Abstract: Prodrug compounds of GLP-1/GIP receptor co-agonists are provided wherein the GLP-1/GIP receptor co-agonists have been modified by the linkage of a dipeptide to the GLP-1/GIP receptor co-agonist through an amide bond. The prodrugs disclosed herein have extended half-lives and are converted to the active GLP-1/GIP receptor co-agonist at physiological conditions through a non-enzymatic reaction driven by chemical instability.

Abstract: A method of repairing a mitral valve of a heart of a subject comprises positioning an elongate support of an implant at the heart such that the support is aligned with a coronary sinus of the heart. A first anchor of the implant is anchored to a first location on an anterior side of the valve, such that a first tether-segment of the implant spans across the valve between the first anchor and a first end of the support. A second anchor of the implant is anchored to a second location on the anterior side of the valve, such that a second tether-segment of the implant spans across the valve between the second anchor and a second end of the support. Other embodiments are also described.

Abstract: The present disclosure generally relates to partial integrated core-shell investment casting molds that can be assembled into complete molds. Each section of the partial mold may contain both a portion of a core and portion of a shell. Each section can then be assembled into a mold for casting of a metal part. The partial integrated core-shell investment casting molds and the complete molds may be provided with filament structures corresponding to cooling hole patterns on the surface of the turbine blade or the stator vane, which provides a leaching pathway for the core portion after metal casting. The invention also relates to core filaments that can be used to supplement the leaching pathway, for example in a core tip portion of the mold.

Abstract: The present invention relates to compositions and methods for adding bitter flavor to beer and other beverages. The present invention concerns the use of compositions comprising compounds that are present in hop extracts or in beer and result from natural processes that occur during processing or storage (aging) of hops or beer. The present invention further concerns the use of suitable amounts of a composition comprising humulinones for adding bitter flavor to beer and other beverages.

Abstract: A unit-dose dentifrice composition includes a soluble fibrous composition and a nonfibrous composition. The soluble fibrous composition includes web forming material and tin ion source. The nonfibrous composition includes abrasive. The abrasive and the tin ion source are in separate locations within the unit-dose dentifrice composition.

Abstract: A textile formulation adapted to impart an odor-controlling property to a textile material. The textile formulation is an odor capturing formulation comprising a carrier and an odor capturing agent. The odor capturing agent is a liquid dispersible boehmite. An odor absorbing article and a method of treating the odor absorbing article is also provided.

Abstract: A translatable carriage exercise machine comprising elongate side rails. A moveable carriage is translatable along the side rails. An upper support surface on the carriage is useable to at least partially support a user. A plurality of elastic tension members can be secured to a bottom of the moveable carriage and are fixable to a plurality of spring anchors near an end of the machine. A pair of handles under elastic tension are directed toward an end of the machine. An upright footbar can be positioned at an end of the machine. A rotational resistance mechanism is integrated in the machine comprising an elongate resistance band having an extended configuration and a retracted configuration. The rotational resistance mechanism comprises a resistor comprising a load member. A user can option to utilize one or more of the elastic tension members and/or rotational resistance mechanism during exercise on the machine.

Abstract: Anti-microbial compositions for cleaning and sanitizing skin are disclosed. The anti-microbial compositions preferably comprises at least one quaternary ammonium chloride active and results in low irritation cleansing and sanitizing products that allow more frequent application.

Abstract: A detergent product containing a detergent composition is provided.

Abstract: A semiconductor package may include a line array of single-photon avalanche diodes (SPADs). The line array of single-photon avalanche diodes may be split between multiple silicon dice. Each silicon die may be overlapped by at least one lens to focus light away from gaps between the dice and towards the single-photon avalanche diodes. There may be one single-photon avalanche diode for each silicon die or multiple single-photon avalanche diodes for each silicon die. When there are multiple single-photon avalanche diodes for each silicon die, lenses may be formed over only the edge single-photon avalanche diodes.

Abstract: An imaging device may include single-photon avalanche diodes (SPADs). The single-photon avalanche diodes may be arranged in a one-dimensional or two-dimensional array in a SPAD-based semiconductor device. The SPAD-based semiconductor device may also include a transparent cover glass that is formed over the array of SPADs. Each line of SPADs within the SPAD-based semiconductor device may be covered by a respective light spreading lens. The light spreading lens may be formed as a groove in an upper surface of the transparent cover glass. The light spreading lens may have a uniform cross-section along its length. The light spreading lens may be formed as a convex lens on an upper or lower surface of the transparent cover glass.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for generating author vectors. One of the methods includes obtaining a set of sequences of words, the set of sequences of words comprising a plurality of first sequences of words and, for each first sequence of words, a respective second sequence of words that follows the first sequence of words, wherein each first sequence of words and each second sequence of words has been classified as being authored by a first author; and training a neural network system on the first sequences and the second sequences to determine an author vector for the first author, wherein the author vector characterizes the first author.

Abstract: A semiconductor package may include a line array of single-photon avalanche diodes (SPADs). The line array of single-photon avalanche diodes may be split between multiple silicon dice. The silicon dice may have a staggered arrangement, with prisms on the package lid redirecting incident light to the silicon dice. The silicon dice may alternate between a first side of the package substrate and a second side of the package substrate. The prisms may alternate between a first structure that redirects incident light to the first side of the package substrate and a second structure that redirects incident light to the second side of the package substrate. The silicon dice may overlap to allow satisfactory alignment between the silicon dice and the prisms.

Abstract: A method or process for a system for applying high, elevated levels of zinc borate additives to composite or manufactured wood panels, such as oriented strand board, for improved surface antifungal and anti-termite properties. Zinc borate is applied to one or more surface layers of a manufactured wood panel at approximately 2.0% (m/m) or higher, more preferably above 2.0% (m/m) to approximately 2.5% (m/m), which produces the surprising result of resisting surface fungal growth. In particular, OSB panels generated from Aspen and Southern Yellow Pine (SYP) wood species are successfully treated with zinc borate levels of at least approximately 2.0% (m/m), and found to resist surface fungal growth.

Abstract: The present disclosure relates to absorbent articles comprise a first belt and a second belt with frangible pathways. An accessibility opening may also be positioned in the first and/or second belt, and a fastener component may be connected with the belt adjacent the accessibility opening. Such frangible pathway configurations provide a feature that allows an elastic belt of a diaper pant to be relatively easily torn along the frangible pathway when removing the diaper pant from a wearer, and the fastener component may provide a feature that helps maintain a used diaper pant in a disposal configuration. An absorbent article may also comprise opening facilitation features, such as opening operational indicia and opening mechanical aids, and combinations thereof. Such opening facilitation features may help a user to successfully determine the location and/or function of the fastener component and frangible pathway and/or successfully complete pant opening operations.

Abstract: In one embodiment, a portable thermite fire starter kit is provided. For instance, one or more small pieces or solid blocks of thermite may be contained within a portable kit container along with one or more ignition items. The ignition items may comprise thermite matches. In one embodiment, the ignition items are kept separate from the pieces of thermite. In one embodiment, one or both of the thermite pieces and/or thermite matches are constructed as multiple layers of progressively ignitable materials and/or compounds. In particular, the layers may start at a first layer and that can reach a first burn temperature that is at least a subsequent adjacent layer ignition temperature, where each subsequent intermediate layer leading to the thermite progressively increases in ignition temperature to not more than a previously adjacent layer burn temperature and also increases in burn temperature to at least a subsequent adjacent layer ignition temperature.

Abstract: Prodrug compounds of GLP-1/GIP receptor co-agonists are provided wherein the GLP-1/GIP receptor co-agonists have been modified by the linkage of a dipeptide to the GLP-1/GIP receptor co-agonist through an amide bond. The prodrugs disclosed herein have extended half-lives and are converted to the active GLP-1/GIP receptor co-agonist at physiological conditions through a non-enzymatic reaction driven by chemical instability.

Abstract: A textile formulation adapted to impart an odor-controlling property to a textile material. The textile formulation is an odor capturing formulation comprising a carrier and an odor capturing agent. The odor capturing agent is a liquid dispersible boehmite. An odor absorbing article and a method of treating the odor absorbing article is also provided.