Abstract: An intravascular catheter for peri-vascular or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. A method can involve injection/infusion of the ablative fluid over an extended time period of at least 10 seconds or with two injections at two different penetration depths to reduce or eliminate patient pain during ablation.

Abstract: An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand with open ends around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and/or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system also includes means to limit and/or adjust the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The preferred embodiment of the catheter includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall.

Abstract: Safety systems and material testing systems including safety systems are disclosed. An example material testing system includes: an actuator configured to control an operator-accessible component of the material testing system; an actuator disabling circuit configured to disable the actuator; and one or more processors configured to: control the actuator based on a material testing process; monitor a plurality of inputs associated with operation of the material testing system; determine, based on the plurality of inputs and the material testing process, a state of the material testing system from a plurality of predetermined states, the predetermined states comprising one or more unrestricted states and one or more restricted states; and control the actuator disabling circuit based on the determined state.

Abstract: A retainer sleeve configured for use in a retainer system for a ground engaging tool includes a plurality of plate-like sections, each section being flexibly joined with an adjacent section along either a radially inner edge or a portion of a radially outer edge. The radially inner edges of the plurality of sections form part of a segmented inner surface configured for engagement with an outer surface of a locking member of the retainer system. The inner surface extends partially around a central axis of the retainer sleeve to form a substantially C-shaped retainer sleeve having opposite circumferential ends that are spaced from each other. The radially outer edges of the plurality of sections form part of a segmented, frustoconical outer surface configured for engagement in an internal lock cavity of a ground engaging tool tip.

Abstract: A visual characteristic on a physical surface in the physical space is determined from an image of a physical space, with the physical surface including a first area inside the visual characteristic and a second area outside of the visual characteristic. A first region of virtual space that corresponds to the first area and a second region of virtual space that corresponds to the second area is determined based at least in part on the visual characteristic. Information that includes a position and orientation of a digital object relative to the first region and the second region in the virtual space is determined based at least in part on the visual characteristic. The digital object is rendered at a position and orientation in the virtual space in accordance with the information.

Abstract: The disclosed technology can be used to increase lifetimes of quantum coherent devices such as qubits including transmons and xmons and to reduce the losses in resonators. Energy stored in superconducting devices can be lost by emission of phonons that couple to the environment. Defects in one or more materials in the quantum coherent device can cause the coupling to phonons. Patterning one or more of the layers creates a phononic bandgap that reduces or eliminates the emission of the phonons to the environment. The energy then couples back to the quantum coherent device.

Abstract: The present disclosure is directed to centralized de-identification of protected data associated with subjects in multiple modalities based on a hierarchal taxonomy of policies and handlers. In various embodiments, data set(s) associated with subject(s) may be received. Each of the data set(s) may contain data points associated with a respective subject. The data points associated with the respective subject may include multiple data types, at least some of which are usable to identify the respective subject. For each respective subject: a classification of each of the data points may be determined in accordance with a hierarchal taxonomy; based on the classifications, respective handlers for the data points may be identified; and each data point of the plurality of data points may be processed using a respective identified handler, thereby de-identifying the plurality of data points associated with the respective subject.

Abstract: An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and/or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system may also include a means to limit and/or adjust the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The catheter may also include structures which provide radial and/or lateral support to the guide tubes so that the guide tubes expand uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall.

Abstract: Techniques disclosed herein relate to removing potentially identifying features of a specific subject from a data set to prevent re-identification of the subject using an external data source. In various embodiments, the data set contains, as potential identifying features of the specific subject, multiple bursts of temporally-proximate events. Time blocks within the data set can be identified to capture one or more of the bursts of temporally-proximate events for the specific subject. Adding random time shifts for each time block can add noise to the data set and remove or obfuscate the identifying features of a specific subject to generate a time shifted data set.

Abstract: An online social networking system for conducting commerce utilizes a grid environment, a widget architecture including a widget operating system, and semantic integration technologies to provide personalized bundling of products and services tied to an individual's life, emergent marketplaces that support collaboratively-based product and service development, merchandising, and recommendations, emergent user experiences, emergent gaming, emergent behavior predictions, collaborative discover, i.e., social searching, and content and/or people voyeurism. These features are achieved through the use of various techniques including emergent programming, emergent widget processing, emergent computations, emergent applications, widget composition, data integration and exchange, complex system management, security graphs, trust/reputation management, intersecting graphs, database sharding, use of fractal graphs (which may be thinned and expanded), and content mashups.

Abstract: The present invention encompasses compounds of the formula (I) wherein the groups R1, Cy and Y are defined herein, which are suitable for the treatment of diseases related to BTK, and processes for making these compounds, pharmaceutical preparations containing these compounds, and their methods of use.

Abstract: Apparatus and methods for synchronizing media files available from multiple sources provide a mechanism to enhance user interaction with multimedia devices. Additional apparatus, systems, and methods are disclosed.

Abstract: A retainer sleeve configured for use in a retainer system for a ground engaging tool includes a plurality of plate-like sections, each section being flexibly joined with an adjacent section along either a radially inner edge or a portion of a radially outer edge. The radially inner edges of the plurality of sections form part of a segmented inner surface configured for engagement with an outer surface of a locking member of the retainer system. The inner surface extends partially around a central axis of the retainer sleeve to form a substantially C-shaped retainer sleeve having opposite circumferential ends that are spaced from each other. The radially outer edges of the plurality of sections form part of a segmented, frustoconical outer surface configured for engagement in an internal lock cavity of a ground engaging tool tip.

Abstract: A visual characteristic on a physical surface in the physical space is determined from an image of a physical space, with the physical surface including a first area inside the visual characteristic and a second area outside of the visual characteristic. A first region of virtual space that corresponds to the first area and a second region of virtual space that corresponds to the second area is determined based at least in part on the visual characteristic. Information that includes a position and orientation of a digital object relative to the first region and the second region in the virtual space is determined based at least in part on the visual characteristic. The digital object is rendered at a position and orientation in the virtual space in accordance with the information.

Abstract: System (10) for extracting a fetal heart rate from at least one maternal signal using a computer processor (26). The system includes sensors (12-18) attached to a patient to receive abdominal ECG signals and a recorder and digitizer (20) to record and digitize each at least one maternal signal in a maternal signal buffer (22A-22D). The system further includes a peak detector (40) to identify candidate peaks in the maternal signal buffer. The signal stacker (42) of the system stacks the divides at least one maternal signal buffer into a plurality of snippets, each snippet including one candidate peak and a spatial filter (44) to identify and attenuate a maternal QRS signal in the plurality of snippets of the maternal signal buffer, the spatial filter including at least one of principal component analysis and orthogonal projection, to produce a raw fetal ECG signal which is stored in a raw fetal ECG buffer.

Abstract: The disclosed technology can be used to increase lifetimes of quantum coherent devices such as qubits including transmons and xmons and to reduce the losses in resonators. Energy stored in superconducting devices can be lost by emission of phonons that couple to the environment. Defects in one or more materials in the quantum coherent device can cause the coupling to phonons. Patterning one or more of the layers creates a phononic bandgap that reduces or eliminates the emission of the phonons to the environment. The energy then couples back to the quantum coherent device.

Abstract: System (10) for extracting a fetal heart rate from at least one maternal signal using a computer processor (26). The system includes sensors (12-18) attached to a patient to receive abdominal ECG signals and a recorder and digitizer (20) to record and digitize each at least one maternal signal in a maternal signal buffer (22A-22D). The system further includes a peak detector (40) to identify candidate peaks in the maternal signal buffer. The signal stacker (42) of the system stacks the divides at least one maternal signal buffer into a plurality of snippets, each snippet including one candidate peak and a spatial filter (44) to identify and attenuate a maternal QRS signal in the plurality of snippets of the maternal signal buffer, the spatial filter including at least one of principal component analysis and orthogonal projection, to produce a raw fetal ECG signal which is stored in a raw fetal ECG buffer.

Abstract: A method (100) for training a scoring system (600) comprising the steps of: (i) providing (110) a scoring system comprising a scoring module (606); (ii) receiving (120) a training dataset comprising a plurality of patient data and treatment outcomes; (iii) analyzing (130), using a clinical decision support algorithm, the training dataset to generate a plurality of clinical decision support recommendations; (iv) clustering (140), using the scoring module, the plurality of clinical decision support recommendations into a plurality of clusters; and (v) identifying (160), using the scoring module, one or more features of at least one of the plurality of clusters, and generating, based on the identified one or more features, one or more inclusion criteria for the at least one of the plurality of clusters.

Abstract: The present disclosure provides systems and methods that allow a first user to anchor a virtual object to a physical location and a second user to view the virtual object at the physical location. In particular, aspects of the present disclosure are directed to workflows, application programming interfaces (“APIs”), and computing system infrastructure that enable a first computing device to generate an ad hoc mapping of its physical surroundings (e.g., based on sensor data collected by the first device) and to position and anchor a virtual object at a physical location within such mapping. Data descriptive of the mapping and virtual object can be stored in a cloud database and can then be used by or for a second device to render the virtual object at the location of the anchor.

Abstract: The present disclosure is directed toward a system that includes a first optical sensor, a second optical sensor, and a gear feature controller. The first optical sensor measures a plurality of first distances measured from a first reference point to a surface provided between a pair of adjacent teeth among a plurality of teeth circumferentially distributed about a first side of a gear. The second optical sensor measures a plurality of second distances measured from a second reference point to a surface along a second side of the gear opposite the first side. The gear feature controller configured to determine a stock removal amount of the gear based on the first distances and the second distances.