitro, cyano, carboxyl, sulfonyl, including the carboxyl or sulfonyl esters or amides, and salts thereof.
    Type: Grant
    Filed: July 28, 2010
    Date of Patent: September 17, 2013
    Assignee: bioMérieux, S.A.
    Inventors: Arthur James, Sylvain Orenga, John Perry, Vindhya Salwatura, Stephen Stanforth
  • Method and system for performing non-contact based determination of the position of an implement
    Patent number: 8478492
    Abstract: Embodiments of the present invention are directed to a method and system for performing non-contact based determination of the position of an implement. In one embodiment, a non-contact based measurement system is used to determine the relative position of an implement coupled with a mobile machine. The geographic position of the mobile machine is determined and the geographic position of said implement based upon the geographic position of the mobile machine and the position of the implement relative to the mobile machine.
    Type: Grant
    Filed: August 26, 2004
    Date of Patent: July 2, 2013
    Assignee: Caterpillar Trimble Control Technologies, Inc.
    Inventors: Arthur James Taylor, Mark Nichols, Philip Jackson
  • METHOD AND SYSTEM FOR NON-LINEARITY COMPENSATION IN OPTICAL TRANSMISSION SYSTEMS
    Publication number: 20130156443
    Abstract: An equaliser (200) for equalisation of a signal transmitted via an optical fibre link from a transmitter to a corresponding receiver employs a backpropagation model (300) which comprises one or more sequential segments collectively representing an inverse fibre link. Each sequential segment comprises a linear backpropagation element (304), and a non-linear backpropagation element (306) having an associated compensation bandwidth (312). The equaliser (200) generates a distortion-mitigated signal by computing, for each sequential segment in turn, a first linear compensated signal from a signal input to the segment in accordance with the linear backpropagation element (304), and a non-linear compensated signal from the first linear compensated signal in accordance with the non-linear backpropagation element (306).
    Type: Application
    Filed: March 1, 2011
    Publication date: June 20, 2013
    Applicant: OFIDIUM PTY LTD
    Inventors: Arthur James Lowery, Liang Bangyuan Du
  • Factor VIII T Cell Epitope Variants Having Reduced Immunogenicity
    Publication number: 20130123181
    Abstract: Provided herein are methods and compositions for preventing or reducing an initial immune response to factor VIII in patients suffering from hemophilia A, and for reducing the intensity of the immune response in patients having pre-formed inhibitor antibodies against factor VIII.
    Type: Application
    Filed: November 15, 2010
    Publication date: May 16, 2013
    Inventors: Kathleen Pratt, Ruth Ettinger, Eddie Arthur James
  • Factor VIII B Cell Epitope Variants Having Reduced Immunogenicity
    Publication number: 20130116182
    Abstract: Provided herein are methods and compositions for preventing or reducing an initial immune response to factor VIII in patients suffering from hemophilia A, and for reducing the intensity of the immune response in patients having pre-formed inhibitor antibodies against factor VIII.
    Type: Application
    Filed: November 15, 2010
    Publication date: May 9, 2013
    Inventors: Kathleen Pratt, Ruth Ettinger, Eddie Arthur James
  • Method for identifying at least two groups of microorganisms
    Patent number: 8420345
    Abstract: The present invention relates to a method for identifying at least two groups of microorganisms expressing the same enzymatic activity, comprising the following steps: a) incubating said groups of microorganisms in a reaction medium comprising a first enzyme substrate and a second enzyme substrate, said first and second enzyme substrates being metabolized by the same enzymatic activity; b) identifying said groups of microorganisms.
    Type: Grant
    Filed: February 23, 2007
    Date of Patent: April 16, 2013
    Assignee: Biomerieux
    Inventors: Sylvain Orenga, Celine Roger-Dalbert, Arthur James, John Perry
  • Fuzz testing and attack-surface scoping for URI handlers and pluggable protocols
    Patent number: 8417993
    Abstract: Systems and methods for testing uniform resource identifier protocols, comprising a fuzzer that can accept an input, and produce a fuzzed uniform resource identifier (URI), and a debugger that monitors effects of invoking the fuzzed uniform resource identifier. The input can comprise a directory containing a plurality of valid uniform resource identifier bodies, which can be fuzzed and invoked. The debugger can monitor a target application as well as other applications and/or processes affected by the uniform resource identifier as invoked.
    Type: Grant
    Filed: June 21, 2007
    Date of Patent: April 9, 2013
    Assignee: Microsoft Corporation
    Inventor: Arthur James O'Leary
  • LOAD BEARING STRUCTURE HAVING ANTIMICROBIAL PROPERTIES
    Publication number: 20130014676
    Abstract: The present invention provides a movable load bearing structure with a surface that includes antimicrobial agents capable of eliminating, preventing, retarding or minimizing the growth of microbes and also minimizing cross-contamination when the load bearing structure is being reused for cargos that differ from a previously transported cargo, for example, different food types, such as poultry, fresh vegetables, and fresh fruit. The load bearing structure may be a dunnage platform or a container for storing and/or shipping cargo.
    Type: Application
    Filed: July 15, 2012
    Publication date: January 17, 2013
    Applicant: AIRDEX INTERNATIONAL, INC.
    Inventors: Rick D. Imbrecht, Vance L. Seagle, Arthur James McCreary
  • Tilt and/or acceleration sensing apparatus and method
    Patent number: 8352116
    Abstract: A tilt or acceleration sensing apparatus and method that allows a tilt or acceleration sensing device of a vehicle to determine: 1) a maximum fall angle of the vehicle, regardless of the orientation of the vehicle and the vehicle's tilt sensor(s) to the incline; or 2) the downward acceleration of the vehicle. In one embodiment, a method of determining a maximum fall angle of a vehicle includes sensing tilt angles of two sensing axes of the vehicle relative to a horizontal reference plane and calculating the maximum fall angle of the vehicle based on the tilt angles. The apparatus and method may also include comparing the maximum fall angle to predetermined values and generating output signals when the maximum fall angle exceeds the predetermined values. In another embodiment, a method of determining when a vehicle is sliding downhill includes sensing the accelerations of three sensing axes.
    Type: Grant
    Filed: January 13, 2010
    Date of Patent: January 8, 2013
    Assignee: Delta Systems, Inc.
    Inventors: Clifford H. Boylston, Arthur James Harvey, Nicholas Schragal
  • METHOD AND APPARATUS FOR QUENCHING A HOT GASEOUS STREAM
    Publication number: 20130001132
    Abstract: The invention comprises a process for cracking liquid hydrocarbon feed to produce cracked gaseous hydrocarbons comprising feeding a liquid hydrocarbon feed stream to an olefins furnace; cracking the liquid hydrocarbon feed stream in the olefins furnace to produce a gaseous cracked effluent stream; feeding the cracked effluent from the olefins furnace to a primary transfer line heat exchanger (TLE) having two sections; injecting a first wetting fluid in a weight ratio of wetting fluid to hot gaseous effluent tangentially into the hot gaseous effluent stream at a particular location in the second section of the primary TLE; feeding the hot gaseous effluent stream exiting from the TLE to a separator; separating a separator bottoms stream comprising tar and heavier hydrocarbons and a separator product stream comprising an olefin product; and recovering an olefin product from the separator product stream.
    Type: Application
    Filed: January 25, 2011
    Publication date: January 3, 2013
    Inventors: Arthur James Baumgartner, A. Haluk Bilgic, Danny Yuk Kwan Ngan
  • MULTICHANNEL NONLINEARITY COMPENSATION IN AN OPTICAL COMMUNICATIONS LINK
    Publication number: 20120263461
    Abstract: An apparatus (104) mitigates cross-channel nonlinear distortion of an optical signal (138) carried on one of a plurality of wavelength channels (118) in a wavelength division multiplexed (WDM) transmission system (100). The apparatus includes a first optical receiver (126) which is arranged to detect a measure (134) of aggregate optical power of the plurality of wavelength channels. A nonlinear dispersion compensator includes means (144) for applying a phase modulation to the optical signal in proportion to the measure of aggregate optical power.
    Type: Application
    Filed: October 6, 2010
    Publication date: October 18, 2012
    Applicant: Ofidium Pty Ltd
    Inventors: Arthur James Lowery, Liang Bangyuan Du
  • Process For Preparing Amino-Mercapto Functional Organopolysiloxanes
    Publication number: 20120245373
    Abstract: A method of making amino-mercapto functional organopolysiloxanes is disclosed by reacting (A) a dialkoxydialkylsilane, (B) an amino functional alkoxy silane, and (C) a mercapto functional alkoxy silane, via a condensation reaction. The amino-mercapto functional organopolysiloxanes products are useful in textile and fabric treatments.
    Type: Application
    Filed: December 17, 2010
    Publication date: September 27, 2012
    Inventors: David John Bunge, Michael David Telgenhoff, Arthur James Tselepis
  • Methods for forming wellbores in heated formations
    Patent number: 8272455
    Abstract: A method for forming a wellbore in a heated formation includes flowing liquid cooling fluid to a bottom hole assembly in a wellbore in a heated formation. At least a portion of the liquid cooling fluid is vaporized at or near a region to be cooled. Vaporizing the liquid cooling fluid absorbs heat from the region to be cooled.
    Type: Grant
    Filed: October 13, 2008
    Date of Patent: September 25, 2012
    Assignee: Shell Oil Company
    Inventors: Rosalvina Ramona Guimerans, Arthur James Mansure
  • Method and apparatus for improving reception of optical signals
    Patent number: 8233799
    Abstract: A method and apparatus for receiving digital information transmitted via an optical signal over an optical channel wherein the optical signal includes an optical carrier (402) and at least one information-bearing optical sideband (404) in the optical frequency domain. The transmitted optical power is distributed between the optical carrier (402) and the optical side band (404). The received optical signal is processed in order to increase the received power in the optical carrier (402) relative to the power in the optical side-band (404). The processed optical signal is detected in order to produce a corresponding electrical signal. The electrical signal is then processed in order to recover the digital information.
    Type: Grant
    Filed: October 15, 2008
    Date of Patent: July 31, 2012
    Assignee: Ofidium Pty, Ltd.
    Inventor: Arthur James Lowery
  • Substrates for detecting peptidase activity and methods using the substrates
    Patent number: 8216800
    Abstract: An enzyme substrate of formula (I) detects peptidase activity: Methods of detecting peptidase activity of a microorganism may include incubating a biological sample with the enzyme substrate of formula (I), and detecting peptidase activity if a microorganism having peptidase activity is present in the biological sample. The enzyme substrate may be included in a reaction medium.
    Type: Grant
    Filed: May 29, 2008
    Date of Patent: July 10, 2012
    Assignee: Biomerieux
    Inventors: Olivier Fabrega, Arthur James, Vindhya Lakshika Salwatura, Sylvain Orenga, Stephen Stanforth
  • Nitroreductase enzymatic substrates
    Patent number: 8211662
    Abstract: The present invention relates to an enzyme substrate for detecting nitroreductase activity of formula (I) below: in which X is S, NX1, O or NX1-CO; R1 is nothing or a substituent selected from Cl, CH3, Br, F, I, alkyl, aryl and carboxyl; R2 is nothing or a substituent selected from Cl, O—CH2—O, O—CH3, F, diethylenediamine-CH3, NR3R4, Br, I, alkyl, aryl, carboxyl, NO2 and R3 and R4 are independently H or an alkyl group containing from 1 to 4 carbon atoms; and X1 is selected from H, CH3, C2H4Ph, OH, alkyl and aryl.
    Type: Grant
    Filed: May 29, 2008
    Date of Patent: July 3, 2012
    Assignee: Biomerieux
    Inventors: Olivier Fabrega, Arthur James, Vindhya Lakshika Salwatura, Sylvain Orenga, Stephen Stanforth
  • NOVEL NITROREDUCTASE ENZYMATIC SUBSTRATES
    Publication number: 20120129204
    Abstract: The invention relates to the use of a compound having formula (I) as an enzymatic substrate for the detection of a nitroreductase activity, wherein: W1, W2, W3 and W4 are independently H, Br, Cl, F, I, alkyl, alkoxy, thiomethyl, perfluoroalkyl, nitro, cyano, carboxyl (including the esters or amides thereof) or any combination of same; n=0, 1 or 2; U is N or N+R and V is CZ6 N or N+R or V is N or N+R and U is CZ6, R being H, alkyl, aralkyl, aryl, alkanoic or alkylsulphonic; and Z1, Z2, Z3, Z4, Z5 and Z6 are independently H, Br, Cl, F, I, alkyl, aryl, alkoxy, perfluoroalkyl, nitro, cyano, carboxyl, sulphonyl, including the sulphonyl or carboxyl amides or esters thereof, and the salts of same.
    Type: Application
    Filed: July 29, 2010
    Publication date: May 24, 2012
    Applicant: bioMerieux, SA
    Inventors: Olivier Fabrega, Arthur James, Sylvain Orenga, John Perry, Vindhya Salwatura, Stephen Stanforth
  • Novel Peptidase Substrates
    Publication number: 20120129203
    Abstract: The present invention relates to the use of a compound of the following formula (I) for detecting a peptidase activity and/or a variation in pH: according to which: Y1 is a peptide, H or an alkyl; W1, W2, W3 and W4 are independently H, Br, Cl, F, I, alkyl, alkoxy, thiomethyl, perfluoroalkyl, nitro, cyano, carboxyl (including the esters or amides thereof) or any combination thereof; n=0, 1 or 2; X is NR, CZ5Z6, S or O, R being H, alkyl, aralkyl, aryl, alkanoyl or alkylsulfonyl, Z5 and Z6 being an alkyl; Y is N or N+R, R being alkyl, aralkyl, aryl, alkanoyl or alkylsulfonyl; Z1, Z2, Z3 and Z4 being independently H, Br, Cl, F, I, alkyl, aryl, alkoxy, perfluoroalkyl, nitro, cyano, carboxyl, sulfonyl, including the carboxyl or sulfonyl esters or amides, and salts thereof.
    Type: Application
    Filed: July 27, 2010
    Publication date: May 24, 2012
    Applicant: bioMerieux, SA
    Inventors: Olivier Fabrega, Arthur James, Sylvain Orenga, John Perry, Vindhya Salwatura, Stephen Stanforth
  • Novel Nitroreductase Enzymatic Substrates
    Publication number: 20120129205
    Abstract: The invention relates to the use of a compound having formula (I) as an enzymatic substrate for the detection of a nitroreductase activity or as an enzymatic substrate for the detection of a nitroreductase activity and indicator of pH, wherein: W1, W2, W3 and W4 are independently H, Br, Cl, F, I, alkyl, alkoxy, thiomethyl, perfluoroalkyl, nitro, cyano, carboxyl (including the esters or amides thereof) or any combination of same; n=0, 1 or 2; U and V are N, N+R, CZ4, R being H, alkyl, aralkyl, aryl, alkanoic or alkylsulphonic, preferably if U is CZ4, V is N or N+R and, if V is CZ4, U is N or N+R; and Z1, Z2, Z3 and Z4 are independently H, Br, Cl, F, I, alkyl, aryl, alkoxy, perfluoroalkyl, nitro, cyano, carboxyl, sulphonyl, including the sulphonyl or carboxyl amides or esters thereof, and the salts of same.
    Type: Application
    Filed: July 29, 2010
    Publication date: May 24, 2012
    Applicant: bioMerieux
    Inventors: Arthur James, Sylvain Orenga, John Perry, Vindhya Salwatura, Stephen Stanforth