Patents by Inventor Christian Lange

Christian Lange has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210292423
    Abstract: The present invention concerns antibody-like binding protein specifically binding to CD3 and binding specifically to at least one further antigen, for example CD123. The present invention also concerns antibody-like binding protein specifically binding to CD123 and binding specifically to at least one further antigen. The invention further concerns anti-CD3 antibodies and anti-CD123 antibodies. The invention also relates to pharmaceutical compositions comprising the antibody-like binding protein, anti-CD3 antibodies or anti-CD123 antibodies of the invention, and their use to treat cancer. The invention further relates to isolated nucleic acids, vectors and host cells comprising a sequence encoding said antibody-like binding protein, anti-CD3 or anti-CD123 antibody and the use of said anti-CD123 antibody as a diagnostic tool.
    Type: Application
    Filed: January 12, 2021
    Publication date: September 23, 2021
    Inventors: Jana Albrecht, Cédric Barriere, Christian Beil, Jochen Beninga, Chantal Carrez, Stéphane Guerif, Katja Kroll, Christian Lange, Cendrine Lemoine, Wulf-Dirk Leuschner, Ercole Rao, Marion Schneider, Marie-Cécile Wetzel, Peter Wonerow
  • Publication number: 20210189011
    Abstract: The invention provides antibody-like binding proteins comprising four polypeptide chains that form four antigen binding sites, wherein each pair of polypeptides forming an antibody-like binding protein possesses dual variable domains having a cross-over orientation. The invention also provides methods for making such antigen-like binding proteins.
    Type: Application
    Filed: December 28, 2020
    Publication date: June 24, 2021
    Inventors: Nicolas Baurin, Christian Beil, Carsten Corvey, Christian Lange, Danxi Li, Vincent Mikol, Anke Steinmetz, Ercole Rao
  • Publication number: 20210152176
    Abstract: A vehicle floor assembly includes a floor structure and a capacitive proximity sensor assembly configured to detect a user touch command and a user pressure command. The floor assembly further includes a controller for receiving the user touch command and pressure command and controlling a vehicle related operation based on the detected user input commands.
    Type: Application
    Filed: April 1, 2020
    Publication date: May 20, 2021
    Applicant: Ford Global Technologies, LLC
    Inventors: Stuart C. Salter, Pietro Buttolo, Vivien J. Martinage, Christian Lange, Michael Contino, Nir Siegel
  • Patent number: 10970998
    Abstract: Systems, methods, and devices for remotely controlling functionalities of vehicles are disclosed herein. Example systems, methods and devices may include determining that a remote control device is located at a position associated with a functionality, establishing a communication connection between the remote control device and the functionality based on a machine readable medium associated with the position, and causing a user interface on the remote control device to present one or more settings associated with the functionality.
    Type: Grant
    Filed: October 1, 2019
    Date of Patent: April 6, 2021
    Assignee: Ford Global Technologies, LLC
    Inventors: Christian Lange, Ryan Oberholzer, Laura Longworth, Dennis Sartorello, Vivien Jean Martinage
  • Publication number: 20210097851
    Abstract: Systems, methods, and devices for remotely controlling functionalities of vehicles are disclosed herein. Example systems, methods and devices may include determining that a remote control device is located at a position associated with a functionality, establishing a communication connection between the remote control device and the functionality based on a machine readable medium associated with the position, and causing a user interface on the remote control device to present one or more settings associated with the functionality.
    Type: Application
    Filed: October 1, 2019
    Publication date: April 1, 2021
    Applicant: Ford Global Technologies, LLC
    Inventors: Christian Lange, Ryan Oberholzer, Laura Longworth, Dennis Sartorello, Vivien Jean Martinage
  • Patent number: 10947284
    Abstract: The present invention relates to fusion molecules that have binding specificity for pyoverdine type I, II and III and pyochelin and can be used in various applications, including diagnostic and/or therapeutic applications, for example, to inhibit or reduce growth of P. aeruginosa and/or to prevent or treat P. aeruginosa biofilm infection as well as diseases or disorders associated with P. aeruginosa biofilm infection. The present invention also concerns methods of producing the fusion molecules described herein as well as compositions and kits comprising such fusion molecules. The present invention further relates to nucleic acid molecules encoding the fusion molecules described herein.
    Type: Grant
    Filed: April 24, 2019
    Date of Patent: March 16, 2021
    Assignee: Pieris Pharmaceuticals GmbH
    Inventors: Carsten Corvey, Heike Stump, Jochen Kruip, Christian Lange, Ingo Focken, Dorothea Rat, Thomas Stuedemann, Hans-Falk Rasser, Juergen Schaefer, Bernard Calandra, Astrid Rey, Michael Mourez, Laurent Fraisse, Christine Rothe, Andrea Allersdorfer, Alexander Wiedenmann, Marlon Hinner, Bradley Lunde, Kristian Jensen, Martin Hülsmeyer
  • Publication number: 20210061925
    Abstract: The disclosure provides trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. The disclosure also provides methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins.
    Type: Application
    Filed: November 16, 2020
    Publication date: March 4, 2021
    Inventors: Zhi-Yong YANG, Gary J. NABEL, Lan WU, Edward SEUNG, Ronnie WEI, Jochen BENINGA, Ercole RAO, Wulf Dirk LEUSCHNER, Christian BEIL, Christian LANGE, Carsten CORVEY
  • Patent number: 10906978
    Abstract: The present invention concerns antibody-like binding protein specifically binding to CD3 and binding specifically to at least one further antigen, for example CD123. The present invention also concerns antibody-like binding protein specifically binding to CD123 and binding specifically to at least one further antigen. The invention further concerns anti-CD3 antibodies and anti-CD123 antibodies. The invention also relates to pharmaceutical compositions comprising the antibody-like binding protein, anti-CD3 antibodies or anti-CD123 antibodies of the invention, and their use to treat cancer. The invention further relates to isolated nucleic acids, vectors and host cells comprising a sequence encoding said antibody-like binding protein, anti-CD3 or anti-CD123 antibody and the use of said anti-CD123 antibody as a diagnostic tool.
    Type: Grant
    Filed: April 2, 2018
    Date of Patent: February 2, 2021
    Assignee: SANOFI
    Inventors: Jana Albrecht, Cédric Barriere, Christian Beil, Jochen Beninga, Chantal Carrez, Stéphane Guerif, Katja Kroll, Christian Lange, Cendrine Lemoine, Wulf-Dirk Leuschner, Ercole Rao, Marion Schneider, Marie-Cécile Wetzel, Peter Wonerow
  • Patent number: 10882922
    Abstract: The disclosure provides trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. The disclosure also provides methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins.
    Type: Grant
    Filed: April 13, 2017
    Date of Patent: January 5, 2021
    Assignee: SANOFI
    Inventors: Zhi-Yong Yang, Gary J. Nabel, Lan Wu, Edward Seung, Ronnie Wei, Jochen Beninga, Ercole Rao, Wulf Dirk Leuschner, Christian Beil, Christian Lange, Carsten Corvey
  • Publication number: 20200317761
    Abstract: Provided herein multispecific (e.g., bispecific) binding molecules comprising a first binding domain that binds an extracellular portion of dystroglycan and a second binding domain that binds laminin-2. Further provided herein are methods for making such binding molecules and uses of such binding molecules for treating and/or preventing alpha-dystroglycanopathies.
    Type: Application
    Filed: March 13, 2020
    Publication date: October 8, 2020
    Inventors: Christian BEIL, William H. BRONDYK, Yangde CHEN, Seng H. CHENG, Timothy D. CONNORS, Catherine DEVAUD, Dietmar HOFFMANN, Christian LANGE, Maureen MAGNAY, Tristan MAGNAY, Catherine PRADES, Ercole RAO, Leila SEVIGNY, Ronnie WEI, Hongmei ZHAO, Yunxiang ZHU
  • Publication number: 20200277010
    Abstract: An impact protection reinforcement of a vehicle construction, which is supportively fastenable in the vehicle construction against the action of external mechanical extraordinary load conditions and comprises the following features: an elongated profile element with a longitudinal center line and a transversal center line arranged transversely to the longitudinal center line, which has in the longitudinal direction at each end side a fastening end and a central part therebetween, wherein the central part consists of a circumferentially closed hollow profile with a base layer and a top layer arranged opposite to the base layer, which are connected to each other via lateral faces, and the fastening ends each have a flat shape with at least two fastening points which are spaced apart differently from the transversal center line and the longitudinal center line and are provided as welding connection points to the vehicle construction.
    Type: Application
    Filed: February 26, 2020
    Publication date: September 3, 2020
    Inventors: Sergej Hartwig-Biglau, Christian Lange
  • Publication number: 20200262926
    Abstract: Binding proteins comprising a VL region paired with a VH region, and a CH1 region paired with a CL region, wherein the VL region and VH region comprise opposite charged mutations to facilitate pairing, and wherein the CH1 region and CL region comprise mutations to facilitate pairing, are provided. Binding proteins comprising one or more cysteine residues engineered into the VH/VL pair to form one or more disulfide bonds, are also provided. Multispecific binding proteins, nucleic acids encoding binding proteins and multispecific binding proteins, expression vectors, host cells, pharmaceutical composition and methods of treatment administering the binding proteins or multispecific binding proteins described herein are also provided.
    Type: Application
    Filed: December 23, 2019
    Publication date: August 20, 2020
    Inventors: Marta Amaral, Christian Beil, Ingo Focken, Gerhard Hessler, Soraya Hoelper, Jennifer Jung, Christian Lange, Wulf-Dirk Leuschner, Ercole Rao, Garima Tiwari, Sandra Weil
  • Publication number: 20200255540
    Abstract: Binding proteins comprising a pseudoFab domain including a stabilised knockout domain and a second VH/VL that form a first functional antigen binding domain are provided. Multispecific binding proteins comprising at least one pseudoFab are also provided. Multispecific binding proteins, nucleic acids encoding binding proteins and multispecific binding proteins, expression vectors, host cells, pharmaceutical composition and methods of treatment administering the binding proteins or multispecific binding proteins described herein are also provided.
    Type: Application
    Filed: December 23, 2019
    Publication date: August 13, 2020
    Inventors: Christian Beil, Karl-Christian Engel, Gerhard Hessler, Soraya Hoelper, Christian Lange, Thomas Langer, Cendrine Lemoine, Wulf-Dirk Leuschner, Sevim Oezguer Bruederle, Ercole Rao, Nadja Spindler, Sandra Weil
  • Publication number: 20200149237
    Abstract: The present invention relates to street sweeper. According to a first aspect of the invention, different mechanisms are disclosed for controlling the movement of the brush-holder arms in a horizontal plane, while also damping side and front impacts. According to a second aspect, a sweeper is disclosed, in which the movement of the brush-holder arms (3) in a vertical plane is imparted by a set of four profile members, arranged in two pairs which each forms a deformable parallelogram, wherein the deformation of the parallelogram is actuated by a jack (25) and the own weight of the sweeping arm. The jack is configured to remain below the upper profile members (11) of the two pairs when the brush-holder arm is raised to its maximum height. According to a third aspect, the suction turbine (103) is arranged in such a way that load losses are reduced during the operation of the sweeper.
    Type: Application
    Filed: November 23, 2017
    Publication date: May 14, 2020
    Inventors: Christian Lange, Jean-Benoît Langouche, Franck Buddeker, Adrien Marèchal, Tom Bruggeman
  • Publication number: 20200147669
    Abstract: A method of forming a heat exchanger tube, particularly suited for condensing applications, contemplates cold-rolling a metallic strip to emboss a hydrophobic surface texture, to thereby form an embossed surface on the metallic strip. The method includes roll forming the metallic strip to a tubular shape, with the embossed surface on the exterior of the tubular shape, and welding the edges of the roll-formed strip to form a heat exchanger tube.
    Type: Application
    Filed: November 14, 2019
    Publication date: May 14, 2020
    Inventors: Daniel S. Janikowski, Charles Murphy, Christian Lange
  • Patent number: 10626169
    Abstract: Provided herein multispecific (e.g., bispecific) binding molecules comprising a first binding domain that binds an extracellular portion of dystroglycan and a second binding domain that binds laminin-2. Further provided herein are methods for making such binding molecules and uses of such binding molecules for treating and/or preventing alpha-dystroglycanopathies.
    Type: Grant
    Filed: February 16, 2018
    Date of Patent: April 21, 2020
    Assignee: Sanofi
    Inventors: Christian Beil, William H. Brondyk, Yangde Chen, Seng H. Cheng, Timothy D. Connors, Catherine Devaud, Dietmar Hoffmann, Christian Lange, Maureen Magnay, Tristan Magnay, Catherine Prades, Ercole Rao, Leila Sevigny, Ronnie Wei, Hongmei Zhao, Yunxiang Zhu
  • Patent number: 10603693
    Abstract: The invention relates to an appliance which is more particularly applicable in an urban or industrial vacuum cleaner into which the waste is sucked up and then collected in a container. The appliance comprises a flexible tube, the proximal end of which receives the waste and the distal end of which is held by a ring which is pivotable such that the ring can be positioned in one of several pre-defined positions. This variable positioning allows the waste to be deposited in different containers or compartments, according to the characteristics thereof. The appliance can be controlled manually or automatically on the basis of electronic or optical sensors.
    Type: Grant
    Filed: September 29, 2016
    Date of Patent: March 31, 2020
    Assignee: Lange Christian sa
    Inventors: Xavier De Ghellinck D'Elseghem Vaernewijk, Christian Lange
  • Publication number: 20200054765
    Abstract: Provided herein are compositions comprising trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more HIV target proteins or one or more T-cell receptors, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. Also provided herein are methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins for the treatment and/or prevention of HIV/AIDS.
    Type: Application
    Filed: October 21, 2019
    Publication date: February 20, 2020
    Inventors: Zhi-Yong YANG, Gary J. NABEL, Ling XU, Ronnie WEI, Huawei QIU, Jochen BENINGA, Jochen KRUIP, Ercole RAO, Wulf Dirk LEUSCHNER, Christian BEIL, Christian LANGE, Mark CONNORS, John R. MASCOLA, Richard A. KOUP, Jinghe HUANG, Nicole A. DORIA-ROSE, Tongqing ZHOU, Peter D. KWONG, Young Do KWON, Amarendra PEGU, Mangaiarkarasi ASOKAN
  • Publication number: 20200010833
    Abstract: A modified L-nucleic acid, containing an L-nucleic acid part conjugated to a non-L-nucleic acid part is described. The conjugate has extended retention time in and demonstrates a delayed elimination from an organism.
    Type: Application
    Filed: September 18, 2019
    Publication date: January 9, 2020
    Applicant: NOXXON Pharma AG
    Inventors: Christian Lange, Bernd Eschgfaller, Sven Klussmann
  • Patent number: D927810
    Type: Grant
    Filed: May 7, 2019
    Date of Patent: August 10, 2021
    Assignee: LANGE CHRISTIAN SA
    Inventor: Christian Lange