Abstract: The present disclosure relates to methods that include the use of a first multi-chain chimeric polypeptide and a second multi-chain chimeric polypeptide for stimulating the NK cells, inducing or increasing proliferation of the NK cells, inducing differentiation of the NK cells, and treating a subject in need thereof using activated NK cells.

Abstract: The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making the proteins. The instant invention additionally provides methods of stimulating or suppressing immune responses in a mammal using the fusion protein complexes and IL-15 variants of the invention.

Abstract: Techniques are disclosed relating to improving memory reliability, e.g., in the context of memory circuits with limited reliability features. In some embodiments, memory controller circuitry is configured to communicate with memory circuitry via an interface that supports link error detection. The memory controller circuitry may, based on a corruption indicator, transmit a data and parity combination for the first data block that causes the memory circuitry to detect an uncorrectable write interface error. Subsequent reads of the location may therefore cause an uncorrectable error indication. This may advantageously allow the memory controller circuitry to propagate a corruption indicator as an uncorrectable error in the memory circuit, without requiring additional tracking of the indicator by the memory circuit or memory controller, in some embodiments.

Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-12 or IL-18.

Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.

Abstract: An electronic circuit includes a differential output circuit that produces a differential output signal at a differential output. A primary winding of a balun has a first balun terminal coupled to a first differential output terminal, and a second balun terminal coupled to a second differential output terminal. A configurable harmonic reduction circuit includes first and second configurable shunt capacitance circuits coupled between the first differential output terminal or the second differential output terminal, respectively, and a ground reference node. A control circuit receives tuning data associated with a calibrated tuning state. The tuning data indicates a first and second calibrated capacitance values, which are unequal, for the first and second configurable shunt capacitance circuits, respectively.

Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.

Abstract: The present invention provides thiazole compounds of Formula I wherein W, Y, R0, R2, R4, R5, R6, R7, X1, X2, X3 and X4 are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt, prodrug ester or solvate form thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of platelet aggregation and thus can be used as medicaments for treating or preventing thromboembolic disorders.

Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.

Abstract: A user interface (UI), data structures and algorithms facilitate programming, analyzing, debugging, embedding, and/or modifying problems that are embedded or to be embedded on an analog processor (e.g., quantum processor), increasing computational efficiency and/or accuracy of problem solutions. The UI provides graph representations (e.g., source graph, target graph and correspondence therebetween) with nodes and edges which may map to hardware components (e.g., qubits, couplers) of the analog processor. Characteristics of solutions are advantageously represented spatially associated (e.g., overlaid or nested) with characteristics of a problem. Characteristics (e.g., bias state) may be represented by color, pattern, values, icons. Issues (e.g., broken chains) may be detected and alerts provided.

Abstract: First lithography and etching are carried out on a semiconductor structure to provide a first intermediate semiconductor structure having a first set of surface features corresponding to a first portion of desired fin formation mandrels. Second lithography and etching are carried out on the first intermediate structure, using a second mask, to provide a second intermediate semiconductor structure having a second set of surface features corresponding to a second portion of the mandrels. The second set of surface features are unequally spaced from the first set of surface features and/or the features have different pitch. The fin formation mandrels are formed in the second intermediate semiconductor structure using the first and second sets of surface features; spacer material is deposited over the mandrels and is etched back to form a third intermediate semiconductor structure having a fin pattern. Etching is carried out on same to produce the fin pattern.

Abstract: A turbofan gas turbine engine includes, in axial flow sequence, a heat exchanger module, a fan assembly, a compressor module, and a turbine module. The fan assembly includes fan blades defining a corresponding fan area (AFAN). The heat exchanger module is in fluid communication with the fan assembly by an inlet duct, and includes radially-extending vanes arranged in a circumferential array with at least one vane including a heat transfer element for heat transfer from a first fluid contained within each element to an airflow passing over a surface of each heat transfer element before entering the fan assembly inlet. Each heat transfer element extends axially along the corresponding vane, with a swept heat transfer element area (AHTE) being the wetted surface area of all heat transfer elements in contact with the airflow. A Fan to Element Area parameter FEA of AHTE/AFAN lies in the range of 47 to 132.

Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.

Abstract: An aircraft includes a machine body that encloses a turbofan gas turbine engine and a plurality of ancillary systems. The turbofan gas turbine engine includes, in axial flow sequence, a first heat exchanger module, a fan assembly, a compressor module, a combustor module, a turbine module, and an exhaust module. The aircraft includes a second heat exchanger module. The machine body comprises a single fluid inlet aperture, with the fluid inlet aperture being configured to allow a fluid cooling flow to enter the machine body and to pass through the first heat exchanger module. When a temperature of the fluid cooling flow is less than a temperature of a fluid to be cooled, the fluid to be cooled is directed to the first heat exchanger module, and when a temperature of the fluid cooling flow is greater than a temperature of the fluid to be cooled, the fluid to be cooled is directed to the second heat exchanger module and cooled using a fuel supply for the gas turbine engine.

Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.

Abstract: The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making the proteins. The instant invention additionally provides methods of stimulating or suppressing immune responses in a mammal using the fusion protein complexes and IL-15 variants of the invention.

Abstract: Provided herein are proteins comprising an anti-CD26 antigen-binding domain. Also provided herein are methods of treating an aging-related disease or an inflammatory disease in a subject that include administering to the subject one of these proteins or a cell expressing one of these proteins.

Abstract: A turbofan gas turbine engine comprises, in axial flow sequence, a heat exchanger module, an inlet duct, a fan assembly, a compressor module, and a turbine module. The fan assembly comprises a plurality of fan blades defining a fan diameter D, and the heat exchanger module comprises a plurality of heat transfer elements for transfer of heat from a first fluid contained within the heat transfer elements to an airflow passing over a surface of the heat transfer elements prior to entry of the airflow into the fan assembly. In use, the first fluid has a maximum temperature of 80° C., and the heat exchanger module transfers at least 300 kW of heat energy from the first fluid to the airflow.

Abstract: An aircraft gas turbine engine includes a heat exchanger module, and a core engine including an intermediate-pressure compressor, a high-pressure compressor, a high pressure turbine, and a low-pressure turbine. The high-pressure compressor is connected to the high-pressure turbine by a first shaft, and the intermediate-pressure compressor is connected to the low-pressure turbine by a second shaft. The heat exchanger module includes a central hub and heat transfer elements extending radially from the central hub and spaced in a circumferential array, for transferring heat energy from a fluid within the heat transfer elements to an inlet airflow passing over the heat transfer elements prior to entry of the airflow into an inlet to the core engine. The gas turbine engine further includes a first electric machine connected to the first shaft and positioned downstream of the heat exchanger module, and a second electric machines connected to the second shaft.

Abstract: A base station in a first wireless network provides first wireless connectivity to user equipment operated by a subscriber. The first wireless network supports first wireless communications such as non-voice communications. A network management resource receives configuration information assigned to the subscriber operating the user equipment. The configuration information indicates that the subscriber is assigned use of a second wireless network that provides support of second wireless communications (such as voice communications). In response to detecting a trigger event (such as a voice call) indicating a need to switch to use of the second wireless network, the network management resource initiates termination of the first wireless connectivity and establishment of second wireless connectivity between the user equipment and a base station in the second wireless network.