Abstract: A compound of formula (I), or a pharmaceutically acceptable salt thereof, for use in the treatment of autoimmune diseases and inflammatory conditions.

Abstract: A compound of formula I, (I) or a pharmaceutically-acceptable salt thereof. The compound is useful in the treatment of cancer.

Abstract: A downhole tool and a method for fracturing a well, of which the method includes running downhole tool into a wellbore, the downhole tool including a ball seat including a dissolvable material and a protective layer that substantially prevents the dissolvable material from dissolving, and deploying an obstructing member into the wellbore. The obstructing member is caught by the ball seat. The method also includes performing one or more fracturing operations while the obstructing member engages the ball seat. Performing the one or more fracturing operations comprises introducing an abrading fluid to the ball seat, and the abrading fluid erodes at least a portion of the protective layer from the ball seat. The method also includes, after eroding the at least a portion of the protective layer, causing the dissolvable material of the ball seat to at least partially dissolve.

Abstract: Downhole tools and methods, of which the downhole tool includes an expandable sleeve defining a bore therethrough, and a first body positioned at least partially within the bore of the expandable sleeve. The first body is slidable relative to the expandable sleeve, and sliding the first body along the bore of the expandable sleeve causes the expandable sleeve to radially expand so as to actuate the downhole tool from a run-in configuration to a set configuration. The downhole tool also includes an isolation device received at least partially in the expandable sleeve in the set configuration. A pressure on the isolation device is at least partially transmitted to the expandable sleeve as a radially-outward force.

Abstract: The present invention provides methods and systems for eluting and an analyte from a solid phase. The invention further provides methods and systems for transferring liquid analyte reagent mixtures from a solid phase to a second vessel, such as a microtitre plate well. The invention is useful in the manipulation of biological molecules such as nucleic acids, carbohydrates, proteins and peptides. In particular, the invention has utility for manipulating proteins and peptides in isoelectric focusing gels.

Abstract: The present invention relates to methods and compositions for the detection of lung cancer. More particularly, the present invention provides monoclonal antibodies for the detection of lung cancer.

Abstract: The invention relates to compositions and methods for genotypically screening pepper lines for the presence of a polymorphism at the Bs2_5859 locus genetically linked to the Bs2 gene conferring resistance to Bacterial Spot caused by Xanthomonas campestris. Further provided are methods for producing plants displaying Bs2-mediated resistance, and fruit and seeds therefrom.

Abstract: The invention provides methods and compositions for breeding pepper (Capsicum sp. such as Capsicum annuum) lines, including isogenic and nearly isogenic lines, displaying one or more mature fruit color(s) of interest. Predictive genetic markers and associated sequences and primers, associated with phenotypic diversity at the Ccs locus encoding Capsanthin-Capsorubin Synthase, and the Ze locus encoding Zeaxanthin Epoxidase are also provided, as well as methods for breeding pepper lines. Further provided are pepper plants, and plant parts including seeds, seed mixtures, fruit, and packaged fruit, which display mature fruit color(s) of interest.

Abstract: A litter receptacle system, including: a support frame; a container for receiving and storing litter; a coupler; and a retention device; wherein the coupler rotatably couples the container to the support frame; the retention device is in communication with the support frame and the container; and the retention device is operable to releasably secure the container to the support frame, and a method of using the same.

Abstract: A method is described for detecting lung cancer comprising detecting an elevated level of a CTAP III-related biomarker in a biological sample from a subject at risk for developing lung cancer. Further, a method is described for predicting risk of developing lung cancer in a subject comprising detecting an elevated level of a CTAP III-related biomarker in a biological sample from a subject. Additionally, a method of monitoring the success of lung cancer treatment is described comprising detecting levels of a CTAP III-related biomarker in a biological sample from a subject undergoing treatment for lung cancer for comparison with a previous level obtained from the subject. Multivariate analysis may be incorporated into these methods, evaluating such clinical, or demographic risk factors as age, sex, smoking history, smoking status, smoking family history, education level, COPD, socio-economic status, body mass index and lung function. Kits for conducting such methods are described.

Abstract: A trailer wall hook is provided as a single unit that includes a U-shaped hook with a rounded or square base. The U-shaped hook includes an open eye-loop and j-hook support brackets. The open eye-loop is attached to the top front of the U-shaped hook and two smaller j-hooks are attached upside down on the rear of the U-shaped hook. The j-hooks provide for mounting the trailer wall hook on a cargo control or tie-down system on the inside wall of a trailer. The trailer wall hook provides for loading and supporting linear shaped or irregular shaped freight onto the wall.

Abstract: A device (10) and method for aseptically or non-aseptically accessing a fluid in a container (210) using an existing container opening (211). The device (10) includes a sanitary fitting (12) for attaching the device to the container over the existing container opening, and a sample coupling (14) associated with the sanitary fitting. The sanitary fitting (12) includes a first port (32), and the sample coupling (14) includes at least two second ports (52). The sample coupling (14) is rotatable relative to the sanitary fitting (12) in one direction to cause the first port (32) to successively align with each of the second ports (52), and thereby allows access to the fluid through the aligned first and second ports (32,52).

Abstract: A system (10) and method for substantially automatically aseptically or non-aseptically filling a container with a fluid. The transfer of fluid occurs via a movable nozzle mechanism (20) substantially automatically inserted into a side opening (32) in a connector (12) attached to the container. More specifically, the side opening (32) in the connector (12) is exposed, the nozzle mechanism (20) is moved into the side opening (32), the fluid is transferred into the container via the nozzle mechanism (20) and the connector (12), the nozzle mechanism (20) is removed from the side opening (32) in the connector (12), and the side opening (32) in the connector (12) is closed. The aseptic transfer of fluid includes a substantially automatic sterilization procedure accomplished by both spray and contact components (54,56).

Abstract: A trailer wall hook is provided as a single unit that includes a U-shaped hook with a rounded or square base. The U-shaped hook includes an open eye-loop and j-hook support brackets. The open eye-loop is attached to the top front of the U-shaped hook and two smaller j-hooks are attached upside down on the rear of the U-shaped hook. The j-hooks provide for mounting the trailer wall hook on a cargo control or tie-down system on the inside wall of a trailer. The trailer wall hook provides for loading and supporting linear shaped or irregular shaped freight onto the wall.

Abstract: A mounting system made to hold secure a custom insert device and be attached securely to a water sport board or vessel by an adhesive layer. The purpose of the insert device holding mount is to provide a small, lightweight, durable, reliable and convenient electronic device holder that can be unobtrusively attached to a water sport board or vessel and endure rough water environments and conditions. Our patent application includes our primary insert device as a water resistant time piece device, yet we plan to design a variety of insert devices with different functions for the benefit of the users. The device holding mount will be made of a soft, yet rigid water and weather resistant material. The material we will use is EVA foam, which is a type of polyethylene foam material. This EVA material is commonly used as a durable padding material in a wide variety of products.

Abstract: A method is described for detecting lung cancer comprising detecting an elevated level of a CTAP III-related biomarker in a biological sample from a subject at risk for developing lung cancer. Further, a method is described for predicting risk of developing lung cancer in a subject comprising detecting an elevated level of a CTAP III-related biomarker in a biological sample from a subject. Additionally, a method of monitoring the success of lung cancer treatment with curative intent is described comprising detecting levels of a CTAP III-related biomarker in a biological sample from a subject undergoing treatment for lung cancer for comparison with the a previous level obtained from the subject. Multivariate analysis may be incorporated into these methods, evaluating such clinical, or demographic risk factors as age, sex, smoking history, smoking status, smoking family history, education level, COPD, socio-economic status, body mass index and lung function. Kits for conducting such methods are described.

Abstract: A device (10) for clamping and separating a length of tubing comprises first and second subassemblies (12, 14) for, in a closed position, clamping the tubing at first and second locations, respectively. The subassemblies (12, 14) face each other and are connected by a connection that includes an indent element (28) to weaken the tubing for subsequent separation.

Abstract: The invention relates to compositions and methods for genotypically screening pepper lines for the presence of a polymorphism at the Bs2_5859 locus genetically linked to the Bs2 gene conferring resistance to Bacterial Spot caused by Xanthomonas campestris. Further provided are methods for producing plants displaying Bs2-mediated resistance, and fruit and seeds therefrom.

Abstract: A device (10) for clamping and separating a length of tubing. The device (10) comprises first and second subassemblies (12,14) for, in their closed positions, clamping the tubing at first and second locations, respectively, and at least weakening the tubing for subsequent separation. The subassemblies (12,14) face each other and are connected by a breakable connection. Each subassembly (12,14) includes clamping elements (26,34) for clamping the tubing, a perforating or cutting element (28) for perforating or otherwise weakening or cutting the tubing, and locking elements (24,32) for locking the subassembly (12,14) in the closed position. The perforating element (28) may be at least one hard plastic or metal spike. Once each subassembly (12,14) is locked in the closed position, the breakable connection is broken to result in respective lengths of clamped tubing.