Patents by Inventor David L. Kaplan

David L. Kaplan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9936574
    Abstract: Described herein are flexible and stretchable LED arrays and methods utilizing flexible and stretchable LED arrays. Assembly of flexible LED arrays alongside flexible plasmonic crystals is useful for construction of fluid monitors, permitting sensitive detection of fluid refractive index and composition. Co-integration of flexible LED arrays with flexible photodetector arrays is useful for construction of flexible proximity sensors. Application of stretchable LED arrays onto flexible threads as light emitting sutures provides novel means for performing radiation therapy on wounds.
    Type: Grant
    Filed: March 11, 2011
    Date of Patent: April 3, 2018
    Assignees: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, TRUSTEES OF TUFTS COLLEGE
    Inventors: John A. Rogers, Rak-Hwan Kim, Dae-Hyeong Kim, David L. Kaplan, Fiorenzo G. Omenetto
  • Patent number: 9925299
    Abstract: The disclosure provides ceramic materials comprising calcium phosphate material and silk and processes and methods for preparing and uses thereof.
    Type: Grant
    Filed: October 28, 2013
    Date of Patent: March 27, 2018
    Assignee: Tufts University
    Inventors: David L. Kaplan, Tim Jia-Ching Lo, Stephanie McNamara
  • Patent number: 9925301
    Abstract: Provided herein relates to methods for preparing micron range silk fibers (or silk microfibers) and compositions comprising a micron range silk fiber (or a silk microfiber). The micron range silk fibers (or silk microfibers) can be used in various applications ranging from fillers in cosmetics to reinforcement materials to design high strength composites, e.g., reinforced scaffolds. In some embodiments, the silk microfiber-reinforced scaffolds can be used for bone graft applications because of their high compressive strength.
    Type: Grant
    Filed: April 5, 2013
    Date of Patent: March 27, 2018
    Assignee: TRUSTEES OF TUFTS COLLEGE
    Inventors: David L. Kaplan, Biman B. Mandal
  • Publication number: 20180071434
    Abstract: The present disclosure relates to scaffolds such as protein hydrogel scaffolds. The present disclosure provides methods and technologies that permit formation of cavities within hydrogel scaffolds; in some embodiments, such technologies permit controlled formation of cavities of particular predetermined shape and/or arrangement. In particular embodiments, the present disclosure provides multiphoton absorption technologies that achieve production of cavity-containing scaffolds.
    Type: Application
    Filed: September 15, 2016
    Publication date: March 15, 2018
    Inventors: Fiorenzo G. Omenetto, David L. Kaplan, Matthew B. Applegate
  • Publication number: 20180050109
    Abstract: The present application relates to silk fibroin-based materials, methods for making and using the same. Provided materials exhibit shape memory characteristics while showing comparable or better volumetric swelling, biocompatibility and/or degradability when compared to current memory polymers derived from either natural or synthetic materials.
    Type: Application
    Filed: March 11, 2016
    Publication date: February 22, 2018
    Inventors: David L. Kaplan, Fiorenzo G. Omenetto, Joseph E. Brown, Rodrigo R. Jose
  • Publication number: 20180036453
    Abstract: This invention relates to a lamellae tissue layer, comprising a grooved silk fibroin substrate comprising tissue-specific cells. The silk fibroin substrates provides an excellent means of controlling and culturing cell and extracellular matrix development. A multitude of lamellae tissue layers can be used to create a tissue-engineered organ, such as a tissue-engineered cornea. The tissue-engineered organ is non-immunogenic and biocompatible.
    Type: Application
    Filed: May 19, 2017
    Publication date: February 8, 2018
    Inventors: David L. Kaplan, Fiorenzo G. Omenetto, Jeffrey K. Marchant, Noorjahan Panjwani, Brian Lawrence
  • Publication number: 20170333351
    Abstract: Provided herein relates to methods and compositions for preparing a silk microsphere and the resulting silk microsphere. In some embodiments, the methods and compositions described herein are all aqueous, which can be used for encapsulating an active agent in a silk microsphere, while maintaining activity of the active agent during processing. In some embodiments, the resulting silk microsphere can be used for sustained delivery of an active agent encapsulated therein.
    Type: Application
    Filed: July 11, 2017
    Publication date: November 23, 2017
    Inventors: David L. Kaplan, Tuna Yucel, Xiaoqin Wang, Michael Lovett
  • Patent number: 9808557
    Abstract: Described are tubular silk fibroin compositions and methods for their manufacture and use. Tubular compositions as described herein can be produced in a range of high burst strengths, can easily be made in a range of inner diameters, can be derivatized with functional moieties, and can be produced in a range of permeabilities suitable for particularized uses. In one aspect, the tubular compositions can be used in the repair or replacement of damaged or diseased blood vessels, including, but not limited to vessels smaller than about 6 mm.
    Type: Grant
    Filed: August 11, 2008
    Date of Patent: November 7, 2017
    Assignees: Trustees of Tufts College, The Trustees of Columbia University in the City of New York, Massachussets Institute of Technology
    Inventors: Michael L. Lovett, Xianyan Wang, Christopher M. Cannizzaro, Gordana Vunjak-Novakovic, David L. Kaplan
  • Patent number: 9802374
    Abstract: A method of manufacturing a biopolymer sensor including providing a biopolymer, processing the biopolymer to yield a biopolymer matrix solution, adding a biological material in the biopolymer matrix, providing a substrate, casting the matrix solution on the substrate, and drying the biopolymer matrix solution to form a solidified biopolymer sensor on the substrate. A biopolymer sensor is also provided that includes a solidified biopolymer film with an embedded biological material.
    Type: Grant
    Filed: August 9, 2013
    Date of Patent: October 31, 2017
    Assignee: TUFTS UNIVERSITY
    Inventors: David L. Kaplan, Fiorenzo Omenetto, Brian Lawrence, Mark Cronin-Golomb, Irene Georgakoudi
  • Publication number: 20170296696
    Abstract: The present invention provides for concentrated aqueous silk fibroin solutions and an all-aqueous mode for preparation of concentrated aqueous fibroin solutions that avoids the use of organic solvents, direct additives, or harsh chemicals. The invention further provides for the use of these solutions in production of materials, e.g., fibers, films, foams, meshes, scaffolds and hydrogels.
    Type: Application
    Filed: February 16, 2017
    Publication date: October 19, 2017
    Inventors: David L. Kaplan, Ung-Jin Kim, Jaehyung Park, Hyoung-Joon Jin
  • Publication number: 20170258889
    Abstract: Provided herein are methods and compositions for stabilization of active agents. The active agents are distributed, mixed or embedded in a silk fibroin matrix, thereby retaining the bioactivity of the active agents upon storage and/or transportation. In some embodiments, the storage-stable vaccine-silk compositions are also provided herein.
    Type: Application
    Filed: April 20, 2017
    Publication date: September 14, 2017
    Inventors: David L. Kaplan, Fiorenzo G. Omenetto
  • Patent number: 9731052
    Abstract: The invention provides a method for the controlled assembly of layered silk fibroin coatings using aqueous silk fibroin material. The methods described herein can be used to coat substrates of any material, shape, or size. Importantly, the described methods enable control of the biomaterial surface chemistry, thickness, morphology and structure using layered thin film coatings, or bulk coatings. Furthermore, the methods can be performed in all water and do not require intensive chemical processing enabling controlled entrapment of labile molecules such as, drugs, cytokines, and even cells or viruses to generate functional coatings that can be used in a variety of applications.
    Type: Grant
    Filed: May 6, 2015
    Date of Patent: August 15, 2017
    Assignee: Trustees of Tufts College
    Inventors: David L. Kaplan, Xianyan Wang
  • Publication number: 20170218339
    Abstract: The present invention provides, among other things, methods for producing platelets including the steps of providing a silk membrane about 2 ?m and 100 ?m thick, inclusive, contacting the silk membrane with a porogen to form a porous silk membrane comprising at least one silk wall defining a lumen, associating the porous silk membrane with stromal derived factor-1? and at least one functionalizing agent, forming a three dimensional silk matrix comprising interconnected pores wherein the pores have a diameter of between about 5 and 500 ?m, inclusive, wherein the silk matrix is formed around at least a portion of the porous silk membrane, introducing a plurality of megakaryocytes to the silk matrix such that the megakaryocytes are located at least partially within the porous silk matrix, and stimulating the plurality of megakaryocytes to produce platelets. Also provided are various new compositions and methods of making those compositions.
    Type: Application
    Filed: August 6, 2015
    Publication date: August 3, 2017
    Inventors: Alessandra Balduini, David L. Kaplan, Lindsay Wray, Christian Andrea Di Buduo, Lorenzo Tozzi, Ying Chen
  • Patent number: 9694082
    Abstract: This invention provides for compositions, methods and devices for rapidly converting silk fibroin solution into a silk fibroin gel using direct application of voltage, in a process called electrogelation. The silk fibroin gel may be reversibly converted back to liquid form by applying reverse voltage or may be converted further to ?-sheet structure by applying shear force or other treatments. The electrogelated silk may be used as an extracted bulk gel, spray or stream of gel for processing into materials or devices, or may be used as silk gel coating to devices. Active agents may be embedded in the silk gel for various medical applications. This invention also provides for methods and compositions for preparing adhesive silk pH-gels. For example, the method comprises reducing pH level of a silk fibroin solution to increase the bulk or local proton concentration of the silk fibroin solution, thereby forming adhesive silk gels.
    Type: Grant
    Filed: July 2, 2013
    Date of Patent: July 4, 2017
    Assignee: Trustees of Tufts College
    Inventors: David L. Kaplan, Tuna Yucel, Tim Jia-Ching Lo, Gary G. Leisk
  • Publication number: 20170173161
    Abstract: Embodiments of various aspects described herein are directed to silk-based compositions for ocular delivery of at least one active agent, e.g., at least one therapeutic agent and methods of using the same. In some embodiments, the silk-based compositions can provide sustained release of at least one therapeutic agent to at least a portion of an eye. Thus, some embodiments of the silk-based compositions can be used for treatment of an ocular condition, e.g., age-related macular degeneration.
    Type: Application
    Filed: September 28, 2016
    Publication date: June 22, 2017
    Applicants: Trustees of Tufts College, Trustees of Tufts College
    Inventors: David L. Kaplan, Michael L. Lovett, Tuna Yucel, Xiaoqin Wang
  • Patent number: 9674771
    Abstract: Systems and methods for power aggregation are described. One method includes charging an electric resource or vehicle over a power connection to an electric network, obtaining, with a processor, a unique identifier of a device associated with the electric resource or vehicle at the power connection, and determining, with the processor, a location of the electric resource or vehicle from the unique identifier.
    Type: Grant
    Filed: November 25, 2014
    Date of Patent: June 6, 2017
    Assignee: V2Green, Inc.
    Inventors: Seth W. Bridges, Seth B. Pollack, David L. Kaplan
  • Patent number: 9655993
    Abstract: This invention relates to a lamellae tissue layer, comprising a grooved silk fibroin substrate comprising tissue-specific cells. The silk fibroin substrates provides an excellent means of controlling and culturing cell and extracellular matrix development. A multitude of lamellae tissue layers can be used to create a tissue-engineered organ, such as a tissue-engineered cornea. The tissue-engineered organ is non-immunogenic and biocompatible.
    Type: Grant
    Filed: July 7, 2015
    Date of Patent: May 23, 2017
    Assignee: Trustees of Tufts College
    Inventors: David L. Kaplan, Fiorenzo Omenetto, Jeffrey K. Marchant, Noorjahan Panjwani, Brian Lawrence
  • Patent number: 9623147
    Abstract: The present invention provides for concentrated aqueous silk fibroin solutions and an all-aqueous mode for preparation of concentrated aqueous fibroin solutions that avoids the use of organic solvents, direct additives, or harsh chemicals. The invention further provides for the use of these solutions in production of materials, e.g., fibers, films, foams, meshes, scaffolds and hydrogels.
    Type: Grant
    Filed: June 2, 2014
    Date of Patent: April 18, 2017
    Assignee: Trustees of Tufts College
    Inventors: David L. Kaplan, Ung-Jin Kim, Jaehyung Park, Hyoung-Joon Jin
  • Patent number: 9603971
    Abstract: Disclosed herein are pH-dependent silk fibroin-based ionomeric compositions and colloids, and methods of making the same. The state of the silk fibroin ionomeric compositions is reversible and can transform from a gel-like colloid to a more fluid-like solution, or vice versa, upon an environmental stimulus, e.g., pH. Thus, the silk-based ionomeric compositions and colloids can be applied in various industries, ranging from electronic applications to biomedical applications, such as sensors, gel diodes, absorbent materials, drug delivery systems, tissue implants and contrast agents.
    Type: Grant
    Filed: March 4, 2011
    Date of Patent: March 28, 2017
    Assignee: Trustees of Tufts College
    Inventors: David L. Kaplan, Monica A. Serban
  • Patent number: 9603810
    Abstract: The present invention provides for photonic nanoimprinted silk fibroin-based materials and methods for making same, comprising embossing silk fibroin-based films with photonic nanometer scale patterns. In addition, the invention provides for processes by which the silk fibroin-based films can be nanoimprinted at room temperature, by locally decreasing the glass transition temperature of the silk film. Such nanoimprinting process increases high throughput and improves potential for incorporation of silk-based photonics into biomedical and other optical devices.
    Type: Grant
    Filed: April 30, 2014
    Date of Patent: March 28, 2017
    Assignee: TUFTS UNIVERSITY
    Inventors: Jason J. Amsden, David L. Kaplan, Fiorenzo G. Omenetto