Abstract: Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.

Abstract: Compounds are described that are active on PPARs, including pan-active compounds and compounds selective for any one or any two of PPAR?, PPAR? and PPAR?. Also described are methods of use of the compounds in treating various diseases.

Abstract: Compounds active on Ret are described, as well as methods of using such compounds. Also described are crystal structures of Ret surrogates that were determined using X-ray crystallography. The use of such Ret surrogate crystals and strucural information can, for example, be used for identifying molecular scaffolds and for developing ligands that bind to and modulate Ret and for identifying improved ligands based on known ligands.

Abstract: A system for measuring gains of a plurality of photo diodes includes a chamber adapted to host the plurality of photo diodes and a temperature control unit configured to control the temperature within the chamber to a predetermined temperature. A control unit selects at least one of the plurality of photo diodes. A hosting unit is configured to provide a bias voltage to the selected photo diode at the predetermined temperature. A light source transmits photo signals to the selected photo diode at the predetermined temperature. A measurement unit configured to measure current signals generated by the selected photo diode in response to the photo signals under the bias voltage at the predetermined temperature.

Abstract: Compounds active on the receptor protein tyrosine kinases c-kit and c-fms are provided herewith. Also provided herewith are compositions useful for treatment of c-kit mediated diseases or condition and c-fms-mediated diseases or condition, and methods for the use thereof.

Abstract: An optical transceiver includes a multi-layer printed circuit board comprising a plurality of layers and a first electric circuit and a flexible printed circuit board comprising a second electric circuit in connection with the first electric circuit. At least one of the layers is a rigid printed circuit board layer. A flexible printed circuit board is an extension of one of the layers in the multi-layer printed circuit board. An electro-optical component in communication with the first electric circuit and the second electric circuit can convert an electric signal to an optical signal or an optical signal to an electric signal.

Abstract: A system for measuring gains of a plurality of photo diodes includes a chamber adapted to host the plurality of photo diodes and a temperature control unit configured to control the temperature within the chamber to a predetermined temperature. A control unit selects at least one of the plurality of photo diodes. A hosting unit is configured to provide a bias voltage to the selected photo diode at the predetermined temperature. A light source transmits photo signals to the selected photo diode at the predetermined temperature. A measurement unit configured to measure current signals generated by the selected photo diode in response to the photo signals under the bias voltage at the predetermined temperature.

Abstract: Structures of SF1 and LRH are described, along with methods for identifying or developing modulators of those receptors and uses for such modulators.

Abstract: Compounds are described that are active on at least one of PPAR?, PPAR?, and PPAR?, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPAR?, PPAR?, and PPAR?.

Abstract: Compounds are described that are active on at least one of PPAR?, PPAR?, and PPAR?, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPAR?, PPAR?, and PPAR?.

Abstract: A method and apparatus for reducing noise in at least one frame in an image sequence is disclosed. A minimum function is applied to the at least one frame to produce a plurality of minimum values. A mask is generated in accordance with the plurality of minimum values. The mask is applied to reduce the noise in the at least one frame. In one embodiment, impulse noise is reduced. In another embodiment wideband non-linear noise is reduced.

Abstract: Compounds are described that are active on PDE4. Also described are crystal structures of PDE4B determined using X-ray crystallography, the use of PDE4B crystals and strucural information for identifying molecular scaffolds, for developing ligands that bind to and modulate PDE4B, and for identifying improved ligands based on known ligands.

Abstract: A switch including a processor and method for monitoring bandwidth in the storage switch. The switch includes at least one physical port coupling at least one target and at least one initiator via the physical port. The monitoring method may include the steps of determining whether congestion occurs on the physical port and assigning a weight to bandwidth usage between the initiator and the target based on a minimum and maximum bandwidth settings for each target. The switch may further include a step of controlling bandwidth usage by each of said at least two targets based on minimum and maximum bandwidth settings for each of the targets.

Abstract: One or more derived timers based on a source timer are provided to accommodate a plurality of periodic tasks while maintaining the high resolution of the source timer. To accommodate a number of periodic tasks, a number of derived timers can be selected utilizing a novel method based on the number of periodic tasks that are most time-critical, the number of tasks that are less time-critical, and the number of tasks that can be performed during the source timer interval. The interval and start time for each derived timer is selected based the source timer and number of the derived timer. After establishing the derived timers, the most time-critical tasks can be assigned to the source timer and the less time-critical tasks arranged amongst the derived timers.

Abstract: Compounds with 7-azaindole core structure with activity toward the receptor protein tyrosine kinase c-kit, compositions useful for treatment c-kit-mediate diseases or conditions, and methods of use thereof, are provided. Further provided are methods of c-kit ligand identification and design.

Abstract: Compounds with generic structure 5-((1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-N-benzylpyridine-2-amine with activity toward the receptor protein tyrosine kinase c-kit, compositions useful for treatment c-kit-mediate diseases or conditions, and methods of use thereof are described.

Abstract: In accordance with the objectives of the invention a new method is provided for the creation of an interconnect pattern. The invention provides for a layer of Photo-Active Dielectric (PAD) to be used for the insulation material in which the interconnect pattern is created, this without the use of an overlying exposure mask of photoresist.

Abstract: Systems and methods in accordance with various disclosed embodiments are provided for multi-chassis, multi-pathing solutions in storage area networks. A physical target connected to a first storage switch can be virtualized as a member of a virtual logical unit at a second storage switch to which the physical target is not connected. An inter-chassis link can be provided between the storage switches. If the first storage switch becomes inaccessible, the physical target can be accessed via the second storage switch. A virtual logical unit can also be provisioned at the first switch with a member corresponding to the same physical target. The virtual logical units provisioned at each storage switch can be assigned the same identifier to create a clustered virtual logical unit apparent to host devices. Multiple paths to the same logical unit are thus provided to host devices via either switch.

Abstract: Compounds active on phosphodiesterase PDE4B are provided. Also provided herewith are compositions useful for treatment of PDE4B-mediated diseases or conditions, and methods for the use thereof.

Abstract: Systems and methods in accordance with various disclosed embodiments can manage a mirrored virtual target to synchronize the members of the virtual target and/or to verify that the members of the virtual target are synchronized. In one embodiment, a mirrored virtual target is synchronized by first provisioning at least one first internal virtual logical unit (IVLU) corresponding to at least one destination target of the mirrored target and a second IVLU corresponding to a source target of the mirrored target. A write command is first issued, via one or more internal virtual logical units, to each of the destination target members of the mirrored target. When each destination target is available to receive data, as evidenced by a returned transfer ready signal, a read command is provided to the source target via the second internal virtual logical unit. In this manner, a data path between the source and destination targets is established prior to reading data from the source target.