Abstract: Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and compounds I for use to treat or prevent diseases or conditions associated with the enzyme glucosylceramide synthase (GCS).

Abstract: Provided herein are methods of improving asthma symptoms, e.g., as measured by an asthma control questionnaire, comprising administering to the patient an effective amount of benralizumab or an antigen-binding fragment thereof.

Abstract: Provided herein is are methods of reducing exacerbations of asthma in an asthma patient, comprising administering to the patient an effective amount of the anti-interleukin-5 receptor (IL-5R) antibody benralizumab or an antigen-binding fragment thereof.

Abstract: Provided herein is are methods of increasing forced expiratory volume in one second (FEV1) in an asthma patient, comprising administering to the patient an effective amount of benralizumab or an antigen-binding fragment thereof.

Abstract: A touch panel including a substrate and a touch sensing element is provided. The substrate has an element disposing surface. The touch sensing element is disposed on the element disposing surface and includes a plurality of first electrodes and a plurality of second electrodes electrically insulated to the first electrodes. Each of the first electrodes includes a plurality of bridge portions crossing the second electrodes. Viewing from a direction perpendicular to the element disposing surface, each of the bridge portion is configured in a curvy pattern, a zigzag pattern or combination thereof. A touch display panel is also provided.

Abstract: A circuit includes a write driver, a data circuit, a memory cell, a tracking write buffer, a tracking write driver, and a tracking cell. The circuit is configured that, during a write operation of the memory cell based on a clock signal, the write driver circuit is configured to generate a write control signal to control the memory cell; the data circuit is configured to provide write data to the memory cell; the tracking write buffer is configured to generate a tracking write control signal; and the tracking write driver is configured to generate a tracking write data signal to be transferred to the tracking cell. The tracking cell is configured to adjust a signal at a first node of the tracking cell based on a logical value of the tracking write data signal in response to the tracking write control signal.

Abstract: Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions associated with the enzyme glucosylceramide synthase (GCS).

Abstract: A network device includes a plurality of blades, each having a plurality of CPU cores that process requests received by the network device. Each blade further includes an accumulator circuit. Each accumulator circuit periodically aggregates the local counter values of the CPU cores of the corresponding blade. One accumulator circuit is designated as a master, and the other accumulator circuit(s) are designated as slave(s). The slave accumulator circuits transmit their aggregated local counter values to the master accumulator circuit. The master accumulator circuit aggregates the sets of aggregated local counter values to create a set of global counter values. The master accumulator circuit transmits the global counter values to a management processor (for display), to the CPU cores located on its corresponding blade, and to each of the slave accumulator circuits. Each slave accumulator circuit then transmits the global counter values to the CPU cores located on its corresponding blade.

Abstract: A circuit comprises a first transistor, a capacitive component, a second transistor, and a data line. The first transistor has a threshold voltage value. A first terminal of the first transistor is coupled with a first terminal of the capacitive component and a second terminal of the second transistor. A second terminal of the first transistor is configured to receive a second-terminal voltage value. A third terminal of the first transistor is configured to receive a third-terminal voltage value. A first terminal of the second transistor is coupled with the data line. A third terminal of the second transistor is configured to receive a second-transistor control signal. The first transistor is configured to be on and off to maintain the data line at a data line voltage value.

Abstract: A memory array includes an array of memory cells. The memory array further includes at least two read tracking cells in a read tracking column. The memory array further includes a read tracking circuit coupled to the at least two read tracking cells, wherein the read tracking circuit is configured to generate a global tracking result signal based on outputs from the at least two read tracking cells. The memory array further includes memory control circuitry, wherein the memory control circuitry is configured to reset a memory clock based on the global tracking result signal.

Abstract: An electrostatic modification reagent as described herein. The electrostatic modification reagent may be used in an electric separation process for separating components from a mineral ore or sand.

Abstract: A full-automatic dynamic tobacco moisture analysis climate chamber comprises an enclosed constant-temperature constant-humidity cabin, which is communicated with an air temperature and humidity processor to form an air circulation loop; a weighing platform is disposed inside the constant-temperature constant-humidity cabin, a sample delivery hanger is hung inside the constant-temperature constant-humidity cabin, at least one placement carrier is disposed below the sample delivery hanger, a sample vessel is placed on the placement carrier, the sample delivery hanger is further connected to a drive mechanism outside the constant-temperature constant-humidity cabin and the drive mechanism drives the sample delivery hanger to perform operations, to place the sample vessel on the weighing platform for weighing.

Abstract: The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.

Abstract: An acid composition comprising 2-formyl-furan-5-carboxylic acid and 2,5-furandicarboxylic acid is purified in a process which comprises; contacting the acid composition with an alcohol to obtain an esterified composition; and separating the ester of 2-formyl-furan-5-carboxylic acid from the esterified composition to obtain a purified esterified product; and contacting the purified esterified composition with water for saponification or hydrolysis, to obtain a product composition, comprising 2,5-furandicarboxylic acid and a reduced amount of 2-formyl-furan-5-carboxylic acid.

Abstract: The present invention pertains to a UHMWPE film having a tensile strength of at least 2.0 GPa, a tensile energy to break of at least 30 J/g, an Mw of at least 500 000 gram/mole, and a Mw/Mn ratio of at most 6. The film may be manufactured via a process which comprises subjecting a starting UHMWPE with a weight average molecular weight of at least 500 000 gram/mole, an elastic shear modulus determined directly after melting at 160° C. of at most 0.9 MPa, and a Mw/Mn ratio of at most 6 to a compacting step and a stretching step under such conditions that at no point during the processing of the polymer its temperature is raised to a value above its melting point. The film may be used as starting material in any applications where high tensile strength and high energy to break are important. Suitable applications include ballistic applications, ropes, cables, nets, fabrics, and protective applications.

Abstract: A mobile terminal and a liquid metal heat dissipation method thereof. The liquid metal heat dissipation method of the mobile terminal includes: when an inner or surface temperature of a mobile terminal exceeds a set temperature, controlling liquid metal pre-positioned in the mobile terminal to flow to a high-temperature area whose temperature exceeds the set temperature to perform a head absorption operation, and controlling the heat-absorbed liquid metal to flow to a non-high-temperature zone lower than the set temperature to perform a heat dissipation operation.

Abstract: The present invention generally relates to the development of cognitive function in infants. More particularly, the present invention provides the use of lactoferrin for improving memory and/or learning speed, and/or for promoting brain maturation in infants under physiological, i.e. non-pathological conditions. In one aspect, the present invention shows the utility of lactoferrin for improving long-term memory, e.g. long-term location memory in a healthy infant.

Abstract: A circuit comprises a driver, a first capacitive device, and a second capacitive device. The driver has an input node, an output node, and a driver supply voltage node. The first capacitive device has a first terminal and a second terminal. The second capacitive device has a first terminal and a second terminal. The first terminal of the first capacitive device is configured to receive a first signal. The second terminal of the first capacitive device is coupled with the driver supply voltage node. The output of the driver is coupled with a first end of the second capacitive device.

Abstract: A screw locking device includes a feeding mechanism, a conveying mechanism, and a pneumatic screw driver. The conveying mechanism includes a base, a pneumatic driver slidably mounted on the base, a pair of blocking members slidably mounted on the base, a conveying bridge, a flexible tube, and a controller. Each blocking member includes a blocking end positioned below the pneumatic driver. The conveying bridge communicates with the feeding mechanism, and extends to the blocking ends. The flexible tube aligned with a gap between the blocking ends, and communicates with the pneumatic screw driver.

Abstract: The present invention provides compounds, including resolved enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula: A-L-CR where CR is a cyclical core group, L is a linking group and A is as defined herein. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.