Abstract: One embodiment is directed to a system for creating translumenal vascular access, comprising a dilator adaptor member having proximal and distal ends and defining a dilator adaptor lumen therethrough, wherein the dilator adaptor lumen is defined by an inner diameter profile sized to accommodate insertion of one or more portions of a guidewire, and wherein the dilator adaptor is further defined by an outer diameter profile sized to accommodate at least partial insertion of the proximal end of the dilator adaptor into a dilator member lumen formed through a dilator member, the dilator member being coupleable to an introducer catheter member through an introducer member lumen formed through the introducer member.

Abstract: A method of removing an auger from a food grinder via a food stomper. The food stomper has structure to engage the auger to transmit force on the stomper to the auger. As such, the stomper serves dual purpose of filling the grinder with food and as a tool for cleaning or otherwise removing an auger from the appliance.

Abstract: The present invention provides a method of treating a cognitive or neu-rodegerative disease, comprising administering to a patient in need of such treatment an effective amount of a compound of the formula (I):or a pharmaceutically acceptable salt thereof in combination with an effective amount of an anti-N3pGlu Abeta antibody selected from the group consisting of hE8L, B12L, R17L, Antibody I, and Antibody II.

Abstract: Systems for management of a large computing cluster. A set of computing nodes within the cluster are identified. The identified nodes are to be reimaged with an operating system image and parameters. One or more reimaging algorithms in the form of computer code are stored in a networked storage device within a storage pool that comprises the networked storage device and a plurality of local storage devices that correspond to respective individual ones of the set of computing nodes. An agent that can execute the reimaging algorithm code is configured to run on any one of the set of computing nodes, wherein the agent is further configured to retrieve reimaging data from a storage device that is within the storage pool. An agent running on a leader node initiates reimaging of a second node. The second node initiates reimaging of a third node. The third node reimages the leader node.

Abstract: One embodiment is directed to a method for acoustically modulating activity of cells comprising a targeted tissue portion of a patient. An implantable probe system may be utilized for delivering acoustical energy to a targeted tissue portion of a patient, comprising a plurality of substrate portions, each substrate portion comprising at least one acoustical emitter; a probe body portion having proximal and distal ends and being movably coupled to the plurality of substrates and configured to at least partially encapsulate the plurality of substrates; and a distal end portion coupled to the distal end of the probe body portion, the distal end portion comprising at least one guiding feature configured to redirect a path of at least one of the substrate portions as such substrate portion is extended through and past the distal end portion by moving the plurality of substrates relative to the probe body portion.

Abstract: One embodiment is directed to an implantable probe system for delivering acoustical energy to a targeted tissue portion of a patient, comprising: a plurality of substrate portions, each substrate portion comprising at least one acoustical emitter; a probe body portion having proximal and distal ends and being movably coupled to the plurality of substrates and configured to at least partially encapsulate the plurality of substrates; and a distal end portion coupled to the distal end of the probe body portion, the distal end portion comprising at least one guiding feature configured to redirect a path of at least one of the substrate portions as such substrate portion is extended through and past the distal end portion by moving the plurality of substrates relative to the probe body portion

Abstract: A stomper for a food grinder comprises a distal end adapted to push food into a receiving tube of a food grinder, a proximal handle end adapted for a user to grasp the stomper while pushing food into the receiving tube of the food grinder, an elongated shaft between the distal end and the proximal handle end, a channel defined in the proximal handle end, and a bayonet projecting from one or more internal walls of the channel. The bayonet is adapted to engage a protrusion on an auger of the food grinder to apply a pulling force to remove the auger from the food grinder.

Abstract: A computerized process for managing member participation and progression in a health engagement program including the steps of automatically validating eligible members, queuing for manual review and validation, members not automatically validated, and providing an interactive portal to enable an administrator to manually validate. Also, gathering with the assistance of a communication device in communication with a server, member screening information that includes access to equipment required for the health engagement program, and at least one medical factor associated with each member's health history.

Abstract: Provided herein are systems, methods and computer readable media for classification of documents using a location hierarchy.

Abstract: System and methods are described for automatic pairing a plurality of devices within a vehicle. Based on a seat mapping stored within a server, a seat display unit and its allocated peripherals can be paired in sequence, one-by-one. Thus, a first seat display unit and its allocated peripherals can be powered on. Then, the peripherals can be paired with the first seat display unit, and the first seat display unit and the allocated peripherals can be powered down. Once this is complete, the next seat display unit and its allocated peripherals can be powered on, paired, and then powered down before continuing in sequence until all peripherals are paired with their allocated seat display units.

Abstract: The present invention provides compounds of Formula (I), as defined in the specification, or pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in particular Nav 1.7. The compounds are useful for the treatment of diseases treatable by inhibition of sodium channels such as pain disorders, cough, or itch. Also provided are pharmaceutical compositions containing compounds of the present invention.

Abstract: Systems for management of a large computing cluster. A set of computing nodes within the cluster are identified. The identified nodes are to be reimaged with an operating system image and parameters. One or more reimaging algorithms in the form of computer code are stored in a networked storage device within a storage pool that comprises the networked storage device and a plurality of local storage devices that correspond to respective individual ones of the set of computing nodes. An agent that can execute the reimaging algorithm code is configured to run on any one of the set of computing nodes, wherein the agent is further configured to retrieve reimaging data from a storage device that is within the storage pool. An agent running on a leader node initiates reimaging of a second node. The second node initiates reimaging of a third node. The third node reimages the leader node.

Abstract: A downhole under-reamer for use in reaming a downhole bore. The under-reamer comprises a body and a plurality of cutters mounted on the body. The cutters are mounted on the body so as to be extendable from a retracted position to at least two extended positions. The at least two extended positions comprise reaming positions at respective first and second reaming diameters.

Abstract: Configurations are described for creating and using separable optical feedthroughs. These are especially useful in their at least semi-hermetic form when integrated with implantable photomedical devices. One embodiment is directed to a system for operatively coupling an optical output from a light source positioned inside of a sealed housing to an external optical fiber, comprising: a first optical fiber disposed adjacent to the light source and configured to receive at least a portion of the optical output; a second optical fiber operatively coupled to the first optical fiber and configured to capture at least a portion of an output from the first optical fiber; a primary seal operatively coupled to the housing between the light source and the second optical fiber that is at least partially transparent; and a secondary seal positioned between the second optical fiber and the environment.

Abstract: Systems and methods to generate a playlist based on content meta data. In one embodiment, a method includes: receiving user-defined parameters; generating a playlist comprising a plurality of content portions, the generating comprising selecting the plurality of content portions from a data repository based on the user-defined parameters and further based on meta data for content stored in the data repository; and providing the playlist for display on a user device.

Abstract: The present invention provides a system for training tendons and muscles of a kinetic chain including the finger tips through the elbow, including muscles, ligaments, and tendons. The system uses finger attachments to secure the digits or other anatomical components to one or more resistance members that allow the attachments to be positionable in any direction with respect to one another when a force is applied.

Abstract: There is provided a modular storage rack comprising flat panels each comprising one or more flat segments and cross panels each comprising one or more cross segments. Each flat segment comprises a slit extending partway through it. Each cross segment comprises: a first and a second planar portion each terminating in a first and second lip respectively. The first lip faces the second lip, and they define a slot for receiving the flat segment. Each cross segment also comprises an island joining the first planar portion to the second planar portion, the island disposed in the slot and between the first and second lips. The island is configured to be received in the slit. Each flat segment is matingly connected to a corresponding cross segment such that the flat segment is received in the corresponding slot and the corresponding island is received in the corresponding slit.