Abstract: Binding proteins comprising a VL region paired with a VH region, and a CH1 region paired with a CL region, wherein the VL region and VH region comprise opposite charged mutations to facilitate pairing, and wherein the CH1 region and CL region comprise mutations to facilitate pairing, are provided. Binding proteins comprising one or more cysteine residues engineered into the VH/VL pair to form one or more disulfide bonds, are also provided. Multispecific binding proteins, nucleic acids encoding binding proteins and multispecific binding proteins, expression vectors, host cells, pharmaceutical composition and methods of treatment administering the binding proteins or multispecific binding proteins described herein are also provided.

Abstract: An antibody that specifically binds to IL-1R3, comprising an antibody heavy chain amino acid sequence of SEQ ID NO: 1 and a light chain amino acid sequence of SEQ ID NO: 2. A pharmaceutical composition is provided comprising the said antibody and a pharmaceutically acceptable diluent, carrier or excipient. Also said antibody for use in treating a disease or disorder in a subject in need thereof. The disease or disorder may be an autoimmune or autoinflammatory disease or disorder.

Abstract: The disclosure provides trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. The disclosure also provides methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins.

Abstract: The present invention provides molecules comprising a modified Fc region which do not mediate antibody effector functions such as antibody-dependent cellular cytotoxicity (ADCC) but maintain a long serum half-life due to binding to the neonetal Fc receptor (FcRn). To this end, the molecules of the present invention do not comprise the disulfide bridges of the antibody hinge region but are linked C-terminally by at least two covalent bonds. Furthermore, the molecules of the present invention comprise CH2 domains with an additional disulfide bond.

Abstract: A concrete compaction system includes an unbalance exciter for concrete compaction, a compaction detection device for detecting progress of the compaction in the concrete, and a vibration device for generating a haptic feedback when a prescribed progress of the compaction has been detected by the compaction detection device. An electric motor may drive the unbalance exciter and may be powered by an electric power supply and a converter device for converting an electric current from the electric power supply to a drive current for the electric motor. The compaction detection device may comprise a measurement device for measuring the current drawn from the electric motor. The compaction detection device may also comprise an evaluation device for evaluating the current drawn measured by the measurement device, for determining therefrom the progress of the compaction in the concrete, and for detecting whether a prescribed progress of the compaction has been achieved.

Abstract: A compaction system has a compaction device with an electric motor for generating a compaction movement, an energy device for providing electric energy for the electric motor, a measurement device for measuring the current drawn by the electric motor, and an evaluation device for evaluating the current draw as measured by the measurement device and for determining, from this determination, the compaction progress in the medium being compacted. The evaluation device is arranged at least partly in an external device, spatially separate from the energy device and/or from the compaction device.

Abstract: A concrete compaction device includes a vibrator housing for immersion in flowable concrete, and an unbalance exciter which is driven by an electric motor and which is arranged in the vibrator housing. A current detection device detects the electric current absorbed by the electric motor. Ann evaluation device determines an operating state of the concrete compaction device based on the electric current that is currently detected. The operating state is selected from the group consisting of: positioning of the vibrator housing in the air, immersion of the vibrator housing in the concrete, performance of a compaction process with the vibrator housing immersed in the concrete, and emersion of the vibrator housing from the concrete. The evaluation device is configured to recognize all of these operating states.

Abstract: A crash management system for a vehicle having a longitudinal direction X a transverse direction Y perpendicular to the longitudinal direction X and a vertical direction Z perpendicular to the plane defined by said directions X and Y, comprising a bumper cross member globally oriented in said transverse direction Y, at least a longitudinal member arrangement, at least a crash extension attached to at least one of the ends of said bumper cross member and extending over a predetermined length behind said bumper cross member in the longitudinal direction wherein said crash extension is a hollow profile having at least one chamber and having at least one flange attached on said bumper cross member, wherein said flange bends in the event of a deformation of the end portion of said bumper cross member following a collision of the vehicle, in particular a collision with small overlap.

Abstract: Binding proteins comprising a pseudoFab domain including a stabilised knockout domain and a second VH/VL that form a first functional antigen binding domain are provided. Multispecific binding proteins comprising at least one pseudoFab are also provided. Multispecific binding proteins, nucleic acids encoding binding proteins and multispecific binding proteins, expression vectors, host cells, pharmaceutical composition and methods of treatment administering the binding proteins or multispecific binding proteins described herein are also provided.

Abstract: Provided herein are multispecific antibodies, e.g. bispecific antibodies, which are modified such that the desired chain pairing takes place and/or can be selected for. Specifically, this is achieved by using different dimerization domains for light chain pairing. Also disclosed herein are nucleic acids encoding for these antibodies, expression vectors comprising these nucleic acids, cells expressing them, and further to pharmaceutical compositions comprising the antibodies, as well as methods of isolating the antibodies.

Abstract: The present invention relates to street sweeper. According to a first aspect of the invention, different mechanisms are disclosed for controlling the movement of the brush-holder arms in a horizontal plane, while also damping side and front impacts. According to a second aspect, a sweeper is disclosed, in which the movement of the brush-holder arms (3) in a vertical plane is imparted by a set of four profile members, arranged in two pairs which each forms a deformable parallelogram, wherein the deformation of the parallelogram is actuated by a jack (25) and the own weight of the sweeping arm. The jack is configured to remain below the upper profile members (11) of the two pairs when the brush-holder arm is raised to its maximum height. According to a third aspect, the suction turbine (103) is arranged in such a way that load losses are reduced during the operation of the sweeper.

Abstract: Provided herein are bivalent, bispecific binding proteins that specifically bind to two different HIV-1 Env protein epitopes.

Abstract: Binding proteins comprising a pseudoFab domain including a stabilised knockout domain and a second VH/VL that form a first functional antigen binding domain are provided. Multispecific binding proteins comprising at least one pseudoFab are also provided. Multispecific binding proteins, nucleic acids encoding binding proteins and multispecific binding proteins, expression vectors, host cells, pharmaceutical composition and methods of treatment administering the binding proteins or multispecific binding proteins described herein are also provided.

Abstract: A lighting apparatus for a motor vehicle, wherein a first structural component of the lighting apparatus is connected to a second structural component of the lighting apparatus, and the connection between the first and second structural components is formed by a twist-on connection. The second structural component comprises at least two coupling elements that fit over, in particular at the perimeter of, the first structural component in the fully assembled state, at least in part, and the first structural component ends up in this engaged position, in particular on the perimeter thereof, through a rotation in relation to the second structural component.

Abstract: A remote control module for a self-propelled working device has a terminal data interface for interchanging data with a mobile terminal using a terminal data protocol specific to the terminal type, and a working device data interface for interchanging data with the working device using a working device data protocol specific to the working device type. A processing unit is adapted, when the mobile terminal is coupled to the self-propelled working device, to determine the identity and the type of the terminal and the identity and the type of the working device via the respective data interface or to retrieve them from a data memory, to reciprocally translate the respective data protocols when interchanging data between the terminal and the working device, and to transmit machine control data (MCD) from the terminal to the working device and to transmit machine status data (MSD) from the working device to the terminal.

Abstract: The invention relates to a protein complex comprising at least two polypeptide chains A (PCA) and B (PCB), wherein PCA comprises a heterodimerization domain A (HDA) and PCB comprises a heterodimerization domain B (HDB), wherein HDA and HDB bind to each other and wherein one heterodimerization domain comprises or consists of two N-terminal ?-strands (N-?) of an immunoglobulin (Ig) domain and the other heterodimerization domain comprises or consists of two C-terminal ?-strands (C-?) of an Ig domain. The invention further relates to polynucleotides encoding one or more polypeptides of the protein complex, expression vectors comprising the polynucleotides and a cell comprising the polynucleotides or the expression vectors.

Abstract: Provided herein are bivalent, bispecific binding proteins that specifically bind to two different HIV-1 Env protein epitopes.

Abstract: A vehicle steering wheel is provided that includes a rotatable rim comprising a core structure, a steering angle sensor sensing an angle of rotation of the rim, and a plurality of proximity sensors located on the rim and spaced apart from one another along an arc length. The vehicle steering wheel also includes a controller processing sensed outputs generated by each of the plurality of proximity sensors and determining operator input commands based on the sensed outputs. The controller assigns a function to each of the proximity sensors that changes as the rim is rotated at an angle such that a given function associated with a proximity sensor remains at the same position in space.

Abstract: The disclosure provides trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. The disclosure also provides methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins.