Abstract: A lock assembly that has a first lock state and a second lock state. The lock assembly includes a latch assembly that has a latch movable between an extended position and a retracted position, and a handle operatively coupled to the latch to move the latch between the extended position and the retracted position. The lock assembly also includes a hub that is coupled to the handle for movement therewith, a member that is operatively coupled to the handle to permit or prevent movement of the latch, and a lock element. The member is engaged with the hub to permit or prevent movement of the hub. The lock element is engaged with the member in the second lock state such that the member prevents movement of the handle, and the lock element is disengaged from the member in the first lock state such that the member permits movement of the handle.

Abstract: Tripyolide-nucleic acid aptamer derivatives, a preparation method and use thereof are shown. The structure of the triptolide-nucleic acid aptamer derivatives is as shown by formula I, wherein the definitions of R1-R7, G, A, B, M, Z and X are described. The present invention uses a nucleic acid aptamer and triptolide or modified compounds thereof as the starting materials, and introduces a linking group A at the C-14 hydroxyl group, epoxy groups and five-membered ring lactones in triptolide, then connects it to a nucleic acid aptamer B, and obtains the triptolide-nucleic acid aptamer derivatives. The triptolide-nucleic acid aptamer derivatives of the present invention have the characteristics of good targeting, a high anti-cancer activity, low toxicity and side effects, good water solubility and high bioavailability, and the preparation method of the present invention is scientific and reasonable and has a controllable quality and good repeatability, and is thereby suitable for production.

Abstract: The invention provides a series of bioactive small molecules that target expanded r(CGG) repeats, termed r(CGG)exp, that causes Fragile X-associated Tremor Ataxia Syndrome (FXTAS). The compound was identified by using information on the chemotypes and RNA motifs that interact. Specifically. 9-hydroxy-5,11-dimethyl-2-(2-(piperidin-1-yl)ethyl)-6H-pyrido[4,3-b]carbazol-2-ium, binds the 5?CGG/3?GGC motifs in r(CGG)exp and disrupts a toxic r(CGG)exp-protein complex. Specifically, dimeric compounds incorporating two 9-hydroxyellipticine analog structures can even more potently bind the 5?CGG/3?GGC motifs in r(CGG)exp and disrupts a toxic r(CGG)exp-protein complex. Structure-activity relationships (SAR) studies determined that the alkylated pyridyl and phenolic side chains are important chemotypes that drive molecular recognition of r(CGG) repeats, such as r(CGG)exp.

Abstract: A lock assembly (10) that has a first lock state and a second lock state. The lock assembly (10) includes a latch assembly (30) that has a latch (55) movable between an extended position and a retracted position, and a handle operatively coupled to the latch (55) to move the latch (55) between the extended position and the retracted position. The lock assembly (10) also includes a hub that is coupled to the handle for movement therewith, a member that is operatively coupled to the handle to permit or prevent movement of the latch (55) and a lock element. The member is engaged with the hub to permit or prevent movement of the hub. The lock element is engaged with the member in the second lock state such that the member prevents movement of the handle, and the lock element is disengaged from the member in the first lock state such that the member permits movement of the handle.

Abstract: The invention provides a series of bioactive small molecules that target expanded r(CGG) repeats, termed r(CGG)exp, that causes Fragile X-associated Tremor Ataxia Syndrome (FXTAS). The compound was identified by using information on the chemotypes and RNA motifs that interact. Specifically, 9-hydroxy-5,11-dimethyl-2-(2-(piperidin-1-yl)ethyl)-6H-pyrido[4,3-b]carbazol-2-ium, binds the 5?CGG/3?GGC motifs in r(CGG)exp and disrupts a toxic r(CGG)exp-protein complex. Specifically, dimeric compounds incorporating two 9-hydroxyellipticine analog structures can even more potently bind the 5?CGG/3?GGC motifs in r(CGG)exp and disrupts a toxic r(CGG)exp-protein complex. Structure-activity relationships (SAR) studies determined that the alkylated pyridyl and phenolic side chains are important chemotypes that drive molecular recognition of r(CGG) repeats, such as r(CGG)exp.

Abstract: Tripyolide-nucleic acid aptamer derivatives, a preparation method and use thereof are shown. The structure of the triptolide-nucleic acid aptamer derivatives is as shown by formula I, wherein the definitions of R1-R7, G, A, B, M, Z and X are described. The present invention uses a nucleic acid aptamer and triptolide or modified compounds thereof as the starting materials, and introduces a linking group A at the C-14 hydroxyl group, epoxy groups and five-membered ring lactones in triptolide, then connects it to a nucleic acid aptamer B, and obtains the triptolide-nucleic acid aptamer derivatives. The triptolide-nucleic acid aptamer derivatives of the present invention have the characteristics of good targeting, a high anti-cancer activity, low toxicity and side effects, good water solubility and high bioavailability, and the preparation method of the present invention is scientific and reasonable and has a controllable quality and good repeatability, and is thereby suitable for production.

Abstract: Provided is a ternary inorganic compound crystal having a molecular formula of Ca8Al12P2O31, and a preparation method thereof comprising the following steps: weighing calcium salts, aluminum salts and phosphate respectively according to the molar ratio of calcium, aluminum and phosphorus in the molecular formula Ca8Al12P2O31; calcining at 1550˜1570° C., cooling, and grinding to obtain the ternary inorganic compound crystal. Also provided is an application of the ternary inorganic compound in gelling materials and molecular sieves, nonlinear optical crystals, and photochromic materials.

Abstract: A tiltable motor tricycle as in the present invention comprises a front part and a rear part. The front part comprises a front frame, a front fork, a front wheel attached to the front fork, a steering bar, and a seat. The rear part comprises a rear frame, one pair of laterally spaced rear wheels. The front frame is connected to the rear frame rotatably around an axis line which points at the ground contact area of the front wheel and therefore the front part can tilt right or left around the axis line without affecting the position of the rear part. The rear frame has two footrests at two sides of the tricycle. The tricycle further comprises a motor and a power source. When in operation, the rider of the tricycle seats on the seat with two feet stepping on the footrests of the rear frame to keep balance and can tilt the front part of the tricycle around the axis line to maintain balance in response to road condition, speed, or turning while the rear part with two rear wheels remain stable.

Abstract: A wire winding machine (100) is disclosed which includes holders (106, 108) for holding a workpiece having a body (104a) with a hole (104b). A wire manipulator includes wire holders (116a, 116b, 116c) which are adapted for moving a piece of wire through the hole of the workpiece to form turns of winding of the piece of wire on the body of the workpiece.

Abstract: The invention provides a series of bioactive small molecules that target expanded r(CGG) repeats, termed r(CGG)exp, that causes Fragile X-associated Tremor Ataxia Syndrome (FXTAS). The compound was identified by using information on the chemotypes and RNA motifs that interact. Specifically, 9-hydroxy-5,11-dimethyl-2-(2-(piperidin-1-yl)ethyl)-6H-pyrido[4,3-b]carbazol-2-ium, binds the 5?CG/3?GGC motifs in r(CGG)exp and disrupts a toxic r(CGG)exp-protein complex. Specifically, dimeric compounds incorporating two 9-hydroxyellipticine analog structures can even more potently bind the 5?CGG/3?GGC motifs in r(CGG)exp and disrupts a toxic r(CGG)exp-protein complex. Structure-activity relationships (SAR) studies determined that the alkylated pyridyl and phenolic side chains are important chemotypes that drive molecular recognition of r(CGG) repeats, such as r(CGG)exp.

Abstract: A lock assembly (10) that has a first lock state and a second lock state. The lock assembly (10) includes a latch assembly (30) that has a latch (55) movable between an extended position and a retracted position, and a handle operatively coupled to the latch (55) to move the latch (55) between the extended position and the retracted position. The lock assembly (10) also includes a hub that is coupled to the handle for movement therewith, a member that is operatively coupled to the handle to permit or prevent movement of the latch (55) and a lock element. The member is engaged with the hub to permit or prevent movement of the hub. The lock element is engaged with the member in the second lock state such that the member prevents movement of the handle, and the lock element is disengaged from the member in the first lock state such that the member permits movement of the handle.

Abstract: Embodiments described herein generally relate to methods of creating super-hydrophobic and super-oleophobic layers and the resulting composition of matter. A method for creating a super-hydrophobic and super-oleophobic surface can include positioning a substrate with an exposed surface in a processing chamber, injecting an electrically charged silicon-containing deposition material towards the surface of the substrate, depositing silicon-containing nanofibers onto the exposed surface of the substrate, and depositing a thin low surface energy layer over the exposed surface of the substrate and the silicon-containing nanofibers. A substrate with a super-hydrophobic and super-oleophobic surface can include a substrate with an exposed surface, one or more layers of nanofibers disposed on the exposed surface, and a thin low surface energy material deposited over both the nanofibers and the exposed surface.

Abstract: A method of operation of a measurement system includes: providing a specimen having a film; controlling a beam generator to direct a charged particle beam into the specimen; detecting a reference signal emitted from the specimen; normalizing the reference signal to create a film L-ratio; and determining a thickness of the film by correlating the film L-ratio to a calibration curve.

Abstract: A heat dissipation device for dissipating heat from an electronic component mounted on a printed circuit board, includes a fin unit, a centrifugal fan located adjacent to the fin unit, a heat-conducting board attached to the electronic component and a heat pipe thermally connecting the fin unit and the electronic component. An engaging portion protrudes upwardly from a top face of the heat-conducting board. The heat pipe has an evaporating section extending through the engaging portion and being fixed to the top face of the heat-conducting board, and a condensing section attached to the fin unit.

Abstract: A method, a system and a computer readable medium for dynamic mode AFM amplitude versus distance curve acquisition. In an embodiment, a constant force feedback mechanism is enabled prior to the first time an AFM probe tip contacts a sample. The feedback mechanism setpoint is iteratively reduced while at least phase and amplitude of the probe tip are recorded as a function of the relative z-height of a cantilever coupled to the probe tip. The feedback mechanism setpoint may be repeatedly swept between upper and lower bounds to average out drift between the cantilever and sample. Upon detecting a threshold, an absolute tip-to-sample distance is determined and correlated to the relative z-heights. The amplitude and phase data recorded prior to tip-sample contact is then determined as a function of absolute tip-to-sample distance.

Abstract: A thermal module includes a mounting plate, a centrifugal fan with a fin assembly arranged at an air outlet thereof, and a heat pipe connected the fin assembly with the heat mounting plate. The centrifugal fan includes a fan housing and an impeller rotatably received in the fan housing. The fan housing is disposed immediately neighboring to the mounting plate and mounted to a lateral side of the mounting plate via a securing structure formed between the fan housing and the mounting plate. The fan housing consists of a base and a cover. The base is made of a plastic material.

Abstract: A locking device is used for securing a heat sink to an electronic device mounted on a first face of a printed circuit board which defines a first hole. The heat sink defines a second hole therein. The locking device has a fastener including a head portion located aside the heat sink, a foot portion located aside a second face of the printed circuit board, and a body portion extending through the holes of the heat sink and the printed circuit board and interconnecting the head portion and the foot portion. The foot portion includes a buckling part abutting against the second face of the printed circuit board, and a positioning part extending towards the head portion to a position above the buckling part. When the buckling part abuts against the printed circuit board, the positioning part has a portion thereof entering into the first hole.

Abstract: A heat dissipation device for dissipating heat from an electronic component mounted on a printed circuit board, includes a fin unit, a centrifugal fan located adjacent to the fin unit, a heat-conducting board attached to the electronic component and a heat pipe thermally connecting the fin unit and the electronic component. An engaging portion protrudes upwardly from a top face of the heat-conducting board. The heat pipe has an evaporating section extending through the engaging portion and being fixed to the top face of the heat-conducting board, and a condensing section attached to the fin unit.

Abstract: A heat dissipation device for dissipating heat generated by an electronic device on a printed circuit board includes a heat sink and a plurality of mounting devices. A plurality of retaining pillars are secured on the printed circuit board at positions around the electronic device. Each of the mounting devices includes a fixing portion connecting with the heat sink, a mounting portion extending from the fixing portion and a locating portion extending from the mounting portion to a position below the mounting portion. The retaining pillars on the printed circuit board extend through the locating portions and abut against bottoms of the mounting portions to accurately position the heat dissipation device on the electronic device on the circuit board before fasteners are brought to extend through the mounting portions to screw in the retaining pillars.