Abstract: Systems and methods are provided for computed tomography (CT) imaging. In one embodiment, a method comprises adaptively blending at least two input image volumes with different spatially-variant noise characteristics to generate an output image volume with uniform noise throughout the output image volume. In this way, images may be reconstructed from projection data with data redundancy without introducing image artifacts from stitching images or variance in image noise due to the data redundancy.

Abstract: The present invention is directed to, in part, compositions or dosage forms comprising fused heteroaryl compounds useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including neurological disorders (e.g., Dravet syndrome, epilepsy), pain, neuromuscular disorders, trigeminal autonomic cephalalgia (TAC), migraine, cranial neuropathy or multiple cranial neuropathy, and cortical spreading depression (CSD) are also provided herein. In another aspect, the present invention provides a method of making ion channel modulators.

Abstract: A locking power cord receptacle configured to receive an electric power cord plug that includes a ground pin comprises a base receptacle and a locking assembly. The base receptacle includes a first female connector, a second female connector, and a ground female connector positioned on an upper surface and arranged to receive the power cord plug. The base receptacle further includes a body cavity on the upper surface. The locking assembly has a locked state in which the locking assembly blocks access to the base receptacle and an unlocked state in which the power cord plug can be plugged in to the base receptacle. The locking assembly includes a locking cover and a locking component. The locking cover includes a disc and a sleeve coupled to the disc and the base receptacle. The locking component is retained in the body cavity and has a locked configuration and an unlocked configuration.

Abstract: Systems, methods, and articles for assigning content, such as advertisements, to similar content breaks, such as advertisement placement opportunities, across multiple content providers. The systems disclosed herein automatically identify similar advertisement placement opportunities, such as advertisement placement opportunities occurring at the same time, across a plurality of media content providers, and assign an indicated advertisement spot to as many of the identified advertisement placement opportunities as possible. This is achieved by re-assigning advertisement spots which are already assigned to a slot in one of the advertisement placement opportunities to another slot in order to allow the indicated advertisement spot to be assigned to the slot.

Abstract: The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including Dravet syndrome or epilepsy are also provided herein.

Abstract: The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. The fused heteroaryl compounds of the disclosure are represented by Formula (I): wherein X, Y, Z, A, R1 and R2 are as defined in the specification. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including Dravet syndrome or epilepsy are also provided herein.

Abstract: A fill pack includes a first sheet and a second sheet. The first sheet has a first end, a second end and a first plurality of flutes. A first microstructure includes first top flat strips, first bottom flat strips and first conduit sides connecting the first top flat strips to the first bottom flat strips. A plurality of first radii connect the first top flat strips to the first conduit sides and the first bottom flat strips to the first conduit sides. The second sheet has a second plurality of flutes. A second microstructure includes second top flat strips, second bottom flat strips and second conduit sides connecting the second top flat strips to the second bottom flat strips. A plurality of second radii connect the second top flat strips to the second conduit sides and second bottom flat strips to the second conduit sides.

Abstract: The present invention is directed to, in part, fused heteroaryl compounds of Formula (II-II): and compositions thereof, useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including neurological disorders (e.g., Dravet syndrome, epilepsy), pain, and neuromuscular disorders are also provided herein.

Abstract: Disclosed herein is a data storage device. A data port transmits data between a host computer system and the data storage device. A non-volatile storage medium stores encrypted user content data and a cryptography engine connected between the data port and the storage medium uses a cryptographic key to decrypt the encrypted user content data. The access controller generates authorization request data indicative of multiple devices to be authorized, and stores the authorization request data on non-volatile configuration memory of the data storage device. Upon approval of the authorization request data by a manager device that is registered with the access controller as a manager device, the access controller locates the authorization request data of one of the multiple devices to be authorized and registers the one of the multiple devices to be authorized as an authorized device.

Abstract: Disclosed herein is a data storage device. A data port transmits data between a host computer system and the data storage device. A non-volatile storage medium stores encrypted user content data and a cryptography engine connected between the data port and the storage medium uses a cryptographic key to decrypt the encrypted user content data. Multiple manager device records each comprise a first key identical for each of the records, and a second key that different for each of the records. The controller generates an authorization request using the first key and receives a response to the request generated by a manager device. The response is specific to that manager device. The controller uses the response to locate the record; decrypts the located manager device record to obtain key data; and generates configuration data based on the key data to register the device.

Abstract: Disclosed herein is a data storage device. A data port transmits data between a host computer system and the data storage device. A non-volatile storage medium stores encrypted user content data and a cryptography engine connected between the data port and the storage medium uses a cryptographic key to decrypt the encrypted user content data. The access controller generates a challenge for a manager device. The challenge comprises a blinded public key of an ephemeral unlock key pair that is blinded by an unlock blinding key. The challenge further comprises the unlock blinding key in encrypted form. The access controller further provides the challenge to the device to be authorized for sending the challenge to the manager device; receives a response to the challenge; decrypts the unlock blinding key and calculates a shared secret; and upon determining that the response indicates approval of registering the device, registers the device to be authorized as an authorized device.

Abstract: Provided, in part, are compounds of Formula I. pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of conditions associated with the activity of sodium channels. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including neurological disorders (e.g., Dravet syndrome, epilepsy), pain, and neuromuscular disorders are also provided herein.

Abstract: Disclosed herein is a data storage device. A data port transmits data between a host computer system and the data storage device. A non-volatile storage medium stores encrypted user content data and a cryptography engine connected between the data port and the storage medium uses a cryptographic key to decrypt the encrypted user content data. The access controller generates an authorization request for a manager device. The authorization request comprises a certificate. The certificate comprising key data. In response to receiving the key data in a response to the authorization request generated by the manager device, the access controller generates configuration data based on the key data to register the device to be authorized as an authorized device.

Abstract: A web of cleaning products and a method of manufacturing the same is disclosed. The web includes first and second carrier sheets and a plurality of pouches containing a cleaning composition. Each of the pouches is disposed in a respective depression formed in an upper surface of the first carrier sheet. A first internal atmosphere is enclosed within each of the pouches. The first carrier sheet is sealed to the second carrier sheet such that a second internal atmosphere exists between the second carrier sheet and the plurality of pouches. The second internal atmosphere has a greater absolute pressure than the first internal atmosphere so that the plurality of pouches and at least a portion of the cleaning composition in the plurality of pouches are compressed into the plurality of depressions in the first carrier sheet by the second internal atmosphere.

Abstract: The disclosure provides antibody molecules that bind to TCR V? regions and multispecific molecules comprising said antibody molecules. Additionally, disclosed are nucleic acids encoding the same, methods of producing the aforesaid molecules, pharmaceutical compositions comprising aforesaid molecules, and methods of treating a cancer using the aforesaid molecules.

Abstract: Multispecific, e.g., bispecific, antibody molecules that include a kappa light chain polypeptide and one lambda light chain polypeptide, and methods of making and using the multispecific antibody molecules, are disclosed.

Abstract: An apparatus for supporting a user includes a faceplate, an arm, and a base. The faceplate has an opening to receive a user's face. The arm is attached to the faceplate and the base. The base includes a base slide that is slidable within a slot of a base body. The base slide includes one or more lock pins that releasably engage one of multiple holes in a lock bar. The lock bar is mechanically coupled to a button body. When the button body is pulled distally, the lock bar moves away from the base slide such that the lock pin(s) is/are removed from the corresponding hole(s) to allow the base slide to slide within the slot. When the button body is released, the lock bar moves towards the base slide such that the lock pin(s) is/are inserted into the same or different hole(s) to lock the slide's position.

Abstract: Data storage devices, methods, and systems for passcode authentication based on automatically generated and dynamically changing unlock passcodes are described. An access controller of a data storage device is configured to receive a first passcode based on an externally generated input passcode that is synchronized with internal generation of an unlock passcode by the access controller. The access controller generates a second passcode based on the internally generated unlock passcode, and unlocking the data storage device is responsive to the first passcode matching the second passcode.

Abstract: The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including Dravet syndrome or epilepsy are also provided herein.