Abstract: A turbofan gas turbine engine includes, in axial flow sequence, a heat exchanger module, a fan assembly, a compressor module, a turbine module, and an exhaust module. The fan assembly includes a plurality of fan blades defining a fan diameter (D). The heat exchanger module is in fluid communication with the fan assembly by an inlet duct, and the heat exchanger module includes a plurality of radially-extending hollow vanes arranged in a circumferential array with a channel extending axially between each pair of adjacent hollow vanes. An airflow entering the heat exchanger module is divided between a set of vane airflows through each of the hollow vanes and a set of channel airflows through each of the channels.

Abstract: An aircraft comprises a machine body. The machine body encloses a turbofan gas turbine engine and a plurality of ancillary systems. The turbofan gas turbine engine comprises, in axial flow sequence, a heat exchanger module, a fan assembly, a compressor module, a combustor module, a turbine module, and an exhaust module. The machine body comprises a single fluid inlet aperture, with the fluid inlet aperture being configured to allow a fluid cooling flow to enter the machine body and to pass through the heat exchanger module. The heat exchanger module is configured to transfer a waste heat load from the gas turbine engine and the ancillary systems to the fluid cooling flow prior to an entry of the entire fluid cooling flow into the fan module.

Abstract: A turbofan gas turbine engine includes, in axial flow sequence, a heat exchanger module, a fan assembly, a compressor module, a turbine module, and an exhaust module. The fan assembly includes a plurality of fan blades defining a fan diameter. The heat exchanger module is in fluid communication with the fan assembly by an inlet duct, and the heat exchanger module including a plurality of heat transfer elements for transfer of heat from a first fluid contained within the heat transfer elements to an airflow passing over a surface of the heat transfer elements prior to entry of the airflow into an inlet to the fan assembly. Each heat transfer element may be individually and independently fluidly isolated from the remaining heat transfer elements.

Abstract: A turbofan gas turbine engine includes, in axial flow sequence, a heat exchanger module, a fan assembly, a compressor module, a turbine module, and an exhaust module. The fan assembly includes fan blades defining a fan diameter. The heat exchanger module is in communication with the fan assembly by an inlet duct, and the heat exchanger module further includes radially-extending hollow vanes arranged in a circumferential array, with a channel extending axially between hollow vanes. Each hollow vane accommodates at least one heat transfer element to transfer heat from a first fluid contained within the or each heat transfer element to a corresponding vane airflow passing through the hollow vane and over a surface of the or each heat transfer element. Each hollow vane further includes a flow modulator configured to regulate airflow in proportion to total airflow entering the heat exchanger module in response to a user requirement.

Abstract: Method and/or apparatus embodiments for 3-D cephalometric analysis of a patient according to the application can display reconstructed volume image data from a computed tomographic scan of a patient's head including segmented dentition elements having an initial arrangement from one or more 2D/3D views; can compute and display a plurality of cephalometric parameters for the patient according to the reconstructed volume image data; then use the patient specific cephalometric parameters and population biometry data, to identify one or more maxillofacial/dental abnormalities; and compose patient specific treatment plans to correct selected dentition abnormalities using maxillofacial/dental structure, which can be composed in a final tooth arrangement in a final virtual CT volume. One or more aligners can be generated to incrementally move dentition from the initial arrangement to the final tooth arrangement.

Abstract: Provided herein are multi-chain chimeric polypeptides and use thereof in the treatment of liver diseases.

Abstract: A method of controlling a gas turbine engine includes the steps of: detecting a shaft break event in a shaft connecting a compressor of the gas turbine engine to a turbine of the gas turbine engine; and in response to this detection, activating a shaft break mitigation system which introduces a fluid into a gas flow of the gas turbine engine downstream of the turbine, or increases an amount of a fluid being provided into the gas flow of the gas turbine engine downstream of the turbine, whereby the fluid reduces an effective area of a nozzle for the gas flow so as to reduce the mass flow rate of the gas flow through the turbine.

Abstract: A method for color shade matching obtains a 3D tooth surface representation using an intraoral scanner wherein the 3D tooth surface representation comprises surface data and a spatially resolved angular distribution of color vectors, wherein the spatially resolved angular distribution of color vectors associates one or more point positions from the surface data to the corresponding angular distribution of color vectors. The method identifies one or more shade values, where each shade value is associated with one angular distribution of color vectors from the spatially resolved angular distribution of color vectors, by comparing the angular distribution of color vectors to a set of reference angular distributions of color vectors, wherein each reference angular distribution in the set is associated with a corresponding shade value. The method displays, stores, or transmits the surface data with an indication of the one or more shade values.

Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-12 or IL-18.

Abstract: Apparatus and method configured to determine locations of man-made objects within synthetic aperture radar (SAR) imagery. The apparatus and method prescreen SAR imagery to identify potential locations of man-made objects within SAR imagery. The potential locations are processed using a change detector to remove locations of natural objects to produce a target image containing location of substantially only man-made objects.

Abstract: The present embodiments relate generally to applicators of on-skin sensor assemblies for measuring an analyte in a host, as well as their method of use and manufacture. In some aspects, an applicator for applying an on-skin sensor assembly to a skin of a host is provided. The applicator includes an applicator housing, a needle carrier assembly comprising an insertion element configured to insert a sensor of the on-skin sensor assembly into the skin of the host, a holder releasably coupled to the needle carrier assembly and configured to guide the on-skin sensor assembly while coupled to the needle carrier assembly, and a drive assembly configured to drive the insertion element from a proximal starting position to a distal insertion position, and from the distal insertion position to a proximal retraction position.

Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-12 or IL-18.

Abstract: The present embodiments relate generally to applicators of on-skin sensor assemblies for measuring an analyte in a host, as well as their method of use and manufacture. In some aspects, an applicator for applying an on-skin sensor assembly to a skin of a host is provided. The applicator includes an applicator housing, a needle carrier assembly comprising an insertion element configured to insert a sensor of the on-skin sensor assembly into the skin of the host, a holder releasably coupled to the needle carrier assembly and configured to guide the on-skin sensor assembly while coupled to the needle carrier assembly, and a drive assembly configured to drive the insertion element from a proximal starting position to a distal insertion position, and from the distal insertion position to a proximal retraction position.

Abstract: According to one configuration, a shared wireless access node supports wireless access for multiple wireless network service providers. A mobile communication device receives notification of multiple wireless network service providers, each of which provides access to a remote network through the shared wireless access node. The notification includes connection information such as priority information assigned to the wireless network service providers. The priority information indicates an order in which to select amongst the multiple available wireless network service providers to access the remote network. Based at least in part on the priority information, the mobile communication device selects a wireless network service provider amongst the multiple wireless network service providers.

Abstract: A turbofan gas turbine engine includes heat exchanger module, fan assembly, compressor, turbine and exhaust modules. The fan includes a plurality of fan blades. The heat exchanger in fluid communicates with the fan assembly by an inlet duct, and the heat exchanger includes a plurality of radially-extending hollow vanes arranged in a circumferential array, with a channel extending axially between each pair of adjacent hollow vanes. An airflow entering the heat exchanger is divided between a set of vane airflows and a set of channel airflows. Each vane airflow has a vane mass flow rate FlowVane, and each channel air flow has a channel mass flow rate FlowChan. Each hollow vane includes, an inlet, heat transfer, and exhaust portions, with the inlet portion comprising a diffuser element and the heat transfer portion including at least one heat transfer element. The diffuser element causes FlowVane to be lower than FlowChan.

Abstract: A method for intraoral imaging generates one or more output imaging signals from an intraoral probe and acquires multimodal image content from intraoral surface locations according to tissue response from the one or more imaging signals and associates spatial coordinates to the acquired multimodal image content. A surface contour of the patient dentition is generated by stitching the acquired multimodal image content and preserving the association of spatial coordinates with the stitched multimodal image content. Tooth outlines for one or more teeth are generated from the generated surface contour and the generated outlines arranged as a dental chart representing a spatial ordering of the one or more teeth and of supporting gum tissue adjacent to the teeth. The dental chart is populated by analyzing the acquired multimodal image content and associating the analysis to positions on the dental chart according to the preserved association of spatial coordinates and is displayed.

Abstract: An apparatus for oral imaging has a light source energizable to generate a light frequency signal ranging from a minimum to a maximum frequency. An image acquisition apparatus scans the generated light frequency signal to successive positions on a sample surface and to combine a returned signal from each successive position with the generated light frequency signal. The image acquisition apparatus has a detector that obtains a beat frequency signal from the combined returned signal and the generated light frequency signal. A processor that is in signal communication with the detector generates a processed beat signal from the combined signals, wherein the processed beat signal is indicative of the distance from the tunable laser source to the sample surface at the corresponding position. A display is in signal communication with the processor and is energizable to display distance data according to the processed beat signal for each scanned position.

Abstract: An intraoral scanning apparatus has a mouthpiece and a transport apparatus that defines at least a first curved track within the mouthpiece. An image sensor is movable along the first curved track. A scanner is movable along the first curved track, scanning in synchronization with the image sensor and having an illumination source that has a laser light source and beam-shaping optics in the path of the laser light for forming a linear light pattern. At least one actuator is energizable to move the image sensor and scanner along the first curved track for image acquisition. A control logic processor synchronizes the scanner and image sensor for automated acquisition of surface contour data. A display is in signal communication with the control logic processor to process and display the acquired surface contour data.

Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-12 or IL-18.

Abstract: A user interface (UI), data structures and algorithms facilitate programming, analyzing, debugging, embedding, and/or modifying problems that are embedded or to be embedded on an analog processor (e.g., quantum processor), increasing computational efficiency and/or accuracy of problem solutions. The UI provides graph representations (e.g., source graph, target graph and correspondence therebetween) with nodes and edges which may map to hardware components (e.g., qubits, couplers) of the analog processor. Characteristics of solutions are advantageously represented spatially associated (e.g., overlaid or nested) with characteristics of a problem. Characteristics (e.g., bias state) may be represented by color, pattern, values, icons. Issues (e.g., broken chains) may be detected and alerts provided.