Abstract: The present invention provides compounds acting as Insulin/IGF signaling modulators useful in the treatment of neurodegenerative diseases and disorders. The invention provides pharmaceutical compositions including such compounds, and methods of using these compounds and compositions for the treatment of neurodegenerative diseases, in particular neurodegenerative diseases caused by proteotoxicity such as Alzheimer's disease.

Abstract: Short bioactive sequences derived from the 2nd loop of the 7-transmembranal receptor of endothelial differentiation gene 3 (EDG3) useful in stimulation of angiogenesis, and peptide conjugates comprising a permeability enhancing moiety, are provided. Also provided are pharmaceutical compositions comprising the peptides and methods of use in conditions were insufficient blood-supply occurs, or which are associated with endothelia dysfunction such as peripheral vascular diseases, coronary artery diseases, cerebrovascular diseases, diabetes and delayed wound healing, pulmonary disease, eye diseases and pathological condition related to severe infection.

Abstract: The present invention provides compounds acting as Insulin/IGF signaling modulators useful in the treatment of neurodegenerative diseases and disorders. The invention provides pharmaceutical compositions including such compounds, and methods of using these compounds and compositions for the treatment of neurodegenerative diseases, in particular neurodegenerative diseases caused by proteotoxicity such as Alzheimer's disease.

Abstract: For serving sequential read patterns from a compressed journal storage system, a construction area cache algorithm is used to temporarily store the read and decompressed data in a user view sequential order to minimize disk I/Os and CPU utilization while serving the data to the user.

Abstract: Calculating fingerprints for each one of a multiplicity of alignment combinations of fixed-size deduplication data blocks and comparing each of the fingerprints to stored deduplicated data fingerprints in a lookup database for determining a preferred deduplication data block alignment. A deduplication data block comprises each of the fixed-size deduplication data blocks.

Abstract: While discharging a data chunk the chunk is compressed into a storage block. If the chunk is found to be too large to be able to be completely compressed into the storage block certain characteristics of the data chunk are examined to determine whether or not the data chunk should be split. If the data chunk should be split, a remaining portion of the data chunk is compressed to a storage block that is next in chronological order to the original storage block. If the data chunk should not be split, all of the data chunk is moved to the next chronological storage block while leaving any remaining space in the storage block as unused.

Abstract: While discharging a data chunk, the chunk is compressed into a storage block. If the chunk is found to be too large to be able to be completely compressed into the storage block, certain characteristics of the data chunk are examined to determine whether or not the data chunk should be split. If the data chunk should be split, a remaining portion of the data chunk is compressed to a storage block that is next in chronological order to the original storage block. If the data chunk should not be split, all of the data chunk is moved to the next chronological storage block while leaving any remaining space in the storage block as unused.

Abstract: The present invention is directed to a degradation composition, methods and kits for degrading organic pollutants comprising reduced copper based nanoparticles-polymer complex (Cu-NPs) and an oxidant.

Abstract: The present invention relates to a method including reacting a solution of a salt of a biocidal metal with an active layer of water purification membrane, discarding the biocidal metal salt solution such that a thin layer of the biocidal metal salt solution remains on the membrane surface, reacting a reducing agent solution with the active layer of the membrane and the thin layer of the biocidal metal salt solution thereby forming a biocidal metal nanoparticle-modified membrane, removing the reducing agent solution, and rinsing the biocidal metal nanoparticle-modified membrane.

Abstract: Various embodiments for optimizing deduplication in a computing storage environment by a processor. Links between data regions are intelligently formed, based on up-to-date popularity statistics, including a number of times a particular one of the data regions was a target for a potential link with another one of the data regions.

Abstract: This invention relates to novel penetrating compositions including one or more effectors included within a water soluble composition, immersed in a hydrophobic medium. The invention also relates to methods of treating or preventing diseases by administering such penetrating compositions to affected subjects.

Abstract: For efficiently storing and retrieving data and metadata in phases, in a first phase, metadata tokens, which are assigned to metadata-emitting entities, are used for storing the data and the metadata together in a single input/output operation while piggybacking the metadata of least active metadata-emitting entities onto one of the metadata-emitting entities having one of the metadata tokens. In a second phase, the metadata is re-written to a metadata delta journal for reclaiming the metadata tokens. In a third phase, the metadata journal is applied to a metadata structure containing the metadata of the storage system, the metadata delta journal is then cleared after successfully updating the main metadata structure with the metadata of the metadata journal. The metadata journal is swapped with an empty metadata journal for concurrently adding metadata while retaining the metadata journal until applying the metadata delta journal to the metadata structure.

Abstract: Short bioactive sequences derived from the 2nd loop of the 7-transmembranal receptor of endothelial differentiation gene 3 (EDG3) useful in stimulation of angiogenesis, and peptide conjugates comprising a permeability enhancing moiety, are provided. Also provided are pharmaceutical compositions comprising the peptides and methods of use in conditions were insufficient blood-supply occurs, or which are associated with endothelia dysfunction such as peripheral vascular diseases, coronary artery diseases, cerebrovascular diseases, diabetes and delayed wound healing, pulmonary disease, eye diseases and pathological condition related to severe infection.

Abstract: An electronic device is presented; the device comprises an electrode structure located in electrical contact with a semiconducting element. The electrode structure is configured with two or more groups of regions comprising regions of a first group having first charge injection properties and regions of a second group having second charge injection properties being lower than the first charge injection properties. The regions of the second group are configured to provide barrier for injection of charge carriers from regions of the first group into the semiconductor element to thereby allow tailoring of desired electronic properties of the device.

Abstract: For combining virtual mapping metadata and physical space mapping metadata in a storage system by a processor device in a computing environment, data and metadata are maintained into separate virtual streams. The separate virtual streams include a metadata stream for the metadata and a data stream for the data. Metadata for each input/output (I/O) operation received is determined using a linear function operation, the function operation being an offset of the metadata in the metadata stream that is equal to the I/O operation multiplied by a maximal metadata ratio. The metadata is allocated on the metadata stream and the metadata stream is divided into fixed size block that is responsible for describing a size of a logical space, where the logical space is equal to one divided by the maximal metadata ratio, and it is determined if the metadata has been previously loaded.

Abstract: Tricyclic compounds, compositions and uses thereof in the treatment of at least one disease, disorder or condition such as for example obesity, overweight, abnormal fat-distribution and any conditions or disease associated therewith.

Abstract: For combining virtual mapping metadata and physical space mapping metadata in a storage system by a processor device in a computing environment, data and metadata are maintained into separate virtual streams. The separate virtual streams include a metadata stream for the metadata and a data stream for the data. Metadata for each input/output (I/O) operation received is determined using a linear function operation, the function operation being an offset of the metadata in the metadata stream that is equal to the I/O operation multiplied by a maximal metadata ratio. The metadata is allocated on the metadata stream and the metadata stream is divided into fixed size block that is responsible for describing a size of a logical space, where the logical space is equal to one divided by the maximal metadata ratio, and it is determined if the metadata has been previously loaded.

Abstract: B-Tree data is serialized to existing data for all types of workloads by converting a B-Tree data structure into a format capable of being stored and resurrected while containing all data stored in the B-Tree data structure and information relating to the B-Tree data structure. The serialized B-Tree data is divided into a plurality of sections. The serialized B-Tree data is stored into a plurality of buffers, where storing the B-Tree information section in a first binary buffer, the B-Tree key section in a second binary buffer, and the B-Tree data section in a third binary buffer. In the B-Tree data section, B-Tree data elements stored in the B-Tree data structure are saved, where a size of the B-Tree data section is equal to a total number of the B-Tree data elements in the B-Tree data structure multiplied by a size of each of the B-Tree data elements.

Abstract: B-Tree data is serialized to existing data for all types of workloads. Each of an identified data range is encoded with frequency encoding, wherein a first value in a frequency encoded identified data range is a first value in original data and all subsequent values in the frequency encoded identified data range are equal to a difference between a corresponding value in an input file and a previous value in the input file.

Abstract: The present invention provides compounds acting as Insulin/IGF signaling modulators useful in the treatment of neurodegenerative diseases and disorders. The invention provides pharmaceutical compositions including such compounds, and methods of using these compounds and compositions for the treatment of neurodegenerative diseases, in particular neurodegenerative diseases caused by proteotoxicity such as Alzheimer's disease.