Abstract: Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions associated with the enzyme glucosylceramide synthase (GCS).

Abstract: Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions associated with the enzyme glucosylceramide synthase (GCS).

Abstract: A compound having the structure set forth in Formula (I) and Formula (II): wherein the substituents Y, Z, A, B, R1, R2, R3, R4 and R5 are as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions associated with a PTEN deficiency that are ameliorated by the inhibition of PARP activity.

Abstract: The present disclosure describes a power supply switch that includes a voltage generator, a switch circuit, and a confirmation circuit. The voltage generator is configured to compare a first power supply voltage to a second power supply voltage and to output the first power supply voltage or the second power supply voltage as a bulk voltage (Vbulk). The switch circuit includes one or more transistors and is configured to (i) bias bulk terminals of the one or more transistors with the Vbulk and (ii) output either the first power supply voltage or the second power supply voltage as a voltage output signal. The confirmation circuit is configured to output a confirmation signal that indicates whether the voltage output signal transitioned from the first power supply voltage to the second power supply voltage.

Abstract: Embodiments of the present disclosure relate to data processing technologies, and disclose a fingerprint data processing method and a processing apparatus. In some embodiments, the fingerprint data processing method includes: receiving a first ciphertext that carries fingerprint data; decrypting the first ciphertext to obtain the fingerprint data; identifying the fingerprint data and generating an identification result; encrypting the identification result and generating a second ciphertext that carries the identification result; and sending the second ciphertext. Some embodiments of the present disclosure further provide a fingerprint data processing apparatus. With some embodiments of the present disclosure, the fingerprint data can be transmitted in a ciphertext form, thereby ensuring the confidentiality of the fingerprint data, and improving the security of the fingerprint data.

Abstract: Embodiments of the present disclosure relate to a method and an apparatus for acquiring a fingerprint image and a terminal device. The method includes determining target light information of a light environment of a to-be-identified fingerprint; determining a target operating parameter corresponding to the target light information according to a correspondence between light information and operating parameters; and acquiring a first fingerprint image of the to-be-identified fingerprint according to the target operating parameter. According to the method and the apparatus for acquiring the fingerprint image and the terminal device of the embodiments of the present disclosure, the operating parameter used for a time when the fingerprint image of the to-be-identified fingerprint is acquired can be dynamically adjusted according to different light environments, so that an intended result of using an optical fingerprint in different environments is achieved without increasing hardware cost.

Abstract: Particles encapsulating a glucocorticoid such as dexamethasone sodium phosphate (DSP) into a matrix such as biodegradable poly(lactic-coglycolic acid) (PLGA) which is densely coated with hydrophilic polymer such as PEG or PLURONIC® F127, exhibit sustained release of DSP for up to 7 days in vitro. These nanoparticles can be used to prevent corneal graft rejection or corneal neovascularization.

Abstract: Provided herein are (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one tosylate salt forms, including crystalline forms, and methods of their preparation. Pharmaceutical compositions comprising a (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one tosylate salt are also provided, as are methods of using (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one tosylate salt to treat a disease or condition, such as a cancer.

Abstract: The present disclosure provides an ionic liquid produced from a renewable source and with excellent lubricating properties, and methods of making the same. The ionic liquid includes an anion salt of at least one of a fatty acid, a rosin acid, or derivative thereof. The method for making the ionic liquid or lubricant composition of the present disclosure includes admixing a cation and an anion in a ratio of about a 1.5:1 to about 1:1.5 at room temperature to form a reaction mixture, wherein the anion comprises at least one of a fatty acid, a rosin acid, derivative thereof, or a combination thereof, and the cation comprises at least one of choline, imidazolium, pyridium, pyrrolidinium, ammonium, phosphonium, sulfonium, derivatives thereof, or combinations thereof; maintaining the reaction mixture at a pH of about 6 to about 9; and drying under reduced pressure to yield a lubricant including an ionic liquid.

Abstract: The present disclosure provides an efficient process for separating components of tall oil fatty acids (TOFA) and for purifying TOFA from rosin. The process includes mixing TOFA with a novel solvent system containing urea to form urea clathrates, resulting in separation of saturated fatty acids from unsaturated ones and rosin from TOFA by utilizing proper urea to TOFA ratio.

Abstract: Aspects of the subject disclosure may include, for example, embodiments include obtaining a first estimated bandwidth capacity of a communication network and selecting a target buffer level to temporarily store media content. Further embodiments include requesting a first portion of the media content according to the first estimated bandwidth capacity and the target buffer level and receiving the first portion of the media content. Additional embodiments include determining a current buffer level and receiving a second estimated bandwidth capacity of the communication network. Also, embodiments include requesting a second portion of the media content according to the current buffer level and the second estimated bandwidth capacity. Other embodiments are disclosed.

Abstract: The present invention relates to certain novel substituted thiophene compounds and the finding that they display useful efficacy in the inhibition of the p38? MAPK enzyme. This provides for use of the compounds in various treatment methodologies related to MAPK inhibition, including the treatment of inflammation.

Abstract: Provided herein is are methods of treating Chronic Obstructive Pulmonary Disease (COPD) in a patient, comprising administering to the patient an effective amount of benralizumab or an antigen-binding fragment thereof.

Abstract: A method for prompting a fingerprint operation, includes the steps of: determining whether a fingerprint input position needs to be prompted; if the fingerprint input position needs to be prompted, displaying a first prompt graphic in an effective fingerprint detection area, wherein the effective fingerprint detection area is located in at least a part of a display area of a display; enabling a fingerprint collection function, and collecting fingerprint information in the effective fingerprint detection area; and processing the collected fingerprint information, and generating a fingerprint recognition processing result according to the fingerprint information. The method displays a prompt graphic in a corresponding display area of a fingerprint apparatus, so as to prompt a fingerprint recognition position without affecting the integrity of a display, thereby implementing functions of a fingerprint recognition and processing.

Abstract: A method for preparing an itraconazole formulation including: dissolving a mixture of itraconazole and L-ascorbic acid with a mixed solvent of dichloromethane and methanol, adding a hydroxypropyl methylcellulose and a pluronic F-127 and then dichloromethane into the mixed solvent to obtain a raw material solution; feeding a carbon dioxide into a crystallization autoclave in a supercritical fluid crystallization equipment system through a pressure regulating valve; spraying the solution into the crystallization autoclave via a spray nozzle, separating out composite particles from the solution and collecting the composite particles at a bottom of the crystallization autoclave, and encapsulating the composite particles to obtain a itraconazole formulation with decreased particle size and increased bioavailability.

Abstract: The present disclosure discloses a method and a mobile terminal for quickly opening an application based on a lock screen. The method includes: displaying a touch position on an area of a lock screen interface when a mobile terminal enters the lock screen; displaying a recently used application list after the touch position is detected to have been touched; and opening an application corresponding to an application icon of the application list after the application icon is selected.

Abstract: The present disclosure provides an information processing method, a server, a terminal, and a computer storage medium. The method includes: obtaining first information from a terminal, the first information comprising at least a media object on which an operation is performed and a user identifier; obtaining second information associated with the media object on which the operation is performed, the second information comprising more than one piece of media information; obtaining third information according to the user identifier, the third information comprising at least basic user information, user behavior information, and user relationship chain information; obtaining fourth information associated with the third information, the fourth information comprising more than one piece of media information; and sending the second information and the fourth information to the terminal, so that the terminal aggregates and displays the media information in the second information and the fourth information.

Abstract: A variety of methods and compositions are provided, including methods and compositions for targeted modification of a specific target site in a cell or organism, methods for integrating polynucleotides of interest, methods to assess promoter activity, directly select transformed organisms, minimize or eliminate expression resulting from random integration into the genome of an organism, such as a plant, remove polynucleotides of interest, combine multiple transfer cassettes, invert or excise a polynucleotide, silence a gene, and identify and/or characterize transcriptional regulating regions. The methods involve the introduction of a cell proliferation factor and a double-strand break-inducing enzyme into an organism.

Abstract: A method of forming an integrated circuit is disclosed. The method includes: (i) forming at least a pair of optoelectronic devices from at least a first wafer material arranged on a semiconductor substrate, the first wafer material different to silicon; (ii) etching the first wafer material to form a first recess to be filled with a second material; (iii) processing the second material to form a waveguide for coupling the pair of optoelectronic devices to define an optical interconnect; and (iv) bonding at least one partially processed CMOS device layer having at least one transistor to the second semiconductor substrate to form the integrated circuit, the partially processed CMOS device layer arranged adjacent to the optical interconnect. An integrated circuit is also disclosed.