Abstract: Provided herein are processes for synthesizing dihydropyridophthalazinone derivatives, such as for example, 5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one and its stereoisomers, which are potent poly(ADP-ribose)polymerase (PARP) inhibitors as well as novel synthetic intermediate compounds.

Abstract: A variety of methods and compostions are provided, including methods and compositions for targeted modification of a specific target site in a cell or organism, methods for integrating polynucleotides of interest, methods to assess promoter activity, directly select transformed organisms, minimize or eliminate expression resulting from random integration into the genome of an organism, such as a plant, remove polynucleotides of interest, combine multiple transfer cassettes, invert or excize a polynucleotide, silence a gene, and identify and/or characterize transcriptional regulating regions. The methods involve the introduction of a cell proliferation factor and a double-strand break-inducing enzyme into an organism.

Abstract: This invention relates to the use of a nutritional composition comprising sialylated oligosaccharides for enhancing cognitive development and learning skills in mammals. The nutritional composition comprises 3?-Siallylactose (3?-SL) and 6?-Siallylactose (6?-SL) in a weight ratio between 10:1 and 1:10 and is specifically for use in enhancing learning skills and/or enhancing memory function in an individual by increasing the sialic acid (Neu5Ac) concentration in the brain of said individual.

Abstract: A polyester, including ethylene 2,5-furandicarboxylateunits, also includes diethylene glycol residues, the content of which is less than 0.045, in moles per mole of 2,5-furandicarboxylate moieties. The polyester composition can be prepared with a method where a starting mixture is subjected to esterification of 2,5-furandicarboxylic acid or transesterification of an ester thereof with ethylene glycol in the presence of a basic compound and/or an ammonium compound capable of suppressing the formation of diethylene glycol.

Abstract: This disclosure relates to bioelectric signal detecting circuits, lead wire detecting circuits and medical devices. The lead wire detecting circuit may include a reference voltage generator, at least one comparator, and a logic control module, wherein input ends of the comparator are connected to an output end of the reference voltage generator and an signal output end of a lead wire, respectively, for inputting a reference voltage and a lead signal, and the comparator compares the lead signal with the reference voltage and changes an output voltage at an output end of the comparator according to a comparison result; wherein an input end of the logic control module is connected to the output end of the comparator, and the logic control module determines whether the lead wire is in a connected state or disconnected state by the output voltage at the output end of the comparator.

Abstract: An acid composition comprising 2-formyl-furan-5-carboxylic acid and 2,5-furandicarboxylic acid is purified in a process which comprises; contacting the acid composition with an alcohol to obtain an esterified composition; and separating the ester of 2-formyl-furan-5-carboxylic acid from the esterified composition to obtain a purified esterified product; and contacting the purified esterified composition with water for saponification or hydrolysis, to obtain a product composition, comprising 2,5-furandicarboxylic acid and a reduced amount of 2-formyl-furan-5-carboxylic acid.

Abstract: Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions associated with the enzyme glucosylceramide synthase (GCS).

Abstract: A polyester, including ethylene 2,5-furandicarboxylate units, has an intrinsic viscosity of at least 0.45 d L/g, and has a relative content of carboxylic acid end groups, expressed as the fraction of the molar amount of carboxylic acid end groups divided by the sum of the molar amounts of hydroxyl end groups and carboxylic acid end groups in the range of 0.10 to 0.70. The polyester can be prepared with a method wherein a starting mixture comprising 2,5-furandicarboxylic acid and ethylene glycol is subjected to esterification and subsequent polycondensation at reduced pressure when the molar ratio of 2,5-furandicarboxylic acid to ethylene glycol in the starting mixture is 1:1.01 to 1:1.15, where water, that is formed during the reaction between 2,5-furandicarboxylic acid and ethylene glycol, and some ethylene glycol are removed in a distillation system, and where ethylene glycol that is removed with water, is separated from water and at least partly recycled.

Abstract: In various embodiments, a circuit includes a first switch coupled to a voltage source and a bit-line (BL). The first switch is configured to couple the BL to the voltage source to charge the BL in response to a charge control signal. A second switch is coupled to the voltage source and a complimentary bit-line (BLB) and is configured to couple the BLB to the voltage source to charge the BLB in response to the charge control signal. A control circuit is electrically coupled to each of the first switch and the second switch. The control circuit is configured to generate the charge control signal. The charge control signal is configured to control the first switch and the second switch to selectively couple the BL and the BLB to the voltage source to charge the BL and the BLB from an initial voltage to a first predetermined voltage during a first discrete charging period and from the first voltage to a second predetermined voltage during a second discrete charging period.

Abstract: A method (100) of forming an integrated circuit is disclosed. The method comprises: (i) forming at least a pair of optoelectronic devices from at least a first wafer material arranged on a semiconductor substrate, the first wafer material different to silicon; (ii) etching the first wafer material to form a first recess to be filled with a second material; (iii) processing (104) the second material to form a waveguide for coupling the pair of optoelectronic devices to define an optical interconnect; and (iv) bonding (106) at least one partially processed CMOS device layer having at least one transistor to the second semiconductor substrate to form the integrated circuit, the partially processed CMOS device layer arranged adjacent to the optical interconnect. An integrated circuit is also disclosed.

Abstract: Provided herein are (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one tosylate salt forms, including crystalline forms, arid methods of their preparation. Pharmaceutical compositions comprising a (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one tosylate salt are also provided, as are methods of using (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one tosylate salt to treat a disease or condition, such as a cancer.

Abstract: A polyester including poly(ethylene 2,5-furandicarboxylate is prepared by esterification of a starting mixture including 2,5-furandicarboxylic acid and ethylene glycol to form an ester composition, and by subjecting the ester composition thus obtained to polycondensation at reduced pressure in the presence of a polycondensation catalyst to obtain a polycondensate. The mixture is reacted under conditions such that the esterification potential as defined by Esterification Potential (EsPo)=(MR?1)2*PH2O(T), where MR represents the molar ratio of ethylene glycol over 2,5-furandicarboxylic acid, MR being greater than 1; PH2O(T) represents the pure component vapor pressure (in bar) of water at temperature T, which is the final reaction temperature in the esterification mixture before the pressure is reduced to effect the polycondensation, is less than 0.8.

Abstract: A compound having the structure set forth in Formula (I) and Formula (II): wherein the substituents Y, Z, A, B, R1, R2, R3, R4 and R5 are as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions that are ameliorated by the inhibition of PARP activity.

Abstract: Systems and methods for integrating ultra-fast programmable networks in microgrid are disclosed to provide flexible and easy-to-manage communication solutions, thus enabling resilient microgrid operations in face of various cyber and physical disturbances. The system is configured to establish a novel software-defined networking (SDN) based communication architecture which abstracts the network infrastructure from the upper-level applications to significantly expedite the development of microgrid applications, develop three functions of the SDN controller for microgrid emergency operations, including time delay guarantee, failover reconfiguration and rate limit and create a hardware-in-the-loop cyber-physical platform for evaluating and validating the performance of the presented architecture and control techniques.

Abstract: A circuit includes a first latch for generating a first latched signal; and a first comparator for comparing the first latched signal and a write address, and generating a first comparator signal. The circuit includes a first logic circuit for receiving the first comparator signal and a fourth latched signal, and generating a first logic circuit output signal; and a second latch for receiving the first logic circuit output signal and generating a second latched signal. The circuit includes a third latch for generating a third latched signal; and a second comparator for comparing the third latched signal and a read address, and generating a second comparator signal. The circuit includes a second logic circuit for receiving the second comparator signal and the second latched signal, and generating a second logic circuit signal; and a fourth latch for receiving the second logic circuit signal and generating the fourth latched signal.

Abstract: A handheld multi-parameter measuring instrument includes: a housing having a sidewall and opposed first and second surfaces, the sidewall, the first surface and the second surface cooperatively forming a cavity; a cover attached to the sidewall and rotatably connected to the housing; the blood oxygen transducer includes a light emitting unit and a light receiving unit; the light emitting unit is configured to emit red light and infrared light alternately; the light receiving unit is configured to receive the red light and the infrared light emitted from the light emitting unit; the signal processing unit is received in the cavity of the housing and is configured to control the light emitting unit to emit the red light and the infrared light alternately; the signal processing unit is further configured to calculate oxygen saturation based on a signal received by the light receiving unit; the light emitting unit is located at a side of the cover attached to the housing, and the light receiving unit is located a

Abstract: A laser surgery system includes: a gantry configured to be attached to a structural frame; a docking receptacle configured to be removably attached to an eye docking assembly which is attached to an eye; an adjustable table attached to the gantry; a lens assembly attached to the adjustable table, wherein the adjustable table is configured to move the lens assembly relative to the eye; one or more connectors configured to attach the docking receptacle to the gantry, at least one of the connectors being configured to dynamically adjust the distance between a surface of the gantry and a surface of the docking receptacle; and a controller configured to maintain a target distance between the lens assembly and a reference area of the eye docking assembly.

Abstract: The embodiments of the present invention provide a method and a trusted gateway for a WiFi terminal to access a PS service domain. The method comprises: receiving an accounting request message sent by an authentication, authorization and accounting AAA server or a dynamic host configuration protocol DHCP request message sent by the WiFi terminal; establishing, by a trusted gateway, a first packet data protocol PDP context connection or a first packet data network PDN connection with the PS service domain according to attribute information of the WiFi terminal after receiving the accounting request message or the DHCP request message, so that the WiFi terminal accesses the PS service domain via the wireless local area network, the trusted gateway, and the established first PDP context connection or the first PDN connection.

Abstract: A height adjusting mechanism for an inlet valve includes a valve body, and inlet pipe, a retaining member and an actuator. The inlet pipe is sleeved in the valve body and connected to the valve body; the retaining member is assembled in the valve body; and the actuator can drive the retaining member to move to make the valve body fixed to the inlet pipe or moved relatively to the inlet pipe in the axial direction. The actuator drives the retaining member to move in order to let the valve body and the inlet pipe to be fixed or moved relatively to each other in the axial direction. There is no need to rotate the valve body during adjusting process, and the float won't affect the tank wall when the water valve body is rotating.

Abstract: Provided herein is are methods of reducing exacerbations of asthma in an asthma patient, comprising administering to the patient an effective amount of the anti-interleukin-5 receptor (IL-5R) antibody benralizumab or an antigen-binding fragment thereof.