Abstract: The invention provides compositions and methods for treating celiac sprue.

Abstract: Compositions and methods are provided for the detection of small molecules in a cell using biosensor molecules comprising conditionally active ligand binding domains. Compositions for conditionally activating transcription based on the presence of a small molecules in a cell are further provided, together with methods of designing, producing, and expressing biosensor molecules in cells.

Abstract: Provided herein are scaffold polypeptides, fusion proteins of the scaffold polypeptides and hemagglutinin (HA) binding proteins, and methods for using the fusion proteins for treating and diagnosing influenza infections.

Abstract: Disclosed are various embodiments for employing artificial intelligence to programmatically generate virtual frames that are aesthetically pleasing. A computing device may include an inference engine and a knowledge base to identify characteristics of a provided image. A virtual frame may be programmatically generated based on the characteristics of the image, expert design criteria stored in the knowledge base, and a consumer's subjective and personal design preferences.

Abstract: Systems and methods for managing pressures present in an annular space defined between casing strings contained within a subterranean well. These systems and methods may include providing a pressure distribution casing that includes a plurality of pressure distribution passages and distributing fluids present within the annular space along a length of the pressure distribution casing and/or between the annular space and the subterranean formation using a portion of the plurality of pressure distribution passages. Pressure distribution passages may be present on an inner surface of the pressure distribution casing, on an outer surface of the pressure distribution casing, and/or within a wall of the pressure distribution casing and may distribute the fluids along the length of the pressure distribution casing without distributing the fluids across and/or through a wall of the pressure distribution casing, such as between the inner surface and the outer surface of the pressure distribution casing.

Abstract: Synthetic nanostructures, polypeptides that are useful, for example, in making synthetic nanostructures, and methods for using such synthetic nanostructures are disclosed herein.

Abstract: Aircraft gas turbine engine spinner includes conical forward spinner section extending aftwardly from spinner tip to a curved aft spinner section circumscribed about centerline axis, a spinner aspect ratio greater than about 1.8, and wherein spinner aspect ratio is an axial distance between spinner tip and spinner end divided by radial distance from axis to spinner end. Aspect ratio may be in a range of about 2.0-2.2 or about 2.2-2.8. Aft spinner section may be substantially tangential to platform leading edges of platforms of fan blades. Aft spinner section may have cambered or an elliptical axially curved cross-section. Spinner axial cross-section may have longer spinner axial distance compared to baseline axial distance of baseline cross-section and spinner aspect ratio greater than baseline aspect ratio of baseline cross-section.

Abstract: A bridge plug arrangement includes a plug having an upper end and a bottom end. The bridge plug arrangement also optionally includes a cylindrical seat. The bridge plug arrangement further includes a tubular member. The tubular member may be part of a casing string. The tubular member is configured to receive the plug and, when used, the seat. The plug and/or the seat may be fabricated from a frangible material. Also disclosed is a method for diverting fluids in a wellbore using the bridge plug arrangement. The method may include landing the plug onto the seat within the wellbore below a subsurface zone of interest. Treatment fluids are then injected into the wellbore, where they are diverted through perforations and into a formation. The plug and/or seat is then optionally broken into a plurality of pieces through use of a downward mechanical force.

Abstract: Disclosed herein are polypeptides that bind to the hemagglutinin protein of influenza virus, and which can be used for treating and diagnosing influenza infection.

Abstract: The present disclosure relates to an apparatus and method for liquid level detection. The method may include providing a circuit board including a plurality of horizontally mounted emitter/receiver pairs arranged vertically along the circuit board within a liquid containment area. The method may further include determining, using one or more processors associated with the circuit board, if liquid is present between each of the plurality of emitter/receiver pairs based upon, at least in part, data received from one or more of the plurality of emitter/receiver pairs.

Abstract: The present invention provides porous membrane-binding polypeptides, fusion proteins thereof, and methods for use of the polypeptides and fusion proteins in binding assays.

Abstract: Designed polypeptides having the amino acid sequence of SEQ ID NQ: 1 are described that bind with high affinity and selectivity to the influenza hemagglutinin protein, and which can be used for treating and/or limiting an influenza infection, as well as diagnosing an influenza infection and identifying candidate compounds for treating an influenza infection.

Abstract: Disclosed are various embodiments for facilitating an electronic framing process. A virtual framing system may access a digital image provided by or otherwise selected by a user of the virtual framing system to be examined on a pixel-by-pixel basis to identify relevant and/or dominant colors located within the digital image. By utilizing the most relevant and/or the most dominant colors of the digital image, the virtual framing system may subsequently generate recommendations to be presented to the user by comparing the most relevant and/or most dominant colors to one or more predefined design templates, such as those created by an expert designer, that are stored in a data store.

Abstract: The present invention provides designed polypeptides that selectively bind to and inhibit Epstein Barr protein BHFR1, and B cell lymphoma family proteins, and are thus useful for treating Epstein Barr-related diseases and cancer.

Abstract: This document relates to two dimensional (2D) protein arrays can be used in biotechnology applications, as well as methods of making and using 2D protein arrays. In some cases, a 2D protein array can be used to evaluate (e.g., image) a structure (e.g., a three dimensional (3D) structure) of a protein of interest. In some cases, a 2D protein array can be used to evaluate (e.g., characterize) protein-protein interactions (e.g., stable interactions vs. transient interactions). In some cases, a 2D protein array can be used to evaluate a binding domain in a protein of interest. In some cases, a 2D protein array can be used to evaluate (e.g., identify) binding targets and/or partners of a protein of interest.