Abstract: A channel mode switching method, a device, and a storage medium. When a user uses an electronic device to make a real-time voice call with another device, or exchange voice chat messages with another device, the electronic device can detect a volume change in real time. When a specified current volume is low, a private channel mode may be used. This reduces far-field loudness and maintains near-field loudness when the electronic device plays voice content. When a specified current volume is high, the user may use a standard channel mode to play sound at a high volume in both a near field and a far field. In this method, a playing volume can be adjusted depending on an actual requirement, and channel mode switching can be performed in real time, privacy and security of the user can be protected.

Abstract: The present disclosure relates to the field of biomedicine, and specifically provides a 5?-phosphate modified nucleoside, and a preparation method and use thereof. The present disclosure provides a modified nucleoside compound, wherein the modified nucleoside compound is a compound represented by formula (I), a pharmaceutically acceptable salt thereof, or a stereoisomer thereof. The oligonucleotide comprising the modified nucleoside compound provided by the present disclosure exhibits significantly enhanced drug efficacy.

Abstract: This application discloses a beauty instrument which includes: a housing, where the housing includes a working head; and an electrical stimulation component which includes an EMS stimulation circuit, an RF radio frequency circuit, and a ring electrode, a first group of electrodes, and a second group of electrodes that are all disposed on the working head, the ring electrode is separately connected to the EMS stimulation circuit and the RF radio frequency circuit, the first group of electrodes includes a plurality of first electrodes that are distributed at intervals around the ring electrode, the plurality of first electrodes are all connected to the RF radio frequency circuit and/or connected to the EMS stimulation circuit, the second group of electrodes includes a plurality of second electrodes that are all connected to the EMS stimulation circuit.

Abstract: The present invention discloses a Toll-like receptor agonist-based vaccine adjuvant lipid compound and use thereof, and specifically discloses a compound of formula (I), or a stereoisomer, an N-oxide, a solvate, or a pharmaceutically acceptable salt thereof. The mRNA-TLP composition prepared from the adjuvant lipid compound of the present disclosure significantly enhances targeting to antigen-presenting cells in mouse spleen and can significantly inhibit tumor growth.

Abstract: An event prediction method based on a satellite orbit threat domain knowledge graph is provided. By constructing a knowledge graph of the satellite orbit threat domain, and utilizing steps such as meta-path extraction, hyperedge construction, feature encoding, and feature aggregation, target features that can comprehensively and accurately describe each entity and the complex relationships between each entity in the satellite orbit threat domain are obtained, and a prediction model is trained by using the target features of each entity.

Abstract: A control method for a wired braking system includes, when estimating that the current forward stroke of the main piston cannot satisfy the braking request, executing the current forward stroke until the stroke of the main piston reaches a first threshold, and then cutting off the communication between the master brake cylinder and each of the sub-brake cylinders; retracting the main piston until the master brake cylinder communicates with the reservoir, allowing brake fluid from the reservoir to replenish the master brake cylinder; advancing the main piston again and re-establishing communication between the master brake cylinder and each of the sub-brake cylinders to further increase the brake fluid pressure in each of the sub-brake cylinders; and estimating again whether the current forward stroke can satisfy the braking request.

Abstract: A computer-implemented method of controlling a patient positioning apparatus for a radiotherapy system. The patient positioning apparatus comprises a tiltable patient support apparatus. The method comprises receiving a reference position of the patient support apparatus, and determining a position adjustment signal for controlling at least one actuator to adjust the position of the patient positioning apparatus from a current position to the reference position based on a parameter dependent on a physical characteristic of a patient.

Abstract: An electromechanical brake includes a main braking module and a braking actuator module. The main braking module includes (i) a motor, (ii) an electronic control unit, and (iii) a housing having an outer wall defining a notch. The braking actuator module includes (i) a housing having a housing wall defining a cavity, and (ii) an actuator assembly disposed in the cavity. The actuator assembly includes a spindle supported by a bearing on an inner side of the housing wall. The housing wall is positioned in the notch, such that (i) the outer wall is positioned to surround the housing wall, and (ii) the motor is connected to the spindle for transmission.

Abstract: An optical connector has a first connection end configured to fit with a peer adapter. The electrical connector has a second connection end configured to fit with the peer adapter. The first connection end and the second connection end have a same opening direction. In addition, the first connection end may slide along a plugging direction of the peer adapter relative to the second connection end. The first connection end is configured to be connected to the peer adapter before the second connection end. The optical connector is connected to the peer adapter before the electrical connector. This ensures that a channel for transmitting an optical signal is communicated before a channel for transmitting an electrical signal is communicated, thereby avoiding fiber burning and improving security and reliability of the opto-electronic adapter during use.

Abstract: The present disclosure relates to the field of beauty instruments, and a skin care assembly are disclosed. The skin care assembly provided in the present disclosure includes a first cover, an electrode, and a cold compress component. The electrode is fixed on the first cover to discharge for a skin. The first cover is defined with a first opening, and the cold compress component is received in the first opening to contact and cool the skin during the electrode discharging for the skin. The electrode may provide a beauty effect to the skin by generating micro-current and radio frequency, and the cold compress component provides a suitable environment temperature for the skin, thus the beauty effect is improved.

Abstract: A beauty device including an isolation circuit and a working circuit is provided. A first terminal of the isolation circuit is configured to access a test voltage or output a driving signal, and a second terminal of the isolation circuit is electrically connected to the working circuit. The working circuit is configured to output the driving signal to the isolation circuit.

Abstract: Embodiments of the disclosure provide a method, an apparatus, a device and a storage medium for object processing. The method for object processing includes: in response to receiving a predetermined operation by a user on a first selection control for pre-trained at least one generic model presented in a user interface, selecting the at least one generic model; at least acquiring at least one generic feature that is generated by the at least one generic model and associated with a sample of an object of a target category among a plurality of categories; and training an individual model for processing the object of the target category at least based at least on the at least one generic feature and annotation information of the sample of the object of the target category. Therefore, the efficiency of model training can be improved.

Abstract: Disclosed herein are compounds, and salts thereof, which inhibit targeted NRAS mutants, pharmaceutical formulations, and methods of treatment of NRAS-mediated diseases, such as certain cancers.

Abstract: The present disclosure relates generally to processes for preparing seladelpar, an agonist of peroxisome proliferator-activated receptor (PPAR)-delta, and compositions thereof.

Abstract: An optical connector has a first connection end configured to fit with a peer adapter. The electrical connector has a second connection end configured to fit with the peer adapter. The first connection end and the second connection end have a same opening direction. In addition, the first connection end may slide along a plugging direction of the peer adapter relative to the second connection end. The first connection end is configured to be connected to the peer adapter before the second connection end. The optical connector is connected to the peer adapter before the electrical connector. This ensures that a channel for transmitting an optical signal is communicated before a channel for transmitting an electrical signal is communicated, thereby avoiding fiber burning and improving security and reliability of the opto-electronic adapter during use.

Abstract: An event prediction method based on a satellite orbit threat domain knowledge graph is provided. By constructing a knowledge graph of the satellite orbit threat domain, and utilizing steps such as meta-path extraction, hyperedge construction, feature encoding, and feature aggregation, target features that can comprehensively and accurately describe each entity and the complex relationships between each entity in the satellite orbit threat domain are obtained, and a prediction model is trained by using the target features of each entity.

Abstract: The present disclosure describes systems and methods for naturally joining human talking sounds. An example method includes determining a first audio sequence and a second audio sequence from a full audio sequence based on a desired edit point. The method also includes determining a first separation point that defines a front portion of the first audio sequence and a back portion of the first audio sequence. The method yet further includes determining a second separation point that defines a front portion of the second audio sequence and a back portion of the second audio sequence, further defining an audio portion to be replaced. The method includes determining a regenerated audio portion, blending the regenerated audio portion with respective extensions of the front portion of the first audio sequence and the back portion of the second audio sequence, and replacing the audio portion to be replaced with the blended regenerated audio.

Abstract: The present application provides a multi-surface airtight packaging ceramic shell, a multi-surface packaging device, and preparation method, belonging to the field of ceramic packaging technology. The multi-surface airtight packaging ceramic shell includes: a ceramic body, a shape of which is a polyhedron; where at least one surface of the ceramic body is provided with a shared solder pad, remaining surfaces other than the at least one surface having the shared solder pad are provided with sealing rings, and a packaging cavity for packaging a chip is formed inside each sealing ring. The ceramic body provided in the present application is a polyhedron, with one surface of shared solder pad as the bottom surface, and the other surfaces having chip mounting areas, bonding areas, and sealing rings.

Abstract: This application relates to a configuration method and system for a drive circuit in an optical module. The method includes: A motherboard obtains port number information of the optical module; determines target link configuration information based on a link configuration information list in the motherboard and the port number information of the optical module, where the link configuration information list includes port numbers of a plurality of ports on the motherboard and link configuration information of the plurality of ports; and sends the target link configuration information to the optical module, so that the optical module configures the drive circuit in the optical module based on the target link configuration information. According to embodiments of this application, the drive circuit in the optical module can be automatically configured. This helps improve configuration efficiency of the drive circuit in the optical module.

Abstract: The present application provides a multi-surface airtight packaging ceramic shell, a multi-surface packaging device, and preparation method, belonging to the field of ceramic packaging technology. The multi-surface airtight packaging ceramic shell includes: a ceramic body, a shape of which is a polyhedron; where at least one surface of the ceramic body is provided with a shared solder pad, remaining surfaces other than the at least one surface having the shared solder pad are provided with sealing rings, and a packaging cavity for packaging a chip is formed inside each sealing ring. The ceramic body provided in the present application is a polyhedron, with one surface of shared solder pad as the bottom surface, and the other surfaces having chip mounting areas, bonding areas, and sealing rings.