Abstract: Wax-based compositions for making barrier layers used in oral treatment devices are thermally stable when formed into a flat sheet or three-dimensional article to a temperature of at least 45° C. and are plastically deformable at room temperature (25° C.). The wax-based compositions include a wax fraction homogeneously blended with a polymer fraction. The wax fraction includes at least one wax and the polymer fraction includes at least one polymer selected such that, when the at least one wax and at least one polymer are homogeneously blended together, they yield a wax-based composition having the desired properties of thermal stability and plastic deformability. Barrier layers in oral treatment devices made from such wax-based compositions are dimensionally stable to a temperature of at least 40° C. without external support and can be plastically deformed in a user's mouth to become at least partially customized to the size and shape of user's unique dentition.

Abstract: A device for monitoring breathing or movement of a living being. The device includes a sensor having a conductive elastomer having a variable resistance and a textile engaged to the sensor.

Abstract: The application pertains to methods of treating and/or preventing actinic keratosis, comprising administering a therapeutically effective amount of KX-01, to a subject in need thereof.

Abstract: Computer program products and methods for displaying information relating to one or more digital looseleafs are disclosed. In one embodiment, a computer program product includes a computer usable medium having computer readable instructions embodied therein. The computer readable instructions cause a processor to display of a first table of contents page of a digital looseleaf. In response to receipt of a user selection of a representation of an individual one of the plurality of main sections, a second table of contents page is displayed overtop the first table of contents page such that an edge portion of the first table of contents page is unobstructed by the second table of contents page. In response to receipt of a user input in the edge portion of the first table of contents page, an entirety of the first table of contents page is displayed.

Abstract: The subject matter of the invention of the present application is non-invasive equipment for monitoring blood flows and/or respiratory cycles of a human or animal body, comprising at least one segment of conductive elastomer with variable resistance arranged so as to extend over the circumference of the body element and sensitive to the length of the circumference of said element, means for capturing said length by virtue of said variable resistance and supplying a signal representing said length, and means for processing said signal, comprising means for extracting parameters of the blood flows and/or respiratory cycles to be monitored.

Abstract: A method and system for classifying a target nucleic acid includes exposing, in a test system, one or more capture probes to the target nucleic acid. The one or more capture probes is attached to a surface. A first hybridization condition is established in the test system. A first degree of hybridization of the one or more capture probes with the target nucleic acid under the first hybridization condition is determined. A second hybridization condition in the test system is established. A second degree of hybridization of the one or more capture probes with the target nucleic acid under the second hybridization condition is determined and the target nucleic acid is classified by comparing the first and the second degrees of hybridization.

Abstract: A Rogowski coil in a sensor unit has voltage induced by a conductor surrounded by the Rogowski coil. The voltage is integrated to represent current which is converted to digital data representing current in the conductor and sent wirelessly to a multimeter. The sensor unit may receive control signals from the multimeter and a remote control apparatus. A plurality of sensor units may be networked and controlled by the remote control apparatus.

Abstract: A power-based control system and method for an engine comprising a turbocharger involve obtaining a set of parameters that each affect exhaust gas energy and using the set of parameters to (i) determine a target mass flow into the engine and a target boost for the turbocharger to achieve a torque request, (ii) determine a target power for a compressor of the turbocharger to achieve the target engine mass flow and the target turbocharger boost, (iii) determine a target pressure ratio and a target mass exhaust flow for the turbine of the turbocharger to achieve a target turbine power equal to the target compressor power, and (iv) determine a target position of the wastegate valve to achieve the target turbine pressure ratio and mass exhaust flow, and commanding a wastegate valve to the target position.

Abstract: A method includes identifying data objects for a file system to be installed on a computer system. Each of the data objects is to be stored in the file system using a respective path. The method also includes creating an intermediate file system structure that includes elements representing the data objects to be stored in the file system, each of the elements being placed in the intermediate file system structure at the respective path. Creating the intermediate file system structure may include identifying a subset of the data objects that each includes a symbolic link in a portion of the respective path, and for each data object in the subset, replacing the symbolic link in the portion of the respective path with a target path associated with the symbolic link. The method also includes installing the file system on the computer system using the intermediate file system structure.

Abstract: A method for codeless development of an application includes registering one or more actions in a registry. Each action is coded in a reusable block of code, each action having an action definition including an action type name, an input parameters map, and an output parameters map. The method further includes performing an action type name look up in the registry for an invoked action with an action service ensuring that a number of arguments included in the action definition matches a number of arguments specified by the action type, passing an input to and receiving a return value from the invoked action, updating the output parameters map included in the definition of the invoked action, and returning the updated output parameters map to an application in development for updating processing variables in the application.

Abstract: Embodiments provide a person support system including support pads having cooling features. According to one embodiment, a person support system may include a longitudinal frame comprising at least one side rail. A support pad may be positioned on the longitudinal frame. The support pad may comprise a thermally conductive core portion comprising a support matrix and at least one thermally conductive element. A cooling source may be thermally coupled to the thermally conductive core portion through the side rail with a connector comprising thermally conductive fibers. The cooling source may draw heat from the thermally conductive core portion through the at least one thermally conductive element and the thermally conductive fibers of the connector thereby cooling at least the thermally conductive core portion of the support pad.

Abstract: Methods of identifying target binding molecules by target guided synthesis are provided. The methods include providing two or more fragments capable of reacting to form the target binding molecule and mixing the fragments with the target. The methods can be used to identify target binding molecules that bind targets such as proteins or nucleic acids, including those that bind shallow binding pockets on the surface of such targets. The methods are applied to the Bcl-XL and Mcl-1 proteins from the Bcl-2 family of proteins. Using thio acid and sulfonyl azide fragments capable of reacting through sulfo-click chemistry, new acyl sulfonamides are identified that bind one or both of the Bcl-XL and Mcl-1 proteins. Pharmaceutical formulations of these target binding molecules are also provided.

Abstract: A control system and method for an engine including a turbocharger without a surge valve involve utilizing one or more pressure sensors configured to measure air pressure in an intake system of the engine, the intake system comprising a compressor of the turbocharger and a throttle valve downstream from the compressor, and a controller configured to control the engine to avoid surge at the compressor and eliminate a need for the surge valve by determining a desired position for the throttle valve based on a driver requested engine torque, determining a minimum mass flow through the compressor that avoids surge based on the measured air pressure in the intake system and a predetermined compressor map, and commanding the throttle valve to a target position to maintain at least the minimum compressor mass flow, wherein the target position is greater than the desired position, thereby avoiding surge at the compressor.

Abstract: A wellhead assembly includes a tubular wellhead housing having a bore and an annular gallery slot. The annular gallery slot is defined by an enlarged inner diameter of the bore. A tubular hanger is selectively landed in the bore of the wellhead housing, defining an annular cavity between the bore and an outer diameter of the tubular hanger. The tubular hanger is supported by the wellhead housing with a hanger support located in the annular cavity. A flow-by passage is in fluid communication with the annular cavity at locations above and below the hanger support. The flow-by passage intersects with the gallery slot and intersects an outer radial surface of the tubular hanger.

Abstract: In one general aspect, a method can include creating an action, the creating including annotating a block of code with metadata, and encapsulating the annotated block of code into a reusable building block of code. The method can further include publishing the action, the publishing including registering the action in a service registry. The method can further include dynamically discovering the action in the service registry by an application during runtime, invoking the action by the application, and executing the action by the application, the executing performing a method specified by the action.

Abstract: The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating D1-mediated (or D1-associated) disorders including, e.g., schizophrenia (e.g., its cognitive and negative symptoms), cognitive impairment (e.g., cognitive impairment associated with schizophrenia, AD, PD, or pharmacotherapy therapy), and Parkinson's disease.

Abstract: A Rogowski coil in a sensor unit has voltage induced by a conductor surrounded by the Rogowski coil. The voltage is integrated to represent current which is converted to digital data representing current in the conductor and sent wirelessly to a multimeter. The sensor unit may receive control signals from the multimeter and a remote control apparatus. A plurality of sensor units may be networked and controlled by the remote control apparatus.

Abstract: A device for reducing communications crosstalk including a plurality of channel inputs each configured to receive an incoming signal from a respective device. The device further includes at least one control input configured such that, when the control input is triggered, the control input activates a voltage divider that attenuates at least one of the incoming signals, thereby reducing crosstalk between a first channel carrying the at least one attenuated incoming signal and a second channel not carrying the at least one attenuated incoming signal. The at least one attenuated incoming signal and the remaining incoming signals are output to a respective receiver.