Abstract: Provided herein are multispecific antibodies, e.g. bispecific antibodies, which are modified such that the desired chain pairing takes place and/or can be selected for. Specifically, this is achieved by using different dimerization domains for light chain pairing. Also disclosed herein are nucleic acids encoding for these antibodies, expression vectors comprising these nucleic acids, cells expressing them, and further to pharmaceutical compositions comprising the antibodies, as well as methods of isolating the antibodies.

Abstract: The present invention relates to street sweeper. According to a first aspect of the invention, different mechanisms are disclosed for controlling the movement of the brush-holder arms in a horizontal plane, while also damping side and front impacts. According to a second aspect, a sweeper is disclosed, in which the movement of the brush-holder arms (3) in a vertical plane is imparted by a set of four profile members, arranged in two pairs which each forms a deformable parallelogram, wherein the deformation of the parallelogram is actuated by a jack (25) and the own weight of the sweeping arm. The jack is configured to remain below the upper profile members (11) of the two pairs when the brush-holder arm is raised to its maximum height. According to a third aspect, the suction turbine (103) is arranged in such a way that load losses are reduced during the operation of the sweeper.

Abstract: What is proposed is a method for optically measuring distances, in the case of which a first plurality of measuring pulses is emitted during a first measuring interval by means of a transmitting element of a transmitting unit at first emitting times, and wherein a second plurality of measuring pulses is emitted during a second measuring interval by means of the transmitting element of the transmitting unit at second emitting times. The method comprises the reception of reflected measuring pulses by means of a receiving element of a receiving unit assigned to the transmitting element at receiving times. The method further comprises the determining of a first amount of times-of-flight for each received measuring pulse, wherein the first amount of times-of-flight is determined by using the first emitting times.

Abstract: Provided herein are bivalent, bispecific binding proteins that specifically bind to two different HIV-1 Env protein epitopes.

Abstract: A component for a vehicle interior configured to be illuminated by a light source may comprise a substrate; a light guide; and a cover comprising an exterior surface. The light guide may transmit light between the substrate and the cover. The cover may be at least partially light-transmissive. The cover may present an effect on the exterior surface. The effect may comprise an illumination/dynamic lighting effect when illuminated. The cover may comprise a profile configured to present a visual effect and/or a surface effect. The component may comprise a concealed heating element between a cover base and a cover layer of the cover. The heating element may comprise a three-dimensional form behind the cover. The cover layer may be formed into a three-dimensional form and the cover base may be formed into a three-dimensional form for the surface effect. The light guide may comprise micro-optical structures.

Abstract: Binding proteins comprising a pseudoFab domain including a stabilised knockout domain and a second VH/VL that form a first functional antigen binding domain are provided. Multispecific binding proteins comprising at least one pseudoFab are also provided. Multispecific binding proteins, nucleic acids encoding binding proteins and multispecific binding proteins, expression vectors, host cells, pharmaceutical composition and methods of treatment administering the binding proteins or multispecific binding proteins described herein are also provided.

Abstract: The present invention relates to a process for purifying a crude nitrogen-containing, sulfur-containing, halogen-containing pyrolysis oil originating from the pyrolysis of plastic waste, comprising (i) subjecting the crude pyrolysis oil to a treatment with a trapping agent selected from (a) an elemental metal of group 1, 2, 6, 7, 8, 9, 10, 11, 12, 13 of the IUPAC periodic table, a mixture or an alloy thereof; (b) an oxide of metals of group 1, 2, 6, 7, 8, 9, 10, 11, 12, 13 of the IUPAC periodic table or a mixture thereof; (c) an alkoxide of metals of group 1, 2 of the IUPAC periodic table or a mixture thereof; (d) a solid sorption agent as defined in the claims; or a combination of at least two trapping agents (a), (b), (c) or (d); (ii) separating the product obtained into a purified pyrolysis oil fraction having a reduced nitrogen, sulfur and halogen content in relation to the crude pyrolysis oil and a fraction comprising the trapping agent which has bound at least a part of the sulfur, nitrogen, halogen pre

Abstract: A lighting apparatus for a motor vehicle, wherein a first structural component of the lighting apparatus is connected to a second structural component of the lighting apparatus, and the connection between the first and second structural components is formed by a twist-on connection. The second structural component comprises at least two coupling elements that fit over, in particular at the perimeter of, the first structural component in the fully assembled state, at least in part, and the first structural component ends up in this engaged position, in particular on the perimeter thereof, through a rotation in relation to the second structural component.

Abstract: The present application relates to novel substituted indazoles, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of endometriosis and endometriosis-associated pain and other endometriosis-associated symptoms such as dysmenorrhoea, dyspareunia, dysuria and dyschezia, of lymphoma, rheumatoid arthritis, spondyloarthritis (especially psoriatic spondyloarthritis and Bekhterev's disease), lupus erythematosus, multiple sclerosis, macular degeneration, COPD, gout, fatty liver disorders, insulin resistance, neoplastic disorders and psoriasis.

Abstract: A remote control module for a self-propelled working device has a terminal data interface for interchanging data with a mobile terminal using a terminal data protocol specific to the terminal type, and a working device data interface for interchanging data with the working device using a working device data protocol specific to the working device type. A processing unit is adapted, when the mobile terminal is coupled to the self-propelled working device, to determine the identity and the type of the terminal and the identity and the type of the working device via the respective data interface or to retrieve them from a data memory, to reciprocally translate the respective data protocols when interchanging data between the terminal and the working device, and to transmit machine control data (MCD) from the terminal to the working device and to transmit machine status data (MSD) from the working device to the terminal.

Abstract: The invention relates to a protein complex comprising at least two polypeptide chains A (PCA) and B (PCB), wherein PCA comprises a heterodimerization domain A (HDA) and PCB comprises a heterodimerization domain B (HDB), wherein HDA and HDB bind to each other and wherein one heterodimerization domain comprises or consists of two N-terminal ?-strands (N-?) of an immunoglobulin (Ig) domain and the other heterodimerization domain comprises or consists of two C-terminal ?-strands (C-?) of an Ig domain. The invention further relates to polynucleotides encoding one or more polypeptides of the protein complex, expression vectors comprising the polynucleotides and a cell comprising the polynucleotides or the expression vectors.

Abstract: Provided herein are bivalent, bispecific binding proteins that specifically bind to two different HIV-1 Env protein epitopes.

Abstract: A vehicle steering wheel is provided that includes a rotatable rim comprising a core structure, a steering angle sensor sensing an angle of rotation of the rim, and a plurality of proximity sensors located on the rim and spaced apart from one another along an arc length. The vehicle steering wheel also includes a controller processing sensed outputs generated by each of the plurality of proximity sensors and determining operator input commands based on the sensed outputs. The controller assigns a function to each of the proximity sensors that changes as the rim is rotated at an angle such that a given function associated with a proximity sensor remains at the same position in space.

Abstract: The disclosure provides trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. The disclosure also provides methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins.

Abstract: A method of forming a heat exchanger tube, particularly suited for condensing applications, contemplates cold-rolling a metallic strip to emboss a hydrophobic surface texture, to thereby form an embossed surface on the metallic strip. The method includes roll forming the metallic strip to a tubular shape, with the embossed surface on the exterior of the tubular shape, and welding the edges of the roll-formed strip to form a heat exchanger tube.

Abstract: Provided herein multispecific (e.g., bispecific) binding molecules comprising a first binding domain that binds an extracellular portion of dystroglycan and a second binding domain that binds laminin-2. Further provided herein are methods for making such binding molecules and uses of such binding molecules for treating and/or preventing alpha-dystroglycanopathies.

Abstract: A vehicle steering wheel is provided that includes a rotatable rim comprising a core structure, a steering angle sensor sensing an angle of rotation of the rim, and a plurality of proximity sensors located on the rim and spaced apart from one another along an arc length. The vehicle steering wheel also includes a controller processing sensed outputs generated by each of the plurality of proximity sensors and determining operator input commands based on the sensed outputs. The controller assigns a function to each of the proximity sensors that changes as the rim is rotated at an angle such that a given function associated with a proximity sensor remains at the same position in space.

Abstract: Provided herein are FGFR1/KLB targeting agonistic antigen-binding proteins, or fragments thereof, having improved physico-chemical properties. Also provided herein are conjugates comprising an FGFR1/KLB targeting agonistic antigen-binding protein, or a fragment thereof, and at least one GLP-1R agonistic peptide. Further provided are pharmaceutical compositions comprising the antibody (or fragment thereof), or the conjugate provided herein, and the use of the antibody (or fragment thereof, or the use of the conjugate in medicine.

Abstract: The disclosure provides trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. The disclosure also provides methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins.