Abstract: A modified L-nucleic acid, containing an L-nucleic acid part conjugated to a non-L-nucleic acid part is described. The conjugate has extended retention time in and demonstrates a delayed elimination from an organism.

Abstract: The invention provides antibody-like binding proteins comprising four polypeptide chains that form four antigen binding sites, wherein each pair of polypeptides forming an antibody-like binding protein possesses dual variable domains having a cross-over orientation. The invention also provides methods for making such antigen-like binding proteins.

Abstract: The invention relates to a companion diagnostic antibody-like binding protein based on the humanized monoclonal antibody, DS6, to be used as diagnostic tool for in vivo detection and quantification of the tumor-associated MUC1-sialoglycotope, CA6.

Abstract: The present invention relates to a street or industrial vacuum cleaner (1) on a chassis (50) and self-propelled using at least one drive motor comprising a guide element preferably taking the form of a handlebar (70) with at least one handle (740), a hand grip (730) and means or elements (710) for attachment to the chassis (50) of the vacuum cleaner (1), said attachment means or elements (710) making it possible, by the transmission of the movement applied to the hand grip (730), to steer said vacuum cleaner (1), characterized in that the handle (740) comprises a telescopic zone with a sliding part (745) able to move between a first position referred to as an extended position and a second position referred to as a retracted position, preferably with a return spring (780) and at least a switch (770) for detecting the position of the sliding part (745), said switch (770) being able to cause the street vacuum cleaner drive motor to switch off or reverse if the sliding part (745) is in the retracted position.

Abstract: Method for producing a reinforcement beam for a vehicle, comprising at least one weak zone arranged in such a way that the bending resistance of the beam is less in said weak zone than in the rest of the beam, characterised in that it comprises, in order, a step (A) of extruding a profile part, a step (B) of cutting the profile part so as to obtain at least one profile segment, a step (C) of locally deforming the segment of the profile part in order to create the weak zone or zones.

Abstract: Provided herein are multispecific antibodies, e.g. bispecific antibodies, which are modified such that the desired chain pairing takes place and/or can be selected for. Specifically, this is achieved by using different dimerization domains for light chain pairing. Also disclosed herein are nucleic acids encoding for these antibodies, expression vectors comprising these nucleic acids, cells expressing them, and further to pharmaceutical compositions comprising the antibodies, as well as methods of isolating the antibodies.

Abstract: The present invention concerns antibody-like binding protein specifically binding to CD3 and binding specifically to at least one further antigen, for example CD123. The present invention also concerns antibody-like binding protein specifically binding to CD123 and binding specifically to at least one further antigen. The invention further concerns anti-CD3 antibodies and anti-CD123 antibodies. The invention also relates to pharmaceutical compositions comprising the antibody-like binding protein, anti-CD3 antibodies or anti-CD123 antibodies of the invention, and their use to treat cancer. The invention further relates to isolated nucleic acids, vectors and host cells comprising a sequence encoding said antibody-like binding protein, anti-CD3 or anti-CD123 antibody and the use of said anti-CD123 antibody as a diagnostic tool.

Abstract: The present invention relates to a device in the form of a suction nozzle (10) for an urban or industrial aspirator (1), preferably self-propelled, comprising a rigid hose or tube (1000), said rigid hose or tube comprising gripping means (100, 200, 300, 400) that comprise a first gripping element (110, 210, 310, 410) in the form of a handle, a support element (120, 220, 320, 420) serving as a lever, and a second gripping element (130, 230, 330, 430) and optionally a base (101, 201, 301, 401).

Abstract: A computer-implemented method analyzes resources in a network. An analyzer executing on one or more computing devices receives an input having one or more identifiers to one or more target resources in the network. The analyzer also receives one or more values for one or more performance metrics relevant to the one or more target resources. The analyzer automatically uses pre-stored performance metrics to prepare one or more rankings of performance for the one or more target resources and one or more field resources based on the one or more performance metrics. The analyzer automatically uses the prepared one or more rankings to identify, from one or more target resources, one or more identified target resources having a performance potential higher than remaining target resources of the one or more target resources, a corresponding system, computing device, and non-transitory computer-readable storage medium.

Abstract: The invention relates to a companion diagnostic antibody-like binding protein based on the humanized monoclonal antibody, DS6, to be used as diagnostic tool for in vivo detection and quantification of the tumor-associated MUC1-sialoglycotope, CA6.

Abstract: The disclosure provides trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. The disclosure also provides methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins.

Abstract: A vehicle roof which can be opened, comprising a cover that can be moved between a closed position and an open position in which the cover is raised at least at the rear edge of the cover and is at least partly moved over an adjoining roof portion. The cover is supported by means of a front bearing device, which can be moved by a drive device, such that the cover can be moved along a front guide rail and by means of a rear bearing device such that the cover can be raised over the adjoining roof portion and moved along a rear guide rail.

Abstract: The invention relates to an impact-absorbing structure for a vehicle, the structure of which comprises at least one side rail for supporting a bumper crossbeam, the side rail being a hollow profile member arranged according to the longitudinal axis of the vehicle, the impact-absorbing structure including the bumper crossbeam, at least one absorber placed between the side rail and the bumper crossbeam, the absorber being a hollow profile member intended for deforming in the event of an impact, one end of the profile member being intended to be inserted into the open end of the side rail, the end of the profile member being attached to the side rail via transversely arranged attachment means, and an attachment insert provided with opposing surfaces. Each of the opposing surfaces of the insert is provided with two transverse recesses arranged perpendicular to the opposing surfaces, and offset relative to one another.

Abstract: An assembly mount for the movable fastening of a motor vehicle assembly (such as an engine) having a housing which is connectable to a motor vehicle body, a fastening bolt which is connectable to the motor vehicle assembly and which projects into the housing via a housing opening, a load-bearing spring which is connected to the housing and to the fastening bolt, wherein the load-bearing spring permits at least a relative movement of the fastening bolt in an opening plane of the housing opening within the housing opening, and a compensation element which is movable relative to the housing and relative to the fastening bolt and which serves for the variation of a movement clearance of the fastening bolt in the housing opening in the opening plane.

Abstract: Some embodiments include a system. The system comprises an input device, an output device, one or more processing modules, and one or more non-transitory memory storage modules storing computer instructions. The computer instructions are configured to run on the processing module(s) and perform the acts of: identifying at least one test web page; and analyzing a first test web page of the at least one test web page. The analyzing the first test web page of the at least one test web page comprises crawling the first test web page to detect a first adverse performance condition of the first test web page, and the first adverse performance condition can impact a first search rank assigned to the first test web page when present. Other embodiments of related systems and methods are also provided.

Abstract: The present invention relates to fusion molecules that have binding specificity for pyoverdine type I, II and III and pyochelin and can be used in various applications, including diagnostic and/or therapeutic applications, for example, to inhibit or reduce growth of P. aeruginosa and/or to prevent or treat P. aeruginosa biofilm infection as well as diseases or disorders associated with P. aeruginosa biofilm infection. The present invention also concerns methods of producing the fusion molecules described herein as well as compositions and kits comprising such fusion molecules. The present invention further relates to nucleic acid molecules encoding the fusion molecules described herein.

Abstract: The present invention relates to a device in the form of a suction nozzle (10) for an urban or industrial aspirator (1), preferably self-propelled, comprising a rigid hose or tube (1000), said rigid hose or tube comprising gripping means (100, 200, 300, 400) that comprise a first gripping element (110, 210, 310, 410) in the form of a handle, a support element (120, 220, 320, 420) serving as a lever, and a second gripping element (130, 230, 330, 430) and optionally a base (101, 201, 301, 401).

Abstract: A modified L-nucleic acid, containing an L-nucleic acid part conjugated to a non-L-nucleic acid part is described. The conjugate has extended retention time in and demonstrates a delayed elimination from an organism.

Abstract: The present invention discloses novel antibodies that specifically bind to the human platelet membrane protein Glycoprotein VI (GPVI) and their monovalent fragments or derivatives. The antibodies of the invention are antibodies from hybridoma clone 390 and fragment antibodies thereof able to induce a GPVI depletion phenotype. These antibodies and Fab fragments are able to block collagen binding and thus preventing platelet activation by collagen. The invention also relates to hybridoma clones and expression plasmids for the production of disclosed antibodies and Fab fragments. The present invention further refers to the uses of monovalent antibody fragments to manufacture research, diagnostic and immunotherapeutic agents for the treatment of thrombosis and other vascular diseases. The invention also concerns a Fab bearing a molecule at the C-terminal extremity, as well as method for prevention of recognition of Fab by antibodies using such modified Fab.

Abstract: A vehicle roof which can be opened, comprising a cover that can be moved between a closed position and an open position in which the cover is raised at least at the rear edge of the cover and is at least partly moved over an adjoining roof portion. The cover is supported by means of a front bearing device, which can be moved by a drive device, such that the cover can be moved along a front guide rail and by means of a rear bearing device such that the cover can be raised over the adjoining roof portion and moved along a rear guide rail.