Abstract: Disclosed herein are compositions and methods for treating celiac sprue.

Abstract: The present invention provides methods for multiplex assembly of oligonucleotides.

Abstract: A lawn mower (10) may include a blade housing (20), an engine (30), a mobility assembly (310); and a drive system (300). The engine (30) may be operably coupled to the blade housing (20) and configured to selectively rotate a drive shaft (130). The mobility assembly (310) may include a first set of wheels (40, 42) and be selectively operably coupled to the engine (30) to provide mobility of the lawn mower responsive at least in part to operation of the engine (30). The drive system (300) may include a first transmission (110, 120), a flexible driving member (100), a disengagement assembly (116), and a remote actuator. The a disengagement assembly (116) may include a latching lever (125), where the latching lever (125) is configured to switch the first transmission (110, 120) between a disengaged mode and an engaged mode, and where the latching lever (125) is configured to move between a disengaged position corresponding to the disengaged mode and an engaged position corresponding to the engaged mode.

Abstract: Conduit system for conveying fluids is described. The conduit system comprises a conduit, a tubular, and a sealing component. The tubular is positioned radially interior of an inner surface of the conduit along a length. The tubular comprises a polymeric material. The sealing component is positioned proximate the distal end of the tubular in an annulus formed between an outer surface of the tubular and the inner surface of the conduit, the sealing component constructed and arranged to seal the annulus. Methods for reducing corrosion of or providing pressure integrity to a conduit are also described.

Abstract: The present disclosure is directed to compositions, formulations and methods of use thereof in the treatment and prevention of ocular conditions including cataract and presbyopia.

Abstract: Engineered orthogonal cytokine receptor/ligand pairs, and methods of use thereof, are provided.

Abstract: A drive assembly (140) for a walk-behind, powered device operably couples an engine (110) of the powered device to a mobility assembly (120) to provide mobility of the powered device responsive at least in part to operation of the engine (110). The drive assembly (140) includes a transmission shaft and a mechanical power reversing assembly (150). The transmission shaft selectively receives first drive power or second drive power coupled from the engine (110) to drive a first drivable component (122) and a second drivable component (124) of the mobility assembly (120). The first and second drivable components (122, 124) are disposed substantially at opposing sides of the powered device. The mechanical power reversing assembly (150) is selectively engagable to convert the first drive power generated for the first drivable component (122) into the second drive power provided to the second drivable component (124) and vice versa.

Abstract: The invention relates to methods and a novel powdered curable monomer which may be used to manufacture bulk polymers, adhesives and coatings composite materials with high percentage weight inclusions of particulate filler materials, more specifically to fibre reinforced polymer composite materials with high percentage weight inclusions of particulate filler materials. The preferred particulate filler materials are carbon nanotubes. The method according to the invention allows greater than 0.5 wt % of carbon nanotubes, typically greater 10% wt of carbon nanotubes or other high aspect ratio fillers to be readily incorporated in the resin matrix, before being applied to the fibre reinforcing plys.

Abstract: Disclosed herein are compositions and methods for treating celiac sprue.

Abstract: A lawn mower may include a blade housing configured to house at least one blade, an engine operably coupled to the blade housing and configured to selectively rotate the at least one blade, a handle bracket assembly operably coupled to the blade housing, a handle assembly operably coupled to the handle bracket assembly, a door operably pivot about a first pivot axis and a collector operably coupled to the handle bracket assembly and configured to coupled to the handle bracket assembly and configured to pivot about a second pivot axis between a first position and a second position. In the first position, the collector is configured to receive clippings generated responsive to operation of the at least one blade. In the second position, the collector is configured to dump the clippings from the collector. The door is biased against the collector to maintain a portion of the collector substantially at the second pivot axis as the collector pivots between the first position and the second position.

Abstract: Polypeptides, and methods for their use, are disclosed that have an amino acid sequence at least 75% identical to the amino acid sequence of SEQ ID NO: 1, are provided, wherein (a) the polypeptide degrades a PFQPQLPY (SEQ ID NO: 140) peptide and/or a PFPQPQQPF (SEQ ID NO: 68) at pH 4; (b) residue 467 is Ser, residue 267 is Glu, and residue 271 is Asp; and (c) the polypeptide comprises an amino acid change from SEQ ID NO: 1 at one or more residues selected from the group consisting of 221, 262E, 268, 269, 270, 319A, 320, 354E/Q/R/Y, 358S/Q/T, 368F/Q, 399, 402, 406, 424, 449, 461, 463, 105, 171, 172, 173, 174, and 456.

Abstract: Described herein are polypeptides capable of self-assembling to form homo-oligomers, and methods for designing such polypeptides.

Abstract: A turbofan engine is provided having a fan and a nacelle assembly enclosing the fan. The nacelle assembly includes a thrust reverser system having one or more cascade segments configured to translate at least partially along an axial direction of the turbofan engine. The turbofan engine further includes a core operable with the fan and at least partially enclosed by the nacelle. The core includes a turbine section having a low pressure turbine defining an exit diameter. A ratio of the exit diameter of the low pressure turbine to a fan diameter of the fan is less than 0.5, providing for a more compact turbofan engine.

Abstract: The present invention relates to a compound of formula I, or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein: Z is OR16 or NR17R18; R16 is H or alkyl; R17 is H or alkyl; R18 is alkyl or cycloalkyl, each of which is optionally substituted by one or more substituents selected from OH, halogen and COOR11; X is a group selected from —C?C—<CH2)p—; —C<R5)?C(R6)—(CH2)q—; and —C(R5)(R6)C(R7)(R8)—(CH2)2—; where each of R5, R6, R7 and R8 is independently II or alkyl, and each of p, q and r is independently 1, 2, 3, 4 or 5; Y is a group selected from: CN; COOR2; CONR3R4; SO2NR9R10; NR12COR13; NR14SO2R15; and a heterocyclic group selected from oxadiazolyl, thiazolyl, iso- thiazolyl, oxazolyl, iso-oxazolyl, pyrazoiyl and it-nidazolyl; where each of R2, R3 and R4 is independently H or alkyl; or R3 and R4 are linked, together with the nitrogen to which they are attached, to form a 5 or 6-membered heterocycloalkyl or heterocycloalkenyl group, said heterocycloalkyl or heterocycloalkenyl group opt

Abstract: A cooking accessory insert for a cooking grill includes a heat distribution duct that, installed, extends from a burner proximate to the bottom of the grill's fire box generally to a cooking level near the top of the fire box. The heat distribution duct is defined by a plurality of side walls extending from a top end of the heat distribution duct to a bottom end, tapering inward, or narrowing, from top to bottom. A top surface substantially covers the top end of the heat distribution duct, while the bottom is open. A cover is provided to cover the top surface, defining a baking chamber between the cover and the top surface. A cooking surface element such as a pizza stone is removably disposed on the top surface, spaced apart from the top surface by a plurality of spacers.

Abstract: The present invention relates generally to abuse-deterrent formulations containing dextroamphetamine sulfate.

Abstract: The invention provides compositions and methods for treating celiac sprue.

Abstract: Hyperstable constrained peptides and methods and apparatus for designing such peptides are provided. A computing device can determine a peptide backbone using a computing device. The computing device can place zero or more disulfide bonds in the peptide backbone. The computing device can design one or more peptide sequences based on the peptide backbone. The computing device can validate at least one validated peptide sequence of the one or more peptide sequences. An output can be generated based on the at least one validated peptide sequence.