Abstract: In a method, device and storage medium encoded with programming instructions for automatic image registration of image data of a current medical image MR study and at least one reference study, corresponding image pairs of the current study and the reference study are formed automatically with an association machine without needing the analyze the respective image data or pixel data. The pair determination takes place exclusively on the basis of the DICOM header data. A synchronized image processing and/or presentation of the generated image pairs takes place at a monitor.

Abstract: The present invention relates to a peptide or peptide complex binding to ?2 integrin, to one or more nucleic acid(s) coding for the peptide or peptide complex, a recombinant cell producing the peptide or peptide complex, a method for producing the peptide or peptide complex, a pharmaceutical composition comprising the peptide or peptide complex or the nucleic acid(s) for use as a medicament, a method for detecting ?2 integrin and a screening method.

Abstract: The present invention relates to a polypeptide or polypeptide complex comprising at least the two amino acid sequences arranged to allow for specific binding to the “receptor for advanced glycation endproducts” (RAGE), one or more nucleic acid(s) coding for the polypeptide or polypeptide complex, a cell producing an antibody against RAGE, a pharmaceutical composition comprising at least one polypeptide or nucleic as defined above, optionally for treating a RAGE-related disease or disorder and a method of diagnosing a RAGE-related disease or disorder.

Abstract: The present invention is related to a method for the detection of a nucleic acid molecule comprising at least a strand comprising a sequence of nucleotides in a sample, whereby the method comprises the following steps: providing a sample containing the nucleic acid molecule; providing a capture probe, whereby the capture probe is at least partially complementary to a part of the nucleic acid molecule; allowing the capture probe to react with the nucleic acid molecule or a part thereof; and detecting whether or not the capture probe is hybridized to the nucleic acid molecule or part thereof.

Abstract: The invention provides antibody-like binding proteins comprising four polypeptide chains that form four antigen binding sites, wherein each pair of polypeptides forming an antibody-like binding protein possesses dual variable domains having a cross-over orientation. The invention also provides methods for making such antigen-like binding proteins.

Abstract: The present invention discloses novel antibodies that specifically bind to the human platelet membrane protein Glycoprotein VI (GPVI) and their monovalent fragments or derivatives. The antibodies of the invention are antibodies from hybridoma clone 390 and fragment antibodies thereof able to induce a GPVI depletion pheno-type. These antibodies and Fab fragments are able to block collagen binding and thus preventing platelet activation by collagen. The invention also relates to hybridoma clones and expression plasmids for the production of disclosed antibodies and Fab fragments. The present invention further refers to the uses of monovalent antibody fragments to manufacture research, diagnostic and immunotherapeutic agents for the treatment of thrombosis and other vascular diseases. The invention also concerns a Fab bearing a molecule at the C-terminal extremity, as well as method for prevention of recognition of Fab by antibodies using such modified Fab.

Abstract: A modified L-nucleic acid, containing an L-nucleic acid part conjugated to a non-L-nucleic acid part is described. The conjugate has extended retention time in and demonstrates a delayed elimination from an organism.

Abstract: A method for controlling properties of a medical implant includes locating the medical implant in an interspinous area between two spinal processes of a person. The medical implant is coupled to a container via a conduit. A fluid is received in an interior of the container in fluid communication with the conduit. The fluid flows from the container toward the implant having an interior configured to receive the fluid. A pressure sensor is coupled to the interior of the container and/or an interior of the conduit. An internal pressure is determined of the interior of the interior of the container and/or the interior of the conduit by the sensor. The flow of the fluid is regulated to the interior of the implant to regulate a volume of the implant based on the internal pressure and a medical condition of the person.

Abstract: A modified L-nucleic acid, containing an L-nucleic acid part conjugated to a non-L-nucleic acid part is described. The conjugate has extended retention time in and demonstrates a delayed elimination from an organism.

Abstract: The present invention is related to a method for the detection of a nucleic acid molecule comprising at least a strand comprising a sequence of nucleotides in a sample, whereby the method comprises the following steps: i) providing a sample containing the nucleic acid molecule; j) providing a capture probe, whereby the capture probe is at least partially complementary to a part of the nucleic acid molecule; k) allowing the capture probe to react with the nucleic acid molecule or a part thereof; and d) detecting whether or not the capture probe is hybridized to the nucleic acid molecule or part thereof.

Abstract: The present invention relates to a modified L-nucleic acid, comprising a L-nucleic acid part and a non-L-nucleic acid part, whereby the L-nucleic acid part is conjugated to the non-L-nucleic acid part and the conjugation of the L-nucleic acid part with the non-L-nucleic acid past leads to a slowed elimination out of the organism, in comparison with a L-nucleic acid which only comprises the L-nucleic acid part, said L-nucleic acid part being a spiegelmer.

Abstract: A method for controlling properties of a medical implant includes locating the medical implant in an interspinous area between two spinal processes of a person. The medical implant is coupled to a container via a conduit. A fluid is received in an interior of the container in fluid communication with the conduit. The fluid flows from the container toward the implant having an interior configured to receive the fluid. A pressure sensor is coupled to the interior of the container and/or an interior of the conduit. An internal pressure is determined of the interior of the interior of the container and/or the interior of the conduit by the sensor. The flow of the fluid is regulated to the interior of the implant to regulate a volume of the implant based on the internal pressure and a medical condition of the person.

Abstract: Embodiments of the invention relate to a vector system that allows one to induce expression of therapeutically relevant genes in mammalian cells. Such a vector system may be useful for medicine and in the pharmaceutical industry. A vector comprises base structures suitable for expression in mammalian cells as well as either the whole of or parts of the gene promoter of human Major Vault Protein (MVP), also known as LRP (Lung Resistance Protein) as well as a gene encoding a therapeutic protein or non-translated RNA. As the MVP promoter is inducible by therapy (for example, but not limited to, chemotherapy or hyperthermia), the vector system provides combinations of therapeutic methods with gene therapy in a controlled fashion, resulting in more efficient treatment of tumor diseases.

Abstract: The present invention relates to a modified L-nucleic acid, comprising a L-nucleic acid part and a non-L-nucleic acid part, whereby the L-nucleic acid part is conjugated to the non-L-nucleic acid part and the conjugation of the L-nucleic acid part with the non-L-nucleic acid past leads to a slowed elimination out of the organism, in comparison with a L-nucleic acid which only comprises the L-nucleic acid part, said L-nucleic acid part being a spiegelmer.

Abstract: A process of producing a graft polymer of the ABS type by the emulsion method is disclosed. In the process wherein 5 to 95% by weight of a monomer mixture that contains A) 50 to 99 parts by weight of at least one vinyl aromatic compound and B) 1 to 50 parts by weight of at least one copolymer is polymerized in the presence of C) 95 to 5% by weight of one or more graft substrates having a glass transition temperature <10° C., the improvement includes monitoring continuously in the course of the reaction the Raman spectra of the reaction mixture, determining deviations from the specified desired course of the reaction and making corresponding adjustments.

Abstract: The subject matter of the invention is a therapy-regulatable vector system of the gene promoter of the human lung resistance protein (LRP/MVP). This vector system for the therapy-inducible expression of therapeutically relevant genes in mammalian cells shall be used in the pharmaceutical industry and in medicine.

Abstract: Control device for a multiphase electric motor (M) comprising firstly two two-directional static switches (IS1, IS2) each associated with a terminal of a shunt contactor (S) installed in parallel, these switches (IS1, IS2, S) being controlled by a control circuit (C) controlling progressive operation of the motor, characterized in that the shunt contactor (S) is of the four-pole type and is fitted with solid connection parts (6, 7) each connecting two terminals of the said contactor, these connection parts (6, 7) being connected in pairs (L1, L3) to the terminals of the static switches (IS1, IS2) such that each (IS1 or IS2) is connected to two terminals.

Abstract: A switch device using a main switch coupled to a monostable auxiliary switch through a releasable coupling is disclosed. In this device, the auxiliary switch and the main switch are closed in succession by simultaneous movement of their respective contact-holders and are opened in the reverse order by virtue of the presence of the releasable coupling which is released during closing and engaged during opening.