Patents by Inventor David L. Kaplan

David L. Kaplan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200306415
    Abstract: The present invention provides, in some embodiments, multi-layer silk compositions including a first layer comprising silk fibroin and keratinocytes, a second layer comprising silk fibroin and fibroblasts, a third layer comprising silk fibroin and adipocytes, and a plurality of nervous system cells, wherein at least some of the plurality of nervous system cells span at least two layers, and methods of making and using the same. In some embodiments, provided methods and compositions further include immune cells and/or endothelial cells.
    Type: Application
    Filed: June 30, 2017
    Publication date: October 1, 2020
    Inventors: David L. Kaplan, Sarah Lightfoot Vidal, Rosalyn Abbot, Siwei Zhao, Dana Cairns, Fiorenzo G. Omenetto
  • Publication number: 20200282106
    Abstract: The present invention provides for concentrated aqueous silk fibroin solutions and an all-aqueous mode for preparation of concentrated aqueous fibroin solutions that avoids the use of organic solvents, direct additives, or harsh chemicals. The invention further provides for the use of these solutions in production of materials, e.g., fibers, films, foams, meshes, scaffolds and hydrogels.
    Type: Application
    Filed: May 8, 2019
    Publication date: September 10, 2020
    Inventors: David L. Kaplan, Ung-Jin Kim, Jaehyung Park, Hyoung-Joon Jin
  • Patent number: 10758645
    Abstract: The present invention provides, among other things, a silk ceramic material having enzymatically cross-linked amino acid side chains to generate injectable and flexible foam ceramics. Provided are compositions and methods of producing soft, flexible ceramic foam with silk polymeric crosslinking to serve as binders. Materials have applications in osteochondral and dental replacement and repair.
    Type: Grant
    Filed: December 17, 2015
    Date of Patent: September 1, 2020
    Assignee: Tufts University
    Inventors: Stephanie L. McNamara, Benjamin P. Partlow, David L. Kaplan
  • Publication number: 20200254245
    Abstract: An implantable neurostimulation system comprises a stimulation delivery lead and a neurostimulator. The stimulation delivery lead is coupled to an electrode. The neurostimulator is adapted to deliver a neurostimulation signal to the subject and comprises a microprocessor. The microprocessor is programmed to identify a stimulation operating window for the therapy including a first threshold and a second threshold. The second threshold comprises an awake level and an asleep level. Identifying the stimulation operating window comprises titrating a stimulation setting of the neurostimulator while the subject is awake until the first threshold and the awake level of the second threshold are identified. Identifying the stimulation operating window further comprises subsequently repeating the step of titrating the stimulation setting of the neurostimulator while the subject is asleep until the asleep level of the second threshold is identified.
    Type: Application
    Filed: April 24, 2020
    Publication date: August 13, 2020
    Applicant: LivaNova USA, Inc.
    Inventors: Stephen L. Bolea, Thomas B. Hoegh, Brian D. Kuhnley, Dale G. Suilmann, Bruce J. Persson, John P. Beck, Sidney Hauschild, Paula M. Kaplan, Adam K. Hoyhtya, Wondimeneh Tesfayesus, Robert E. Atkinson, Peter R. Eastwood, David R. Hillman
  • Patent number: 10736943
    Abstract: A method was developed to prepare silk fibroin microspheres using lipid vesicles as templates to efficiently load therapeutic agents in active form for controlled release. The lipids are subsequently removed through the use of a dehydration agent, such as methanol or sodium chloride, resulting in ?-sheet structure dominant silk microsphere structures having about 2 ?m in diameter. The therapeutic agent can be entrapped in the silk microspheres and used in pharmaceutical formulations for controlled-release treatments.
    Type: Grant
    Filed: May 7, 2013
    Date of Patent: August 11, 2020
    Assignee: Trustees of Tufts College
    Inventors: David L. Kaplan, Xiaoqin Wang
  • Publication number: 20200246167
    Abstract: A bioresorbable biopolymer stents can be deployed within a blood vessel and resorbed by the body over a predetermined time period after the blood vessel has been remodeled. A ratcheting biopolymer stent can include a ratcheting mechanism that allows the biopolymer stent to be deployed on a small diameter configuration and then expanded to a predefined larger diameter configuration wherein after expansion, the ratcheting mechanism locks the biopolymer stent in the expanded configuration. A folding biopolymer stent can be deployed in a folded, small diameter configuration and then expanded to an unfolded configuration having a larger diameter. The bioresorbable biopolymer can include silk fibroin and blend that include silk fibroin materials.
    Type: Application
    Filed: August 19, 2019
    Publication date: August 6, 2020
    Inventors: Rodrigo R. Jose, David L. Kaplan, Mark Iafrati, Eun Seok Gil, Gary G. Leisk
  • Patent number: 10731046
    Abstract: The present application discloses biopolymer-based ink formulations that are useful for inkjet printing and other applications. Related methods are also disclosed.
    Type: Grant
    Filed: July 6, 2018
    Date of Patent: August 4, 2020
    Assignee: Tufts University
    Inventors: Fiorenzo G. Omenetto, David L. Kaplan, Hu Tao, Benedetto Marelli, Miaomiao Yang
  • Patent number: 10699333
    Abstract: A method and computer program product is provided for an online bidding system. The method may include receiving a plurality of bids from a plurality of online bidding communities during a live auction event at one of a primary technology provider and a relying technology provider, wherein the live auction event simultaneously occurs on a physical auction floor and virtually. The method may also include processing the plurality of bids at the primary technology provider. The method may further include providing the processed plurality of bids to a single designated clerking console associated with the primary technology provider for the live auction event. The method may also include receiving an accepted bid from the single designated clerking console.
    Type: Grant
    Filed: June 1, 2018
    Date of Patent: June 30, 2020
    Assignee: Invaluable, LLC
    Inventors: David J. Charles, Michael L. Kaplan, Michael A. Greenstein, Elizabeth Beiriger
  • Publication number: 20200181213
    Abstract: The present invention, in some aspects, provides compositions including a solution comprising a plurality of exfoliated silk microfibrils and/or exfoliated silk nanofibrils, wherein the micro- or nano-fibrils are characterized as having a substantially nematic structure, as well as methods for making and using the same.
    Type: Application
    Filed: March 31, 2017
    Publication date: June 11, 2020
    Inventors: Markus J. Buehler, David L. Kaplan, Shengjie Ling, Kai Jin
  • Publication number: 20200165306
    Abstract: The present application relates to silk fibroin-based hydrogels, methods for making and using the same.
    Type: Application
    Filed: August 7, 2019
    Publication date: May 28, 2020
    Inventors: Fiorenzo G. Omenetto, David L. Kaplan, Benedetto Marelli, Alexander Nicholas Mitropolous
  • Patent number: 10662409
    Abstract: In some embodiments, the present invention provides methods including the steps of providing one or more human somatic cells, causing transient increased expression of OCT4, KLF4, SOX2, and cMYC in the somatic cells forming modified somatic cells, providing a plurality of inactivated embryonic fibroblasts, associating the modified somatic cells with the inactivated embryonic fibroblasts in a culture media comprising 20% KO DMEM xeno-free serum replacement and at least 15 ng/ml recombinant bFGF to form human induced neural stem cells.
    Type: Grant
    Filed: September 9, 2016
    Date of Patent: May 26, 2020
    Assignee: Trustees of Tufts College
    Inventors: Dana Cairns, David L. Kaplan
  • Patent number: 10653786
    Abstract: Provided herein relates to compositions and methods for lubrication of a surface. The surface amenable to the compositions and methods described herein can be a non-biological surface, a biological surface, or a combination thereof. In some embodiments, the composition comprising a phospholipid-coated silk microsphere can be used for lubrication of a surface. In some embodiments, the composition comprising a phospholipid-coated silk microsphere can be used for joint lubrication, e.g., for treatment of joint disorders such as arthritis.
    Type: Grant
    Filed: April 25, 2013
    Date of Patent: May 19, 2020
    Assignees: TRUSTEES OF TUFTS COLLEGE, Tulane Educational Fund
    Inventors: David L. Kaplan, Xiaoqin Wang, Vijay John, Noshir Pesika, Rubo Zheng
  • Patent number: 10632306
    Abstract: Devices, systems and methods of neurostimulation for treating obstructive sleep apnea.
    Type: Grant
    Filed: August 25, 2017
    Date of Patent: April 28, 2020
    Assignee: LivaNova USA, Inc.
    Inventors: Stephen L. Bolea, Thomas B. Hoegh, Brian D. Kuhnley, Dale G. Suilmann, Bruce J. Persson, John P. Beck, Sidney Hauschild, Paula M. Kaplan, Adam K. Hoyhtya, Wondimeneh Tesfayesus, Robert E. Atkinson, Peter R. Eastwood, David R. Hillman
  • Publication number: 20200108183
    Abstract: Provided herein relates to implantable devices and systems with dynamic silk coatings. In some embodiments, the dynamic silk coatings can be formed in situ or in vivo.
    Type: Application
    Filed: May 9, 2019
    Publication date: April 9, 2020
    Inventors: David L. Kaplan, Lee W. Tien, Gary G. Leisk, Tim Jia-Ching Lo, Cinzia Metallo, Fiorenzo Omenetto
  • Patent number: 10583090
    Abstract: The present invention provided for a novel process of forming silk fibroin gels, and controlling the rate of ?-sheet formation and resulting hydrogelation kinetics, by vortex treatment of silk fibroin solution. In addition, the vortex treatment of the present invention provides a silk fibroin gel that may be reversibly shear-thinned, enabling the use of these approach for precise control of silk self-assembly, both spatially and temporally. Active agents, including biological materials, viable cells or therapeutic agents, can be encapsulated in the hydrogels formed from the processes, and be used as delivery vehicles. Hence, the present invention provide for methods for silk fibroin gelation that are useful for biotechnological applications such as encapsulation and delivery of active agents, cells, and bioactive molecules.
    Type: Grant
    Filed: February 12, 2016
    Date of Patent: March 10, 2020
    Assignee: Trustees of Tufts College
    Inventors: David L. Kaplan, Tuna Yucel
  • Publication number: 20200069845
    Abstract: The present disclosure provides transparent, elastic silk hydrogels for applications, including corneal reshaping to restore visual acuity and photolithography. The present disclosure also provides methods of photocrosslinking silk fibroin protein using riboflavin as a photoinitiator and exposing such riboflavin doped silk fibroin to light resulting in the formation of a transparent, elastic hydrogel.
    Type: Application
    Filed: December 16, 2016
    Publication date: March 5, 2020
    Inventors: Fiorenzo G. Omenetto, Matthew B. Applegate, David L. Kaplan
  • Publication number: 20200054792
    Abstract: The present application relates to amphiphilic polypeptide materials, methods for making and using the same. Provided amphiphilic polypeptide materials are water-based and manufactured using all aqueous processing. Provided materials exhibit a capacity to encapsulate and store biologically active molecules or macromolecules. Such biologically active molecules or macromolecules retain their structure and the biological activity so that these biologically active molecules or macromolecules are not materially degraded, reduced, and/or inhibited by processing steps or exposure. Provided materials possess unique mechanical and structural properties, including size, density, moldability and machinability.
    Type: Application
    Filed: July 28, 2016
    Publication date: February 20, 2020
    Inventors: Fiorenzo G. Omenetto, David L. Kaplan, Benedetto Marelli, Chunmei Li
  • Publication number: 20200055418
    Abstract: Systems and methods are described for a power aggregation system. In one implementation, a method includes establishing a communication connection with each of multiple electric resources connected to a power grid, receiving an energy generation signal from a power grid operator, and controlling a number of the electric resources being charged by the power grid as a function of the energy generation signal.
    Type: Application
    Filed: March 26, 2019
    Publication date: February 20, 2020
    Inventors: Seth W. BRIDGES, Seth B. POLLACK, David L. KAPLAN
  • Publication number: 20200054796
    Abstract: Bioresorbable silk fibroin tracheal stents can be designed and engineered to maintain a tracheal opening. A tracheal stent will maintain a tracheal opening for a period while tissue structure and function is restored. Bioresorbable silk fibroin tracheal stents programmably degrade without negative biological or clinical outcomes. Bioresorbable silk fibroin tracheal stents do not need to be removed following tracheal restoration. Bioresorbable biopolymer tracheal stents can be internally or externally deployed. Bioresorbable biopolymer tracheal stents, for example can be internally or externally deployed in a patient. Such stents may be affixed to function as a splint with tunable mechanically properties to treat, for example, a patient with severe airway collapse.
    Type: Application
    Filed: February 21, 2018
    Publication date: February 20, 2020
    Inventors: David L. Kaplan, Michael Whalen, Christopher Hartnick, Meghan McGill
  • Patent number: 10562024
    Abstract: The present disclosure relates to paper-based substrates and apparatus comprising such substrates. The apparatus may include a patterned conductive structure coupled to the paper-based substrate, wherein the patterned conductive structure responds to electromagnetic radiation.
    Type: Grant
    Filed: January 4, 2012
    Date of Patent: February 18, 2020
    Assignee: Tufts University
    Inventors: Fiorenzo Omenetto, David L. Kaplan, Hu Tao