Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.

Abstract: The present invention provides thiazole compounds of Formula I wherein W, Y, R0, R2, R4, R1, R6, R7, X1, X2, X3 and X4 are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt, prodrug ester or solvate form thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of platelet aggregation and thus can be used as medicaments for treating or preventing thromboembolic disorders.

Abstract: The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making the proteins. The instant invention additionally provides methods of stimulating or suppressing immune responses in a mammal using the fusion protein complexes and IL-15 variants of the invention.

Abstract: Embodiments of self-heating tracking circuits for a power amplifier (PA) are disclosed. In an embodiment, a self-heating tracking circuit for a PA includes a PA replica circuit in proximity to the PA and an estimation unit configured to estimate a self-heating time constant of the PA in response to turning on the PA replica circuit and turning off the PA replica circuit.

Abstract: An apparatus and method for reducing a pressure differential across a turbine 19 of a gas turbine engine 10 during a shaft break event, comprises a pressure equalization apparatus 200, 300, 400, 500, 600, 700 configured to introduce a pressurised fluid into a core airflow A at a region directly downstream of the turbine 19 in the event of a shaft break to directly increase a local pressure at the downstream region 29 of the turbine 19 and thereby reduce the pressure differential across the turbine 19. The reduction in the pressure differential may result in a reduction in the acceleration of the turbine 19.

Abstract: An apparatus and method for reducing a pressure differential across a turbine 19 of a gas turbine engine 10 during a shaft break event, comprises a pressure equalization apparatus 200 configured to introduce a pressurised fluid into a core airflow A at a region downstream of the turbine 19 in the event of a shaft break to directly increase a local pressure at the downstream region 29 of the turbine 19 and thereby reduce the pressure differential across the turbine 19. The pressure equalization apparatus comprises a sensor 216 configured to directly detect a shaft break event. The reduction in the pressure differential may result in a reduction in the acceleration of the turbine 19.

Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-7 or IL-21.

Abstract: An apparatus and method for reducing a pressure differential across a turbine 19 of a gas turbine engine 10 during a shaft break event, comprises a pressure equalization apparatus 300, 400, 500, 600, 700 configured to introduce a pressurised fluid into a core airflow A at a region downstream of the turbine 19, wherein a rearward movement of the turbine 19 or a shaft 26 in a shaft break event directly actuates the pressure equalisation apparatus 300, 400, 500, 600, 700 to directly increase a local pressure at the downstream region 29 of the turbine 19 and thereby reduce the pressure differential across the turbine 19. The reduction in the pressure differential may result in a reduction in the acceleration of the turbine 19.

Abstract: A turbofan gas turbine engine comprises, in axial flow sequence, a heat exchanger module, a fan assembly, a compressor module, and a turbine module. The fan assembly comprises a plurality of fan blades defining a fan diameter (D), and the heat exchanger module comprises a plurality of heat exchanger elements. The heat exchanger module is in fluid communication with the fan assembly by an inlet duct, with the heat exchanger module having an axial length along a central axis between an upstream-most face of the heat exchanger elements and a downstream-most face of the heat exchanger elements. The axial length is in the range of 0.1*D to 5.0*D.

Abstract: Provided herein are methods of treating an aging-related disease or inflammatory disease in a subject that include (i) a therapeutically effective amount of an NK cell activating agent and/or an NK cell and/or monoclonal antibody; and (ii) a therapeutically effective amount of a Treg cell activating agent and/or a Treg cell and/or a monoclonal antibody and/or AGE inhibitor.

Abstract: A user interface (UI), data structures and algorithms facilitate programming, analyzing, debugging, embedding, and/or modifying problems that are embedded or to be embedded on an analog processor (e.g., quantum processor), increasing computational efficiency and/or accuracy of problem solutions. The UI provides graph representations (e.g., source graph, target graph and correspondence therebetween) with nodes and edges which may map to hardware components (e.g., qubits, couplers) of the analog processor. Characteristics of solutions are advantageously represented spatially associated (e.g., overlaid or nested) with characteristics of a problem. Characteristics (e.g., bias state) may be represented by color, pattern, values, icons. Issues (e.g., broken chains) may be detected and alerts provided.

Abstract: A cancellation circuit includes a limiter connected to an output of a first transmitter power amplifier that converts in input sinewave to a digital square wave and a digital to time converter (DTC) connected to the limiter. A RF digital to RF converter is connected to the DTC that converts the digital square wave input into an analog RF output. A cancellation amplifier with an input receives an output from the RF digital to RF converter and has an output connected to an output of a second transmitter power amplifier. The cancellation amplifier produces a cancellation signal to cancel an interference signal at the output of the second transmitter power amplifier from the output of the first transmitter power amplifier. A power detector is connected to the output of the second power amplifier that produces a power value detected at the output of the second power amplifier.

Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.

Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.

Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.

Abstract: An aircraft gas turbine engine includes a heat exchanger module, and a core engine including an intermediate-pressure compressor, a high-pressure compressor, a high pressure turbine, and a low-pressure turbine. The high-pressure compressor is connected to the high-pressure turbine by a first shaft, and the intermediate-pressure compressor is connected to the low-pressure turbine by a second shaft. The heat exchanger module includes a central hub and heat transfer elements extending radially from the central hub and spaced in a circumferential array, for transferring heat energy from a fluid within the heat transfer elements to an inlet airflow passing over the heat transfer elements prior to entry of the airflow into an inlet to the core engine. The gas turbine engine further includes a first electric machine connected to the first shaft and positioned downstream of the heat exchanger module, and a second electric machines connected to the second shaft.

Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.

Abstract: The present invention provides thiazole compounds of Formula I wherein W, Y, R0, R2, R4, R5, R6, R7, X1, X2, X3 and X4 are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt, prodrug ester or solvate form thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of platelet aggregation and thus can be used as medicaments for treating or preventing thromboembolic disorders.

Abstract: An optical coherence tomography scanner for imaging an intraoral sample has a wavelength-tunable light source configured to generate scanning light having a range of wavelengths and a scanning probe having a scanning head. A light circulator is configured to direct the scanning light to a first sample arm having at least a first optical fiber for conveying light to the sample, to direct a sample signal, having scattered and reflected light from the sample, back from the first optical fiber, to a detector, and to direct a reference signal, having light reflected back along the first optical fiber from a partially reflective surface at the scanning head, to the detector. The detector forms a digital output signal indicative of interference of the combined sample and reference signals. A display is configured to form an image of sample features according to the digital output signal.

Abstract: Certain exemplary ultrasound probe method and/or apparatus embodiments are described, which can be used for 2D and/or 3D imaging soft tissue in an intra oral cavity.