Abstract: The invention provides synergistic combinations of at least two modulators of MOR, as well as combined compositions, kits methods and uses thereof for treating mental and physical pain, suicidality and depression.

Abstract: The invention provides carbazole derivatives for the treatment of fibrotic diseases (pathological collagen deposition) in tissues and organs, and related symptoms, and conditions thereof.

Abstract: A data storage system comprises physical storage, cache memory and a processor connected to the physical storage and the cache memory. The processor is arranged to maintain a set of active regions in the cache memory, each active region having a size equal to an integer multiple of an update size of a flash chip within the physical storage, where the integer could be 1. The processor receives requests for one or more blocks of the cache memory from components within the storage system and allocates one or more blocks from an active region in response to a received request. If the processor determines that all blocks in an active region have been allocated and that all allocated blocks within this region have been written to, then the processor destages the content of this region to the physical storage.

Abstract: A processor may identify a storage system having a cluster of multiple nodes with redundancy for sharing a load of host input/output (IO) operations. The processor may upgrade one or more nodes at a time making use of redundancy. The processor may collect performance statistics of the storage system with the upgraded nodes during active use of the host IO operations. The processor may compare the collected performance statistics with historical performance statistics for the storage system. If the upgraded nodes show a negative performance impact, the processor may take remedial action. Otherwise, the processor may continue to upgrade the remaining nodes.

Abstract: A data storage system configured to deduplicate and store sets of data is presented. The system comprises a computer readable storage device configured to store a plurality of sets of data for a plurality of hosts, wherein each sets of data of the plurality of sets of data corresponding to each host of the plurality of hosts is encrypted with one or more different encryption keys, and wherein at least one of the plurality of sets of data contains deduplicated data. The system also comprises a key translator configured to create at least one translation key based, at least in part, on the one or more different encryption keys and the deduplicated data, and wherein the at least one translation key is configured to translate from a first encryption key to a second encryption key of the one or more different encryption keys.

Abstract: Aspects of the present invention disclose a method, computer program product, and system for stale data recovery using virtual storage metadata. The method includes one or more processors generating a primary virtual storage metadata structure having virtual address areas for a data chunk. Each area includes a plurality of most recent updates of metadata for the data chunk. The metadata of each update includes a sequence number for the update and a pointer to the physical location of the data. The method further includes one or more processors generating an overflow virtual storage metadata structure for multiple virtual address areas. The overflow metadata structure includes updates that have overflowed from the virtual address areas. In addition, wherein an oldest update in a full virtual address area of the primary virtual storage metadata structure includes a link to an overflow location.

Abstract: A method, computer system, and a computer program product for storing a write data in a storage system that operates using a log-structured filing system is provided. The present invention may include compressing a write data. The present invention may also include identifying a region of a storage system based on a first size of the compressed write data. The present invention may further include the storage system operating using a log-structured filing system. The present invention may also include a different region of the storage system having a different compression ratio. The present invention may further include writing the compressed write data in the identified region of the storage system.

Abstract: A computer-implemented method according to one embodiment includes receiving, by a target system from a source system, a description of a set of data updates that are to be written to the target system. For each given portion of data of the target system that is to be rewritten during performance of the set of data updates, forward lookup is performed on the target system for determining a physical storage address of the given portion of data. The method further includes marking each of the determined physical storage addresses of the portions of data of the target system in a copy of a reverse lookup table of the target system. The marked-up reverse lookup table is used for determining an ordering in which the performance of the set of data updates would result in a least amount of garbage collection being performed while performing the set of data updates.

Abstract: The present invention provides compounds and methods for the treatment and prevention of diseases and conditions associate with or aggravated by impaired mitophagy.

Abstract: Short peptides and peptidomimetics useful for treating Type 2 diabetes are provided, and methods for treating and/or preventing Type 2 diabetes and related conditions.

Abstract: Method and system are provided for storage handling guidance for host input/output (I/O) operations. The method includes: providing a guidance array of indications of storage operations handling instructions, the guidance array having multiple dimensions of performance characteristics with each dimension having multiple levels; and associating a reference vector with one or more I/O operations, wherein the reference vector points to a level for each dimension of the array to obtain an indication of a storage operations handling instruction at an intercept of the dimension levels for application by a storage system controller for the one or more I/O operations.

Abstract: Method and system are provided for data validation during data recovery in a log-structure array (LSA) storage system. The method includes reading a log record of a recovery log for a logical address to obtain a physical address at a storage backend for the data at the time of the log record; reading reference metadata at the obtained physical address, wherein the reference metadata indicates the logical address that last wrote data to the physical address; validating that the physical address for the log record contains valid data for the logical address of the log record by comparing the logical address of the reference metadata to the logical address of the log record; and replaying the log record if the physical address is validated for recovery of virtual domain logical metadata mapping the logical address to the physical addresses of the log record.

Abstract: An apparatus for dynamically adjusting a journal snapshot window is disclosed. A computer-implemented method and computer program product also perform the functions of the apparatus. According to an embodiment of the present invention, a failure detection module detects a potential failure of at least a portion of a non-volatile storage device. The non-volatile storage device includes a journal for tracking metadata changes for data that is stored on the non-volatile storage device prior to committing the metadata changes to metadata for the non-volatile storage device. A notification receiving module receives an indication of the potential failure of the non-volatile storage device. A snapshot module adjusts a snapshot window for the journal in response to the indication of the potential failure. The snapshot window includes a set of metadata changes in the journal that have not been committed to the metadata of the non-volatile storage device.

Abstract: A method and a system are provided for controlling deduplication in a storage pool. The method includes creating one or more deduplication domains within a storage pool, wherein storage volumes that are within a deduplication domain are deduplicated only with other volumes within the same deduplication domain and assigning storage volumes to a deduplication domain in order to control deduplication between storage volumes. The method may include, within a deduplication domain, blacklisting a volume from deduplication with a specified volume whilst allowing deduplication with other volumes in the deduplication domain.

Abstract: Method and system are provided for data validation during data recovery in a log-structure array (LSA) storage system. The method includes reading a log record of a recovery log for a logical address to obtain a physical address at a storage backend for the data at the time of the log record; reading reference metadata at the obtained physical address, wherein the reference metadata indicates the logical address that last wrote data to the physical address; validating that the physical address for the log record contains valid data for the logical address of the log record by comparing the logical address of the reference metadata to the logical address of the log record; and replaying the log record if the physical address is validated for recovery of virtual domain logical metadata mapping the logical address to the physical addresses of the log record.

Abstract: Method and system are provided for storage handling guidance for host input/output (I/O) operations. The method includes: providing a guidance array of indications of storage operations handling instructions, the guidance array having multiple dimensions of performance characteristics with each dimension having multiple levels; and associating a reference vector with one or more I/O operations, wherein the reference vector points to a level for each dimension of the array to obtain an indication of a storage operations handling instruction at an intercept of the dimension levels for application by a storage system controller for the one or more I/O operations.

Abstract: A method and a system for permanently deleting data from storage. The method includes receiving a wipe command to permanently delete a data segment stored in a storage system. The data segment includes an address to blocks where the data of the data segment is stored. The method also includes sanitizing the data segment, marking the address as sanitized, locating a last journal entry in a journal. The last journal entry includes metadata regarding the data segment. The method also includes sanitizing the last journal entry, traversing the journal, and sanitizing each journal entry of the data segment.

Abstract: A computer-implemented method according to one embodiment includes receiving, by a target system from a source system, a description of a set of data updates that are to be written to the target system. For each given portion of data of the target system that is to be rewritten during performance of the set of data updates, forward lookup is performed on the target system for determining a physical storage address of the given portion of data. The method further includes marking each of the determined physical storage addresses of the portions of data of the target system in a copy of a reverse lookup table of the target system. The marked-up reverse lookup table is used for determining an ordering in which the performance of the set of data updates would result in a least amount of garbage collection being performed while performing the set of data updates.

Abstract: A computer-implemented method of storing data on a storage device can receive an I/O request to read data from or write data to a data storage device. The data can be stored in special sectors as allocated sectors and regular sectors as a log-structured array (LSA). If the I/O request is to read data from the storage device, a determination can be made as to whether the data to be read is stored as a special sector, which can be read from the LSA, or as a regular sector, which can be can be read from the allocated sectors. If the I/O request is to write data to the storage device, a determination can be made as to whether the data to be written is stored as a special sector, to the LSA or as a regular sector, to the allocated sectors.

Abstract: Prioritizing virtual volumes to take offline in a thin provisioning system with garbage collection. The method categorizes virtual volumes based on garbage collection properties of their write behavior and adds metadata indicating a category of a virtual volume. The method schedules virtual volumes to be taken offline by predicting virtual volume space utilization of active virtual volumes for a defined time period in combination with estimated garbage collection in that period to determine a need to take virtual volumes offline. The method selects virtual volumes to take offline by their category to ensure that the virtual volumes producing the most garbage collection unfriendly workloads are taken offline first.