Patents by Inventor David L. Kaplan

David L. Kaplan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10441808
    Abstract: Methods and devices are provided for activating brown adipose tissue (BAT) with light. Generally, the methods and devices can activate BAT to increase thermogenesis, e.g., increase heat production in the patient, which over time can lead to weight loss and/or improved metabolic function. In one embodiment, a medical device is provided that activates BAT by using light to stimulate nerves that activate the BAT and/or to stimulate brown adipocytes directly, thereby increasing thermogenesis in the BAT and inducing weight loss and/or improved metabolic function through energy expenditure. The light can be configured to directly or indirectly stimulate the nerves and/or the brown adipocytes. The light can be configured to indirectly stimulate the nerves and/or the brown adipocytes by activating a light activatable medium administered to a patient and configured to respond to the light to cause activation of the brown adipose tissue.
    Type: Grant
    Filed: December 21, 2011
    Date of Patent: October 15, 2019
    Assignees: Ethicon Endo-Surgery, Inc., The General Hospital Corporation
    Inventors: Jason L. Harris, Lee M. Kaplan, David N. Plescia, Taylor W. Aronhalt, James W. Voegele, Nicholas Stylopoulos
  • Publication number: 20190300860
    Abstract: The present invention provides, among other things, compositions including a plurality of enterocytes, a plurality of fibroblasts, a plurality of Goblet cells, a plurality of Paneth cells, a plurality of enteroendocrine cells, and a silk fibroin scaffold, wherein the composition exhibits one or more of tight junction formation, microvilli polarization, digestive enzyme secretion, and low oxygen tension and methods of making and using the same. In some embodiments, the composition exhibits one or more of tight junction maintenance, maintenance of microvilli polarization, digestive enzyme secretion, and low oxygen tension for at least 10 days.
    Type: Application
    Filed: July 11, 2017
    Publication date: October 3, 2019
    Inventors: David L. Kaplan, Ying Chen, Wenda Zhou, Dana Cairns, Fiorenzo G. Omenetto, Eleana Manousiouthakis
  • Publication number: 20190282731
    Abstract: In some embodiments, the present disclosure provides compositions including silk fibroin and a phenol-containing polymer, wherein at least one tyrosine group of the silk fibroin is covalently crosslinked to at least one phenol group of the phenol-containing polymer. In some embodiments, the present invention also provides methods including the steps of providing silk fibroin, providing a phenol-containing polymer, associating the silk fibroin with the phenol-containing polymer to form a mixed solution, and crosslinking at least one tyrosine group in the silk fibroin and at least one phenol group of the phenol-containing polymer via at least one enzymatic reaction, wherein the crosslinking comprises covalent bonding between at least one tyrosine group of the silk fibroin and at least one phenol group of the phenol-containing polymer to form a crosslinked composition.
    Type: Application
    Filed: November 22, 2017
    Publication date: September 19, 2019
    Inventors: Nicole R. Raia, David L. Kaplan, Benjamin P. Partlow
  • Publication number: 20190255181
    Abstract: The present disclosure relates generally to compositions and methods for production of three-dimensional constructs with high mechanical strength and/or stiffness.
    Type: Application
    Filed: July 17, 2018
    Publication date: August 22, 2019
    Inventors: David L. Kaplan, Fiorenzo Omenetto, Gary G. Leisk, Tim Jia-Ching Lo, Benjamin Partlow, Rosario Friedman
  • Publication number: 20190247803
    Abstract: The present invention provides, inter alia, compositions including at least one pliable layer comprising a plurality of silk fibroin nanofibrils, and at least one rigid layer comprising a plurality of mineral crystals, wherein each rigid layer is associated with at least one pliable layer, as well as methods for the production and use thereof.
    Type: Application
    Filed: October 24, 2017
    Publication date: August 15, 2019
    Inventors: David L. Kaplan, Markus J. Buehler, Shengjie Ling
  • Publication number: 20190239144
    Abstract: Systems and methods are described for a power aggregation system. In one implementation, a method includes charging an electric resource over a power connection to an electric network, obtaining a unique identifier of a device over the power connection, and determining an electric network location of the electric resource from the unique identifier.
    Type: Application
    Filed: August 9, 2018
    Publication date: August 1, 2019
    Inventors: Seth W. BRIDGES, Seth B. POLLACK, David L. KAPLAN
  • Patent number: 10335519
    Abstract: Provided herein relates to implantable devices and systems with dynamic silk coatings. In some embodiments, the dynamic silk coatings can be formed in situ or in vivo.
    Type: Grant
    Filed: April 20, 2012
    Date of Patent: July 2, 2019
    Assignee: TRUSTEES OF TUFTS COLLEGE
    Inventors: David L. Kaplan, Lee W. Tien, Gary G. Leisk, Tim Jia-Ching Lo, Cinzia Metallo, Fiorenzo Omenetto
  • Publication number: 20190177560
    Abstract: The present application discloses biopolymer-based ink formulations that are useful for inkjet printing and other applications. Related methods are also disclosed.
    Type: Application
    Filed: July 6, 2018
    Publication date: June 13, 2019
    Inventors: Fiorenzo G. Omenetto, David L. Kaplan, Hu Tao, Benedetto Marelli, Miaomiao Yang
  • Publication number: 20190175785
    Abstract: The present invention provides for silk fibroin-based compositions comprising one or more antibiotic agents for prevention or treatment of microbial contamination, methods of making antibiotic-containing silk scaffold, methods of stabilizing antibiotics in silk scaffolds, and methods for preventing or treating microbial contamination using the antibiotic-containing compositions. Various methods may be used to embed the antibiotic(s) into the silk fibroin-based compositions. The antibiotic-containing compositions of the invention are particular useful for stabilizing antibiotics, preventing bacterial infections, and for medical implants, tissue engineering, drug delivery systems, or other pharmaceutical or medical applications.
    Type: Application
    Filed: July 12, 2018
    Publication date: June 13, 2019
    Inventors: David L. Kaplan, Bruce Panilaitis, Eleanor M. Pritchard, Fiorenzo G. Omenetto
  • Patent number: 10314938
    Abstract: The present invention provides for concentrated aqueous silk fibroin solutions and an all-aqueous mode for preparation of concentrated aqueous fibroin solutions that avoids the use of organic solvents, direct additives, or harsh chemicals. The invention further provides for the use of these solutions in production of materials, e.g., fibers, films, foams, meshes, scaffolds and hydrogels.
    Type: Grant
    Filed: February 16, 2017
    Date of Patent: June 11, 2019
    Assignee: TRUSTEES OF TUFTS COLLEGE
    Inventors: David L. Kaplan, Ung-Jin Kim, Jaehyung Park, Hyoung-Joon Jin
  • Patent number: 10285702
    Abstract: A bioresorbable drug-eluting biopolymer suture-free blood vessel anastomosis devices can be deployed to join two blood vessels and resorbed by the body over a predetermined time period after the blood vessel has become joined. The anastomosis device can include a hollow tube that is inserted interconnect the two vessels to be jointed. A non-piercing suture is wrapped around the vessel to secure the anastomosis. The anastomosis device can include hollow tube that extends along an axis from a first end to a second end. The ends can be fitted with elements that facilitate mechanical attachment of the vessel to the anastomosis device and provide for a secure seal.
    Type: Grant
    Filed: April 24, 2014
    Date of Patent: May 14, 2019
    Assignees: Trustees of Tufts College, Beth Israel Deaconess Medical Center, Inc.
    Inventors: Rodrigo R. Jose, Waseem K. Raja, David L. Kaplan, Ahmed Ibrahim, Samuel Lin, Abdurrahman Abdurrob
  • Publication number: 20190133752
    Abstract: In some embodiments, the present invention provides tissue compositions including a first silk scaffold comprising a plurality of epithelial cells, a second silk scaffold comprising a plurality of stromal cells, and a plurality of neurons. In some embodiments, provided compositions can function as physiologically relevant corneal model systems for, inter alia, testing of therapeutics for corneal disease and/or injury and production of functional corneal tissue (e.g., for transplant, etc). The present invention also provides methods for making and using provided compositions.
    Type: Application
    Filed: April 27, 2017
    Publication date: May 9, 2019
    Inventors: David L. Kaplan, Siran Wang, Rachel Gomes, Chiara Ghezzi, Dana Cairns
  • Patent number: 10279698
    Abstract: Systems and methods are described for a power aggregation system. In one implementation, a method includes establishing a communication connection with each of multiple electric resources connected to a power grid, receiving an energy generation signal from a power grid operator, and controlling a number of the electric resources being charged by the power grid as a function of the energy generation signal.
    Type: Grant
    Filed: August 11, 2016
    Date of Patent: May 7, 2019
    Assignee: V2Green, Inc.
    Inventors: Seth W. Bridges, Seth B. Pollack, David L. Kaplan
  • Patent number: 10280204
    Abstract: A method of manufacturing a biopolymer optical device includes providing a polymer, providing a substrate, casting the polymer on the substrate, and enzymatically polymerizing an organic compound to generate a conducting polymer between the provided polymer and the substrate. The polymer may be a biopolymer such as silk and may be modified using organic compounds such as tyrosines to provide a molecular-level interface between the provided bulk biopolymer of the biopolymer optical device and a substrate or other conducting layer via a tyrosine-enzyme polymerization. The enzymatically polymerizing may include catalyzing the organic compound with peroxidase enzyme reactions. The result is a carbon-carbon conjugated backbone that provides polymeric “wires” for use in polymer and biopolymer optical devices. An all organic biopolymer electroactive material is thereby provided that provides optical functions and features.
    Type: Grant
    Filed: February 18, 2016
    Date of Patent: May 7, 2019
    Assignee: Tufts University
    Inventors: David L. Kaplan, Fiorenzo Omenetto, Brian Lawrence, Mark Cronin-Golomb
  • Publication number: 20190105488
    Abstract: The present disclosure relates to programmable hydrogel ionic circuits having properties that are advantageous for use in biological systems. In particular, provided herein are programmable hydrogel ionic circuit that exhibit transparency, stretchability, aqueous-based connective interfaces, high-resolution routing of ionic currents between engineered and biological systems, and reduced tissue damage from electrochemical reactions. As described herein, the programmable hydrogel ionic circuits are produced using a combination of microfluidics and aqueous two-phase systems.
    Type: Application
    Filed: October 6, 2018
    Publication date: April 11, 2019
    Inventors: Siwei Zhao, Peter Tseng, Jonathan Grasman, Yu Wang, Fiorenzo G. Omenetto, David L. Kaplan
  • Publication number: 20190085140
    Abstract: Protein-protein imprinting of silk fibroin is introduced as a rapid, high-fidelity, and/or high-throughput method for the fabrication of nanoscale structures in silk films, through controlled manipulation of heat and/or pressure. High resolution imprinting on conformal surfaces is also demonstrated.
    Type: Application
    Filed: February 26, 2018
    Publication date: March 21, 2019
    Inventors: Fiorenzo G. Omenetto, David L. Kaplan, Mark A. Brenckle
  • Publication number: 20190046647
    Abstract: Methods, compositions, devices and kits for increasing mechanical stiffness of an incompetent or a dilated biological tissue in a subject are provided herein. The methods described herein involve placing (e.g., injecting) a silk fibroin-based composition into at least a portion of an incompetent or dilated tissue of a subject. In some embodiments, the silk fibroin-based composition can further comprise at least two PEG components that will crosslink together upon placement (e.g., injection) into a subject in need thereof. In specific embodiments, the methods, compositions, devices and kits can be used to increase mechanical stiffness of a cervical tissue in a subject, for example, for treatment of cervical insufficiency.
    Type: Application
    Filed: March 7, 2018
    Publication date: February 14, 2019
    Inventors: Michael House, David L. Kaplan, Errol Norwitz, Simona Socrate
  • Publication number: 20190008923
    Abstract: The present invention provides processes for producing porous silk fibroin scaffold material. The porous silk fibroin scaffold can be used for tissue engineering. The porosity of the silk fibroin scaffolds described herein can be adjusted as to mimic the gradient of densities found in natural tissue. Accordingly, methods for engineering of 3-dimensional tissue, e.g. bone and cartilage, using the silk fibroin scaffold material are also provided.
    Type: Application
    Filed: May 17, 2018
    Publication date: January 10, 2019
    Inventors: David L. Kaplan, Rina Sears, Gordana Vunjak-Novakovic, Lorenz Meinel
  • Publication number: 20190001272
    Abstract: The present disclosure provides, among other things, systems for processing silk. Provided systems purify silk fibroin solutions without inducing conformational changes in the silk proteins. Provided systems concentrate silk fibroin solutions. The present disclosure also provides methods of purifying and concentrating silk fibroin solutions. Provided systems and methods are useful for processing silk fibroin for any application.
    Type: Application
    Filed: December 16, 2016
    Publication date: January 3, 2019
    Inventors: Gary G. Leisk, David L. Kaplan, Benjamin P. Partlow, Tim Jia-Ching Lo
  • Publication number: 20180360947
    Abstract: Provided herein are methods and compositions for stabilization of active agents. The active agents are distributed, mixed or embedded in a silk fibroin matrix, thereby retaining the bioactivity of the active agents upon storage and/or transportation. In some embodiments, the storage-stable vaccine-silk compositions are also provided herein.
    Type: Application
    Filed: December 29, 2017
    Publication date: December 20, 2018
    Inventors: David L. Kaplan, Fiorenzo G. Omenetto