Abstract: Synthetic auxotrophs with one or more ligand-dependent essential gene functions and methods of production that can be used for biosafety. The ligand-dependent function of an essential gene product can be produced by a series of mutations in the ORF of an essential gene; N, C, or insertional fusions of ligand-binding domains with essential genes or an engineered ligand-dependent intein splicing to alter essential gene function. A positive and/or negative selection can be used to identify auxotrophs from created mutant libraries. The positive selection is performed by growing a mutant library in conditions where growth or viability depends on the function of mutagenized essential genes. The negative selection eliminates constitutively growing cells that do not require a ligand for growth by growing the library in the absence of complementing ligand and in conditions where growing cells are eliminated. Desirable phenotypes are collected after the selections.

Abstract: A computer vision system includes a camera that captures a plurality of image frames in a target field. A user interface is coupled to the camera. The user interface is configured to perform accelerated parallel computations in real-time on the plurality of image frames acquired by the camera. The system provides identification of common movement pathways within a space.

Abstract: A motor assembly is described and includes a housing; a plurality of motors disposed within the housing; and a drive shaft comprising a plurality of interconnected drive shaft segments, wherein each one of the drive shaft segments is driven by a different one of the motors connected to the drive shaft segment via an integrated overrunning clutch.

Abstract: A cable junction enclosure is described that provides new and improved ways of managing hybridized cable connections. The cable junction enclosures described herein include means for managing fiber cable and means for managing copper cable that originate in a single-sheathed hybridized cable. The cable junction enclosure described herein provides a more efficient way to manage multiple types of cable from a hybridized cable while providing increased security and protection for cables contained therein, entering thereto, and exiting therefrom.

Abstract: A compressor bypass reintroduction system includes a compressor intake manifold and a bypass conduit. The compressor intake manifold defines a fluid plenum. The compressor intake manifold is engageable with a compressor. The bypass conduit extends into the fluid plenum and includes an ejector line. The ejector line is configured to be substantially collinear with the compressor and to discharge flow toward the compressor. In some embodiments, an outlet of the ejector is disposed proximate to an outlet of the fluid plenum that discharges flow into the compressor.

Abstract: A computer vision system includes a camera that captures a plurality of image frames in a target field. A user interface is coupled to the camera. The user interface is configured to perform accelerated parallel computations in real-time on the plurality of image frames acquired by the camera. The system provides an accountability measurement of impact of architecture and design work.

Abstract: Described herein are novel compositions comprising bispecific and multispecific polypeptide agents, and methods using these agents for targeting cells, such as functionally exhausted or unresponsive immune cells, that co-express the inhibitory receptors PD-1 and TIM-3. These compositions and methods are useful for the treatment of chronic immune conditions, such as persistent infections or cancer.

Abstract: Paint mask assemblies are described herein in various embodiments. A paint mask assembly includes a window portion having a removable mask affixed thereto. The paint mask assembly can be affixed over a mark on a surface so that the mark is visible through the window portion of the paint mask assembly. When the paint mask assembly is painted, the paint is applied over the removable mask, but the window portion remains unpainted. When the removable mask is removed, the mark remains visible through the window portion of the paint mask assembly.

Abstract: A burner assembly including a body, the body including a first aperture, a second aperture, a cavity between the first and second aperture, and a gas inlet in fluid communication with the cavity. The assembly also includes a gas nozzle arranged to terminate a first distance from the first aperture of the body. The assembly also includes a fuel tube and a fuel nozzle disposed within the cavity of the body, the fuel tube arranged to terminate within a first through-bore of the gas nozzle, and the fuel nozzle being removably secured to the fuel tube, the fuel nozzle terminating a second distance from the first aperture of the body, wherein the first distance is less than the second distance or the first distance is substantially equal to the second distance.

Abstract: An optical fiber holder includes a first holder having a first upper surface and a first lower surface. The optical fiber holder is configured to be in contact with a working station through the first lower surface. Further, the optical fiber holder can include a second holder having a second upper surface and a second lower surface. The second holder can be operably attached to the first holder through the second lower surface. Also, the second holder is configured to rotate with respect to the first holder. Further, the optical fiber holder can include a third holder having plurality of holes therethrough configured to receive a respective plurality of optical fibers. The third holder can include a plurality of protrusions operably coupled to the second holder and configured to enable the third holder to move with respect to the second holder.

Abstract: An apparatus includes a base that includes a raised surface and a first opening through the raised surface. The apparatus also includes a cover configured to be coupled to the base in order to form a cavity, where the cover includes a second opening through the cover. The raised surface is configured to allow passage of a first portion of optical energy through the first opening and to reflect a second portion of the optical energy. Portions of the cover and the base surrounding the cavity are configured to absorb the reflected second portion of the optical energy. The base may further include one or more baffles positioned around the raised surface, and/or the cover may further include one or more baffles positioned around the second opening.

Abstract: The present disclosure provides a composition. In an embodiment, the composition includes a pest repellent, a barrier polymer, and an ethylene-based polymer. The barrier polymer has a melt temperature, Tm, from 175C to less than 270C. The barrier polymer is selected from the group consisting of one or more polyamides, one or more polyesters, and combinations thereof. Also disclosed is an irrigation tube having an annular wall.

Abstract: A screwdriver comprises a handle including a butt and a shank extending from the handle and including a tip. The butt includes a first indicating element having a shape corresponding to the tip and a plurality of second indicating elements arranged around the first indicating element. Each of the second indicating elements has the shape.

Abstract: Methods and apparatus, including computer program products, implementing and using techniques for identifying a driver of a vehicle. Measurement values representing the movement of a vehicle are received from one or more sensors measuring features relating to the movement of the vehicle. Instantaneous dimensions for measuring driver identification are defined. For each dimension statistical features within a given time frame are calculated and a feature map is built, including the time frame and the statistical features. A set of driving features is extracted from the feature map. The set of extracted driving features is compared with previously extracted sets of driving features to create a set of similarity metrics between two drivers. A classification model is trained based on the similarity metrics and is used with the similarity metrics to determine whether data pertaining to a new trip segment should be associated with a known or unknown driver.

Abstract: The subject matter disclosed herein is generally directed to novel CD8+ and CD4+ T cell subtypes associated with effector, suppressive or regulatory T cell functions. Moreover, the subject matter disclosed herein is generally directed to methods and compositions for use of the subtype. Also, disclosed herein are gene signatures and markers associated with the subtype and use of said signatures and markers. Further disclosed are therapeutic methods of using said gene signatures and immune cell subtype. Further disclosed are pharmaceutical compositions comprising populations of CD4+ and/or CD8+ TILs or populations of immune cells depleted for a specific subtype. Further disclosed are interactions with other T cell subtypes.

Abstract: The disclosure features, inter alia, immunogenic XBP1-, CD138-, and CS1-derived peptides (and pharmaceutical compositions thereof). The peptides can be used in a variety of methods such as methods for inducing an immune response, methods for producing an antibody, and methods for treating a cancer (e.g., a plasma cell disorder such as multiple myeloma or Waldenstrom's macroglobulinemia). The peptides can also be included in MHC molecule multimer compositions and used in, e.g., methods for detecting a T cell in a population of cells.

Abstract: Systems and methods relate to locating connectivity network components in a step structure. Connectivity network components, such as network switches, network access points, etc., are disposed within structural steps in a spectator venue, such as a sports stadium or arena. Locating network components in stadium steps allows network cabling to be brought closer to network access points, thus bringing about efficiencies in cabling costs and connectivity characteristics. Such systems and methods allow for network access points to be located in greater densities in areas with high user access rates.

Abstract: Techniques described herein relate to integrating an electronic component into a ceiling mount in a ceiling tile system so as to maintain the aesthetic integrity of the ceiling while providing a suitable structural system to secure the equipment into the ceiling. The techniques further include one or more apparatuses having a cutting element for efficiently cutting the specified tile to accommodate the electronic component ceiling mount.

Abstract: A computer vision system includes a camera that captures a plurality of image frames in a target field. A user interface is coupled to the camera. The user interface is configured to perform accelerated parallel computations in real-time on the plurality of image frames acquired by the camera. The system provides an identification of where collisions regularly occur.

Abstract: A screwdriver comprises a handle including a butt and a shank extending from the handle and including a tip. The butt includes a first indicating element having a shape corresponding to the tip and a plurality of second indicating elements arranged around the first indicating element. Each of the second indicating elements has the shape.