Abstract: The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery systems and tissues or organ which are targeted as sites for delivery. Also provided are vectors and vector systems some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity and to edit or modify a target site in a genomic locus of interest to alter or improve the status of a disease or a condition.

Abstract: A treatment system includes a guide sheath, and a catheter provided with a pressure-controlled element. The pressure-control element preferably includes an expanded configuration adapted to extend across a small feeder vessel branching from the splenic vein. The pressure-control element is positioned with the feeder vessel, and a therapeutic agent is delivered under pressure directly into the feeder vessel, where it is forced to penetrate deep into tissue. Pressure responsive elements for monitoring intravascular pressure are also provided to time delivery of the therapeutic agent for maximum uptake by the target organ. Methods for treating tissues and organs via vascular pathways are provided.

Abstract: A reusable container includes a container portion and a microcontroller device. The microcontroller device includes a microcontroller and a wireless communication device. The wireless communication device is configured for wireless communication with a local area network including at a least a first radio receiver or the first radio receiver and a first computer. The local area network is external to the reusable container. The local area network is configured to determine location data corresponding to a location of the container based on at least a location of the radio receiver or the first computer. The microcontroller is configured to store the location data.

Abstract: A method is described for enabling Raman Based Distributed Temperature Sensing (DTS) systems to operate over larger environmental temperature ranges than any systems available today.

Abstract: An example method includes obtaining a plurality of data items. Each data item includes an indication of a particular location, an indication that a wireless signal from a first access point was observed at that location, and an indication of a time at which the wireless signal from the first access point was observed at that location. The method also includes determining a locational stability of the first access point based on the data items. Determining the locational stability of the first access point includes clustering the plurality of data items into one or more clusters based on the locations indicated in the plurality of data items, determining whether the N most recent data items are associated with a common cluster, and determining whether a time span between the N most recent data items exceeds a threshold period of time.

Abstract: The invention relates to a computer-implemented system and method for automatic collection, analysis and reporting of data relating to a cybersecurity threat. The method may comprise the steps of: presenting an interface through which an executable can be configured and automatically generated; transmitting the executable to a client to enable the client to execute the executable on client systems to automatically collect forensic data; receiving from the client an encrypted data package that includes the forensic data; using a forensic toolset to automatically analyze the forensic data; presenting an option to select one or more of at least two types of output reports designed for different types of readers; inputting the analysis files into an automatic report generator to automatically generate the types of output reports selected by the client; and sending the output reports selected by the client to the client.

Abstract: Techniques and systems for unlocking a first device based on signals transmitted between the first device and a second device are disclosed. A disclosed technique includes receiving, by a first device, at least one wireless signal from a second device; transmitting, by the first device, at least one wireless signal to the second device; determining, by the first device, transit times of the at least one received wireless signal and the at least one transmitted wireless signal; determining, by the first device, one or more range measurements between the first device and the second device based at least in part on the transit times; determining, by the first device, an unlock decision based at least in part on the one or more range measurements; and causing, by at least the first device, the first device to unlock if the unlock decision is positive.

Abstract: An electrophysiology catheter comprising a tubular shaft, the shaft having a proximal portion, a distal portion having a distal end and a deflection region, the shaft defining a longitudinal axis and including an outer tubular jacket, and articulation member disposed within the jacket in the deflection region, the articulation member comprising a plurality of longitudinally-arranged tubular segments, a plurality of first connecting segments, and a plurality of second connecting segments, wherein adjacent tubular segments are joined by respective ones of the first and second connecting segments, and wherein all of the first and second connecting segments are disposed in a first plane extending through the longitudinal axis. A first reinforcing member and a second reinforcing member extend through the plurality of first and second connecting segments, respectively.

Abstract: An urban design pipeline automatically generates design options for an urban design project based on a financial model. The urban design pipeline includes a geometry engine that generates candidate designs to meet various design criteria and design objectives associated with the urban design project. The urban design pipeline also includes an evaluation engine that evaluates the candidate designs based on the financial model. The financial model quantifies the financial performance of any given candidate design. The urban design pipeline operates iteratively to improve the candidate designs until one or more convergence criteria are met, thereby generating a set of design options with acceptable financial performance.

Abstract: Disclosed is a system and method for improving the performance of downhole Distributed Acoustic Sensing (DAS) systems by simultaneous use of co-propagating and counter-propagating Distributed Raman Amplification (DRA). It uses a surface DRA system with a surface DAS system to combine their laser sources where the distal end of the downhole sensing fiber use uses a Wavelength Division Multiplexer (WDM) to optically split the DRA and DAS signals onto two optical fibers. The DAS fiber/signal is terminated with a low reflectance termination to minimize a potential back reflection whereas the DRA fiber is terminated with a high reflectance termination causing all the light to reflect back up the sensing fiber. This arrangement allows for simultaneous co and counter-propagating DRA of the DAS signals, both the transmitted pulse and the back scattered light, thus creating the maximum amount of gain possible.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for predicting biological functions of proteins. In one aspect, a method comprises: obtaining data defining a sequence of amino acids in a protein; processing the data defining the sequence of amino acids in the protein using a neural network, wherein: the neural network is a convolutional neural network comprising one or more dilated convolutional layers; and the neural network is configured to process the data defining the sequence of amino acids in the protein in accordance with trained parameter values of the neural network to generate a neural network output characterizing at least one predicted biological function of the sequence of amino acids in the protein; and identifying the predicted biological function of the sequence of amino acids in the protein using the neural network output.

Abstract: Embodiments provided herein measure metrics of an athletic action and an object associated therewith, and more particularly, to measuring the metrics and characteristics of a baseball during the wind-up, release, flight, and catch of a pitch sequence. Methods may include: receiving, from at least one motion sensor associated with an object, acceleration data and angular velocity data of the object in response to an athletic action performed on the object; processing the acceleration data to establish vector rotation data between a frame of reference of the object and an Earth frame of reference; applying the vector rotation data to the acceleration data to obtain acceleration of the object in the Earth frame of reference; applying the vector rotation data to the angular velocity data to obtain angular velocity of the object in the Earth frame of reference.

Abstract: A treatment system includes a dual lumen catheter system. The first lumen is open to systemic circulation. The second lumen is open to a target delivery location. In an embodiment, a pressure-control element is provided that includes an expanded configuration adapted to constrain delivery through the second lumen to the target delivery location. Methods for treating tissues and organs via vascular pathways are provided.

Abstract: This disclosure relates to technology for embedding machine-readable labels (“MRLs”) into digital media files. Digital media files may be presented on different screen sizes, having different resolutions, different frame refresh rates and other display properties. Each screen may therefore present an MRL differently, potentially negatively impacting scan-ability of the presented MRL. Systems disclosed herein receive a set of design choices for an MRL. The systems may resize pre-existing content in one or more video frames of the media file and create a space within each video frame for displaying the MRL. The systems may render a resultant video file for a target screen size that includes a reliably scannable MRL embedded in the video frame(s).

Abstract: The present disclosure provides systems and methods that perform face reconstruction based on an image of a face. In particular, one example system of the present disclosure combines a machine-learned image recognition model with a face modeler that uses a morphable model of a human's facial appearance. The image recognition model can be a deep learning model that generates an embedding in response to receipt of an image (e.g., an uncontrolled image of a face). The example system can further include a small, lightweight, translation model structurally positioned between the image recognition model and the face modeler. The translation model can be a machine-learned model that is trained to receive the embedding generated by the image recognition model and, in response, output a plurality of facial modeling parameter values usable by the face modeler to generate a model of the face.

Abstract: The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR/Cas system.

Abstract: Methods are described for safely administering to a subject in need thereof an anti-tau antibody that bind to tau, in particular that bind to a phosphorylated epitope on tau. The methods comprise administering a pharmaceutical composition comprising the anti-tau antibody, in which the anti-tau antibody is administered in an amount of about 500 mg to 5000 mg per dose.

Abstract: The invention provides a method and apparatus subjecting an analyte in an ion concentrating chamber to an electric and velocity field to concentrate analyte ions into a smaller space.

Abstract: A design engine includes a geometry module and a metric module that interoperate to generate optimal design options. The geometry module initially generates a spectrum of design options for a structure based on project constraints and design criteria set forth by potential occupants of the structure. The metric module then analyzes each design option and generates, for any given design option, a set of metrics that indicates how well the given design option meets the design criteria. The geometry module then generates additional design options in an evolutionary manner to improve the metrics generated for subsequent design options.

Abstract: A case (2) for a wristwatch (1) including: a middle part (4) including a wall (10) having two attachment areas (12) of the bracelet (24) disposed on either side of a plane (P) transverse to the middle part (4) substantially perpendicular to a back (20) of the case (2); two horns (6) capable of ensuring the complete attachment of the bracelet (24) to the middle part (4) by being connected to different ends of this bracelet (4), said horns (6) being removably and slidably attached to said attachment areas (12), and the back (20) attached to a mounting area (21) of the case (2) participating in blocking the horns (6) in translation in a direction of sliding (D) on the middle part (4) parallel to a central axis (A) of the case (2).