Abstract: A cooling device includes a vessel having a refrigerant sealed inside, an evaporator that receives heat to evaporate a liquid phase of the refrigerant inside the vessel, a condenser that dissipates heat to condense a vapor phase of the refrigerant inside the vessel, a tube shaped transporter that transports the liquid-phase refrigerant inside the vessel to the evaporator by capillary action, and a gap generator that generates a gap between the transporter and the evaporator for the liquid-phase refrigerant to move from the transporter to the evaporator.

Abstract: A method for manufacturing a semiconductor device includes forming a support on a side surface of a stack that extends from a substrate. The stack includes a second sacrificial film, plural first sacrificial films and plural silicon (Si)-containing films, wherein one first sacrificial film of the plural sacrificial films is stacked upon the second sacrificial film and the plural sacrificial films and the plural Si-containing films are alternately stacked upon one another, and at least a side of the second sacrificial film is not covered by the support, the one first sacrificial film and the substrate. The method further includes removing the second sacrificial film from the stack to form a space between the substrate and the one first sacrificial film and adjacent to the support, and filling the space with a dielectric film.

Abstract: The invention provides methods for the synthesis of a halichondrin macrolides or analogs thereof through a cyclization reaction strategy. The strategy of the present invention involves subjecting an intermediate to Prins reaction conditions to afford a macrolide. The invention also provides compounds useful as intermediates in the synthesis of a halichondrin macrolides or analogs thereof and methods for preparing the same.

Abstract: Embodiments of the disclosure relate to tetrahydropyrazolopyrimidine compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.

Abstract: A cartridge detachably mountable to an image forming apparatus includes a cleaning member; a cleaner container; a discharge opening; a shutter for the opening; an urging member for urging the shutter to a closing position, wherein when the cartridge is mounted, the shutter abuts to a shutter abutting portion provided in the image forming apparatus to be moved from a closing position to an opening position; a locking member rotatable between a locking position and a release position, wherein before the shutter contacts to the shutter abutting portion when mounting the cartridge to the apparatus, the locking member contacts a releasing portion provided in the apparatus to be rotated in a releasing direction, by the releasing portion; and an interrelating mechanism for interrelating relative movement between the shutter and the cleaner container and rotation of the locking member in a direction of the locking.

Abstract: There is provided a method of forming a polysilicon film, which includes: forming an amorphous silicon film on a substrate; forming a cap layer, which is formed of an amorphous germanium film or an amorphous silicon germanium film, on the amorphous silicon film; forming crystal nuclei of a silicon in the amorphous silicon film by heating the substrate at a first temperature; removing the cap layer after the crystal nuclei are formed; and growing the crystal nuclei by heating the substrate from which the cap layer is removed, at a second temperature equal to or higher than the first temperature.

Abstract: Provided herein are methods for the treatment of bladder cancer.

Abstract: We provide diastereomerically pure or substantially diastereomerically pure activated phosphoramidochloridate morpholino nucleosides, methods of their preparation, and methods of their use in stereospecific coupling for stereospecific synthesis of diastereomerically pure phosphorodiamidate morpholino oligomers (PMOs).

Abstract: The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.

Abstract: A cartridge detachably mountable to an image forming apparatus includes a cleaning member; a cleaner container; a discharge opening; a shutter for the opening; an urging member for urging the shutter to a closing position, wherein when the cartridge is mounted, the shutter abuts to a shutter abutting portion provided in the image forming apparatus to be moved from a closing position to an opening position; a locking member rotatable between a locking position and a release position, wherein before the shutter contacts to the shutter abutting portion when mounting the cartridge to the apparatus, the locking member contacts a releasing portion provided in the apparatus to be rotated in a releasing direction, by the releasing portion; and an interrelating mechanism for interrelating relative movement between the shutter and the cleaner container and rotation of the locking member in a direction of the locking.

Abstract: The invention provides methods for the synthesis of a halichondrin macrolides or analogs thereof through a cyclization reaction strategy. The strategy of the present invention involves subjecting an intermediate to Prins reaction conditions to afford a macrolide. The invention also provides compounds useful as intermediates in the synthesis of a halichondrin macrolides or analogs thereof and methods for preparing the same.

Abstract: A cartridge removably attachable to an image forming apparatus, including a resin-made casing, a planar memory chip configured to store information to be outputted to the image forming apparatus, a recess portion provided on an outer surface of the casing to fit the memory chip, and a regulating portion formed integrally with the casing and provided to project out of the outer surface of the casing in a direction intersecting with a surface of the memory chip to regulate a move of the memory chip in the direction intersecting with the surface of the memory chip, wherein the memory chip is attached to the recess portion in a condition of displaceable within the recess portion in a posture substantially surrounded by side wall of the recess portion.

Abstract: A drum cartridge includes a blade, a sheet metal member, a support member, and a fastening member. One of the sheet metal member and the support member includes a first center hole which is formed at a center portion, and a fastening member receiving portion formed at a first end side and configured to fasten the fastening member. The other of the sheet metal member and the support member includes a second center hole which is formed at the center portion, and a through hole which is formed at the first end side and through which the fastening member is passed. The first center hole and the second center hole are arranged such that centers thereof are overlapped. The through hole is configured to be larger than the fastening member receiving portion in a swinging direction with the first and second center holes serving as the center of swing.

Abstract: The present disclosure provides a novel solid state form of pladienolide pyridine compounds, compositions comprising at least one such solid state form, and methods of preparation and use and the same. The novel solid state form of pladienolide pyridine compounds may be useful in the treatment of cancer, such as, for example, cancers in which agents that target the spliceosome and mutations therein are known to be useful.

Abstract: A phosphoramidochloridate morpholino monomer of the following formula is provided:

Abstract: Embodiments of the disclosure relate to tetrahydropyrazolopyrimidine compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.

Abstract: A drum cartridge includes a blade, a sheet metal member, a support member, and a fastening member. One of the sheet metal member and the support member includes a first center hole which is formed at a center portion, and a fastening member receiving portion formed at a first end side and configured to fasten the fastening member. The other of the sheet metal member and the support member includes a second center hole which is formed at the center portion, and a through hole which is formed at the first end side and through which the fastening member is passed. The first center hole and the second center hole are arranged such that centers thereof are overlapped. The through hole is configured to be larger than the fastening member receiving portion in a swinging direction with the first and second center holes serving as the center of swing.

Abstract: Provided herein are compounds useful for the treatment of cancer.

Abstract: The present disclosure provides a novel solid state form of pladienolide pyridine compounds having Formula I, compositions comprising at least one such solid state form, and methods of preparation and use and the same. The novel solid state form of pladienolide pyridine compounds may be useful in the treatment of cancer, such as, for example, cancers in which agents that target the spliceosome and mutations therein are known to be useful.

Abstract: Methods of synthesizing intermediates useful for the synthesis of halichondrin B analogs are described.