Abstract: Binding proteins comprising a VL region paired with a VH region, and a CH1 region paired with a CL region, wherein the VL region and VH region comprise opposite charged mutations to facilitate pairing, and wherein the CH1 region and CL region comprise mutations to facilitate pairing, are provided. Binding proteins comprising one or more cysteine residues engineered into the VH/VL pair to form one or more disulfide bonds, are also provided. Multispecific binding proteins, nucleic acids encoding binding proteins and multispecific binding proteins, expression vectors, host cells, pharmaceutical composition and methods of treatment administering the binding proteins or multispecific binding proteins described herein are also provided.

Abstract: Binding proteins comprising a pseudoFab domain including a stabilised knockout domain and a second VH/VL that form a first functional antigen binding domain are provided. Multispecific binding proteins comprising at least one pseudoFab are also provided. Multispecific binding proteins, nucleic acids encoding binding proteins and multispecific binding proteins, expression vectors, host cells, pharmaceutical composition and methods of treatment administering the binding proteins or multispecific binding proteins described herein are also provided.

Abstract: The present invention relates to street sweeper. According to a first aspect of the invention, different mechanisms are disclosed for controlling the movement of the brush-holder arms in a horizontal plane, while also damping side and front impacts. According to a second aspect, a sweeper is disclosed, in which the movement of the brush-holder arms (3) in a vertical plane is imparted by a set of four profile members, arranged in two pairs which each forms a deformable parallelogram, wherein the deformation of the parallelogram is actuated by a jack (25) and the own weight of the sweeping arm. The jack is configured to remain below the upper profile members (11) of the two pairs when the brush-holder arm is raised to its maximum height. According to a third aspect, the suction turbine (103) is arranged in such a way that load losses are reduced during the operation of the sweeper.

Abstract: A method of forming a heat exchanger tube, particularly suited for condensing applications, contemplates cold-rolling a metallic strip to emboss a hydrophobic surface texture, to thereby form an embossed surface on the metallic strip. The method includes roll forming the metallic strip to a tubular shape, with the embossed surface on the exterior of the tubular shape, and welding the edges of the roll-formed strip to form a heat exchanger tube.

Abstract: Provided herein multispecific (e.g., bispecific) binding molecules comprising a first binding domain that binds an extracellular portion of dystroglycan and a second binding domain that binds laminin-2. Further provided herein are methods for making such binding molecules and uses of such binding molecules for treating and/or preventing alpha-dystroglycanopathies.

Abstract: The invention relates to an appliance which is more particularly applicable in an urban or industrial vacuum cleaner into which the waste is sucked up and then collected in a container. The appliance comprises a flexible tube, the proximal end of which receives the waste and the distal end of which is held by a ring which is pivotable such that the ring can be positioned in one of several pre-defined positions. This variable positioning allows the waste to be deposited in different containers or compartments, according to the characteristics thereof. The appliance can be controlled manually or automatically on the basis of electronic or optical sensors.

Abstract: Provided herein are compositions comprising trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more HIV target proteins or one or more T-cell receptors, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. Also provided herein are methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins for the treatment and/or prevention of HIV/AIDS.

Abstract: A modified L-nucleic acid, containing an L-nucleic acid part conjugated to a non-L-nucleic acid part is described. The conjugate has extended retention time in and demonstrates a delayed elimination from an organism.

Abstract: The present invention relates to fusion molecules that have binding specificity for pyoverdine type I, II and III and pyochelin and can be used in various applications, including diagnostic and/or therapeutic applications, for example, to inhibit or reduce growth of P. aeruginosa and/or to prevent or treat P. aeruginosa biofilm infection as well as diseases or disorders associated with P. aeruginosa biofilm infection. The present invention also concerns methods of producing the fusion molecules described herein as well as compositions and kits comprising such fusion molecules. The present invention further relates to nucleic acid molecules encoding the fusion molecules described herein.

Abstract: The present invention relates to a device in the form of a suction nozzle (10) for an urban or industrial aspirator (1), preferably self-propelled, comprising a rigid hose or tube (1000), said rigid hose or tube comprising gripping means (100, 200, 300, 400) that comprise a first gripping element (110, 210, 310, 410) in the form of a handle, a support element (120, 220, 320, 420) serving as a lever, and a second gripping element (130, 230, 330, 430) and optionally a base (101, 201, 301, 401).

Abstract: Method for producing a reinforcement beam for a vehicle, comprising at least one weak zone arranged in such a way that the bending resistance of the beam is less in said weak zone than in the rest of the beam, characterized in that it comprises, in order, a step (A) of extruding a profile part, a step (B) of cutting the profile part so as to obtain at least one profile segment, a step (C) of locally deforming the segment of the profile part in order to create the weak zone or zones.

Abstract: The present invention concerns antibody-like binding protein specifically binding to CD3 and CD123. The invention also relates to pharmaceutical compositions comprising said antibody-like binding protein and the use of said pharmaceutical compositions and antibody-like binding protein to treat cancer. The invention further relates to isolated nucleic acids, vectors and host cells comprising a sequence encoding said antibody-like binding protein.

Abstract: The present invention relates to fusion molecules that have binding specificity for pyoverdine type I, II and III and pyochelin and can be used in various applications, including diagnostic and/or therapeutic applications, for example, to inhibit or reduce growth of P. aeruginosa and/or to prevent or treat P. aeruginosa biofilm infection as well as diseases or disorders associated with P. aeruginosa biofilm infection. The present invention also concerns methods of producing the fusion molecules described herein as well as compositions and kits comprising such fusion molecules. The present invention further relates to nucleic acid molecules encoding the fusion molecules described herein.

Abstract: The present invention relates to a street or industrial vacuum cleaner (1) on a chassis (50) and self-propelled using at least one drive motor comprising a guide element preferably taking the form of a handlebar (70) with at least one handle (740), a hand grip (730) and means or elements (710) for attachment to the chassis (50) of the vacuum cleaner (1), said attachment means or elements (710) making it possible, by the transmission of the movement applied to the hand grip (730), to steer said vacuum cleaner (1), characterized in that the handle (740) comprises a telescopic zone with a sliding part (745) able to move between a first position referred to as an extended position and a second position referred to as a retracted position, preferably with a return spring (780) and at least a switch (770) for detecting the position of the sliding part (745), said switch (770) being able to cause the street vacuum cleaner drive motor to switch off or reverse if the sliding part (745) is in the retracted position.

Abstract: Provided herein are compositions comprising trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more HIV target proteins or one or more T-cell receptors, where in a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. Also provided herein are methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins for the treatment and/or prevention of HIV/AIDS.

Abstract: The invention relates to an appliance which is more particularly applicable in an urban or industrial vacuum cleaner into which the waste is sucked up and then collected in a container. The appliance comprises a flexible tube, the proximal end of which receives the waste and the distal end of which is held by a ring which is pivotable such that the ring can be positioned in one of several pre-defined positions. This variable positioning allows the waste to be deposited in different containers or compartments, according to the characteristics thereof. The appliance can be controlled manually or automatically on the basis of electronic or optical sensors.

Abstract: Some embodiments include a system. The system comprises an input device, an output device, one or more processing modules, and one or more non-transitory memory storage modules storing computer instructions. The computer instructions are configured to run on the processing module(s) and perform the acts of: identifying at least one test web page; and analyzing a first test web page of the at least one test web page. The analyzing the first test web page of the at least one test web page comprises crawling the first test web page to detect a first adverse performance condition of the first test web page, and the first adverse performance condition can impact a first search rank assigned to the first test web page when present. Other embodiments of related systems and methods are also provided.

Abstract: The invention relates to an impact-absorbing structure for a vehicle, the structure of which comprises at least one side rail for supporting a bumper crossbeam, the side rail being a hollow profile member arranged according to the longitudinal axis of the vehicle, the impact-absorbing structure including the bumper crossbeam, at least one absorber placed between the side rail and the bumper crossbeam, the absorber being a hollow profile member intended for deforming in the event of an impact, one end of the profile member being intended to be inserted into the open end of the side rail, the end of the profile member being attached to the side rail via transversely arranged attachment means, and an attachment insert provided with opposing surfaces. Each of the opposing surfaces of the insert is provided with two transverse recesses arranged perpendicular to the opposing surfaces, and offset relative to one another.

Abstract: Provided herein multispecific (e.g., bispecific) binding molecules comprising a first binding domain that binds an extracellular portion of dystroglycan and a second binding domain that binds laminin-2. Further provided herein are methods for making such binding molecules and uses of such binding molecules for treating and/or preventing alpha-dystroglycanopathies.

Abstract: The present invention concerns antibody-like binding protein specifically binding to CD3 and binding specifically to at least one further antigen, for example CD123. The present invention also concerns antibody-like binding protein specifically binding to CD123 and binding specifically to at least one further antigen. The invention further concerns anti-CD3 antibodies and anti-CD123 antibodies. The invention also relates to pharmaceutical compositions comprising the antibody-like binding protein, anti-CD3 antibodies or anti-CD123 antibodies of the invention, and their use to treat cancer. The invention further relates to isolated nucleic acids, vectors and host cells comprising a sequence encoding said antibody-like binding protein, anti-CD3 or anti-CD123 antibody and the use of said anti-CD123 antibody as a diagnostic tool.