Abstract: The disclosure provides trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. The disclosure also provides methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins.

Abstract: A vehicle roof which can be opened, comprising a cover that can be moved between a closed position and an open position in which the cover is raised at least at the rear edge of the cover and is at least partly moved over an adjoining roof portion. The cover is supported by means of a front bearing device, which can be moved by a drive device, such that the cover can be moved along a front guide rail and by means of a rear bearing device such that the cover can be raised over the adjoining roof portion and moved along a rear guide rail.

Abstract: The invention relates to an impact-absorbing structure for a vehicle, the structure of which comprises at least one side rail for supporting a bumper crossbeam, the side rail being a hollow profile member arranged according to the longitudinal axis of the vehicle, the impact-absorbing structure including the bumper crossbeam, at least one absorber placed between the side rail and the bumper crossbeam, the absorber being a hollow profile member intended for deforming in the event of an impact, one end of the profile member being intended to be inserted into the open end of the side rail, the end of the profile member being attached to the side rail via transversely arranged attachment means, and an attachment insert provided with opposing surfaces. Each of the opposing surfaces of the insert is provided with two transverse recesses arranged perpendicular to the opposing surfaces, and offset relative to one another.

Abstract: An assembly mount for the movable fastening of a motor vehicle assembly (such as an engine) having a housing which is connectable to a motor vehicle body, a fastening bolt which is connectable to the motor vehicle assembly and which projects into the housing via a housing opening, a load-bearing spring which is connected to the housing and to the fastening bolt, wherein the load-bearing spring permits at least a relative movement of the fastening bolt in an opening plane of the housing opening within the housing opening, and a compensation element which is movable relative to the housing and relative to the fastening bolt and which serves for the variation of a movement clearance of the fastening bolt in the housing opening in the opening plane.

Abstract: Some embodiments include a system. The system comprises an input device, an output device, one or more processing modules, and one or more non-transitory memory storage modules storing computer instructions. The computer instructions are configured to run on the processing module(s) and perform the acts of: identifying at least one test web page; and analyzing a first test web page of the at least one test web page. The analyzing the first test web page of the at least one test web page comprises crawling the first test web page to detect a first adverse performance condition of the first test web page, and the first adverse performance condition can impact a first search rank assigned to the first test web page when present. Other embodiments of related systems and methods are also provided.

Abstract: The present invention relates to fusion molecules that have binding specificity for pyoverdine type I, II and III and pyochelin and can be used in various applications, including diagnostic and/or therapeutic applications, for example, to inhibit or reduce growth of P. aeruginosa and/or to prevent or treat P. aeruginosa biofilm infection as well as diseases or disorders associated with P. aeruginosa biofilm infection. The present invention also concerns methods of producing the fusion molecules described herein as well as compositions and kits comprising such fusion molecules. The present invention further relates to nucleic acid molecules encoding the fusion molecules described herein.

Abstract: The present invention relates to a device in the form of a suction nozzle (10) for an urban or industrial aspirator (1), preferably self-propelled, comprising a rigid hose or tube (1000), said rigid hose or tube comprising gripping means (100, 200, 300, 400) that comprise a first gripping element (110, 210, 310, 410) in the form of a handle, a support element (120, 220, 320, 420) serving as a lever, and a second gripping element (130, 230, 330, 430) and optionally a base (101, 201, 301, 401).

Abstract: A modified L-nucleic acid, containing an L-nucleic acid part conjugated to a non-L-nucleic acid part is described. The conjugate has extended retention time in and demonstrates a delayed elimination from an organism.

Abstract: The present invention discloses novel antibodies that specifically bind to the human platelet membrane protein Glycoprotein VI (GPVI) and their monovalent fragments or derivatives. The antibodies of the invention are antibodies from hybridoma clone 390 and fragment antibodies thereof able to induce a GPVI depletion phenotype. These antibodies and Fab fragments are able to block collagen binding and thus preventing platelet activation by collagen. The invention also relates to hybridoma clones and expression plasmids for the production of disclosed antibodies and Fab fragments. The present invention further refers to the uses of monovalent antibody fragments to manufacture research, diagnostic and immunotherapeutic agents for the treatment of thrombosis and other vascular diseases. The invention also concerns a Fab bearing a molecule at the C-terminal extremity, as well as method for prevention of recognition of Fab by antibodies using such modified Fab.

Abstract: A vehicle roof which can be opened, comprising a cover that can be moved between a closed position and an open position in which the cover is raised at least at the rear edge of the cover and is at least partly moved over an adjoining roof portion. The cover is supported by means of a front bearing device, which can be moved by a drive device, such that the cover can be moved along a front guide rail and by means of a rear bearing device such that the cover can be raised over the adjoining roof portion and moved along a rear guide rail.

Abstract: The invention provides antibody-like binding proteins comprising four polypeptide chains that form four antigen binding sites, wherein each pair of polypeptides forming an antibody-like binding protein possesses dual variable domains having a cross-over orientation. The invention also provides methods for making such antigen-like binding proteins.

Abstract: The present invention relates to a device in the form of a suction nozzle (10) for an urban or industrial aspirator (1), preferably self-propelled, comprising a rigid hose or tube (1000), said rigid hose or tube comprising gripping means (100, 200, 300) that comprise a first gripping element (110, 210, 310) in the form of a handle, a support element (120, 220, 320) serving as a lever, and a second gripping element (130, 230, 330) and optionally a base (101, 201, 301).

Abstract: The present invention relates to a peptide or peptide complex binding to ?2 integrin, to one or more nucleic acid(s) coding for the peptide or peptide complex, a recombinant cell producing the peptide or peptide complex, a method for producing the peptide or peptide complex, a pharmaceutical composition comprising the peptide or peptide complex or the nucleic acid(s) for use as a medicament, a method for detecting ?2 integrin and a screening method.

Abstract: An assembly mount for the movable fastening of a motor vehicle assembly (such as an engine) having a housing which is connectable to a motor vehicle body, a fastening bolt which is connectable to the motor vehicle assembly and which projects into the housing via a housing opening, a load-bearing spring which is connected to the housing and to the fastening bolt, wherein the load-bearing spring permits at least a relative movement of the fastening bolt in an opening plane of the housing opening within the housing opening, and a compensation element which is movable relative to the housing and relative to the fastening bolt and which serves for the variation of a movement clearance of the fastening bolt in the housing opening in the opening plane.

Abstract: The present invention relates to a peptide or peptide complex binding to ?2 integrin, to one or more nucleic acid(s) coding for the peptide or peptide complex, a recombinant cell producing the peptide or peptide complex, a method for producing the peptide or peptide complex, a pharmaceutical composition comprising the peptide or peptide complex or the nucleic acid(s) for use as a medicament, a method for detecting ?2 integrin and a screening method.

Abstract: The invention provides antibody-like binding proteins comprising four polypeptide chains that form four antigen binding sites, wherein each pair of polypeptides forming an antibody-like binding protein possesses dual variable domains having a cross-over orientation. The invention also provides methods for making such antigen-like binding proteins.

Abstract: The invention provides antibody-like binding proteins comprising four polypeptide chains that form four antigen binding sites, wherein each pair of polypeptides forming an antibody-like binding protein possesses dual variable domains having a cross-over orientation. The invention also provides methods for making such antigen-like binding proteins.

Abstract: The invention relates to a connecting structure between building blocks and to a building block. The connecting structure according to the invention has a relatively simple structural design so as to be easily producible and releasable. Furthermore the connecting structure allows a quick modification of the orientation of the building blocks relative to one another. In the process an energy and/or information transmission is allowed between the building blocks at the same time.

Abstract: An exemplary method and apparatus are provided for improved control for induction coils in charging systems for movable vehicles. The technique includes determining a set point for a second induction coil from information about a power transfer of a first induction coil. A switching time for operating the first induction coil in a first pre-determined operating mode is triggered based on a first set point, and a switching time for operating the second induction coil in a second pre-determined operating mode is triggered based on a second set point. The second set point may be determined based on the first set point and an offset.

Abstract: The present invention relates to fusion proteins in which a biologically active moiety is linked to a targeting domain. The invention specifically concerns fusion proteins comprising single-chain (sc) TNFalpha monomers as biologically active moiety and a specific targeting domain, preferably fusion proteins comprising at least three scTNFalpha monomers and modified hetero-dimeric ubiquitin proteins with high affinity to target molecules (Affilin® molecules). The invention further relates to these fusion proteins for use in medicine, in particular in the treatment of cancer. The invention is further directed to pharmaceutical compositions comprising such fusion proteins in combination with chemotherapeutics agents.