Abstract: A method for forming a joint between a fiber reinforced composite component and a metallic component and a joint are provided. The metallic component and the composite component each define a joint surface for mating with the joint surface of the other to join the two components together and the composite component defines a free surface opposed to the joint surface thereof. The joint surface of the metallic component defines an array of pins extending therefrom with each pin defining a pin head at an end distal from the joint surface. The method includes the steps of pressing together the joint surfaces of the two components whereby to cause the array of pins to penetrate through the fiber reinforcing material, and modifying the effective cross sectional shape of the pin heads whereby to increase the constraint applied to the composite component against peeling of the composite component from the joint surface of the metallic component.

Abstract: The present disclosure relates to an apparatus and method for liquid level detection. The method may include providing a circuit board including a plurality of horizontally mounted emitter/receiver pairs arranged vertically along the circuit board within a liquid containment area. The method may further include determining, using one or more processors associated with the circuit board, if liquid is present between each of the plurality of emitter/receiver pairs based upon, at least in part, data received from one or more of the plurality of emitter/receiver pairs.

Abstract: The application discloses multimeric assemblies including multiple oligomeric substructures, where each oligomeric substructure includes multiple proteins that self-interact around at least one axis of rotational symmetry, where each protein includes one or more polypeptide-polypeptide interface (“O interface”); and one or more polypeptide domain that is capable of effecting membrane scission and release of an enveloped multimeric assembly from a cell by recruiting the ESCRT machinery to the site of budding by binding to one or more proteins in the eukaryotic ESCRT complex (“L domain”); and where the multimeric assembly includes one or more subunits comprising one or more polypeptide domain that is capable of interacting with a lipid bilayer (“M domain”), as well as membrane-enveloped versions of the multimeric assemblies.

Abstract: The present invention relates to BKCa activators for use in the treatment of a muscular disorder, or for controlling spasticity or tremors, for example, spasticity in MS.

Abstract: A bracket for coupling frames of solar panels includes a spacer for positioning between frames. An elongated body passes through a slot in the spacer and is positionable within channels formed in the frames. A clamp secures to the spacer and is biased toward the slot and elongated body, such as by means of a spring. The clamp defines seats for receiving portions of the frames of the solar panels. Sloped portions on end portions of the clamp facilitate insertion of the frames between the elongated body and the clamp. Another type of bracket includes a spacer and clamp, the spacer having protuberances for insertion into channels in the frames. A flange extends from the spacer such that it extends between the frames when the protuberances are positioned within the channels. An L-foot or other fixture may secure to the flange to secure the solar panels to a structure.

Abstract: Disclosed is a biosensor engineered to conditionally respond to the presence of specific small molecules, the biosensors including conditionally stable ligand-binding domains (LBDs) which respond to the presence of specific small molecules, wherein readout of binding is provided by reporter genes or transcription factors (TFs) fused to the LBDs.

Abstract: Isolated polypeptides with steroid binding activity and methods for their use as therapeutics and detection agents are disclosed herein.

Abstract: The present invention relates to conjugates of cyclosporin with quinolium mitochondrial targeting groups, and their therapeutic uses.

Abstract: The present disclosure provides isolated polypeptides with vitamin D3 binding activity and methods for their use as detection agents. In another aspect, the invention provides recombinant expression vector comprising an isolated nucleic acid of the invention operably linked to a control sequence. In another aspect, the invention provides recombinant host cells comprising the recombinant expression vector of the invention. In another aspect, the invention provides methods for detecting vitamin D3 or one of its metabolites, such as 25-D3, comprising contacting a sample of interest with a detectable polypeptide of the invention.

Abstract: The invention relates to ice lollys comprising a frozen liquid tea based composition comprising: water, tea powder or tea concentrate, methyl glucoside coconut oil ester, guar, gellan or pectin gum, and USDA certified organic non-genetically modified organism (non-GMO) grown fruit or vegetables in the form of a concentrate of liquid, puree, or powder. The processing and subsequent packaging allows the composition to be processed without heating and/or pasteurization but remain shelf stable in the frozen form.

Abstract: The present disclosure relates to an apparatus and method for liquid level detection. The method may include providing a circuit board including a plurality of horizontally mounted emitter/receiver pairs arranged vertically along the circuit board within a liquid containment area. The method may further include determining, using one or more processors associated with the circuit board, if liquid is present between each of the plurality of emitter/receiver pairs based upon, at least in part, data received from one or more of the plurality of emitter/receiver pairs.

Abstract: Wnt signaling agonist compositions and methods for their use are provided. Wnt signaling agonists of the invention comprise a frizzled binding moiety, which is fused or conjugated to an LRP5 or LRP6 binding moiety.

Abstract: The invention provides compositions and methods for treating celiac sprue.

Abstract: The present invention provides porous membrane-binding polypeptides, fusion proteins thereof, and methods for use of the polypeptides and fusion proteins in binding assays.

Abstract: Designed polypeptides having the amino acid sequence of SEQ ID NQ: 1 are described that bind with high affinity and selectivity to the influenza hemagglutinin protein, and which can be used for treating and/or limiting an influenza infection, as well as diagnosing an influenza infection and identifying candidate compounds for treating an influenza infection.

Abstract: Disclosed is a biosensor engineered to conditionally respond to the presence of specific small molecules, the biosensors including conditionally stable ligand-binding domains (LBDs) which respond to the presence of specific small molecules, wherein readout of binding is provided by reporter genes or transcription factors (TFs) fused to the LBDs.

Abstract: The present invention provides designed polypeptides that selectively bind to and inhibit Epstein Barr protein BHFR1, and B cell lymphoma family proteins, and are thus useful for treating Epstein Barr-related diseases and cancer.

Abstract: A drive assembly (140) for a walk-behind, powered device operably couples an engine (110) of the powered device to a mobility assembly (120) to provide mobility of the powered device responsive at least in part to operation of the engine (110). The drive assembly (140) includes a transmission shaft and a mechanical power reversing assembly (150). The transmission shaft selectively receives first drive power or second drive power coupled from the engine (110) to drive a first drivable component (122) and a second drivable component (124) of the mobility assembly (120). The first and second drivable components (122, 124) are disposed substantially at opposing sides of the powered device. The mechanical power reversing assembly (150) is selectively engagable to convert the first drive power generated for the first drivable component (122) into the second drive power provided to the second drivable component (124) and vice versa.

Abstract: Synthetic nanostructures, polypeptides that are useful, for example, in making synthetic nanostructures, and methods for using such synthetic nanostructures are disclosed herein.

Abstract: The present invention provides methods and compositions that can be applied to screening protein-protein interaction networks, screening drug candidates that modulate protein-protein interactions for on- and off-target effects, detecting extracellular targets for which no native S.