Abstract: Techniques and apparatus for producing sampled Optical Coherence Tomography (OCT) interference signals without aliasing, based on a swept-source OCT interference signal. An example apparatus comprises a k-clock circuit configured to selectively output a k-clock signal at any of a plurality of k-clock frequencies ranging from a minimum k-clock frequency to a maximum k-clock frequency, and an anti-aliasing filter configured to filter a swept-source OCT interference signal, to produce a filtered OCT interference signal, where the anti-aliasing filter has a cut-off frequency greater than one-half the minimum k-clock frequency but less than the minimum k-clock frequency. The apparatus further comprises an analog-to-digital (A/D) converter circuit configured to sample the filtered OCT interference signal at twice the k-clock frequency, to produce a sampled OCT interference signal.

Abstract: Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions associated with the enzyme glucosylceramide synthase (GCS).

Abstract: The present disclosure provides an ionic liquid produced from a renewable source and with excellent lubricating properties, and methods of making the same. The ionic liquid includes an anion salt of at least one of a fatty acid, a rosin acid, or derivative thereof. The method for making the ionic liquid or lubricant composition of the present disclosure includes admixing a cation and an anion in a ratio of about a 1.5:1 to about 1:1.5 at room temperature to form a reaction mixture, wherein the anion comprises at least one of a fatty acid, a rosin acid, derivative thereof, or a combination thereof, and the cation comprises at least one of choline, imidazolium, pyridium, pyrrolidinium, ammonium, phosphonium, sulfonium, derivatives thereof, or combinations thereof; maintaining the reaction mixture at a pH of about 6 to about 9; and drying under reduced pressure to yield a lubricant including an ionic liquid.

Abstract: A compound having the structure set forth in Formula (I) and Formula (II): wherein the substituents Y, Z, A, B, R1, R2, R3, R4 and R5 are as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions that are ameliorated by the inhibition of PARP activity.

Abstract: A method of producing sialyloligosaccharides a sialyloligosaccharides-containing source that also contains carbohydrates and minerals. The process includes subjecting the source to a temperature of from about 67° C. and (i) filtration with a heat-resistant filter at a temperature of about 35 to about 95° C. to produce a first retentate and first permeate, or (ii) centrifugal separation to produce a light phase and a heavy phase and filtration of the light phase at a temperature of about 50 to about 70° C. to produce a first retentate and first permeate, (b) nanofiltration of the first permeate, or nanofiltration and diafiltration of the first permeate, to produce a second retentate and second permeate, and (c) concentration of the second retentate, to produce a sialyloligosaccharide-containing extract.

Abstract: The present disclosure discloses a method and a mobile terminal for quickly opening an application based on a lock screen. The method includes: displaying a touch position on an area of a lock screen interface when a mobile terminal enters the lock screen; displaying a recently used application list after the touch position is detected to have been touched; and opening an application corresponding to an application icon of the application list after the application icon is selected.

Abstract: Aspects of the subject disclosure may include, for example, communicating with a source of streaming media, wherein the streaming media is variable bitrate encoded, wherein the streaming media comprises a first plurality of chunks, wherein each of the first plurality of chunks corresponds to a first portion of the streaming media, wherein the streaming media comprises a second plurality of chunks, wherein each of the second plurality of chunks corresponds to a second portion of the streaming media, wherein the streaming media comprises a third plurality of chunks, and wherein each of the third plurality of chunks corresponds to a third portion of the streaming media; obtaining, from the source, a first one of the first plurality of chunks; and determining which of the second plurality of chunks and third plurality of chunks to obtain. Other embodiments are disclosed.

Abstract: A laser surgery system includes: a gantry configured to be attached to a structural frame; a docking receptacle configured to be removably attached to an eye docking assembly which is attached to an eye; an adjustable table attached to the gantry; a lens assembly attached to the adjustable table, wherein the adjustable table is configured to move the lens assembly relative to the eye; one or more connectors configured to attach the docking receptacle to the gantry, at least one of the connectors being configured to dynamically adjust the distance between a surface of the gantry and a surface of the docking receptacle; and a controller configured to maintain a target distance between the lens assembly and a reference area of the eye docking assembly.

Abstract: A data security processing method is disclosed, and includes obtaining subject fingerprint information of a current access subject for a carrier object, the subject fingerprint information of the current access subject being used for indicating a flow path of the carrier object; and embedding the subject fingerprint information of the current access subject into the carrier object as a digital watermark. The method is used for solving the relatively cumbersome problems of real-time risk management of sensitive data in a complicated distributed system and tracing of a data leakage after the data is leaked.

Abstract: Presently described are methods for performing rosin purification. The methods described herein utilize a unique solvent precipitation process that surprisingly and unexpectedly reduces the color of rosin and the sulfur and unsaponifiable contents in the rosin. The described methods are also applicable to rosin derivatives such as rosin esters and amides. Utilizing this purified rosin as raw material, rosin derivatives with much improved characteristics (color, softening point and sulfur content) can be made that would otherwise be difficult to make.

Abstract: The present disclosure provides systems, methods, and compositions for conditionally regulating expression of a target gene. Aspects of the present disclosure utilize intracellular signal transduction pathways to regulate the expression of a gene (e.g., transgene, exogenous gene, endogenous gene).

Abstract: Provided herein is are methods of treating Chronic Obstructive Pulmonary Disease (COPD) in a patient, comprising administering to the patient an effective amount of benralizumab or an antigen-binding fragment thereof.

Abstract: A spammer profile detector uses multi-stage machine learning approach, where a content-based machine learning model, a connection graph machine learning model, and a behavior-based machine learning model are used sequentially, each model generating a score indicating the likelihood that a profile is a spammer profile. The content-based machine learning model examines and evaluates information stored in a member profile. The connection graph machine learning model examines and evaluates a member's connections. The behavior-based machine learning model examines and evaluates activities of a member represented by a member profile. The score produced by the spammer profile detector can be used to determine whether the profile should be flagged as a spammer profile, whether the profile should be omitted when determining a count of the total number of active member profiles within the system, whether the profile should be restricted or removed from the system, etc.

Abstract: Embodiments of the present disclosure relate to a method and an apparatus for acquiring a fingerprint image and a terminal device. The method includes determining target light information of a light environment of a to-be-identified fingerprint; determining a target operating parameter corresponding to the target light information according to a correspondence between light information and operating parameters; and acquiring a first fingerprint image of the to-be-identified fingerprint according to the target operating parameter. According to the method and the apparatus for acquiring the fingerprint image and the terminal device of the embodiments of the present disclosure, the operating parameter used for a time when the fingerprint image of the to-be-identified fingerprint is acquired can be dynamically adjusted according to different light environments, so that an intended result of using an optical fingerprint in different environments is achieved without increasing hardware cost.

Abstract: A refrigerator control method, including: upon acquiring a signal indicating that a person approaches to open a door, controlling a camera to move from an initial position to a first position; upon acquiring a signal indicating that the door switches to an open status, controlling the camera to move to a second position; upon acquiring an opening angle of the door, and controlling the camera to capture an image of an interior of the door when the opening angle is less than a threshold angle; upon acquiring a signal indicating that the door switches to the closed status, controlling the camera to move to the first position and capture an image of an interior of the door; and upon acquiring a signal indicating that the door is closed, controlling the camera to return to the initial position and capture an image of an interior of the refrigerating compartment.

Abstract: Aspects of the subject disclosure may include, for example, communicating with a source of streaming media, wherein the streaming media is variable bitrate encoded, wherein the streaming media comprises a first plurality of chunks, wherein each of the first plurality of chunks corresponds to a first portion of the streaming media, wherein the streaming media comprises a second plurality of chunks, wherein each of the second plurality of chunks corresponds to a second portion of the streaming media, wherein the streaming media comprises a third plurality of chunks, and wherein each of the third plurality of chunks corresponds to a third portion of the streaming media; obtaining, from the source, a first one of the first plurality of chunks; and determining which of the second plurality of chunks and third plurality of chunks to obtain. Other embodiments are disclosed.

Abstract: The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.

Abstract: A variety of methods and compostions are provided, including methods and compositions for targeted modification of a specific target site in a cell or organism, methods for integrating polynucleotides of interest, methods to assess promoter activity, directly select transformed organisms, minimize or eliminate expression resulting from random integration into the genome of an organism, such as a plant, remove polynucleotides of interest, combine multiple transfer cassettes, invert or excise a polynucleotide, silence a gene, and identify and/or characterize transcriptional regulating regions. The methods involve the introduction of a cell proliferation factor and a double-strand break-inducing enzyme into an organism.

Abstract: A compound having the structure set forth in Formula (I) and Formula (II): wherein the substituents Y, Z, A, B, R1, R2, R3, R4 and R5 are as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions that are ameliorated by the inhibition of PARP activity.

Abstract: A method for vehicle-to-vehicle identification and detection and a system for the same are revealed. A plurality of radio frequency (RF) communication units with different communication directions is arranged at a vehicle body. Each RF communication unit sends identification information of the vehicle to nearby vehicles in response to communication requests from the nearby vehicles. The vehicle sends communication requests to the nearby vehicles in different communication directions by antennas of the RF communication units using time-sharing polling or simultaneous communication scheme. Thus RF communication between vehicles is achieved for identification and detection of the nearby vehicles. The precise and accurate positioning of the respective vehicle within the area is achieved to support vehicle active safety control or provide data required for autonomous driving for improving driving safety.