Patents by Inventor David L. Kaplan

David L. Kaplan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9599891
    Abstract: A method of manufacturing a nanopatterned biophotonic structure includes forming a customized nanopattern mask on a substrate using E-beam lithography, providing a biopolymer matrix solution, depositing the biopolymer matrix solution on the substrate, and drying the biopolymer matrix solution to form a solidified biopolymer film. A surface of the film is formed with the nanopattern mask, or a nanopattern is machined directly on a surface of the film using E-beam lithograpy such that the biopolymer film exhibits a spectral signature corresponding to the E-beam lithograpy nanopattern. The resulting bio-compatible nanopatterned biophotonic structures may be made from silk, may be biodegradable, and may be bio-sensing devices. The biophotonic structures may employ nanopatterned masks based on non-periodic photonic lattices, and the biophotonic structures may be designed with specific spectral signatures for use in probing biological substances, including displaying optical activity in the form of opalescence.
    Type: Grant
    Filed: November 5, 2008
    Date of Patent: March 21, 2017
    Assignees: TRUSTEES OF TUFTS COLLEGE, TRUSTEES OF BOSTON UNIVERSITY
    Inventors: David L. Kaplan, Fiorenzo G. Omenetto, Luca Dal Negro
  • Patent number: 9585830
    Abstract: A formulation for a stable ascorbic acid composition which, in a simplified form, is comprised of ascorbic acid in solution with a hygroscopic compound (i.e., a substance with the ability to attract water molecules from the surrounding environment through either absorption or adsorption). Also disclosed herein are methods for the production of such compounds and methods of using such compounds in the prevention, inhibition and treatment of striae gravidarum, radiation dermatitis, rhytids, lentigoes, dyschromia, sun-damage induced hyperpigmentation, cellulite, scars and purpura, among other skin diseases or conditions.
    Type: Grant
    Filed: January 10, 2013
    Date of Patent: March 7, 2017
    Inventor: David L. Kaplan
  • Patent number: 9579274
    Abstract: A formulation for a stable ascorbic acid composition which, in a simplified form, is comprised of ascorbic acid in solution with a hygroscopic compound (i.e., a substance with the ability to attract water molecules from the surrounding environment through either absorption or adsorption). Also disclosed herein are methods for the production of such compounds and methods of using such compounds in the prevention, inhibition and treatment of striae gravidarum, radiation dermatitis, rhytids, lentigoes, dyschromia, sun-damage induced hyperpigmentation, cellulite, scars and purpura, among other skin diseases or conditions.
    Type: Grant
    Filed: January 10, 2013
    Date of Patent: February 28, 2017
    Inventor: David L. Kaplan
  • Patent number: 9566365
    Abstract: This invention relates to methods and compositions for preparation of silk-PEGs based biomaterials through crosslinking by chemically reacting active polyethylene glycols (PEGs) possessing different chemical groups (e.g., thiols and maleimides functionalized PEGs) that are additionally stabilized by the beta-sheet formation of silk fibroin. The crosslinked silk-PEGs biomaterials present strong adhesive properties, which are comparable to or better than the current leading PEG-based sealant, depending on the silk concentration in the silk-PEGs biomaterials. In addition, the silk-PEGs based biomaterials are cytocompatible, show decreased swelling behavior and longer degradation times, which make them suitable for hemostatic applications where the current available tissue sealant products can be contraindicated.
    Type: Grant
    Filed: September 1, 2011
    Date of Patent: February 14, 2017
    Assignee: Trustees of Tufts College
    Inventors: David L. Kaplan, Monica A. Serban
  • Publication number: 20170027879
    Abstract: The inventions provided herein relate to silk-based scaffolds and methods of producing the same, which can be used for a range of tissue engineering applications. The fabrication methods described herein provide a versatile platform to incorporate hollow conduits (e.g., for nutrient/oxygen delivery) through three-dimensional silk-based scaffolds that have tunable bulk properties (e.g., but not limited to, porosity, mechanical, degradation rate) and allow endothelialization and/or cell compartmentalization, for engineering a variety of complex tissue equivalents.
    Type: Application
    Filed: February 29, 2016
    Publication date: February 2, 2017
    Inventors: Lindsay Wray, Jelena Rnjak-Kovacina, David L. Kaplan
  • Patent number: 9554989
    Abstract: The present invention is directed to silk-based drug delivery compositions for controlled, sustained delivery of therapeutic agent(s) as well as methods of making and using the same.
    Type: Grant
    Filed: March 11, 2013
    Date of Patent: January 31, 2017
    Assignee: Trustees of Tufts College
    Inventors: David L. Kaplan, Tuna Yucel, Michael L. Lovett, Xiaoqin Wang
  • Publication number: 20170007738
    Abstract: The inventions provided herein relate to compositions, methods, delivery devices and kits for repairing or augmenting a tissue in a subject. The compositions described herein can be injectable such that they can be placed in a tissue to be treated with a minimally-invasive procedure (e.g., by injection). In some embodiments, the composition described herein comprises a compressed silk fibroin matrix, which can expand upon injection into the tissue and retain its original expanded volume within the tissue for a period of time. The compositions can be used as a filler to replace a tissue void, e.g., for tissue repair and/or augmentation, or as a scaffold to support tissue regeneration and/or reconstruction. In some embodiments, the compositions described herein can be used for soft tissue repair or augmentation.
    Type: Application
    Filed: September 22, 2016
    Publication date: January 12, 2017
    Inventors: Gary G. Leisk, Tim Jia-Ching Lo, Lei Li, Evangelia Bellas, David L. Kaplan
  • Patent number: 9539362
    Abstract: The present invention is directed to a method for forming an inorganic coating on a protein template. The method comprises contacting the template with an anionic polymer interface followed by an inorganic material for a sufficient period of time to allow mineralization of the inorganic material thus forming an inorganic coating on the template. Preferably, the coating is aligned.
    Type: Grant
    Filed: April 19, 2010
    Date of Patent: January 10, 2017
    Assignee: Trustees of Tufts College
    Inventors: David L. Kaplan, Chunmei Li
  • Patent number: 9537318
    Abstract: An energy storage system includes modular energy storage equipment that may be connected to an external system, such as a power grid. In at least one embodiment, the energy storage system includes a power transfer control system comprising a power transfer network and a processing module or controller. The power transfer network has a first interface coupleable to one or more energy storage units and a second interface coupleable to one or more power conversion units. One or more conductors in the power transfer network are selectively coupleable to the first interface and the second interface for transferring power between the energy storage units and the power conversion units based at least in part on information indicating a power or energy supply or demand of an external system or information indicating an amount of energy stored in the energy storage units. The energy storage system is scalable for different implementations.
    Type: Grant
    Filed: November 2, 2012
    Date of Patent: January 3, 2017
    Assignee: Doosan GridTech, Inc.
    Inventors: David L. Kaplan, Joshua I. Kaplan, Gregory P. Darlington
  • Publication number: 20160376331
    Abstract: A method of manufacturing a biopolymer optical device includes providing a polymer, providing a substrate, casting the polymer on the substrate, and enzymatically polymerizing an organic compound to generate a conducting polymer between the provided polymer and the substrate. The polymer may be a biopolymer such as silk and may be modified using organic compounds such as tyrosines to provide a molecular-level interface between the provided bulk biopolymer of the biopolymer optical device and a substrate or other conducting layer via a tyrosine-enzyme polymerization. The enzymatically polymerizing may include catalyzing the organic compound with peroxidase enzyme reactions. The result is a carbon-carbon conjugated backbone that provides polymeric “wires” for use in polymer and biopolymer optical devices. An all organic biopolymer electroactive material is thereby provided that provides optical functions and features.
    Type: Application
    Filed: February 18, 2016
    Publication date: December 29, 2016
    Inventors: David L. KAPLAN, Fiorenzo OMENETTO, Brian LAWRENCE, Mark CRONIN-GOLOMB
  • Patent number: 9517357
    Abstract: Provided herein are silk fibroin-based photothermal elements and uses thereof. The silk fibroin-based photothermal elements comprise a plurality of plasmonic nanoparticle distributed in a silk fibroin matrix, and can generate heat when the plasmonic nanoparticles are exposed to electromagnetic radiation. The silk fibroin-based photothermal elements can be adapted to be conformable and biodegradable, and can further be integrated with various electronic components, such as a thermo-electric device for conversion of heat into electricity. The invention is useful for various in vivo applications, such as photothermal therapy, controlled drug-delivery devices or wireless powering of implanted micro-devices.
    Type: Grant
    Filed: September 3, 2011
    Date of Patent: December 13, 2016
    Assignee: TUFTS UNIVERSITY
    Inventors: Fiorenzo Omenetto, David L. Kaplan, Hu Tao
  • Patent number: 9513405
    Abstract: A method of manufacturing a biopolymer photonic crystal includes providing a biopolymer, processing the biopolymer to yield a biopolymer matrix solution, providing a substrate, casting the matrix solution on the substrate, and drying the biopolymer matrix solution to form a solidified biopolymer film. A surface of the film is formed with a nanopattern, or a nanopattern is machined on a surface of the film. In another embodiment, a plurality of biopolymer films is stacked together. A photonic crystal is also provided that is made of a biopolymer and has a nanopatterned surface. In another embodiment, the photonic crystal includes a plurality of nanopatterned films that are stacked together.
    Type: Grant
    Filed: October 28, 2013
    Date of Patent: December 6, 2016
    Assignee: TUFTS UNIVERSITY
    Inventors: David L. Kaplan, Fiorenzo Omenetto, Brian Lawrence, Mark Cronin-Golomb
  • Publication number: 20160347195
    Abstract: Systems and methods are described for a power aggregation system. In one implementation, a method includes establishing a communication connection with each of multiple electric resources connected to a power grid, receiving an energy generation signal from a power grid operator, and controlling a number of the electric resources being charged by the power grid as a function of the energy generation signal.
    Type: Application
    Filed: August 11, 2016
    Publication date: December 1, 2016
    Applicant: V2Green, Inc.
    Inventors: Seth W. Bridges, Seth B. Pollack, David L. Kaplan
  • Patent number: 9504575
    Abstract: Described herein are methods and compositions comprising a mixture of silk polymer and hydroxyapatite. The methods described herein can be used to prepare a mixture of silk polymer and hydroxyapatite and further provide mixtures that can be molded into a desired shape. Also encompassed herein are compositions comprising a mixture of silk polymer and hydroxyapatite having a desired shape, which can further be implanted, for example, to facilitate bone healing or tooth structure or support. Such compositions can also include agents, such as therapeutic agents, or cells.
    Type: Grant
    Filed: February 6, 2009
    Date of Patent: November 29, 2016
    Assignee: Trustees of Tufts College
    Inventors: David L. Kaplan, Hyeon Joo Kim, Gerard Kugel
  • Patent number: 9492504
    Abstract: The inventions provided herein relate to compositions, methods, delivery devices and kits for repairing or augmenting a tissue in a subject. The compositions described herein can be injectable such that they can be placed in a tissue to be treated with a minimally-invasive procedure (e.g., by injection). In some embodiments, the composition described herein comprises a compressed silk fibroin matrix, which can expand upon injection into the tissue and retain its original expanded volume within the tissue for a period of time. The compositions can be used as a filler to replace a tissue void, e.g., for tissue repair and/or augmentation, or as a scaffold to support tissue regeneration and/or reconstruction. In some embodiments, the compositions described herein can be used for soft tissue repair or augmentation.
    Type: Grant
    Filed: November 9, 2012
    Date of Patent: November 15, 2016
    Assignee: Trustees of Tufts College
    Inventors: Gary G. Leisk, Tim Jia-Ching Lo, Lei Li, Evangelia Bellas, David L. Kaplan
  • Publication number: 20160279299
    Abstract: The present invention is directed to systems and/or biopolymer devices and methods of using the same. The systems and/or biopolymer devices described herein can be used for delivery of a fluid and/or molecules such as therapeutic agent(s), and/or for recruitment or collection of body fluids, e.g., for medical diagnosis. Methods of making and using the systems and/or biopolymer devices are also provided herein. In some embodiments, the systems and/or biopolymer devices can be used for continuous delivery of a therapeutic agent to repair or regenerate a tissue in a subject. In some embodiments, the biopolymer devices can be adapted for use as a catheter for fluid delivery to a target site.
    Type: Application
    Filed: November 21, 2014
    Publication date: September 29, 2016
    Inventors: David L. Kaplan, Eun Seok Gil, J. Peter Rubin, Jolene E. Valentin
  • Publication number: 20160263046
    Abstract: The present invention provided for a novel process of forming silk fibroin gels, and controlling the rate of ?-sheet formation and resulting hydrogelation kinetics, by vortex treatment of silk fibroin solution. In addition, the vortex treatment of the present invention provides a silk fibroin gel that may be reversibly shear-thinned, enabling the use of these approach for precise control of silk self-assembly, both spatially and temporally. Active agents, including biological materials, viable cells or therapeutic agents, can be encapsulated in the hydrogels formed from the processes, and be used as delivery vehicles. Hence, the present invention provide for methods for silk fibroin gelation that are useful for biotechnological applications such as encapsulation and delivery of active agents, cells, and bioactive molecules.
    Type: Application
    Filed: February 12, 2016
    Publication date: September 15, 2016
    Inventors: David L. Kaplan, Tuna Yucel
  • Publication number: 20160263228
    Abstract: The present disclosure provides certain silk-fibroin compositions with particular characteristics and/or properties. In some embodiments, the disclosure provides low molecular weight compositions. In some embodiments, the disclosure provides silk fibroin compositions that comprise an active (e.g., a biological) agent or component. In some embodiments, the disclosure provides low molecular weight silk fibroin compositions that comprise an active (e.g., a biological) agent or component. In some embodiments, an active agent is stabilized in a silk composition, e.g., for a period of time and/or against certain conditions or events. In some embodiments, a component present in a silk fibroin composition may be subject to analysis and/or characterization. In some embodiments, a component present in a silk fibroin composition may be recovered from the composition.
    Type: Application
    Filed: March 11, 2016
    Publication date: September 15, 2016
    Inventors: Jonathan A. Kluge, Fiorenzo G. Omenetto, David L. Kaplan
  • Publication number: 20160256604
    Abstract: The present invention provides, among other things, a elastomeric biomaterial having enzymatically cross-linked amino acid phenolic side chains to generate highly elastic hydrogels. Materials are characterized by tunable mechanical properties, gelation kinetics and swelling properties of these new protein polymers. Provided materials are support encapsulation of cells. Methods of making and using of provided particles are also disclosed.
    Type: Application
    Filed: October 6, 2014
    Publication date: September 8, 2016
    Inventors: Craig W. Hanna, Benjamin P. Partlow, David L. Kaplan
  • Patent number: 9436948
    Abstract: Systems and methods are described for a power aggregation system. In one implementation, a method includes establishing a communication connection with each of multiple electric resources connected to a power grid, receiving an energy generation signal from a power grid operator, and controlling a number of the electric resources being charged by the power grid as a function of the energy generation signal.
    Type: Grant
    Filed: August 18, 2014
    Date of Patent: September 6, 2016
    Assignee: V2Green, Inc.
    Inventors: Seth W. Bridges, Seth B. Pollack, David L. Kaplan