Abstract: An apparatus includes a seabed-disposed pump that includes an inlet to receive a fluid flow and an outlet. The apparatus includes a liquid retainer that is adapted to receive a fluid flow that is produced by a subsea well. The liquid retainer selectively retains and releases liquid from the fluid flow to regulate a gas volume fraction of the fluid flow that is received at the inlet of the pump.

Abstract: The present invention provides 1H-pyrazolo[4,3-b]pyridin-7-amines of formula (I) as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.

Abstract: A downhole tool includes an upper wedge member and a lower wedge member. The upper and lower wedge members each have a circumferential width that decreases proceeding from an outer axial end thereof to an inner axial end thereof. As the downhole tool actuates from a first state to a second state, the upper and lower wedge members move axially with respect to a central longitudinal axis through the downhole tool, the upper and lower wedge members move radially-outward with respect to the central longitudinal axis, and the upper and lower wedge members remain coupled to one another as the upper and lower wedge members move.

Abstract: A compound of formula I, (I) or a pharmaceutically-acceptable salt thereof. The compound is useful in the treatment of cancer.

Abstract: A compound of formula (I), or a pharmaceutically acceptable salt thereof, for use in the treatment of autoimmune diseases and inflammatory conditions.

Abstract: Downhole tools and methods, of which the downhole tool includes an expandable sleeve defining a bore therethrough, and a first body positioned at least partially within the bore of the expandable sleeve. The first body is slidable relative to the expandable sleeve, and sliding the first body along the bore of the expandable sleeve causes the expandable sleeve to radially expand so as to actuate the downhole tool from a run-in configuration to a set configuration. The downhole tool also includes an isolation device received at least partially in the expandable sleeve in the set configuration. A pressure on the isolation device is at least partially transmitted to the expandable sleeve as a radially-outward force.

Abstract: A downhole tool and a tool assembly, of which the downhole tool includes an expandable sleeve defining a bore extending axially therethrough, a first swage positioned at least partially within the bore and including a valve seat configured to receive an obstructing member, such that the obstructing member and the first swage substantially prevent fluid communication through the bore when the obstructing member is seated in the valve seat, and a second swage positioned at least partially within the bore. The first and second swages are configured to move toward one another in the bore, such that the first and second swages deform end portions of the expandable sleeve radially outwards and into engagement with a surrounding tubular, and the expandable sleeve, in an expanded configuration in which the end portions engage the surrounding tubular, defines an unexpanded portion between the expanded end portions.

Abstract: A compound of formula (I), or a pharmaceutically acceptable salt thereof, for use in the treatment of autoimmune diseases and inflammatory conditions.

Abstract: An electromagnetic flow sensor for an electromagnetic flow meter (201) is disclosed. The sensor comprises a body (204) or frame, a flow passage (252) through the body or frame, a part of a magnetic circuit (248, 295) supported by the body or frame for applying a magnetic field across the flow passage, and at least first and second electrodes (298) supported by the body or frame, the at least first and second electrodes arranged to sense a voltage in response to a conductive fluid flowing through the flow passage. At least a portion of the body supporting the magnetic circuit part and the at least first and second electrodes is configured to be insertable into a flow tube (206) through a single aperture in the flow tube.

Abstract: The present invention provides 1H-pyrazolo[4,3-b]pyridin-7-amines of formula (I) as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.

Abstract: The present disclosure provides pepper plants exhibiting resistance to Phytophthora capsici. Such plants may comprise novel introgressed chromosomal regions associated with disease resistance. In certain aspects, compositions, including novel polymorphic markers and methods for producing, breeding, identifying, and selecting plants or germplasm with a disease resistance phenotype are provided.

Abstract: A downhole tool includes an upper wedge member and a lower wedge member. The upper and lower wedge members each have a circumferential width that decreases proceeding from an outer axial end thereof to an inner axial end thereof. As the downhole tool actuates from a first state to a second state, the upper and lower wedge members move axially with respect to a central longitudinal axis through the downhole tool, the upper and lower wedge members move radially-outward with respect to the central longitudinal axis, and the upper and lower wedge members remain coupled to one another as the upper and lower wedge members move.

Abstract: The present invention provides methods and systems for eluting and an analyte from a solid phase. The invention further provides methods and systems for transferring liquid analyte reagent mixtures from a solid phase to a second vessel, such as a microtiter plate well. The invention is useful in the manipulation of biological molecules such as nucleic acids, carbohydrates, proteins and peptides. In particular, the invention has utility for manipulating proteins and peptides in isoelectric focusing gels.

Abstract: A downhole tool, tool assembly, and method, of which the downhole tool includes an expandable sleeve defining a bore extending axially therethrough, and including a shoulder that extends inward from the bore, a first swage positioned at least partially within the bore and including a valve seat configured to receive an obstructing member, such that the obstructing member and the first swage substantially prevent fluid communication through the bore when the obstructing member is seated in the valve seat, a second swage positioned at least partially within the bore. The first and second swages are configured to deform the expandable sleeve radially outwards when the first and second swages are moved toward one another within the expandable sleeve, and the shoulder is configured to prevent at least one of the first and second swages from sliding therepast.

Abstract: A downhole tool and method for use, in which the tool includes a housing defining a first bore axially therethrough, and a valve shaft disposed in the first bore of the housing. The valve shaft defines a second bore extending axially therein and one or more openings extending radially from the second bore, the valve shaft being rotatable relative to the housing. The tool also includes a valve sleeve disposed in the housing and defining one or more openings extending radially therethrough. The valve shaft is rotatable relative to the valve sleeve, such that the one or more openings of the valve sleeve are periodically aligned and misaligned with the one or more openings of the valve sleeve as the valve shaft rotates.

Abstract: A downhole tool, tool assembly, and method, of which the downhole tool includes an expandable sleeve defining a bore extending axially therethrough, and including a shoulder that extends inward from the bore, a first swage positioned at least partially within the bore and including a valve seat configured to receive an obstructing member, such that the obstructing member and the first swage substantially prevent fluid communication through the bore when the obstructing member is seated in the valve seat, a second swage positioned at least partially within the bore. The first and second swages are configured to deform the expandable sleeve radially outwards when the first and second swages are moved toward one another within the expandable sleeve, and the shoulder is configured to prevent at least one of the first and second swages from sliding therepast.

Abstract: A personal protective equipment (PPE) monitoring system is disclosed that includes a set of wireless transmitting devices and a mobile application executable on a mobile device. The mobile device receives a wireless signal from a transmitting device associated with a workstation and determines the type of workstation based on an identifier included in the wireless signal. The mobile device also receives wireless signals from transmitting devices attached to PPE items located in proximity to the mobile device and determines the types of PPE items based on respective identifiers included in the wireless signals. The mobile application determines PPE items required to operate equipment at the workstation and further determines whether the set of detected PPE items includes all of the required PPE items. The mobile application generates a user interface that indicates the presence or absence of each required PPE item and displays the UI on the mobile device.

Abstract: The present invention provides 1H-pyrazolo[4,3-b]pyridin-7-amines of formula (I) as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.

Abstract: The invention provides methods and compositions for breeding pepper (Capsicum sp. such as Capsicum annuum) lines, including isogenic and nearly isogenic lines, displaying one or more mature fruit color(s) of interest. Predictive genetic markers and associated sequences and primers, associated with phenotypic diversity at the Ccs locus encoding Capsanthin-Capsorubin Synthase, and the Ze locus encoding Zeaxanthin Epoxidase are also provided, as well as methods for breeding pepper lines. Further provided are pepper plants, and plant parts including seeds, seed mixtures, fruit, and packaged fruit, which display mature fruit color(s) of interest.

Abstract: The invention provides methods and compositions for breeding pepper (Capsicum sp. such as Capsicum annuum) lines, including isogenic and nearly isogenic lines, displaying one or more mature fruit color(s) of interest. Predictive genetic markers and associated sequences and primers, associated with phenotypic diversity at the Ccs locus encoding Capsanthin-Capsorubin Synthase, and the Ze locus encoding Zeaxanthin Epoxidase are also provided, as well as methods for breeding pepper lines. Further provided are pepper plants, and plant parts including seeds, seed mixtures, fruit, and packaged fruit, which display mature fruit color(s) of interest.