Abstract: The present invention provides 1H-pyrazolo[4,3-b]pyridin-7-amines of formula (I) as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders,

Abstract: An apparatus includes a seabed-disposed pump that includes an inlet to receive a fluid flow and an outlet. The apparatus includes a liquid retainer that is adapted to receive a fluid flow that is produced by a subsea well. The liquid retainer selectively retains and releases liquid from the fluid flow to regulate a gas volume fraction of the fluid flow that is received at the inlet of the pump.

Abstract: The present invention provides 1H-pyrazolo[4,3-b]pyridin-7-amines of formula (1) as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.

Abstract: A downhole tool and method for use, in which the tool includes a housing defining a first bore axially therethrough, and a valve shaft disposed in the first bore of the housing. The valve shaft defines a second bore extending axially therein and one or more openings extending radially from the second bore, the valve shaft being rotatable relative to the housing. The tool also includes a valve sleeve disposed in the housing and defining one or more openings extending radially therethrough. The valve shaft is rotatable relative to the valve sleeve, such that the one or more openings of the valve sleeve are periodically aligned and misaligned with the one or more openings of the valve sleeve as the valve shaft rotates.

Abstract: The present invention provides 1H-pyrazolo[4,3-b]pyridin-7-amines of formula (I) as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.

Abstract: The invention provides methods and compositions for breeding pepper (Capsicum sp. such as Capsicum annuum) lines, including isogenic and nearly isogenic lines, displaying one or more mature fruit color(s) of interest. Predictive genetic markers and associated sequences and primers, associated with phenotypic diversity at the Ccs locus encoding Capsanthin-Capsorubin Synthase, and the Ze locus encoding Zeaxanthin Epoxidase are also provided, as well as methods for breeding pepper lines. Further provided are pepper plants, and plant parts including seeds, seed mixtures, fruit, and packaged fruit, which display mature fruit color(s) of interest.

Abstract: A downhole tool includes an expandable sleeve. The expandable sleeve includes a lower portion and an upper portion. The downhole tool also includes a lower cone positioned at least partially within the lower portion of the expandable sleeve. The downhole tool also includes an upper cone positioned at least partially within the upper portion of the expandable sleeve. The lower and upper cones are configured to expand the respective lower and upper portions of the expandable sleeve radially outward when the lower and upper cones are adducted toward one another. The downhole tool also includes an isolation device extending through the bore of the expandable sleeve and positioned radially inward of the lower and upper cones. The isolation device is configured to engage the upper cone so as to block fluid flow therethrough in at least one direction.

Abstract: The present invention provides 1H-pyrazolo[4,3-b]pyridines of formula (I) as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.

Abstract: A downhole tool includes a sleeve having a first end and a second end, a slip assembly coupled to the second end of the sleeve, a first cone positioned at least partially in the sleeve, proximal to the first end thereof, and a second cone positioned at least partially in the slip assembly. The first and second cones are configured to be moved toward one another from a run-in configuration to a set configuration. When actuating from the run-in configuration to the set configuration, the sleeve is forced radially outward by the first cone. When actuating from the run-in configuration to the set configuration, the slip assembly is forced radially outward by the second cone.

Abstract: A downhole tool includes a cone having a tapered outer surface, a slip assembly positioned at least partially around the tapered outer surface of the cone, and a sealing ring positioned at least partially around the tapered outer surface of the cone. The slip assembly directly engages the sealing ring, such that the slip assembly is configured to transmit a setting force directly onto the sealing ring, which moves the sealing ring on the tapered outer surface of the cone and expands the sealing ring radially outward.

Abstract: The present invention provides 1H-pyrazolo[4,3-b]pyridin-7-amines of formula (I) as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.

Abstract: A compound of formula (I), or a pharmaceutically acceptable salt thereof, for use in the treatment of autoimmune diseases and inflammatory conditions.

Abstract: The present invention provides macrocycles of formula (I) as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.

Abstract: A downhole tool includes an expandable sleeve having an outer surface. The expandable sleeve is configured to expand radially outwards without fracturing apart. The tool also includes a plurality of button inserts positioned at least partially in the expandable sleeve and extending outward past the outer surface by a first distance, so as to engage a surrounding tubular when the expandable sleeve is expanded. The tool further includes a first band of grit material on the outer surface, adjacent to at least one row of the plurality of button inserts. The first band of grit material extends outward from the outer surface by at least the first distance, to shield the plurality of button inserts during run-in of the downhole tool.

Abstract: The present invention provides 1H-pyrazolo[4,3-b]pyridin-7-amines of formula (I) as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.

Abstract: The invention relates to an optical flow cell comprising a housing forming an enclosed and elongated fluid channel arranged along a first axis, an inlet arranged to connect a first outer surface area of the housing to a first end of the fluid channel and an outlet arranged to connect a second outer surface area to a second end of the fluid channel, a first light guide and a second light guide concentrically arranged along a second axis and on opposite side walls of the fluid channel. The invention further relates to a corresponding method to produce an optical flow cell.

Abstract: A downhole tool and a tool assembly, of which the downhole tool includes an expandable sleeve defining a bore extending axially therethrough, a first swage positioned at least partially within the bore and including a valve seat configured to receive an obstructing member, such that the obstructing member and the first swage substantially prevent fluid communication through the bore when the obstructing member is seated in the valve seat, and a second swage positioned at least partially within the bore. The first and second swages are configured to move toward one another in the bore, such that the first and second swages deform end portions of the expandable sleeve radially outwards and into engagement with a surrounding tubular, and the expandable sleeve, in an expanded configuration in which the end portions engage the surrounding tubular, defines an unexpanded portion between the expanded end portions.

Abstract: A personal protective equipment (PPE) monitoring system is disclosed that includes a set of wireless transmitting devices and a mobile application executable on a mobile device. The mobile device receives a wireless signal from a transmitting device associated with a workstation and determines the type of workstation based on an identifier included in the wireless signal. The mobile device also receives wireless signals from transmitting devices attached to PPE items located in proximity to the mobile device and determines the types of PPE items based on respective identifiers included in the wireless signals. The mobile application determines PPE items required to operate equipment at the workstation and further determines whether the set of detected PPE items includes all of the required PPE items. The mobile application generates a user interface that indicates the presence or absence of each required PPE item and displays the UI on the mobile device.

Abstract: The present invention provides 1H-pyrazolo[4,3-b]pyridines of formula (I) as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.

Abstract: The present invention provides macrocycles of formula (I) as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.